JP2017536096A5 - - Google Patents
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- JP2017536096A5 JP2017536096A5 JP2017518955A JP2017518955A JP2017536096A5 JP 2017536096 A5 JP2017536096 A5 JP 2017536096A5 JP 2017518955 A JP2017518955 A JP 2017518955A JP 2017518955 A JP2017518955 A JP 2017518955A JP 2017536096 A5 JP2017536096 A5 JP 2017536096A5
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- JP
- Japan
- Prior art keywords
- composition
- mir
- exosomes
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- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 35
- 210000001808 exosome Anatomy 0.000 claims description 34
- 210000004027 cell Anatomy 0.000 claims description 30
- 230000001464 adherent effect Effects 0.000 claims description 29
- 210000002826 placenta Anatomy 0.000 claims description 15
- 238000012239 gene modification Methods 0.000 claims description 12
- 230000005017 genetic modification Effects 0.000 claims description 12
- 235000013617 genetically modified food Nutrition 0.000 claims description 12
- 102100025680 Complement decay-accelerating factor Human genes 0.000 claims description 6
- 102100031780 Endonuclease Human genes 0.000 claims description 6
- 108010042407 Endonucleases Proteins 0.000 claims description 6
- 108020005004 Guide RNA Proteins 0.000 claims description 6
- 101000856022 Homo sapiens Complement decay-accelerating factor Proteins 0.000 claims description 6
- 102000003729 Neprilysin Human genes 0.000 claims description 6
- 108090000028 Neprilysin Proteins 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- 102100033400 4F2 cell-surface antigen heavy chain Human genes 0.000 claims description 4
- 102100022464 5'-nucleotidase Human genes 0.000 claims description 4
- 102100022749 Aminopeptidase N Human genes 0.000 claims description 4
- 102100032912 CD44 antigen Human genes 0.000 claims description 4
- 102100022002 CD59 glycoprotein Human genes 0.000 claims description 4
- 102100025222 CD63 antigen Human genes 0.000 claims description 4
- 102100027221 CD81 antigen Human genes 0.000 claims description 4
- 102100027217 CD82 antigen Human genes 0.000 claims description 4
- 101000800023 Homo sapiens 4F2 cell-surface antigen heavy chain Proteins 0.000 claims description 4
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims description 4
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims description 4
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 4
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims description 4
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims description 4
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims description 4
- 101000914469 Homo sapiens CD82 antigen Proteins 0.000 claims description 4
- 101001078133 Homo sapiens Integrin alpha-2 Proteins 0.000 claims description 4
- 101000994378 Homo sapiens Integrin alpha-3 Proteins 0.000 claims description 4
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims description 4
- 101000605020 Homo sapiens Large neutral amino acids transporter small subunit 1 Proteins 0.000 claims description 4
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims description 4
- 102100025305 Integrin alpha-2 Human genes 0.000 claims description 4
- 102100032819 Integrin alpha-3 Human genes 0.000 claims description 4
- 102100025304 Integrin beta-1 Human genes 0.000 claims description 4
- 108700011259 MicroRNAs Proteins 0.000 claims description 4
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims description 4
