CA2964957A1 - Semi-synthesis procedures - Google Patents

Semi-synthesis procedures Download PDF

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Publication number
CA2964957A1
CA2964957A1 CA2964957A CA2964957A CA2964957A1 CA 2964957 A1 CA2964957 A1 CA 2964957A1 CA 2964957 A CA2964957 A CA 2964957A CA 2964957 A CA2964957 A CA 2964957A CA 2964957 A1 CA2964957 A1 CA 2964957A1
Authority
CA
Canada
Prior art keywords
alkyl
group
hydrogen
alkoxy
alkylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2964957A
Other languages
English (en)
French (fr)
Inventor
Wu-Yan Zhang
Danny LAFRANCE
Magnus P. Ronn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tetraphase Pharmaceuticals Inc
Original Assignee
Tetraphase Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tetraphase Pharmaceuticals Inc filed Critical Tetraphase Pharmaceuticals Inc
Publication of CA2964957A1 publication Critical patent/CA2964957A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/20—Diazonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
CA2964957A 2014-10-23 2015-10-23 Semi-synthesis procedures Abandoned CA2964957A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462067697P 2014-10-23 2014-10-23
US62/067,697 2014-10-23
PCT/US2015/057167 WO2016065290A1 (en) 2014-10-23 2015-10-23 Semi-synthesis procedures

Publications (1)

Publication Number Publication Date
CA2964957A1 true CA2964957A1 (en) 2016-04-28

Family

ID=54478255

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2964957A Abandoned CA2964957A1 (en) 2014-10-23 2015-10-23 Semi-synthesis procedures

Country Status (10)

Country Link
US (2) US10087157B2 (enExample)
EP (1) EP3209642A1 (enExample)
JP (1) JP2017533203A (enExample)
CN (1) CN107108472B (enExample)
AU (1) AU2015335661A1 (enExample)
CA (1) CA2964957A1 (enExample)
EA (1) EA201790897A1 (enExample)
MA (1) MA40836A (enExample)
MX (1) MX369167B (enExample)
WO (1) WO2016065290A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015004523B1 (pt) 2012-08-31 2020-08-04 Tetraphase Pharmaceuticals, Inc Compostos de tetraciclina, composições farmacêuticas e seus usos
MA40836A (fr) 2014-10-23 2017-08-29 Tetraphase Pharmaceuticals Inc Procédures de semi-synthèse
WO2017097891A1 (en) 2015-12-10 2017-06-15 Sandoz Ag Crystalline eravacycline
CN107759503A (zh) * 2016-08-16 2018-03-06 四川科伦博泰生物医药股份有限公司 一种四环素衍生物及其用途
CN110582486B (zh) * 2016-10-19 2024-01-12 四相制药公司 艾若威四环素的结晶形式
CN111362829B (zh) * 2018-12-26 2021-11-30 浙江昌海制药有限公司 一种米诺环素二对氯苯磺酸盐晶型及其制备方法和应用
CN109734668B (zh) * 2019-03-08 2020-06-23 杭州华樾新材料有限公司 四氟硼酸盐离子液体的合成方法
CN110156624B (zh) * 2019-05-29 2022-03-08 河北冀衡药业股份有限公司 一种米诺环素及其衍生物的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB935384A (en) * 1959-03-30 1963-08-28 Pfizer & Co C Tetracycline derivatives and preparation thereof
US3239499A (en) * 1961-05-19 1966-03-08 Pfizer & Co C Tetracycline derivative
RU2300380C2 (ru) * 2001-10-05 2007-06-10 Тетрадженекс Фармасьютикалс, Инк. Производные тетрациклина и способы их применения
PT2323972E (pt) * 2008-08-08 2013-10-09 Tetraphase Pharmaceuticals Inc Compostos de tetraciclina substituídos com c7-flúor
WO2010126607A2 (en) * 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
IN2012DN02502A (enExample) * 2009-08-28 2015-08-28 Tetraphase Pharmaceuticals Inc
TWI592390B (zh) * 2010-03-31 2017-07-21 四相製藥公司 聚環狀四環素化合物
WO2012047907A1 (en) 2010-10-04 2012-04-12 President And Fellows Of Harvard College Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
MA40836A (fr) 2014-10-23 2017-08-29 Tetraphase Pharmaceuticals Inc Procédures de semi-synthèse

Also Published As

Publication number Publication date
MX2017005223A (es) 2017-06-21
WO2016065290A1 (en) 2016-04-28
CN107108472A (zh) 2017-08-29
CN107108472B (zh) 2020-03-13
JP2017533203A (ja) 2017-11-09
US10618879B2 (en) 2020-04-14
MA40836A (fr) 2017-08-29
MX369167B (es) 2019-10-30
EA201790897A1 (ru) 2017-08-31
US20170334872A1 (en) 2017-11-23
US20190210988A1 (en) 2019-07-11
AU2015335661A1 (en) 2017-05-04
EP3209642A1 (en) 2017-08-30
US10087157B2 (en) 2018-10-02

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20220113