|
DE3378250D1
(en)
|
1982-04-22 |
1988-11-24 |
Ici Plc |
Continuous release formulations
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US5128326A
(en)
|
1984-12-06 |
1992-07-07 |
Biomatrix, Inc. |
Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
|
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
|
AU600575B2
(en)
|
1987-03-18 |
1990-08-16 |
Sb2, Inc. |
Altered antibodies
|
|
WO1991003493A1
(en)
|
1989-08-29 |
1991-03-21 |
The University Of Southampton |
Bi-or trispecific (fab)3 or (fab)4 conjugates
|
|
WO1991005548A1
(en)
|
1989-10-10 |
1991-05-02 |
Pitman-Moore, Inc. |
Sustained release composition for macromolecular proteins
|
|
CA2071867A1
(en)
|
1989-11-06 |
1991-05-07 |
Edith Mathiowitz |
Method for producing protein microspheres
|
|
AU666852B2
(en)
|
1991-05-01 |
1996-02-29 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
A method for treating infectious respiratory diseases
|
|
GB9112536D0
(en)
|
1991-06-11 |
1991-07-31 |
Celltech Ltd |
Chemical compounds
|
|
CA2078539C
(en)
|
1991-09-18 |
2005-08-02 |
Kenya Shitara |
Process for producing humanized chimera antibody
|
|
AU2605592A
(en)
|
1991-10-15 |
1993-04-22 |
Atrix Laboratories, Inc. |
Polymeric compositions useful as controlled release implants
|
|
US5912015A
(en)
|
1992-03-12 |
1999-06-15 |
Alkermes Controlled Therapeutics, Inc. |
Modulated release from biocompatible polymers
|
|
GB9225453D0
(en)
|
1992-12-04 |
1993-01-27 |
Medical Res Council |
Binding proteins
|
|
US5934272A
(en)
|
1993-01-29 |
1999-08-10 |
Aradigm Corporation |
Device and method of creating aerosolized mist of respiratory drug
|
|
JPH10511957A
(ja)
|
1995-01-05 |
1998-11-17 |
ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティ オブ ミシガン |
表面改質ナノ微粒子並びにその製造及び使用方法
|
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
|
US5916597A
(en)
|
1995-08-31 |
1999-06-29 |
Alkermes Controlled Therapeutics, Inc. |
Composition and method using solid-phase particles for sustained in vivo release of a biologically active agent
|
|
US5736152A
(en)
|
1995-10-27 |
1998-04-07 |
Atrix Laboratories, Inc. |
Non-polymeric sustained release delivery system
|
|
JP2000506165A
(ja)
|
1996-03-04 |
2000-05-23 |
ザ ペン ステイト リサーチ ファウンデーション |
細胞インターナリゼーションを増強するための物質および方法
|
|
US5985309A
(en)
|
1996-05-24 |
1999-11-16 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
|
US5855913A
(en)
|
1997-01-16 |
1999-01-05 |
Massachusetts Instite Of Technology |
Particles incorporating surfactants for pulmonary drug delivery
|
|
US5874064A
(en)
|
1996-05-24 |
1999-02-23 |
Massachusetts Institute Of Technology |
Aerodynamically light particles for pulmonary drug delivery
|
|
US5922845A
(en)
|
1996-07-11 |
1999-07-13 |
Medarex, Inc. |
Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
|
|
PT954282E
(pt)
|
1997-01-16 |
2005-06-30 |
Massachusetts Inst Technology |
Preparacao de particulas para inalacao
|
|
US5989463A
(en)
|
1997-09-24 |
1999-11-23 |
Alkermes Controlled Therapeutics, Inc. |
Methods for fabricating polymer-based controlled release devices
|
|
SE512663C2
(sv)
|
1997-10-23 |
2000-04-17 |
Biogram Ab |
Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
|
|
WO1999066903A2
(en)
|
1998-06-24 |
1999-12-29 |
Advanced Inhalation Research, Inc. |
Large porous particles emitted from an inhaler
|
|
EP1294904A1
(en)
|
2000-06-30 |
2003-03-26 |
Vlaams Interuniversitair Instituut voor Biotechnologie vzw. |
Heterodimeric fusion proteins
|
|
WO2002043658A2
(en)
|
2000-11-06 |
2002-06-06 |
The Jackson Laboratory |
Fcrn-based therapeutics for the treatment of auto-immune disorders
|
|
ITRM20010408A1
(it)
|
2001-07-10 |
2003-01-10 |
Univ Napoli Federico Ii |
Mini-anticorpo umano citotossico per cellule tumorali che esprimono il recettore erbb2.
