JP2017536096A5 - - Google Patents
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- JP2017536096A5 JP2017536096A5 JP2017518955A JP2017518955A JP2017536096A5 JP 2017536096 A5 JP2017536096 A5 JP 2017536096A5 JP 2017518955 A JP2017518955 A JP 2017518955A JP 2017518955 A JP2017518955 A JP 2017518955A JP 2017536096 A5 JP2017536096 A5 JP 2017536096A5
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- JP
- Japan
- Prior art keywords
- composition
- mir
- exosomes
- derived
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 35
- 210000001808 exosome Anatomy 0.000 claims description 34
- 210000004027 cell Anatomy 0.000 claims description 30
- 230000001464 adherent effect Effects 0.000 claims description 29
- 210000002826 placenta Anatomy 0.000 claims description 15
- 238000012239 gene modification Methods 0.000 claims description 12
- 230000005017 genetic modification Effects 0.000 claims description 12
- 235000013617 genetically modified food Nutrition 0.000 claims description 12
- 102100025680 Complement decay-accelerating factor Human genes 0.000 claims description 6
- 102100031780 Endonuclease Human genes 0.000 claims description 6
- 108010042407 Endonucleases Proteins 0.000 claims description 6
- 108020005004 Guide RNA Proteins 0.000 claims description 6
- 101000856022 Homo sapiens Complement decay-accelerating factor Proteins 0.000 claims description 6
- 102000003729 Neprilysin Human genes 0.000 claims description 6
- 108090000028 Neprilysin Proteins 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- 102100033400 4F2 cell-surface antigen heavy chain Human genes 0.000 claims description 4
- 102100022464 5'-nucleotidase Human genes 0.000 claims description 4
- 102100022749 Aminopeptidase N Human genes 0.000 claims description 4
- 102100032912 CD44 antigen Human genes 0.000 claims description 4
- 102100022002 CD59 glycoprotein Human genes 0.000 claims description 4
- 102100025222 CD63 antigen Human genes 0.000 claims description 4
- 102100027221 CD81 antigen Human genes 0.000 claims description 4
- 102100027217 CD82 antigen Human genes 0.000 claims description 4
- 101000800023 Homo sapiens 4F2 cell-surface antigen heavy chain Proteins 0.000 claims description 4
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims description 4
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims description 4
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 4
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims description 4
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims description 4
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims description 4
- 101000914469 Homo sapiens CD82 antigen Proteins 0.000 claims description 4
- 101001078133 Homo sapiens Integrin alpha-2 Proteins 0.000 claims description 4
- 101000994378 Homo sapiens Integrin alpha-3 Proteins 0.000 claims description 4
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims description 4
- 101000605020 Homo sapiens Large neutral amino acids transporter small subunit 1 Proteins 0.000 claims description 4
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims description 4
- 102100025305 Integrin alpha-2 Human genes 0.000 claims description 4
- 102100032819 Integrin alpha-3 Human genes 0.000 claims description 4
- 102100025304 Integrin beta-1 Human genes 0.000 claims description 4
- 108700011259 MicroRNAs Proteins 0.000 claims description 4
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims description 4
- 239000002679 microRNA Substances 0.000 claims description 4
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 4
- 229930182490 saponin Natural products 0.000 claims description 4
