JP2017532962A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017532962A5 JP2017532962A5 JP2017520492A JP2017520492A JP2017532962A5 JP 2017532962 A5 JP2017532962 A5 JP 2017532962A5 JP 2017520492 A JP2017520492 A JP 2017520492A JP 2017520492 A JP2017520492 A JP 2017520492A JP 2017532962 A5 JP2017532962 A5 JP 2017532962A5
- Authority
- JP
- Japan
- Prior art keywords
- rna polynucleotide
- helicase
- dna
- polynucleotide
- leader sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 12
- 108060004795 Methyltransferase Proteins 0.000 claims 11
- 108090000133 DNA helicases Proteins 0.000 claims 10
- 102000003844 DNA helicases Human genes 0.000 claims 10
- 239000011148 porous material Substances 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 238000005259 measurement Methods 0.000 claims 4
- 241000588653 Neisseria Species 0.000 claims 2
- 101710203389 Outer membrane porin F Proteins 0.000 claims 2
- 101710203388 Outer membrane porin G Proteins 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102100022536 Helicase POLQ-like Human genes 0.000 claims 1
- 108010006464 Hemolysin Proteins Proteins 0.000 claims 1
- 101000899334 Homo sapiens Helicase POLQ-like Proteins 0.000 claims 1
- 108010014603 Leukocidins Proteins 0.000 claims 1
- 102000004895 Lipoproteins Human genes 0.000 claims 1
- 108090001030 Lipoproteins Proteins 0.000 claims 1
- 241000187480 Mycobacterium smegmatis Species 0.000 claims 1
- 108010013381 Porins Proteins 0.000 claims 1
- 108010073429 Type V Secretion Systems Proteins 0.000 claims 1
- 238000012512 characterization method Methods 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 239000003228 hemolysin Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000011987 methylation Effects 0.000 claims 1
- 238000007069 methylation reaction Methods 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 108010014203 outer membrane phospholipase A Proteins 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 102000007739 porin activity proteins Human genes 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1418459.2 | 2014-10-17 | ||
| GB201418459A GB201418459D0 (en) | 2014-10-17 | 2014-10-17 | Method |
| GB1508270.4 | 2015-05-14 | ||
| GBGB1508270.4A GB201508270D0 (en) | 2015-05-14 | 2015-05-14 | Method |
| GBGB1517634.0A GB201517634D0 (en) | 2015-10-06 | 2015-10-06 | Method |
| GBPCT/GB2015/052916 | 2015-10-06 | ||
| PCT/GB2015/052916 WO2016055777A2 (en) | 2014-10-07 | 2015-10-06 | Modified enzymes |
| GB1517634.0 | 2015-10-06 | ||
| PCT/GB2015/053097 WO2016059436A1 (en) | 2014-10-17 | 2015-10-19 | Method for nanopore rna characterisation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532962A JP2017532962A (ja) | 2017-11-09 |
| JP2017532962A5 true JP2017532962A5 (OSRAM) | 2018-11-29 |
| JP6824881B2 JP6824881B2 (ja) | 2021-02-03 |
Family
ID=54337815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017520492A Active JP6824881B2 (ja) | 2014-10-17 | 2015-10-19 | ナノ細孔ｒｎａを特徴付けるための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US10480026B2 (OSRAM) |
| EP (1) | EP3207155B1 (OSRAM) |
| JP (1) | JP6824881B2 (OSRAM) |
| KR (1) | KR102457147B1 (OSRAM) |
| CN (2) | CN113981055A (OSRAM) |
| WO (1) | WO2016059436A1 (OSRAM) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| EP2987870B1 (en) | 2011-10-21 | 2020-02-19 | Oxford Nanopore Technologies Limited | Method of characterizing a target polynucleotide using a transmembrane pore and molecular motor |
| IN2014DN06796A (OSRAM) | 2012-02-15 | 2015-05-22 | Oxford Nanopore Tech Ltd | |
| KR102083695B1 (ko) | 2012-04-10 | 2020-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 리세닌 기공 |
