AR096148A1 - Terapia combinada para el tratamiento del cáncer - Google Patents
Terapia combinada para el tratamiento del cáncerInfo
- Publication number
- AR096148A1 AR096148A1 ARP140101779A ARP140101779A AR096148A1 AR 096148 A1 AR096148 A1 AR 096148A1 AR P140101779 A ARP140101779 A AR P140101779A AR P140101779 A ARP140101779 A AR P140101779A AR 096148 A1 AR096148 A1 AR 096148A1
- Authority
- AR
- Argentina
- Prior art keywords
- heteroaryl
- aryl
- alkyl
- optionally substituted
- occurrence
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 238000002648 combination therapy Methods 0.000 title 1
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 6
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 5
- 230000001028 anti-proliverative effect Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229940124302 mTOR inhibitor Drugs 0.000 abstract 2
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 239000003981 vehicle Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
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- A61K31/131—Amines acyclic
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- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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Abstract
Reivindicación 1: Una combinación farmacéutica que comprende un inhibidor de Pl3K/mTOR seleccionado de los compuestos de la fórmula (1); en donde, R¹ es arilo C₆₋₁₄ o heteroarilo, en donde cada uno de arilo C₆₋₁₄ o heteroarilo está sustituido en forma opcional con uno o más de Rᵃ; R² es -CN; R³ es hidrógeno o alquilo C₁₋₈, en donde alquilo C₁₋₈ está sustituido en forma opcional con -CN; R⁴ es arilo C₆₋₁₄ o heteroarilo, en donde cada uno de arilo C₆₋₁₄ o heteroarilo está sustituido en forma opcional con uno o más de Rᵃ; Rᵃ en cada ocurrencia es halógeno, -CN, -ORˣ, -SRˣ, -NRˣRʸ, alquilo C₁₋₈, arilo C₆₋₁₄ heterociclilo o alquilheterociclilo, en donde alquilo C₁₋₈ y heterociclilo está sustituido en forma opcional con uno o más de Rᵇ; Rˣ y Rʸ en cada ocurrencia son en forma independiente hidrógeno, alquilo C₁₋₈, arilo C₆₋₁₄ o heteroarilo, en donde cada uno de alquilo C₁₋₈, arilo C₆₋₁₄ o heteroarilo están sustituidos en forma opcional con Rᵇ; y Rᵇ en cada ocurrencia es halógeno, -CN o -NH₂; o sus sales o solvatos aceptables desde el punto de vista farmacéutico; y uno o más agentes anti-proliferativos. Reivindicación 37: Una composición farmacéutica que comprende una cantidad terapéuticamente efectiva de un inhibidor de Pl3K/mTOR seleccionado de los compuestos de la fórmula (1); y una cantidad terapéuticamente efectiva de uno o más agentes anti-proliferativos; en asociación con uno o más aceptable desde el punto de vista farmacéutico vehiculo, diluyente o excipiente.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/IB2013/053433 WO2014177915A1 (en) | 2013-05-01 | 2013-05-01 | Cancer combination therapy using imidazo[4,5-c]quinoline derivatives |
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AR096148A1 true AR096148A1 (es) | 2015-12-09 |
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ARP140101779A AR096148A1 (es) | 2013-05-01 | 2014-04-30 | Terapia combinada para el tratamiento del cáncer |
Country Status (3)
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AR (1) | AR096148A1 (es) |
TW (1) | TW201529071A (es) |
WO (1) | WO2014177915A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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US9259399B2 (en) | 2007-11-07 | 2016-02-16 | Cornell University | Targeting CDK4 and CDK6 in cancer therapy |
WO2015145369A1 (en) * | 2014-03-27 | 2015-10-01 | Piramal Enterprises Limited | Process for the preparation of substituted imidazo[4,5-c]quinoline compounds, intermediates and polymorphs thereof |
JP6847835B2 (ja) | 2014-12-12 | 2021-03-24 | ザ ジェネラル ホスピタル コーポレイション | 乳がん脳転移の処置 |
AU2018209164B2 (en) | 2017-01-17 | 2021-11-04 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
CN107789614A (zh) * | 2017-11-27 | 2018-03-13 | 河北新世纪药业有限公司 | 一种防治海参疾病的药物组合物及其制备方法 |
KR102150821B1 (ko) * | 2020-01-22 | 2020-09-03 | 주식회사 에이스바이오메드 | 간 질환 치료용 또는 치료 효과 증진을 위한 콜히친 복합제제 |
CN114470216B (zh) * | 2020-10-23 | 2024-08-06 | 和记黄埔医药(上海)有限公司 | 多受体酪氨酸激酶抑制剂与化疗剂的药物组合及其使用方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
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GB0211649D0 (en) | 2002-05-21 | 2002-07-03 | Novartis Ag | Organic compounds |
AU2004295061B2 (en) * | 2003-11-21 | 2008-11-20 | Novartis Ag | 1H-imidazoquinoline derivatives as protein kinase inhibitors |
JPWO2005054327A1 (ja) | 2003-12-05 | 2007-06-28 | 株式会社ブリヂストン | 軟質ポリウレタンフォーム及び布貼り軟質ポリウレタンフォーム製品 |
US20080213308A1 (en) * | 2004-09-14 | 2008-09-04 | Nicholas Valiante | Imidazoquinoline Compounds |
GB0423653D0 (en) | 2004-10-25 | 2004-11-24 | Piramed Ltd | Pharmaceutical compounds |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
GB0520657D0 (en) | 2005-10-11 | 2005-11-16 | Ludwig Inst Cancer Res | Pharmaceutical compounds |
BRPI0807893A2 (pt) | 2007-02-20 | 2014-06-17 | Novartis Ag | Imidazoquinolinas como inibidores duais de lipídio quinase e mtor. |
ES2401557T3 (es) | 2007-08-02 | 2013-04-22 | Amgen, Inc | Moduladores de Pl3 cinasas y métodos de uso |
MX2010010505A (es) | 2008-03-26 | 2010-10-26 | Novartis Ag | Imidazoquinolinas y derivados de pirimidina como moduladores potentes de los procesos angiogenicos impulsados por el factor de crecimiento endotelial vascular (vegf). |
AU2010236825A1 (en) * | 2009-04-16 | 2011-09-15 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer |
UY32582A (es) | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
AU2010321773A1 (en) * | 2009-11-20 | 2012-06-14 | Infinity Pharmaceuticals, Inc. | Methods and compositions for treating hedgehog-associated cancers |
CA2805608A1 (en) | 2010-07-16 | 2012-01-19 | Piramal Enterprises Limited | Substituted imidazoquinoline derivatives as kinase inhibitors |
WO2012143879A1 (en) | 2011-04-21 | 2012-10-26 | Piramal Healthcare Limited | A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation |
WO2013007768A1 (en) * | 2011-07-13 | 2013-01-17 | F. Hoffmann-La Roche Ag | Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors |
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2013
- 2013-05-01 WO PCT/IB2013/053433 patent/WO2014177915A1/en active Application Filing
-
2014
- 2014-04-28 TW TW103115147A patent/TW201529071A/zh unknown
- 2014-04-30 AR ARP140101779A patent/AR096148A1/es unknown
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TW201529071A (zh) | 2015-08-01 |
WO2014177915A1 (en) | 2014-11-06 |
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