|
|
US6833441B2
(en)
|
2001-08-01 |
2004-12-21 |
Abmaxis, Inc. |
Compositions and methods for generating chimeric heteromultimers
|
|
DE60124912T2
(de)
|
2001-09-14 |
2007-06-14 |
Affimed Therapeutics Ag |
Multimerische, einzelkettige, Tandem-Fv-Antikörper
|
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
|
US9296816B2
(en)
|
2005-04-15 |
2016-03-29 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
US9284375B2
(en)
*
|
2005-04-15 |
2016-03-15 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
US9963510B2
(en)
|
2005-04-15 |
2018-05-08 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
US7612181B2
(en)
*
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
KR101410521B1
(ko)
|
2005-12-16 |
2014-06-20 |
아이비씨 파마슈티컬스, 인코퍼레이티드 |
다가 면역글로불린-계 생동성 어셈블리들
|
|
CN105837690A
(zh)
|
2006-06-12 |
2016-08-10 |
新兴产品开发西雅图有限公司 |
具有效应功能的单链多价结合蛋白
|
|
AT503889B1
(de)
|
2006-07-05 |
2011-12-15 |
Star Biotechnologische Forschungs Und Entwicklungsges M B H F |
Multivalente immunglobuline
|
|
AT503902B1
(de)
|
2006-07-05 |
2008-06-15 |
F Star Biotech Forsch & Entw |
Verfahren zur manipulation von immunglobulinen
|
|
WO2008027236A2
(en)
|
2006-08-30 |
2008-03-06 |
Genentech, Inc. |
Multispecific antibodies
|
|
AU2008265984B2
(en)
|
2007-06-21 |
2014-07-17 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
|
DK2211904T3
(en)
|
2007-10-19 |
2016-10-24 |
Seattle Genetics Inc |
Cd19-binding agents and uses thereof
|
|
EP2113255A1
(en)
|
2008-05-02 |
2009-11-04 |
f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. |
Cytotoxic immunoglobulin
|
|
WO2010028797A1
(en)
|
2008-09-10 |
2010-03-18 |
F. Hoffmann-La Roche Ag |
Multivalent antibodies
|
|
WO2010028795A1
(en)
|
2008-09-10 |
2010-03-18 |
F. Hoffmann-La Roche Ag |
Multivalent antibodies
|
|
WO2010028796A1
(en)
|
2008-09-10 |
2010-03-18 |
F. Hoffmann-La Roche Ag |
Trispecific hexavalent antibodies
|
|
MX2011006416A
(es)
|
2008-12-19 |
2011-07-12 |
Macrogenics Inc |
Diacuerpos covalentes y sus usos.
|
|
NZ594665A
(en)
|
2009-03-20 |
2013-08-30 |
Genentech Inc |
Bispecific anti-her antibodies
|
|
BRPI1007602A2
(pt)
|
2009-05-27 |
2016-02-16 |
Hoffmann La Roche |
"anticorpo tri ou tetraespecífico, método para preparação de um anticorpo triespecífico ou tetraespecífico, célula hospedeira, composição, composição farmacêutica e método para o tratamento de um paciente com necessidade de terapia"
|
|
GB201000467D0
(en)
|
2010-01-12 |
2010-02-24 |
Ucb Pharma Sa |
Antibodies
|
|
EP2525820B1
(en)
*
|
2010-01-19 |
2016-05-11 |
Immunomedics, Inc. |
Novel class of monospecific and bispecific humanized antibodies that target the insulin-like growth factor type i receptor (igf-1r)
|
|
US20110206672A1
(en)
*
|
2010-02-25 |
2011-08-25 |
Melvyn Little |
Antigen-Binding Molecule And Uses Thereof
|
|
RU2624027C2
(ru)
|
2010-04-23 |
2017-06-30 |
Дженентек, Инк. |
Получение гетеромультимерных белков
|
|
EP2601216B1
(en)
|
2010-08-02 |
2018-01-03 |
MacroGenics, Inc. |
Covalent diabodies and uses thereof
|
|
WO2012156430A1
(en)
|
2011-05-17 |
2012-11-22 |
Trion Research Gmbh |
Vaccine preparation containing trifunctional antibodies with antigen immunogenicity enhancer properties
|
|
CN107722124A
(zh)
*
|
2011-05-21 |
2018-02-23 |
宏观基因有限公司 |
能够与人和非人cd3结合的cd3结合分子
|
|
ES2605784T3
(es)
*
|
2011-05-21 |
2017-03-16 |
Macrogenics, Inc. |
Dominios de enlazamiento a suero desinmunizados y su uso para extender la vida media en suero
|
|
WO2012162583A1
(en)
|
2011-05-26 |
2012-11-29 |
Ibc Pharmaceuticals, Inc. |
Design and construction of novel multivalent antibodies
|
|