| GB2559073A (en) | 2012-06-08 | 2018-07-25 | Pacific Biosciences California Inc | Modified base detection with nanopore sequencing |
| US10808231B2 (en) | 2012-07-19 | 2020-10-20 | Oxford Nanopore Technologies Limited | Modified helicases |
| GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
| CN118086476A (zh) | 2013-10-18 | 2024-05-28 | 牛津纳米孔科技公开有限公司 | 经修饰的酶 |
| GB201417712D0 (en) | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
| US10400014B2 (en) | 2014-09-01 | 2019-09-03 | Oxford Nanopore Technologies Ltd. | Mutant CsgG pores |
| KR102457147B1 (ko) | 2014-10-17 | 2022-10-19 | 옥스포드 나노포어 테크놀로지즈 피엘씨 | 나노 세공 rna 특징 규명을 위한 방법 |
| US10975428B2 (en) | 2016-03-02 | 2021-04-13 | Oxford Nanopore Technologies Ltd. | Mutant pore |
| US11514289B1 (en) * | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
| CN118326018B (zh) | 2016-04-06 | 2025-11-07 | 牛津纳米孔科技公开有限公司 | 突变体孔 |
| EP4063521B1 (en) * | 2016-05-25 | 2024-02-21 | Oxford Nanopore Technologies PLC | Method of nanopore sequencing |
| GB201609221D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| GB201617886D0 (en) * | 2016-10-21 | 2016-12-07 | Oxford Nanopore Technologies Limited | Method |
| GB201620450D0 (en) | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
| WO2018200847A1 (en) * | 2017-04-27 | 2018-11-01 | The Regents Of The University Of California | Methods of producing ribosomal ribonucleic acid complexes |
| GB201707140D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| KR102885764B1 (ko) * | 2017-06-29 | 2025-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 나노포어를 통한 폴리머의 결정적 스텝핑 |
| CN117106037B (zh) | 2017-06-30 | 2025-07-25 | 弗拉芒区生物技术研究所 | 新颖蛋白孔 |
| GB2569977A (en) * | 2018-01-05 | 2019-07-10 | Oxford Nanopore Tech Ltd | Method |
| US12475812B2 (en) | 2018-02-02 | 2025-11-18 | Bayer Aktiengesellschaft | Control of resistent harmful organisms |
| US12195794B2 (en) * | 2018-05-23 | 2025-01-14 | The Regents Of The University Of California | Methods of analyzing capped ribonucleic acids |
| GB201809323D0 (en) | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
| EP3650558A1 (en) * | 2018-11-07 | 2020-05-13 | Siemens Healthcare GmbH | Liquid sample workflow for nanopore sequencing |
| EP3650559B1 (en) * | 2018-11-08 | 2022-06-29 | Siemens Healthcare GmbH | Direct rna nanopore sequencing with help of a stem-loop polynucleotide |
| CN111455031A (zh) * | 2019-01-18 | 2020-07-28 | 中国科学院微生物研究所 | 基于Nanopore测序技术的多组学测序及分析方法 |
| CN110093399A (zh) * | 2019-04-22 | 2019-08-06 | 武汉大学 | 一种利用二磷酸尿嘧啶脱氧核苷酸检测核酸中腺嘌呤n6位发生甲基化修饰的方法 |
| GB201907244D0 (en) * | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| US11926819B2 (en) | 2019-05-28 | 2024-03-12 | The Regents Of The University Of California | Methods of adding polymers to ribonucleic acids |
| WO2021036995A1 (en) * | 2019-08-23 | 2021-03-04 | Nanjing University | Direct microrna sequencing using enzyme assisted sequencing |
| CN110568039B (zh) * | 2019-09-06 | 2021-05-04 | 中国科学院生物物理研究所 | 使用新型电化学传感器的氨基酸特异实时检测方法 |
| CN111164097B (zh) * | 2019-09-29 | 2021-02-19 | 北京齐碳科技有限公司 | 一种Mnep单体变体及其应用 |
| CN113930406B (zh) * | 2021-12-17 | 2022-04-08 | 北京齐碳科技有限公司 | 一种Pif1-like解旋酶及其应用 |
| GB202107192D0 (en) * | 2021-05-19 | 2021-06-30 | Oxford Nanopore Tech Ltd | Method |
| CN114134142B (zh) * | 2021-11-23 | 2024-05-28 | 成都齐碳科技有限公司 | 衔接体、复合物、单链分子、试剂盒、方法和应用 |
| WO2023116575A1 (zh) * | 2021-12-21 | 2023-06-29 | 成都齐碳科技有限公司 | 用于表征目标多核苷酸的衔接体、方法及其用途 |
| GB202204919D0 (en) | 2022-04-04 | 2022-05-18 | Oxford Nanopore Tech Plc | Method |