- 239000002679 microRNA Substances 0.000 claims description 4
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 4
- 229930182490 saponin Natural products 0.000 claims description 4
- 150000007949 saponins Chemical class 0.000 claims description 4
- 230000033115 angiogenesis Effects 0.000 claims description 3
- 230000008774 maternal effect Effects 0.000 claims description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 2
- 210000000987 immune system Anatomy 0.000 claims description 2
- 238000011534 incubation Methods 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 108091091807 let-7a stem-loop Proteins 0.000 claims description 2
- 108091057746 let-7a-4 stem-loop Proteins 0.000 claims description 2
- 108091028376 let-7a-5 stem-loop Proteins 0.000 claims description 2
- 108091024393 let-7a-6 stem-loop Proteins 0.000 claims description 2
- 108091091174 let-7a-7 stem-loop Proteins 0.000 claims description 2
- 108091050724 let-7b stem-loop Proteins 0.000 claims description 2
- 108091033753 let-7d stem-loop Proteins 0.000 claims description 2
- 108091079176 let-7d-1 stem-loop Proteins 0.000 claims description 2
- 108091036331 let-7d-2 stem-loop Proteins 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 2
- 108091056924 miR-124 stem-loop Proteins 0.000 claims description 2
- 108091079016 miR-133b Proteins 0.000 claims description 2
- 108091043162 miR-133b stem-loop Proteins 0.000 claims description 2
- 108091079658 miR-142-1 stem-loop Proteins 0.000 claims description 2
- 108091071830 miR-142-2 stem-loop Proteins 0.000 claims description 2
- 108091027943 miR-16 stem-loop Proteins 0.000 claims description 2
- 108091074057 miR-16-1 stem-loop Proteins 0.000 claims description 2
- 108091056204 miR-16-2 stem-loop Proteins 0.000 claims description 2
- 108091065218 miR-218-1 stem-loop Proteins 0.000 claims description 2
- 108091054980 miR-218-2 stem-loop Proteins 0.000 claims description 2
- 108091086421 miR-223 stem-loop Proteins 0.000 claims description 2
- 108091036689 miR-296 stem-loop Proteins 0.000 claims description 2
- 108091044721 miR-422a stem-loop Proteins 0.000 claims description 2
- -1 miR-451 Proteins 0.000 claims description 2
- 108091047658 miR-564 stem-loop Proteins 0.000 claims description 2
- 108091086737 miR-630 stem-loop Proteins 0.000 claims description 2
- 108091059456 miR-92-1 stem-loop Proteins 0.000 claims description 2
- 108091084336 miR-92-2 stem-loop Proteins 0.000 claims description 2
- 108091027963 non-coding RNA Proteins 0.000 claims description 2
- 102000042567 non-coding RNA Human genes 0.000 claims description 2
- 238000000527 sonication Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 230000008823 permeabilization Effects 0.000 description 2
- 206010029113 Neovascularisation Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462062046P | 2014-10-09 | 2014-10-09 | |
| US62/062,046 | 2014-10-09 | ||
| PCT/US2015/054629 WO2016057755A1 (en) | 2014-10-09 | 2015-10-08 | Placenta-derived adherent cell exosomes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020185503A Division JP2021040635A (ja) | 2014-10-09 | 2020-11-06 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017536096A JP2017536096A (ja) | 2017-12-07 |
| JP2017536096A5 true JP2017536096A5 (https=) | 2018-12-06 |
Family
ID=55653751
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518955A Pending JP2017536096A (ja) | 2014-10-09 | 2015-10-08 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
| JP2020185503A Withdrawn JP2021040635A (ja) | 2014-10-09 | 2020-11-06 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