US20150045540A1
(en)
|
2011-06-28 |
2015-02-12 |
Sea Lane Biotechnologies, Llc |
Multispecific stacked variable domain binding proteins
|
|
EP2729488A4
(en)
|
2011-07-06 |
2015-01-14 |
Medimmune Llc |
PROCESS FOR PREPARING MULTIMANT POLYPEPTIDES
|
|
UA118833C2
(uk)
*
|
2011-08-17 |
2019-03-25 |
Ґлаксо Ґруп Лімітед |
Одиничний варіабельний домен імуноглобуліну, який зв'язується з tnfr1
|
|
AU2013216943B2
(en)
|
2012-02-10 |
2018-04-19 |
Research Corporation Technologies, Inc. |
Fusion proteins comprising immunoglobulin constant domain-derived scaffolds
|
|
WO2013163427A1
(en)
|
2012-04-25 |
2013-10-31 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Antibodies to treat hiv-1 infection
|
|
WO2013174873A1
(en)
|
2012-05-24 |
2013-11-28 |
F. Hoffmann-La Roche Ag |
Multispecific antibodies
|
|
JP2015528003A
(ja)
*
|
2012-07-13 |
2015-09-24 |
ザイムワークス,インコーポレイテッド |
抗cd3構築物を含む二重特異性の非対称ヘテロ二量体
|
|
WO2014022540A1
(en)
|
2012-08-02 |
2014-02-06 |
Regeneron Pharmaceuticals, Inc. |
Multivalent antigen-binding proteins
|
|
EP2938637A2
(en)
|
2012-12-28 |
2015-11-04 |
AbbVie Inc. |
Multivalent binding protein compositions
|
|
HRP20191865T1
(hr)
|
2013-01-14 |
2020-01-10 |
Xencor, Inc. |
Novi heterodimerni proteini
|
|
LT2951203T
(lt)
|
2013-03-15 |
2019-09-10 |
Xencor, Inc. |
Heterodimeriniai baltymai
|
|
UA116479C2
(uk)
*
|
2013-08-09 |
2018-03-26 |
Макродженікс, Інк. |
БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ
|
|
US11384149B2
(en)
*
|
2013-08-09 |
2022-07-12 |
Macrogenics, Inc. |
Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof
|
|
EP2840091A1
(en)
|
2013-08-23 |
2015-02-25 |
MacroGenics, Inc. |
Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof
|
|
RU2718692C2
(ru)
*
|
2014-05-29 |
2020-04-13 |
Мэкроудженикс, Инк. |
Триспецифичные связывающие молекулы, которые специфически связывают антигены множества злокачественных опухолей, и способы их применения
|
|
TWI693232B
(zh)
*
|
2014-06-26 |
2020-05-11 |
美商宏觀基因股份有限公司 |
與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
|
|
CU20170041A7
(es)
*
|
2014-09-26 |
2017-09-06 |
Macrogenics Inc |
Diacuerpos monovalentes biespecíficos que son capaces de unir cd19 y cd3
|
|
US10717778B2
(en)
*
|
2014-09-29 |
2020-07-21 |
Duke University |
Bispecific molecules comprising an HIV-1 envelope targeting arm
|
|
SG11201706024YA
(en)
|
2015-01-26 |
2017-08-30 |
Macrogenics Inc |
Multivalent molecules comprising dr5-binding domains
|
|
EP3337507A4
(en)
*
|
2015-08-17 |
2019-04-24 |
MacroGenics, Inc. |
BIS-SPECIFIC MONOVALENTS DIABODIES WITH ABILITY TO BIND B7-H3 AND CD3 AND USES THEREOF
|
|
TW201720458A
(zh)
*
|
2015-12-04 |
2017-06-16 |
宏觀基因股份有限公司 |
能夠結合cd19 和cd3 的雙特異性單價雙抗體以及其用途
|
|
WO2017186928A1
(en)
*
|
2016-04-29 |
2017-11-02 |
Curevac Ag |
Rna encoding an antibody
|
|
EP3464378A4
(en)
*
|
2016-06-07 |
2020-06-17 |
MacroGenics, Inc. |
METHOD FOR USE OF CD32B X CD79B BINDING MOLECULES IN THE TREATMENT OF INFLAMMATORY DISEASES AND DISORDERS
|
|
CA3053803A1
(en)
*
|
2017-02-24 |
2018-08-30 |
Macrogenics, Inc. |
Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof
|
|
BR112020011810A2
(pt)
*
|
2017-12-12 |
2020-11-17 |
Macrogenics, Inc. |
molécula de ligação cd16 x antígeno de doença, composição farmacêutica, uso da composição farmacêutica, e método para o tratamento de uma doença
|
|
EP3752196A4
(en)
*
|
2018-02-15 |
2022-03-23 |
MacroGenics, Inc. |
CD3-BINDING DOMAIN VARIANTS AND THEIR USE IN COMBINATION THERAPIES FOR THE TREATMENT OF DISEASES
|
|
JP2021524451A
(ja)
*
|
2018-05-18 |
2021-09-13 |
マクロジェニクス,インコーポレーテッド |
最適化済みgp41結合分子及びその使用
|