- 150000007949 saponins Chemical class 0.000 claims description 4
- 230000033115 angiogenesis Effects 0.000 claims description 3
- 230000008774 maternal effect Effects 0.000 claims description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 2
- 210000000987 immune system Anatomy 0.000 claims description 2
- 238000011534 incubation Methods 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 108091091807 let-7a stem-loop Proteins 0.000 claims description 2
- 108091057746 let-7a-4 stem-loop Proteins 0.000 claims description 2
- 108091028376 let-7a-5 stem-loop Proteins 0.000 claims description 2
- 108091024393 let-7a-6 stem-loop Proteins 0.000 claims description 2
- 108091091174 let-7a-7 stem-loop Proteins 0.000 claims description 2
- 108091050724 let-7b stem-loop Proteins 0.000 claims description 2
- 108091033753 let-7d stem-loop Proteins 0.000 claims description 2
- 108091079176 let-7d-1 stem-loop Proteins 0.000 claims description 2
- 108091036331 let-7d-2 stem-loop Proteins 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 2
- 108091056924 miR-124 stem-loop Proteins 0.000 claims description 2
- 108091079016 miR-133b Proteins 0.000 claims description 2
- 108091043162 miR-133b stem-loop Proteins 0.000 claims description 2
- 108091079658 miR-142-1 stem-loop Proteins 0.000 claims description 2
- 108091071830 miR-142-2 stem-loop Proteins 0.000 claims description 2
- 108091027943 miR-16 stem-loop Proteins 0.000 claims description 2
- 108091074057 miR-16-1 stem-loop Proteins 0.000 claims description 2
- 108091056204 miR-16-2 stem-loop Proteins 0.000 claims description 2
- 108091065218 miR-218-1 stem-loop Proteins 0.000 claims description 2
- 108091054980 miR-218-2 stem-loop Proteins 0.000 claims description 2
- 108091086421 miR-223 stem-loop Proteins 0.000 claims description 2
- 108091036689 miR-296 stem-loop Proteins 0.000 claims description 2
- 108091044721 miR-422a stem-loop Proteins 0.000 claims description 2
- -1 miR-451 Proteins 0.000 claims description 2
- 108091047658 miR-564 stem-loop Proteins 0.000 claims description 2
- 108091086737 miR-630 stem-loop Proteins 0.000 claims description 2
- 108091059456 miR-92-1 stem-loop Proteins 0.000 claims description 2
- 108091084336 miR-92-2 stem-loop Proteins 0.000 claims description 2
- 108091027963 non-coding RNA Proteins 0.000 claims description 2
- 102000042567 non-coding RNA Human genes 0.000 claims description 2
- 238000000527 sonication Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 230000008823 permeabilization Effects 0.000 description 2
- 206010029113 Neovascularisation Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462062046P | 2014-10-09 | 2014-10-09 | |
| US62/062,046 | 2014-10-09 | ||
| PCT/US2015/054629 WO2016057755A1 (en) | 2014-10-09 | 2015-10-08 | Placenta-derived adherent cell exosomes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020185503A Division JP2021040635A (ja) | 2014-10-09 | 2020-11-06 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017536096A JP2017536096A (ja) | 2017-12-07 |
| JP2017536096A5 true JP2017536096A5 (https=) | 2018-12-06 |
Family
ID=55653751
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518955A Pending JP2017536096A (ja) | 2014-10-09 | 2015-10-08 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
| JP2020185503A Withdrawn JP2021040635A (ja) | 2014-10-09 | 2020-11-06 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
| JP2022160666A Pending JP2023011580A (ja) | 2014-10-09 | 2022-10-05 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020185503A Withdrawn JP2021040635A (ja) | 2014-10-09 | 2020-11-06 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
