JP2017536096A - 胎盤由来の接着細胞エクソソームおよびそれらの使用 - Google Patents

胎盤由来の接着細胞エクソソームおよびそれらの使用 Download PDF

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JP2017536096A
JP2017536096A JP2017518955A JP2017518955A JP2017536096A JP 2017536096 A JP2017536096 A JP 2017536096A JP 2017518955 A JP2017518955 A JP 2017518955A JP 2017518955 A JP2017518955 A JP 2017518955A JP 2017536096 A JP2017536096 A JP 2017536096A
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placenta
exosomes
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ロウ エリック
ロウ エリック
モルスチャウセル アンドリュー
モルスチャウセル アンドリュー
フランキ アレクサンダー
フランキ アレクサンダー
パレデス ジェニファー
パレデス ジェニファー
イー．カラシエウィクズ−メンデズ キャシー
イー．カラシエウィクズ−メンデズ キャシー
レデュータ アラン
レデュータ アラン
ジャンコビク ウラジミール
ジャンコビク ウラジミール
ドジュレティク イバナ
ドジュレティク イバナ
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アントフロゲネシス コーポレーション
アントフロゲネシス コーポレーション
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    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
    • C12N2502/025—Coculture with; Conditioned medium produced by embryonic cells extra-embryonic cells, e.g. amniotic epithelium, placental cells, Wharton's jelly

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  • Gastroenterology & Hepatology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017518955A 2014-10-09 2015-10-08 胎盤由来の接着細胞エクソソームおよびそれらの使用 Pending JP2017536096A (ja)

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US201462062046P 2014-10-09 2014-10-09
US62/062,046 2014-10-09
PCT/US2015/054629 WO2016057755A1 (en) 2014-10-09 2015-10-08 Placenta-derived adherent cell exosomes and uses thereof

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JP2017536096A true JP2017536096A (ja) 2017-12-07
JP2017536096A5 JP2017536096A5 (https=) 2018-12-06

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JP2017518955A Pending JP2017536096A (ja) 2014-10-09 2015-10-08 胎盤由来の接着細胞エクソソームおよびそれらの使用
JP2020185503A Withdrawn JP2021040635A (ja) 2014-10-09 2020-11-06 胎盤由来の接着細胞エクソソームおよびそれらの使用
JP2022160666A Pending JP2023011580A (ja) 2014-10-09 2022-10-05 胎盤由来の接着細胞エクソソームおよびそれらの使用

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JP2022160666A Pending JP2023011580A (ja) 2014-10-09 2022-10-05 胎盤由来の接着細胞エクソソームおよびそれらの使用

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US (3) US20170252379A1 (https=)
EP (1) EP3204022B1 (https=)
JP (3) JP2017536096A (https=)
CN (2) CN107106615A (https=)
AU (2) AU2015330855A1 (https=)
CA (1) CA2964114A1 (https=)
DK (1) DK3204022T3 (https=)
WO (1) WO2016057755A1 (https=)

Cited By (3)

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JP2020522996A (ja) * 2018-06-19 2020-08-06 フーワイ ホスピタル， チャイニーズ アカデミー オブ メディカル サイエンシズ アンド ペキン ユニオン メディカル カレッジ 薬剤前処理による間葉系幹細胞由来エクソソームの調製方法
JP2021511833A (ja) * 2018-01-30 2021-05-13 ヒストジェン インコーポレイテッド 低酸素条件下にて培養された細胞に由来する細胞外小胞およびその使用方法
WO2021210852A1 (ko) * 2020-04-14 2021-10-21 (주)녹십자웰빙 태반 유래 물질을 포함하는 항바이러스 조성물

