JP2017534654A - 皮膚感染症を処置する、予防する、またはその危険性を低減するための方法 - Google Patents

皮膚感染症を処置する、予防する、またはその危険性を低減するための方法 Download PDF

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JP2017534654A
JP2017534654A JP2017525909A JP2017525909A JP2017534654A JP 2017534654 A JP2017534654 A JP 2017534654A JP 2017525909 A JP2017525909 A JP 2017525909A JP 2017525909 A JP2017525909 A JP 2017525909A JP 2017534654 A JP2017534654 A JP 2017534654A
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JP2017534654A5 (enExample
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エリン エム. ダフィ
エリン エム. ダフィ
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メリンタ セラピューティクス インコーポレイテッド
メリンタ セラピューティクス インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
JP2017525909A 2014-11-14 2015-11-16 皮膚感染症を処置する、予防する、またはその危険性を低減するための方法 Withdrawn JP2017534654A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462080212P 2014-11-14 2014-11-14
US62/080,212 2014-11-14
PCT/US2015/060851 WO2016077818A1 (en) 2014-11-14 2015-11-16 Method for treating, preventing, or reducing the risk of skin infection

Publications (2)

Publication Number Publication Date
JP2017534654A true JP2017534654A (ja) 2017-11-24
JP2017534654A5 JP2017534654A5 (enExample) 2018-12-27

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JP2017525909A Withdrawn JP2017534654A (ja) 2014-11-14 2015-11-16 皮膚感染症を処置する、予防する、またはその危険性を低減するための方法

Country Status (21)