| JP2022160666A Pending JP2023011580A (ja) | 2014-10-09 | 2022-10-05 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20170252379A1 (https=) |
| EP (1) | EP3204022B1 (https=) |
| JP (3) | JP2017536096A (https=) |
| CN (2) | CN107106615A (https=) |
| AU (2) | AU2015330855A1 (https=) |
| CA (1) | CA2964114A1 (https=) |
| DK (1) | DK3204022T3 (https=) |
| WO (1) | WO2016057755A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10900034B2 (en) | 2014-12-03 | 2021-01-26 | Agilent Technologies, Inc. | Guide RNA with chemical modifications |
| EP3280803B1 (en) | 2015-04-06 | 2021-05-26 | The Board of Trustees of the Leland Stanford Junior University | Chemically modified guide rnas for crispr/cas-mediated gene regulation |
| US20180177727A1 (en) | 2015-06-10 | 2018-06-28 | Board Of Regents, The University Of Texas System | Use of exosomes for the treatment of disease |
| CA3023349A1 (en) * | 2016-05-16 | 2017-11-23 | Exostem Biotec Ltd. | Mesenchymal stem cell and use thereof for treatment of muscle injury and muscle-associated diseases |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| AU2018266111B2 (en) | 2017-05-08 | 2024-11-07 | Flagship Pioneering Innovations V, Inc. | Compositions for facilitating membrane fusion and uses thereof |
| US20200163993A1 (en) * | 2017-05-09 | 2020-05-28 | Saint Louis University | Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes |
| US20200188440A1 (en) * | 2017-05-16 | 2020-06-18 | Exostem Biotec Ltd. | Methods of inhibiting aging and treating aging-related disorders |
| IL270864B2 (en) * | 2017-05-24 | 2025-01-01 | Nanosomix Inc | Identification of biomarkers on vesicles for diagnosis and prognosis of diseases and disorders |
| KR102109950B1 (ko) * | 2017-06-02 | 2020-05-12 | (주)엑솔런스바이오테크놀로지 | 체외충격파를 이용한 세포외소포체 내로의 표적물질 전달방법 |
| EP3672573A4 (en) | 2017-08-25 | 2021-05-26 | Codiak BioSciences, Inc. | PREPARATION OF THERAPEUTIC EXOSOMES USING MEMBRANE PROTEINS |
| KR102335710B1 (ko) * | 2017-10-31 | 2021-12-07 | (주)아모레퍼시픽 | 유산균 유래의 세포밖 베지클을 포함하는 면역조절용 조성물 |
| GB201718681D0 (en) * | 2017-11-13 | 2017-12-27 | Evox Therapeutics Ltd | Protein engineered extracellular vesicles |
| CA3082880A1 (en) * | 2017-11-16 | 2019-05-23 | Celularity Inc. | Cultivation of placenta to isolate exosomes |
| WO2019118817A1 (en) * | 2017-12-14 | 2019-06-20 | Mayo Foundation For Medical Education And Research | Purified exosome products, method of making, and methods of using |
| AU2018394238A1 (en) | 2017-12-28 | 2020-06-18 | Lonza Sales Ag | Exosomes for immuno-oncology and anti-inflammatory therapy |
| CN112384200A (zh) * | 2018-01-30 | 2021-02-19 | 希斯托金公司 | 低氧条件下培养的细胞衍生的胞外囊泡及其用途 |
| KR102235141B1 (ko) * | 2018-06-19 | 2021-04-05 | 푸와이 하스피틀, 차이니즈 아카데미 오브 메디컬 사이언시즈 앤드 페킹 유니언 메디컬 칼리지 | 약물 전처리에 기초한 간엽 줄기세포 유래 엑소좀 제조방법 |
| AU2019312212B2 (en) * | 2018-07-24 | 2024-10-10 | Mayo Foundation For Medical Education And Research | Compositions and methods involving transforming extracellular vesicles |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN109554341B (zh) * | 2018-12-18 | 2021-11-19 | 深圳先进技术研究院 | 无创超声处理细胞在制备外泌体中的应用、外泌体及其制备方法和应用 |
| CN110093274B (zh) * | 2019-05-13 | 2020-08-11 | 山东大学 | 一种增加细胞产生的细胞外囊泡数量的挤压装置及其应用 |
| PH12021553167A1 (en) * | 2019-06-19 | 2022-08-15 | Celularity Inc | Exosomes for disease treatment |
| WO2021210852A1 (ko) * | 2020-04-14 | 2021-10-21 | (주)녹십자웰빙 | 태반 유래 물질을 포함하는 항바이러스 조성물 |
| KR20220030552A (ko) * | 2020-09-03 | 2022-03-11 | (주)녹십자웰빙 | 태반 유래 엑소좀을 포함하는 간세포 증식 또는 항염증 효능 조성물 |
| JP2024534945A (ja) | 2021-09-10 | 2024-09-26 | アジレント・テクノロジーズ・インク | 化学修飾を有するプライム編集のためのガイドｒｎａ |
