AR102666A1 - Método para tratar, prevenir, o reducir el riesgo de infección de la piel, formulación y uso - Google Patents
Método para tratar, prevenir, o reducir el riesgo de infección de la piel, formulación y usoInfo
- Publication number
- AR102666A1 AR102666A1 ARP150103729A ARP150103729A AR102666A1 AR 102666 A1 AR102666 A1 AR 102666A1 AR P150103729 A ARP150103729 A AR P150103729A AR P150103729 A ARP150103729 A AR P150103729A AR 102666 A1 AR102666 A1 AR 102666A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- nr4r4
- nr4c
- unsaturated
- aromatic
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 206010040872 skin infection Diseases 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 22
- 125000003118 aryl group Chemical group 0.000 abstract 19
- 229910052760 oxygen Inorganic materials 0.000 abstract 13
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 12
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 11
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 11
- 125000005842 heteroatom Chemical group 0.000 abstract 11
- 229910052757 nitrogen Inorganic materials 0.000 abstract 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 11
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 11
- 239000001301 oxygen Chemical group 0.000 abstract 11
- 229910052717 sulfur Chemical group 0.000 abstract 11
- 239000011593 sulfur Chemical group 0.000 abstract 11
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 241000186427 Cutibacterium acnes Species 0.000 abstract 2
- 241000207201 Gardnerella vaginalis Species 0.000 abstract 2
- 241000191967 Staphylococcus aureus Species 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 229940055019 propionibacterium acne Drugs 0.000 abstract 2
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 2
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1
- BSFODEXXVBBYOC-UHFFFAOYSA-N 8-[4-(dimethylamino)butan-2-ylamino]quinolin-6-ol Chemical group C1=CN=C2C(NC(CCN(C)C)C)=CC(O)=CC2=C1 BSFODEXXVBBYOC-UHFFFAOYSA-N 0.000 abstract 1
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- 239000012049 topical pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462080212P | 2014-11-14 | 2014-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR102666A1 true AR102666A1 (es) | 2017-03-15 |
Family
ID=55955188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150103729A AR102666A1 (es) | 2014-11-14 | 2015-11-16 | Método para tratar, prevenir, o reducir el riesgo de infección de la piel, formulación y uso |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10471046B2 (enExample) |
| EP (1) | EP3217974A4 (enExample) |
| JP (1) | JP2017534654A (enExample) |
| KR (1) | KR20170084200A (enExample) |
| CN (1) | CN107205989A (enExample) |
| AR (1) | AR102666A1 (enExample) |
| AU (1) | AU2015346023A1 (enExample) |
| BR (1) | BR112017009989A2 (enExample) |
| CA (1) | CA2967825A1 (enExample) |
| CL (1) | CL2017001245A1 (enExample) |
| CR (1) | CR20170196A (enExample) |
| EA (1) | EA201791051A1 (enExample) |
| HK (1) | HK1244211A1 (enExample) |
| IL (1) | IL252197A0 (enExample) |
| MX (1) | MX389005B (enExample) |
| NI (1) | NI201700057A (enExample) |
| PH (1) | PH12017500887A1 (enExample) |
| SG (1) | SG11201703856VA (enExample) |
| SV (1) | SV2017005444A (enExample) |
| UY (1) | UY36402A (enExample) |
| WO (1) | WO2016077818A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180011843A (ko) | 2015-06-11 | 2018-02-02 | 바실리어 파마슈티카 인터내셔널 리미티드 | 유출-펌프 억제제 및 이의 치료적 용도 |
| AU2017371353B2 (en) * | 2016-12-09 | 2022-02-03 | Celltaxis, Llc | Monamine and monoamine derivatives as inhibitors of leukotriene A4 hydrolase |
| CN107721943A (zh) * | 2017-10-26 | 2018-02-23 | 沈阳药科大学 | 含联芳基腙结构的噁唑烷酮类化合物及其制备方法 |
| KR20190130243A (ko) | 2018-05-14 | 2019-11-22 | (주)텔리언 | 트러스트 인덱스를 이용한 공유경제 시스템 및 방법 |
| WO2020262996A1 (ko) | 2019-06-25 | 2020-12-30 | (주)앰틱스바이오 | 신규한 아미노알칸산에 바이페닐기를 도입한 유도체 화합물 및 이를 포함하는 항진균성 약학적 조성물 |
