JP2017533203A5 - - Google Patents
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- Publication number
- JP2017533203A5 JP2017533203A5 JP2017521573A JP2017521573A JP2017533203A5 JP 2017533203 A5 JP2017533203 A5 JP 2017533203A5 JP 2017521573 A JP2017521573 A JP 2017521573A JP 2017521573 A JP2017521573 A JP 2017521573A JP 2017533203 A5 JP2017533203 A5 JP 2017533203A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- solvate
- salt
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 48
- 150000001875 compounds Chemical class 0.000 claims 39
- 239000012453 solvate Substances 0.000 claims 39
- 150000003839 salts Chemical class 0.000 claims 38
- 238000000034 method Methods 0.000 claims 24
- 125000000623 heterocyclic group Chemical group 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- 125000001072 heteroaryl group Chemical group 0.000 claims 15
- 125000004452 carbocyclyl group Chemical group 0.000 claims 14
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000002947 alkylene group Chemical group 0.000 claims 8
- 125000005275 alkylenearyl group Chemical group 0.000 claims 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000005218 alkyleneheteroaryl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000000524 functional group Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical group 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 238000006396 nitration reaction Methods 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- -1 C b Chemical group 0.000 claims 1
- 239000002608 ionic liquid Substances 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 230000000802 nitrating effect Effects 0.000 claims 1
- 239000003495 polar organic solvent Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462067697P | 2014-10-23 | 2014-10-23 | |
| US62/067,697 | 2014-10-23 | ||
| PCT/US2015/057167 WO2016065290A1 (en) | 2014-10-23 | 2015-10-23 | Semi-synthesis procedures |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017533203A JP2017533203A (ja) | 2017-11-09 |
| JP2017533203A5 true JP2017533203A5 (enExample) | 2018-11-29 |
Family
ID=54478255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017521573A Pending JP2017533203A (ja) | 2014-10-23 | 2015-10-23 | 半合成法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10087157B2 (enExample) |
| EP (1) | EP3209642A1 (enExample) |
| JP (1) | JP2017533203A (enExample) |
| CN (1) | CN107108472B (enExample) |
| AU (1) | AU2015335661A1 (enExample) |
| CA (1) | CA2964957A1 (enExample) |
| EA (1) | EA201790897A1 (enExample) |
| MA (1) | MA40836A (enExample) |
| MX (1) | MX369167B (enExample) |
| WO (1) | WO2016065290A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015004523B1 (pt) | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
| MA40836A (fr) | 2014-10-23 | 2017-08-29 | Tetraphase Pharmaceuticals Inc | Procédures de semi-synthèse |
| WO2017097891A1 (en) | 2015-12-10 | 2017-06-15 | Sandoz Ag | Crystalline eravacycline |
| CN107759503A (zh) * | 2016-08-16 | 2018-03-06 | 四川科伦博泰生物医药股份有限公司 | 一种四环素衍生物及其用途 |
| ES2978198T3 (es) * | 2016-10-19 | 2024-09-06 | Tetraphase Pharmaceuticals Inc | Formas cristalinas de eravaciclina |
| CN111362829B (zh) * | 2018-12-26 | 2021-11-30 | 浙江昌海制药有限公司 | 一种米诺环素二对氯苯磺酸盐晶型及其制备方法和应用 |
| CN109734668B (zh) * | 2019-03-08 | 2020-06-23 | 杭州华樾新材料有限公司 | 四氟硼酸盐离子液体的合成方法 |
| CN110156624B (zh) * | 2019-05-29 | 2022-03-08 | 河北冀衡药业股份有限公司 | 一种米诺环素及其衍生物的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB935384A (en) | 1959-03-30 | 1963-08-28 | Pfizer & Co C | Tetracycline derivatives and preparation thereof |
| US3239499A (en) | 1961-05-19 | 1966-03-08 | Pfizer & Co C | Tetracycline derivative |
| RU2300380C2 (ru) * | 2001-10-05 | 2007-06-10 | Тетрадженекс Фармасьютикалс, Инк. | Производные тетрациклина и способы их применения |
| ES2655911T3 (es) | 2008-08-08 | 2018-02-22 | Tetraphase Pharmaceuticals, Inc. | Compuestos de tetraciclina sustituidos con C7-fluoro |
| WO2010126607A2 (en) | 2009-04-30 | 2010-11-04 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
| JP5944825B2 (ja) * | 2009-08-28 | 2016-07-05 | テトラフェース ファーマシューティカルズ，インコーポレイテッド | テトラサイクリン化合物 |
| JP5820462B2 (ja) * | 2010-03-31 | 2015-11-24 | テトラフェース ファーマシューティカルズ，インコーポレイテッド | 多環式テトラサイクリン化合物 |
| WO2012047907A1 (en) | 2010-10-04 | 2012-04-12 | President And Fellows Of Harvard College | Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto |
| MA40836A (fr) | 2014-10-23 | 2017-08-29 | Tetraphase Pharmaceuticals Inc | Procédures de semi-synthèse |
-
2015
- 2015-10-22 MA MA040836A patent/MA40836A/fr unknown
- 2015-10-23 US US15/521,162 patent/US10087157B2/en not_active Expired - Fee Related
- 2015-10-23 WO PCT/US2015/057167 patent/WO2016065290A1/en not_active Ceased
- 2015-10-23 CN CN201580070869.6A patent/CN107108472B/zh not_active Expired - Fee Related
- 2015-10-23 EP EP15791440.9A patent/EP3209642A1/en not_active Withdrawn
- 2015-10-23 JP JP2017521573A patent/JP2017533203A/ja active Pending
- 2015-10-23 AU AU2015335661A patent/AU2015335661A1/en not_active Abandoned
- 2015-10-23 MX MX2017005223A patent/MX369167B/es active IP Right Grant
- 2015-10-23 CA CA2964957A patent/CA2964957A1/en not_active Abandoned
- 2015-10-23 EA EA201790897A patent/EA201790897A1/ru unknown
-
2018
- 2018-08-09 US US16/059,857 patent/US10618879B2/en not_active Expired - Fee Related
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