Country Link
US (1) US10471046B2 (enExample)
EP (1) EP3217974A4 (enExample)
JP (1) JP2017534654A (enExample)
KR (1) KR20170084200A (enExample)
CN (1) CN107205989A (enExample)
AR (1) AR102666A1 (enExample)
AU (1) AU2015346023A1 (enExample)
BR (1) BR112017009989A2 (enExample)
CA (1) CA2967825A1 (enExample)
CL (1) CL2017001245A1 (enExample)
CR (1) CR20170196A (enExample)
EA (1) EA201791051A1 (enExample)
HK (1) HK1244211A1 (enExample)
IL (1) IL252197A0 (enExample)
MX (1) MX389005B (enExample)
NI (1) NI201700057A (enExample)
PH (1) PH12017500887A1 (enExample)
SG (1) SG11201703856VA (enExample)
SV (1) SV2017005444A (enExample)
UY (1) UY36402A (enExample)
WO (1) WO2016077818A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107709314A (zh) 2015-06-11 2018-02-16 巴斯利尔药物国际股份公司 外排泵抑制剂及其治疗性用途
WO2018107158A1 (en) * 2016-12-09 2018-06-14 Celtaxsys, Inc. Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase
CN107721943A (zh) * 2017-10-26 2018-02-23 沈阳药科大学 含联芳基腙结构的噁唑烷酮类化合物及其制备方法
KR20190130243A (ko) 2018-05-14 2019-11-22 (주)텔리언 트러스트 인덱스를 이용한 공유경제 시스템 및 방법
KR102286897B1 (ko) 2019-06-25 2021-08-09 (주)앰틱스바이오 신규한 아미노알칸산에 바이페닐기를 도입한 유도체 화합물 및 이를 포함하는 항진균성 약학적 조성물
CN115677679A (zh) * 2021-07-26 2023-02-03 沈阳药科大学 含联芳基腙结构的噁唑烷酮化合物及其制备方法和应用
CN120794967A (zh) * 2024-04-10 2025-10-17 沈阳药科大学 联芳基噁唑烷酮类化合物及其应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES332272A1 (es) 1965-10-20 1967-11-16 Milwaukee Chaplet & Mfg Company Inc Un dispositivo regulador de programa.
GB1185685A (en) 1966-01-11 1970-03-25 Quinoderm Ltd Method of Making Pharmaceutical Compositions
US3418055A (en) 1967-04-03 1968-12-24 Schwartzman Gilbert Pressure operated applicator and cap construction
US3410645A (en) 1967-05-08 1968-11-12 Schwartzman Gilbert Concave diaphragm applicator
US3535422A (en) 1968-03-11 1970-10-20 Stiefel Laboratories Stable benzoyl peroxide composition
US3669323A (en) 1969-12-12 1972-06-13 American Can Co One-way valve insert for collapsible dispensing containers
US4056611A (en) 1973-04-16 1977-11-01 Stiefel Laboratories, Inc. Therapeutic composition
GB1541463A (en) 1975-10-11 1979-02-28 Lion Dentifrice Co Ltd Process for prparing a multiple emulsion having a dispersing form of water-phase/oil-phase/water-phase
US4620648A (en) 1982-07-06 1986-11-04 Dab-O-Matic Corp. Pressure-responsive valve
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4985459A (en) 1984-02-08 1991-01-15 Richardson-Vicks, Inc. Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same
US4693623A (en) 1984-03-02 1987-09-15 Dab-O-Matic Corp. Pressure-responsive valve for an applicator
US4999186A (en) 1986-06-27 1991-03-12 The Procter & Gamble Company Novel sunscreen agents, sunscreen compositions and methods for preventing sunburn
US4937370A (en) 1987-06-02 1990-06-26 The Procter & Gamble Company Novel chromophores, sunscreen compositions and methods for preventing sunburn
US4960764A (en) 1987-03-06 1990-10-02 Richardson-Vicks Inc. Oil-in-water-in-silicone emulsion compositions
US4800197A (en) 1987-07-17 1989-01-24 Richardson-Vicks Inc. Anti-acne composition
US4891227A (en) 1988-02-02 1990-01-02 Richardson-Vicks Inc. Medicated cleansing pads
US4891228A (en) 1988-02-02 1990-01-02 Richardson-Vicks Inc. Medicated cleansing pads
US4919934A (en) 1989-03-02 1990-04-24 Richardson-Vicks Inc. Cosmetic sticks
US5087445A (en) 1989-09-08 1992-02-11 Richardson-Vicks, Inc. Photoprotection compositions having reduced dermal irritation
US5073371A (en) 1990-11-30 1991-12-17 Richardson-Vicks, Inc. Leave-on facial emulsion compositions
US5073372A (en) 1990-11-30 1991-12-17 Richardson-Vicks, Inc. Leave-on facial emulsion compositions
EP0610265B1 (en) 1991-11-01 1996-12-27 PHARMACIA & UPJOHN COMPANY Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
US5688792A (en) 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
JPH10508036A (ja) 1995-03-27 1998-08-04 アイシス・ファーマシューティカルス・インコーポレーテッド 窒素含有大環状化合物
ES2200439T3 (es) 1995-09-22 2004-03-01 Wakunaga Pharmaceutical Co., Ltd. Intermedios para utilizar en la preparacion de nuevos derivados del acido piridonocarboxilico o sus sales.
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US6413981B1 (en) 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
NZ522990A (en) 2000-06-05 2003-08-29 Dong A Pharm Novel oxazolidinone derivatives and a process for the preparation thereof
US20130059774A1 (en) * 2000-08-01 2013-03-07 Mahesh Vithalbhai Patel Efflux pump inhibitors
WO2003030906A1 (en) * 2001-10-11 2003-04-17 Pharmacia & Upjohn Company Treating infections by administration of oxazolidinones to the skin
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
AU2004217919A1 (en) 2003-03-05 2004-09-16 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using the same
TWI378092B (en) 2003-06-03 2012-12-01 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
WO2005012271A2 (en) 2003-07-29 2005-02-10 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
US20060270680A1 (en) 2003-06-03 2006-11-30 Goldberg Joel A Sulfonamide compounds and methods of making and using the same
US20070197541A1 (en) 2003-07-29 2007-08-23 Oyelere Adegboyega K Biaryl heterocyclic amines,amides, and sulfur-containing compounds and methods of making and using the same
JP2007514782A (ja) 2003-12-17 2007-06-07 リブ−エックス ファーマシューティカルズ,インコーポレイテッド ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法
JP2008508271A (ja) 2004-07-28 2008-03-21 リブ−エックス ファーマシューティカルズ,インコーポレイテッド ビアリール複素環式化合物ならびにその化合物を製造および使用する方法
EP1789392A2 (en) 2004-07-30 2007-05-30 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
US7728143B2 (en) 2004-10-08 2010-06-01 Abbott Laboratories Salt and crystalline forms thereof of a drug
SI1868581T1 (sl) 2005-04-11 2012-06-29 Abbott Lab Farmacevtski sestavki z izboljšanim profilom topnosti za slabo topna zdravila
EP1904489B1 (en) 2005-06-08 2011-01-26 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
EP1928893A2 (en) 2005-08-24 2008-06-11 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
EP1934237A2 (en) 2005-08-24 2008-06-25 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
WO2011139832A2 (en) * 2010-04-28 2011-11-10 Rib-X Pharmaceuticals, Inc. Method for treating mycobacterial infections

Also Published As

Publication number Publication date
HK1244211A1 (zh) 2018-08-03
NI201700057A (es) 2017-09-04
CA2967825A1 (en) 2016-05-19
IL252197A0 (en) 2017-07-31
AR102666A1 (es) 2017-03-15
EA201791051A1 (ru) 2018-01-31
AU2015346023A1 (en) 2017-06-01
SG11201703856VA (en) 2017-06-29
MX2017006319A (es) 2017-08-10
MX389005B (es) 2025-03-20
EP3217974A1 (en) 2017-09-20
CN107205989A (zh) 2017-09-26
PH12017500887A1 (en) 2017-11-06
KR20170084200A (ko) 2017-07-19
UY36402A (es) 2016-06-30
CL2017001245A1 (es) 2018-02-09
SV2017005444A (es) 2017-08-31
BR112017009989A2 (pt) 2018-01-02
WO2016077818A1 (en) 2016-05-19
EP3217974A4 (en) 2018-07-25
CR20170196A (es) 2017-07-10
US10471046B2 (en) 2019-11-12
US20160136137A1 (en) 2016-05-19

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