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KR102888521B1 (ko) 2015-04-06 2025-11-19 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna
EP3307890A1 (en) 2015-06-10 2018-04-18 Board of Regents, The University of Texas System Use of exosomes for the treatment of disease
JP2019514416A (ja) * 2016-05-16 2019-06-06 エグゾステム バイオテック リミテッド 間葉系幹細胞と筋損傷及び筋肉関連疾患の治療のための間葉系幹細胞の使用
US10767175B2 (en) 2016-06-08 2020-09-08 Agilent Technologies, Inc. High specificity genome editing using chemically modified guide RNAs
CA3062426A1 (en) 2017-05-08 2018-11-15 Flagship Pioneering Innovations V, Inc. Compositions for facilitating membrane fusion and uses thereof
WO2018208702A1 (en) * 2017-05-09 2018-11-15 Saint Louis University Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes
CA3064064A1 (en) * 2017-05-16 2018-11-22 Exostem Biotec Ltd. Methods of inhibiting aging and treating aging-related disorders
JP7399712B2 (ja) * 2017-05-24 2023-12-18 ナノソミックス・インコーポレイテッド 疾病および障害の診断および予後判定のための小胞上のバイオマーカーの検出
KR102109950B1 (ko) * 2017-06-02 2020-05-12 (주)엑솔런스바이오테크놀로지 체외충격파를 이용한 세포외소포체 내로의 표적물질 전달방법
IL272786B2 (en) 2017-08-25 2025-03-01 Codiak Biosciences Inc Preparation of therapeutic exosomes using membrane proteins
KR102335710B1 (ko) * 2017-10-31 2021-12-07 (주)아모레퍼시픽 유산균 유래의 세포밖 베지클을 포함하는 면역조절용 조성물
GB201718681D0 (en) * 2017-11-13 2017-12-27 Evox Therapeutics Ltd Protein engineered extracellular vesicles
MX2020005100A (es) * 2017-11-16 2020-11-24 Celularity Inc Cultivo de placenta para aislar exosomas.
US12036325B2 (en) 2017-12-14 2024-07-16 Mayo Foundation For Medical Education And Research Purified exosome products, method of making, and methods of using
CN111655271B (zh) 2017-12-28 2025-09-23 隆萨销售股份公司 用于免疫肿瘤学和抗炎疗法的外来体
JP2021531828A (ja) * 2018-07-24 2021-11-25 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 細胞外小胞を形質転換することを伴う組成物及び方法
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CN109554341B (zh) * 2018-12-18 2021-11-19 深圳先进技术研究院 无创超声处理细胞在制备外泌体中的应用、外泌体及其制备方法和应用
CN110093274B (zh) * 2019-05-13 2020-08-11 山东大学 一种增加细胞产生的细胞外囊泡数量的挤压装置及其应用
CA3142020A1 (en) * 2019-06-19 2020-12-24 Celularity Inc. Exosomes for disease treatment
KR20220030552A (ko) * 2020-09-03 2022-03-11 (주)녹십자웰빙 태반 유래 엑소좀을 포함하는 간세포 증식 또는 항염증 효능 조성물
JP2024534945A (ja) 2021-09-10 2024-09-26 アジレント・テクノロジーズ・インク 化学修飾を有するプライム編集のためのガイドｒｎａ
WO2024102969A1 (en) * 2022-11-10 2024-05-16 Board Of Regents, The University Of Texas System Use of fecal derivatives and fecal derived extracellular vesicles to enhance immunity
CN117050936A (zh) * 2023-07-11 2023-11-14 清华大学 新亚群的人脐带间充质干细胞、其外泌体、制剂和应用

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US20130195899A1 (en) * 2012-01-31 2013-08-01 Medistem, Inc. Therapeutic immune modulation by stem cell secreted exosomes
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Cited By (3)

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Publication number Priority date Publication date Assignee Title
JP2021511833A (ja) * 2018-01-30 2021-05-13 ヒストジェン インコーポレイテッド 低酸素条件下にて培養された細胞に由来する細胞外小胞およびその使用方法
JP2020522996A (ja) * 2018-06-19 2020-08-06 フーワイ ホスピタル， チャイニーズ アカデミー オブ メディカル サイエンシズ アンド ペキン ユニオン メディカル カレッジ 薬剤前処理による間葉系幹細胞由来エクソソームの調製方法
WO2021210852A1 (ko) * 2020-04-14 2021-10-21 (주)녹십자웰빙 태반 유래 물질을 포함하는 항바이러스 조성물

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WO2016057755A1 (en) 2016-04-14
EP3204022A4 (en) 2018-06-13
CN107106615A (zh) 2017-08-29
CN116731958A (zh) 2023-09-12
DK3204022T3 (da) 2021-03-08
US20170252379A1 (en) 2017-09-07
AU2015330855A1 (en) 2017-04-27
EP3204022A1 (en) 2017-08-16
EP3204022B1 (en) 2020-12-02
JP2021040635A (ja) 2021-03-18
JP2023011580A (ja) 2023-01-24
CA2964114A1 (en) 2016-04-14
US11173182B1 (en) 2021-11-16
US20220241347A1 (en) 2022-08-04
AU2021204332A1 (en) 2021-07-22

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