| WO2023225988A1 (zh) * | 2022-05-27 | 2023-11-30 | 深圳华大生命科学研究院 | 一种维持纳米孔测序速度的方法 |
| CN120457488A (zh) | 2022-11-10 | 2025-08-08 | 拜耳公司 | 基于遗传谱的靶向性作物保护产品施用 |
| CN116478983B (zh) * | 2022-11-21 | 2023-10-24 | 北京普译生物科技有限公司 | 一种rna-dna嵌合接头及其应用 |
| CN116676175B (zh) * | 2023-03-17 | 2024-04-09 | 四川大学 | 一种多条形码直接rna纳米孔测序分类器 |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5198543A (en) | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
| WO1993015228A1 (en) | 1992-01-29 | 1993-08-05 | Hitachi Chemical Co., Ltd. | Polynucleotide immobilized support |
| US6426231B1 (en) | 1998-11-18 | 2002-07-30 | The Texas A&M University System | Analyte sensing mediated by adapter/carrier molecules |
| CA2384100C (en) | 1999-09-07 | 2011-03-29 | The Regents Of The University Of California | Methods of determining the presence of double stranded nucleic acids in a sample |
| EP1097993A3 (en) * | 1999-11-05 | 2004-01-07 | National Institute of Advanced Industrial Science and Technology | Functional ribozyme chimeric molecules capable of sliding |
| US20020197618A1 (en) | 2001-01-20 | 2002-12-26 | Sampson Jeffrey R. | Synthesis and amplification of unstructured nucleic acids for rapid sequencing |
| US6706203B2 (en) | 2001-10-30 | 2004-03-16 | Agilent Technologies, Inc. | Adjustable nanopore, nanotome, and nanotweezer |
| US20040029158A1 (en) | 2002-05-17 | 2004-02-12 | Eric Olson | HOP - a novel cardiac-restricted transcriptional factor potentially useful for cardiac regeneration and specification |
| CA2498764C (en) * | 2002-09-20 | 2015-11-10 | New England Biolabs, Inc. | Helicase dependent amplification of nucleic acids |
| ATE533857T1 (de) | 2003-01-17 | 2011-12-15 | Univ Hong Kong Chinese | Zirkulierende mrna als diagnostische marker für erkankungen die mit einer schwangerschaft zusammenhängen |
| US20050250094A1 (en) | 2003-05-30 | 2005-11-10 | Nanosphere, Inc. | Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes |
| US7347921B2 (en) | 2003-07-17 | 2008-03-25 | Agilent Technologies, Inc. | Apparatus and method for threading a biopolymer through a nanopore |
| EP1732571A4 (en) | 2004-03-05 | 2009-09-09 | Archemix Corp | CONTROLLED MODULATION OF PHARMACOKINETICS AND BIOLOGICAL DISTRIBUTION OF APTAMERIC THERAPY |
| WO2006028508A2 (en) | 2004-03-23 | 2006-03-16 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
| US9233846B2 (en) | 2005-10-14 | 2016-01-12 | The Regents Of The University Of California | Formation and encapsulation of molecular bilayer and monolayer membranes |
| US20070190543A1 (en) | 2005-11-14 | 2007-08-16 | Applera Corporation | Coded Molecules for Detecting Target Analytes |
| GB0523282D0 (en) | 2005-11-15 | 2005-12-21 | Isis Innovation | Methods using pores |
| EP1994179A2 (en) | 2006-02-18 | 2008-11-26 | Michael Strathmann | Massively multiplexed sequencing |
| US20100291548A1 (en) | 2006-03-12 | 2010-11-18 | Applera Corporation | Methods of Detecting Target Nucleic Acids |
| WO2008066621A2 (en) | 2006-10-19 | 2008-06-05 | Duke University | Reversible platelet inhibition |
| AU2008217578A1 (en) | 2007-02-20 | 2008-08-28 | Oxford Nanopore Technologies Limited | Lipid bilayer sensor system |
| US20110005918A1 (en) | 2007-04-04 | 2011-01-13 | Akeson Mark A | Compositions, devices, systems, and methods for using a nanopore |
| WO2009046149A1 (en) | 2007-10-01 | 2009-04-09 | Applied Biosystems Inc. | Chase ligation sequencing |
| US20100298152A1 (en) | 2007-10-12 | 2010-11-25 | Pronota Nv | Use of aptamers in proteomics |
| EP2209914B2 (en) | 2007-10-22 | 2017-07-26 | Caris Life Sciences Switzerland Holdings GmbH | Method of selecting aptamers |