| CN115677679A (zh) * | 2021-07-26 | 2023-02-03 | 沈阳药科大学 | 含联芳基腙结构的噁唑烷酮化合物及其制备方法和应用 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES332272A1 (es) | 1965-10-20 | 1967-11-16 | Milwaukee Chaplet & Mfg Company Inc | Un dispositivo regulador de programa. |
| GB1185685A (en) | 1966-01-11 | 1970-03-25 | Quinoderm Ltd | Method of Making Pharmaceutical Compositions |
| US3418055A (en) | 1967-04-03 | 1968-12-24 | Schwartzman Gilbert | Pressure operated applicator and cap construction |
| US3410645A (en) | 1967-05-08 | 1968-11-12 | Schwartzman Gilbert | Concave diaphragm applicator |
| US3535422A (en) | 1968-03-11 | 1970-10-20 | Stiefel Laboratories | Stable benzoyl peroxide composition |
| US3669323A (en) | 1969-12-12 | 1972-06-13 | American Can Co | One-way valve insert for collapsible dispensing containers |
| US4056611A (en) | 1973-04-16 | 1977-11-01 | Stiefel Laboratories, Inc. | Therapeutic composition |
| GB1541463A (en) | 1975-10-11 | 1979-02-28 | Lion Dentifrice Co Ltd | Process for prparing a multiple emulsion having a dispersing form of water-phase/oil-phase/water-phase |
| US4620648A (en) | 1982-07-06 | 1986-11-04 | Dab-O-Matic Corp. | Pressure-responsive valve |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4985459A (en) | 1984-02-08 | 1991-01-15 | Richardson-Vicks, Inc. | Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same |
| US4693623A (en) | 1984-03-02 | 1987-09-15 | Dab-O-Matic Corp. | Pressure-responsive valve for an applicator |
| US4937370A (en) | 1987-06-02 | 1990-06-26 | The Procter & Gamble Company | Novel chromophores, sunscreen compositions and methods for preventing sunburn |
| US4999186A (en) | 1986-06-27 | 1991-03-12 | The Procter & Gamble Company | Novel sunscreen agents, sunscreen compositions and methods for preventing sunburn |
| US4960764A (en) | 1987-03-06 | 1990-10-02 | Richardson-Vicks Inc. | Oil-in-water-in-silicone emulsion compositions |
| US4800197A (en) | 1987-07-17 | 1989-01-24 | Richardson-Vicks Inc. | Anti-acne composition |
| US4891228A (en) | 1988-02-02 | 1990-01-02 | Richardson-Vicks Inc. | Medicated cleansing pads |
| US4891227A (en) | 1988-02-02 | 1990-01-02 | Richardson-Vicks Inc. | Medicated cleansing pads |
| US4919934A (en) | 1989-03-02 | 1990-04-24 | Richardson-Vicks Inc. | Cosmetic sticks |
| US5087445A (en) | 1989-09-08 | 1992-02-11 | Richardson-Vicks, Inc. | Photoprotection compositions having reduced dermal irritation |
| US5073371A (en) | 1990-11-30 | 1991-12-17 | Richardson-Vicks, Inc. | Leave-on facial emulsion compositions |
| US5073372A (en) | 1990-11-30 | 1991-12-17 | Richardson-Vicks, Inc. | Leave-on facial emulsion compositions |
| CA2119556C (en) | 1991-11-01 | 2004-07-06 | Michael Robert Barbachyn | Substituted aryl- and heteroaryl-phenyloxazolidinones |
| US5688792A (en) | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
| AU5375896A (en) | 1995-03-27 | 1996-10-16 | Isis Pharmaceuticals, Inc. | Nitrogenous macrocyclic compounds |
| JP3103380B2 (ja) | 1995-09-22 | 2000-10-30 | 湧永製薬株式会社 | 新規ピリドンカルボン酸誘導体又はその塩並びに該物質を有効成分とする抗菌剤 |
| US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
| US6413981B1 (en) | 1999-08-12 | 2002-07-02 | Ortho-Mcneil Pharamceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| US6689779B2 (en) | 2000-06-05 | 2004-02-10 | Dong A Pharm. Co., Ltd. | Oxazolidinone derivatives and a process for the preparation thereof |
| US20130059774A1 (en) * | 2000-08-01 | 2013-03-07 | Mahesh Vithalbhai Patel | Efflux pump inhibitors |
| WO2003030906A1 (en) | 2001-10-11 | 2003-04-17 | Pharmacia & Upjohn Company | Treating infections by administration of oxazolidinones to the skin |
| AR043050A1 (es) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
| CN1780846A (zh) | 2003-03-05 | 2006-05-31 | Rib-X医药品有限公司 | 双官能杂环化合物及其制备和使用方法 |
| WO2005012271A2 (en) | 2003-07-29 | 2005-02-10 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| EP1646617A2 (en) | 2003-06-03 | 2006-04-19 | Rib-X Pharmaceuticals, Inc. | Sulfonamide compounds and methods of making and using the same |
