JP2017533694A5 - - Google Patents

Info

Publication number

JP2017533694A5

JP2017533694A5 JP2017514533A JP2017514533A JP2017533694A5 JP 2017533694 A5 JP2017533694 A5 JP 2017533694A5 JP 2017514533 A JP2017514533 A JP 2017514533A JP 2017514533 A JP2017514533 A JP 2017514533A JP 2017533694 A5 JP2017533694 A5 JP 2017533694A5

Authority

JP

Japan

Prior art keywords

binding protein

ips

seq

bispecific antigen

item

Prior art date

2015-09-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 108091000831 antigen binding proteins Proteins 0.000 claims description 107
• 235000001014 amino acid Nutrition 0.000 claims description 51
• 238000006467 substitution reaction Methods 0.000 claims description 30
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 29
• 150000001413 amino acids Chemical class 0.000 claims description 26
• 206010027599 migraine Diseases 0.000 claims description 21
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 20
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 20
• 108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 claims description 19
• 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 claims description 19
• 102000005737 Type I Pituitary Adenylate Cyclase-Activating Polypeptide Receptors Human genes 0.000 claims description 18
• 208000019695 Migraine disease Diseases 0.000 claims description 17
• 102000014914 Carrier Proteins Human genes 0.000 claims description 16
• 108091008324 binding proteins Proteins 0.000 claims description 16
• 101100117763 Homo sapiens DUSP2 gene Proteins 0.000 claims description 15
• DNKYDHSONDSTNJ-XJVRLEFXSA-N chembl1910953 Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CN=CN1 DNKYDHSONDSTNJ-XJVRLEFXSA-N 0.000 claims description 15
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 15
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• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 13
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 12
• 238000011282 treatment Methods 0.000 claims description 12
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• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 2
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
• 239000004472 Lysine Substances 0.000 claims description 2
• 235000003704 aspartic acid Nutrition 0.000 claims description 2
• CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 2
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 2
• 239000003085 diluting agent Substances 0.000 claims description 2
• 239000012634 fragment Substances 0.000 claims description 2
• 235000013922 glutamic acid Nutrition 0.000 claims description 2
• 239000004220 glutamic acid Substances 0.000 claims description 2
• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims description 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
• 102220283785 rs1344101243 Human genes 0.000 claims description 2
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 4
• 230000004913 activation Effects 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 102000005962 receptors Human genes 0.000 claims 1
• 108020003175 receptors Proteins 0.000 claims 1
• 238000000034 method Methods 0.000 description 10
• 229920001184 polypeptide Polymers 0.000 description 8
• 102000004196 processed proteins & peptides Human genes 0.000 description 8
• 208000000094 Chronic Pain Diseases 0.000 description 4
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• 108010045627 Type I Pituitary Adenylate Cyclase-Activating Polypeptide Receptors Proteins 0.000 description 4
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• 239000003814 drug Substances 0.000 description 2
• 108020004707 nucleic acids Proteins 0.000 description 2
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• 229940079593 drug Drugs 0.000 description 1
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