| JP2022160666A Pending JP2023011580A (ja) | 2014-10-09 | 2022-10-05 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020185503A Withdrawn JP2021040635A (ja) | 2014-10-09 | 2020-11-06 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
| JP2022160666A Pending JP2023011580A (ja) | 2014-10-09 | 2022-10-05 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20170252379A1 (https=) |
| EP (1) | EP3204022B1 (https=) |
| JP (3) | JP2017536096A (https=) |
| CN (2) | CN107106615A (https=) |
| AU (2) | AU2015330855A1 (https=) |
| CA (1) | CA2964114A1 (https=) |
| DK (1) | DK3204022T3 (https=) |
| WO (1) | WO2016057755A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2969619A1 (en) | 2014-12-03 | 2016-06-09 | Agilent Technologies, Inc. | Guide rna with chemical modifications |
| KR102888521B1 (ko) | 2015-04-06 | 2025-11-19 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna |
| EP3307890A1 (en) | 2015-06-10 | 2018-04-18 | Board of Regents, The University of Texas System | Use of exosomes for the treatment of disease |
| JP2019514416A (ja) * | 2016-05-16 | 2019-06-06 | エグゾステム バイオテック リミテッド | 間葉系幹細胞と筋損傷及び筋肉関連疾患の治療のための間葉系幹細胞の使用 |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| CA3062426A1 (en) | 2017-05-08 | 2018-11-15 | Flagship Pioneering Innovations V, Inc. | Compositions for facilitating membrane fusion and uses thereof |
| WO2018208702A1 (en) * | 2017-05-09 | 2018-11-15 | Saint Louis University | Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes |
| CA3064064A1 (en) * | 2017-05-16 | 2018-11-22 | Exostem Biotec Ltd. | Methods of inhibiting aging and treating aging-related disorders |
| JP7399712B2 (ja) * | 2017-05-24 | 2023-12-18 | ナノソミックス・インコーポレイテッド | 疾病および障害の診断および予後判定のための小胞上のバイオマーカーの検出 |
| KR102109950B1 (ko) * | 2017-06-02 | 2020-05-12 | (주)엑솔런스바이오테크놀로지 | 체외충격파를 이용한 세포외소포체 내로의 표적물질 전달방법 |
| IL272786B2 (en) | 2017-08-25 | 2025-03-01 | Codiak Biosciences Inc | Preparation of therapeutic exosomes using membrane proteins |
| KR102335710B1 (ko) * | 2017-10-31 | 2021-12-07 | (주)아모레퍼시픽 | 유산균 유래의 세포밖 베지클을 포함하는 면역조절용 조성물 |
| GB201718681D0 (en) * | 2017-11-13 | 2017-12-27 | Evox Therapeutics Ltd | Protein engineered extracellular vesicles |
| MX2020005100A (es) * | 2017-11-16 | 2020-11-24 | Celularity Inc | Cultivo de placenta para aislar exosomas. |
| US12036325B2 (en) | 2017-12-14 | 2024-07-16 | Mayo Foundation For Medical Education And Research | Purified exosome products, method of making, and methods of using |
| CN111655271B (zh) | 2017-12-28 | 2025-09-23 | 隆萨销售股份公司 | 用于免疫肿瘤学和抗炎疗法的外来体 |
| US20210038652A1 (en) * | 2018-01-30 | 2021-02-11 | Histogen, Inc. | Extracellular vesicles derived from cells cultured under hypoxic conditions and uses thereof |
| KR102235141B1 (ko) * | 2018-06-19 | 2021-04-05 | 푸와이 하스피틀, 차이니즈 아카데미 오브 메디컬 사이언시즈 앤드 페킹 유니언 메디컬 칼리지 | 약물 전처리에 기초한 간엽 줄기세포 유래 엑소좀 제조방법 |
| JP2021531828A (ja) * | 2018-07-24 | 2021-11-25 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 細胞外小胞を形質転換することを伴う組成物及び方法 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN109554341B (zh) * | 2018-12-18 | 2021-11-19 | 深圳先进技术研究院 | 无创超声处理细胞在制备外泌体中的应用、外泌体及其制备方法和应用 |
| CN110093274B (zh) * | 2019-05-13 | 2020-08-11 | 山东大学 | 一种增加细胞产生的细胞外囊泡数量的挤压装置及其应用 |
| CA3142020A1 (en) * | 2019-06-19 | 2020-12-24 | Celularity Inc. | Exosomes for disease treatment |
| WO2021210852A1 (ko) * | 2020-04-14 | 2021-10-21 | (주)녹십자웰빙 | 태반 유래 물질을 포함하는 항바이러스 조성물 |
| KR20220030552A (ko) * | 2020-09-03 | 2022-03-11 | (주)녹십자웰빙 | 태반 유래 엑소좀을 포함하는 간세포 증식 또는 항염증 효능 조성물 |