| MXPA05013132A (es) | 2003-06-03 | 2006-05-25 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos de biarilo y metodos de produccion y su uso. |
| EP1664001A2 (en) | 2003-07-29 | 2006-06-07 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic amines, amides, and sulfur-containing compounds and methods of making and using the same |
| US7129259B2 (en) | 2003-12-17 | 2006-10-31 | Rib-X Pharmaceuticals, Inc. | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
| EP1778653A1 (en) | 2004-07-28 | 2007-05-02 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic compounds and methods of making and using the same |
| EP2816033A1 (en) | 2004-07-30 | 2014-12-24 | Abbvie Inc. | Preparation of pyridonecarboxylic acid antibacterials |
| DK3056492T3 (da) | 2004-10-08 | 2021-12-13 | Abbvie Inc | Megluminsalt og krystallinke former deraf af et lægemiddel (delafloxacin) |
| ES2384333T3 (es) | 2005-04-11 | 2012-07-03 | Abbott Laboratories | Composiciones farmacéuticas que tienen perfiles de disolución mejorados para fármacos poco solubles |
| US8399660B2 (en) | 2005-06-08 | 2013-03-19 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of triazoles |
| EP1928893A2 (en) | 2005-08-24 | 2008-06-11 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
| EP1934237A2 (en) | 2005-08-24 | 2008-06-25 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
| WO2011139832A2 (en) | 2010-04-28 | 2011-11-10 | Rib-X Pharmaceuticals, Inc. | Method for treating mycobacterial infections |
-
2015
- 2015-11-16 AU AU2015346023A patent/AU2015346023A1/en not_active Abandoned
- 2015-11-16 AR ARP150103729A patent/AR102666A1/es unknown
- 2015-11-16 BR BR112017009989-6A patent/BR112017009989A2/pt not_active Application Discontinuation
- 2015-11-16 HK HK18103723.8A patent/HK1244211A1/zh unknown
- 2015-11-16 UY UY0001036402A patent/UY36402A/es not_active Application Discontinuation
- 2015-11-16 WO PCT/US2015/060851 patent/WO2016077818A1/en not_active Ceased
- 2015-11-16 SG SG11201703856VA patent/SG11201703856VA/en unknown
- 2015-11-16 CR CR20170196A patent/CR20170196A/es unknown
- 2015-11-16 CN CN201580073501.5A patent/CN107205989A/zh not_active Withdrawn
- 2015-11-16 MX MX2017006319A patent/MX389005B/es unknown
- 2015-11-16 EA EA201791051A patent/EA201791051A1/ru unknown
- 2015-11-16 US US14/942,021 patent/US10471046B2/en active Active
- 2015-11-16 JP JP2017525909A patent/JP2017534654A/ja not_active Withdrawn
- 2015-11-16 KR KR1020177015770A patent/KR20170084200A/ko not_active Withdrawn
- 2015-11-16 CA CA2967825A patent/CA2967825A1/en active Pending
- 2015-11-16 EP EP15858675.0A patent/EP3217974A4/en active Pending
-
2017
- 2017-05-10 IL IL252197A patent/IL252197A0/en unknown
- 2017-05-12 PH PH12017500887A patent/PH12017500887A1/en unknown
- 2017-05-12 NI NI201700057A patent/NI201700057A/es unknown
- 2017-05-15 CL CL2017001245A patent/CL2017001245A1/es unknown
- 2017-05-15 SV SV2017005444A patent/SV2017005444A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201703856VA (en) | 2017-06-29 |
| MX389005B (es) | 2025-03-20 |
| WO2016077818A1 (en) | 2016-05-19 |
| BR112017009989A2 (pt) | 2018-01-02 |
| NI201700057A (es) | 2017-09-04 |
| HK1244211A1 (zh) | 2018-08-03 |
| US20160136137A1 (en) | 2016-05-19 |
| CR20170196A (es) | 2017-07-10 |
| JP2017534654A (ja) | 2017-11-24 |
| SV2017005444A (es) | 2017-08-31 |
| AU2015346023A1 (en) | 2017-06-01 |
| PH12017500887A1 (en) | 2017-11-06 |
| KR20170084200A (ko) | 2017-07-19 |
| CL2017001245A1 (es) | 2018-02-09 |
| EP3217974A4 (en) | 2018-07-25 |
| IL252197A0 (en) | 2017-07-31 |
| UY36402A (es) | 2016-06-30 |
| US10471046B2 (en) | 2019-11-12 |
| CN107205989A (zh) | 2017-09-26 |
| EP3217974A1 (en) | 2017-09-20 |
| MX2017006319A (es) | 2017-08-10 |
| EA201791051A1 (ru) | 2018-01-31 |
| CA2967825A1 (en) | 2016-05-19 |
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