| GB0724736D0 (en) | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
| US20110263459A1 (en) | 2008-03-12 | 2011-10-27 | Borer Philip N | Direct selection of structurally defined aptamers |
| US8628940B2 (en) | 2008-09-24 | 2014-01-14 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
| WO2010004273A1 (en) | 2008-07-07 | 2010-01-14 | Oxford Nanopore Technologies Limited | Base-detecting pore |
| EP2307540B1 (en) | 2008-07-07 | 2017-04-19 | Oxford Nanopore Technologies Limited | Enzyme-pore constructs |
| US20100092960A1 (en) | 2008-07-25 | 2010-04-15 | Pacific Biosciences Of California, Inc. | Helicase-assisted sequencing with molecular beacons |
| WO2010047797A2 (en) | 2008-10-21 | 2010-04-29 | Research Foundation Of The City University Of New York | Single quantum-dot-based aptameric sensors |
| WO2010062697A2 (en) * | 2008-10-30 | 2010-06-03 | Peixuan Guo | Membrane-integrated viral dna-packaging motor protein connector biosensor for dna sequencing and other uses |
| GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| JP5843614B2 (ja) | 2009-01-30 | 2016-01-13 | オックスフォード ナノポア テクノロジーズ リミテッド | 膜貫通配列決定における核酸構築物のためのアダプター |
| KR20110125226A (ko) | 2009-01-30 | 2011-11-18 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 혼성화 링커 |
| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| US8986928B2 (en) | 2009-04-10 | 2015-03-24 | Pacific Biosciences Of California, Inc. | Nanopore sequencing devices and methods |
| EP2422198B1 (en) | 2009-04-20 | 2013-09-25 | Oxford Nanopore Technologies Limited | Lipid bilayer sensor array |
| CN102741430B (zh) | 2009-12-01 | 2016-07-13 | 牛津楠路珀尔科技有限公司 | 生化分析仪器、用于进行生化分析的第一模块以及相关方法 |
| US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| WO2011103424A2 (en) | 2010-02-19 | 2011-08-25 | The Trustees Of The University Of Pennsylvania | High-resolution analysis devices and related methods |
| US8557529B2 (en) | 2010-04-09 | 2013-10-15 | International Business Machines Corporation | Nanopore capture system |
| EP3190193A1 (en) | 2010-07-14 | 2017-07-12 | The Curators Of The University Of Missouri | Nanopore-facilitated single molecule detection of nucleic acids |
| CN103392008B (zh) * | 2010-09-07 | 2017-10-20 | 加利福尼亚大学董事会 | 通过持续性酶以一个核苷酸的精度控制dna在纳米孔中的移动 |
| US8845880B2 (en) | 2010-12-22 | 2014-09-30 | Genia Technologies, Inc. | Nanopore-based single DNA molecule characterization, identification and isolation using speed bumps |
| CN103460040B (zh) * | 2011-02-11 | 2016-08-17 | 牛津纳米孔技术有限公司 | 突变型孔 |
| US9290815B2 (en) * | 2011-02-21 | 2016-03-22 | Qiagen Gmbh | Method for quantifying human DNA |
| WO2012129242A2 (en) | 2011-03-23 | 2012-09-27 | Pacific Biosciences Of California, Inc. | Isolation of polymerase-nucleic acid complexes and loading onto substrates |
| WO2012164270A1 (en) | 2011-05-27 | 2012-12-06 | Oxford Nanopore Technologies Limited | Coupling method |
| US10228347B2 (en) * | 2011-06-24 | 2019-03-12 | Electronic Biosciences, Inc. | High contrast signal to noise ratio device components |
| IN2014DN00221A (OSRAM) * | 2011-07-25 | 2015-06-05 | Oxford Nanopore Tech Ltd | |
| KR102023754B1 (ko) | 2011-07-27 | 2019-09-20 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 생체분자 특성규명용 나노포어 센서 |
| GB2497838A (en) | 2011-10-19 | 2013-06-26 | Nugen Technologies Inc | Compositions and methods for directional nucleic acid amplification and sequencing |
| EP2987870B1 (en) | 2011-10-21 | 2020-02-19 | Oxford Nanopore Technologies Limited | Method of characterizing a target polynucleotide using a transmembrane pore and molecular motor |