| WO2024102969A1 (en) * | 2022-11-10 | 2024-05-16 | Board Of Regents, The University Of Texas System | Use of fecal derivatives and fecal derived extracellular vesicles to enhance immunity |
| CN117050936A (zh) * | 2023-07-11 | 2023-11-14 | 清华大学 | 新亚群的人脐带间充质干细胞、其外泌体、制剂和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2316918B1 (en) | 2001-02-14 | 2015-07-01 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| PL2471907T3 (pl) | 2005-12-29 | 2019-07-31 | Celularity, Inc. | Populacje komórek macierzystych łożyska |
| CA2734237C (en) | 2008-08-20 | 2019-07-02 | Anthrogenesis Corporation | Treatment of stroke using isolated placental cells |
| RU2539786C2 (ru) * | 2008-09-02 | 2015-01-27 | Плуристем Лтд. | Выращенные в прикрепленной к субстрату культуре клетки из ткани плаценты и их использование при лечении |
| GB2463401B (en) * | 2008-11-12 | 2014-01-29 | Caris Life Sciences Luxembourg Holdings S A R L | Characterizing prostate disorders by analysis of microvesicles |
| FR2950360B1 (fr) * | 2009-09-22 | 2011-11-25 | Centre Nat Rech Scient | Procede d'imagerie cellulaire pour la visualisation de la biogenese des microarns dans les cellules |
| DK2556145T3 (en) * | 2010-04-07 | 2016-11-07 | Anthrogenesis Corp | Angiogenesis using placental stem cells |
| EP2691101A2 (en) * | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| EP2721179A4 (en) * | 2011-06-16 | 2014-10-01 | Caris Life Sciences Luxembourg Holdings S A R L | BIOMARKER COMPOSITIONS AND METHOD THEREFOR |
| US11391741B2 (en) * | 2011-12-22 | 2022-07-19 | Theoria Science Inc. | Method of exosome analysis, reagent for exosome analysis, and analyzer for exosome |
| US9427450B2 (en) * | 2012-01-31 | 2016-08-30 | Xon Cells, Inc. | Therapeutic immune modulation by stem cell secreted exosomes |
| WO2014022852A1 (en) * | 2012-08-03 | 2014-02-06 | Aptamir Therapeutics, Inc. | Cell-specific delivery of mirna modulators for the treatment of obesity and related disorders |
| AU2013302799B2 (en) * | 2012-08-13 | 2018-03-01 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| DK2931897T3 (en) * | 2012-12-12 | 2018-02-05 | Broad Inst Inc | CONSTRUCTION, MODIFICATION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTICAL APPLICATIONS |
| EP2935628B1 (en) * | 2012-12-19 | 2018-03-21 | Caris Life Sciences Switzerland Holdings GmbH | Compositions and methods for aptamer screening |
| EP3608022A1 (en) * | 2013-03-15 | 2020-02-12 | The Trustees of Princeton University | Methods and devices for high throughput purification |
-
2015
- 2015-10-08 CN CN201580054280.7A patent/CN107106615A/zh active Pending
- 2015-10-08 CA CA2964114A patent/CA2964114A1/en active Pending
- 2015-10-08 US US15/517,438 patent/US20170252379A1/en not_active Abandoned
- 2015-10-08 AU AU2015330855A patent/AU2015330855A1/en not_active Abandoned
- 2015-10-08 DK DK15849339.5T patent/DK3204022T3/da active
- 2015-10-08 EP EP15849339.5A patent/EP3204022B1/en not_active Revoked
- 2015-10-08 CN CN202310711769.3A patent/CN116731958A/zh active Pending
- 2015-10-08 WO PCT/US2015/054629 patent/WO2016057755A1/en not_active Ceased
- 2015-10-08 JP JP2017518955A patent/JP2017536096A/ja active Pending
-
2020
- 2020-01-10 US US16/740,054 patent/US11173182B1/en not_active Expired - Fee Related
- 2020-11-06 JP JP2020185503A patent/JP2021040635A/ja not_active Withdrawn
-
2021
- 2021-06-25 AU AU2021204332A patent/AU2021204332A1/en not_active Abandoned
- 2021-10-07 US US17/495,985 patent/US20220241347A1/en not_active Abandoned
-
2022
- 2022-10-05 JP JP2022160666A patent/JP2023011580A/ja active Pending
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