| JP2024534945A (ja) | 2021-09-10 | 2024-09-26 | アジレント・テクノロジーズ・インク | 化学修飾を有するプライム編集のためのガイドｒｎａ |
| WO2024102969A1 (en) * | 2022-11-10 | 2024-05-16 | Board Of Regents, The University Of Texas System | Use of fecal derivatives and fecal derived extracellular vesicles to enhance immunity |
| CN117050936A (zh) * | 2023-07-11 | 2023-11-14 | 清华大学 | 新亚群的人脐带间充质干细胞、其外泌体、制剂和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2316919B1 (en) | 2001-02-14 | 2015-10-07 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| PT2471904T (pt) | 2005-12-29 | 2019-02-25 | Celularity Inc | População de células estaminais placentárias |
| WO2010021715A1 (en) | 2008-08-20 | 2010-02-25 | Anthrogenesis Corporation | Treatment of stroke using isolated placental cells |
| CN105708862B (zh) * | 2008-09-02 | 2020-11-06 | 普拉里斯坦有限公司 | 来自胎盘组织的粘附细胞及其在治疗中的用途 |
| WO2010056337A2 (en) * | 2008-11-12 | 2010-05-20 | Caris Mpi, Inc. | Methods and systems of using exosomes for determining phenotypes |
| FR2950360B1 (fr) * | 2009-09-22 | 2011-11-25 | Centre Nat Rech Scient | Procede d'imagerie cellulaire pour la visualisation de la biogenese des microarns dans les cellules |
| LT2556145T (lt) * | 2010-04-07 | 2016-11-10 | Anthrogenesis Corporation | Angiogenezė naudojant placentos kamienines ląsteles |
| AU2012236099A1 (en) * | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| JP2014519340A (ja) * | 2011-06-16 | 2014-08-14 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス．アー．エール．エル． | バイオマーカー組成物および方法 |
| JP6029112B2 (ja) * | 2011-12-22 | 2016-11-24 | テオリアサイエンス株式会社 | エクソソームの分析方法、エクソソーム分析用試薬およびエクソソーム分析装置 |
| US9427450B2 (en) * | 2012-01-31 | 2016-08-30 | Xon Cells, Inc. | Therapeutic immune modulation by stem cell secreted exosomes |
| WO2014022852A1 (en) * | 2012-08-03 | 2014-02-06 | Aptamir Therapeutics, Inc. | Cell-specific delivery of mirna modulators for the treatment of obesity and related disorders |
| EP3563859B1 (en) * | 2012-08-13 | 2021-10-13 | Cedars-Sinai Medical Center | Cardiosphere-derived exosomes for tissue regeneration |
| EP3031921B1 (en) * | 2012-12-12 | 2025-03-12 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| AU2013361323B2 (en) * | 2012-12-19 | 2018-09-06 | Caris Science, Inc. | Compositions and methods for aptamer screening |
| EP3608022A1 (en) * | 2013-03-15 | 2020-02-12 | The Trustees of Princeton University | Methods and devices for high throughput purification |
-
2015
- 2015-10-08 WO PCT/US2015/054629 patent/WO2016057755A1/en not_active Ceased
- 2015-10-08 DK DK15849339.5T patent/DK3204022T3/da active
- 2015-10-08 US US15/517,438 patent/US20170252379A1/en not_active Abandoned
- 2015-10-08 JP JP2017518955A patent/JP2017536096A/ja active Pending
- 2015-10-08 AU AU2015330855A patent/AU2015330855A1/en not_active Abandoned
- 2015-10-08 CN CN201580054280.7A patent/CN107106615A/zh active Pending
- 2015-10-08 CN CN202310711769.3A patent/CN116731958A/zh active Pending
- 2015-10-08 EP EP15849339.5A patent/EP3204022B1/en not_active Revoked
- 2015-10-08 CA CA2964114A patent/CA2964114A1/en active Pending
-
2020
- 2020-01-10 US US16/740,054 patent/US11173182B1/en not_active Expired - Fee Related
- 2020-11-06 JP JP2020185503A patent/JP2021040635A/ja not_active Withdrawn
-
2021
- 2021-06-25 AU AU2021204332A patent/AU2021204332A1/en not_active Abandoned
- 2021-10-07 US US17/495,985 patent/US20220241347A1/en not_active Abandoned
-
2022
- 2022-10-05 JP JP2022160666A patent/JP2023011580A/ja active Pending
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