| CN102430153A (zh) * | 2011-12-24 | 2012-05-02 | 中国人民解放军第三军医大学第二附属医院 | 一种基于交联技术的仿生骨界面、构建方法及其应用 |
| CN104136631B (zh) | 2011-12-29 | 2017-03-01 | 牛津纳米孔技术公司 | 使用xpd解旋酶表征多核苷酸的方法 |
| JP6228128B2 (ja) * | 2011-12-29 | 2017-11-08 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素法 |
| IN2014DN06796A (OSRAM) | 2012-02-15 | 2015-05-22 | Oxford Nanopore Tech Ltd | |
| BR102012007246A2 (pt) | 2012-03-30 | 2016-02-10 | Fundação Antonio Prudente | métodos para prognóstico e classificação de resultados de um evento |
| KR102083695B1 (ko) | 2012-04-10 | 2020-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 리세닌 기공 |
| US10808231B2 (en) * | 2012-07-19 | 2020-10-20 | Oxford Nanopore Technologies Limited | Modified helicases |
| WO2014013259A1 (en) | 2012-07-19 | 2014-01-23 | Oxford Nanopore Technologies Limited | Ssb method |
| US9797009B2 (en) | 2012-07-19 | 2017-10-24 | Oxford Nanopore Technologies Limited | Enzyme construct |
| US9551023B2 (en) | 2012-09-14 | 2017-01-24 | Oxford Nanopore Technologies Ltd. | Sample preparation method |
| WO2014072703A1 (en) | 2012-11-06 | 2014-05-15 | Oxford Nanopore Technologies Limited | Quadruplex method |
| GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
| EP2964779B1 (en) | 2013-03-08 | 2018-08-29 | Oxford Nanopore Technologies Limited | Use of spacer elements in a nucleic acid to control movement of a helicase |
| GB201406151D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| CN118086476A (zh) | 2013-10-18 | 2024-05-28 | 牛津纳米孔科技公开有限公司 | 经修饰的酶 |
| CN106460061B (zh) | 2014-04-04 | 2020-03-06 | 牛津纳米孔技术公司 | 在双链核酸分子的两端使用纳米孔和锚分子来表征所述双链核酸的方法 |
| KR102457147B1 (ko) | 2014-10-17 | 2022-10-19 | 옥스포드 나노포어 테크놀로지즈 피엘씨 | 나노 세공 rna 특징 규명을 위한 방법 |
-
2015
- 2015-10-19 KR KR1020177013136A patent/KR102457147B1/ko active Active
- 2015-10-19 CN CN202111321280.2A patent/CN113981055A/zh active Pending
- 2015-10-19 US US15/519,599 patent/US10480026B2/en active Active
- 2015-10-19 WO PCT/GB2015/053097 patent/WO2016059436A1/en not_active Ceased
- 2015-10-19 JP JP2017520492A patent/JP6824881B2/ja active Active
- 2015-10-19 EP EP15784137.0A patent/EP3207155B1/en active Active
- 2015-10-19 CN CN201580069027.9A patent/CN107109489B/zh active Active
-
2019
- 2019-09-19 US US16/575,610 patent/US11021747B2/en active Active
-
2021
- 2021-04-30 US US17/246,462 patent/US12129518B2/en active Active
-
2024
- 2024-09-19 US US18/889,917 patent/US20250084472A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017532962A5 (OSRAM) | ||
| JP2017503517A5 (OSRAM) | ||
| JP2014534812A5 (OSRAM) | ||
| JP2010539966A5 (OSRAM) | ||
| MY149161A (en) | Methods using pores | |
| JP2014519823A5 (OSRAM) | ||
| JP2014532430A5 (OSRAM) | ||
| JP2016516735A5 (OSRAM) | ||
| JP2014531196A5 (OSRAM) | ||
| WO2012109500A3 (en) | Analysis of nucleic acids | |
| JP2018516541A5 (OSRAM) | ||
| ATE515488T1 (de) | Click-chemie zur herstellung von reportermolekülen | |
| CA2873099C (en) | Aptamer-based multiplexed assays | |
| WO2012135815A3 (en) | Methods and kits for detecting cell-free pathogen-specific nucleic acids | |
| GB2500360A (en) | Nanopore-based single DNA molecule characterization, identification and isolation using speed bumps | |
| JP2009519705A5 (OSRAM) | ||
| JP2010529435A5 (OSRAM) | ||
| BR112012006678A2 (pt) | método para criar um arranjo proteico, arranjo proteico e métodos para determinar a especificidade da ligação de um anticorpo ou preparação de anticorpos, para determinar biomarcadores de doenças, para diagnosticar uma doença, para monitorar as vias de transdução de sinais e para determinar interações entre pequenas moléculas e proteínas | |
| EA201000427A1 (ru) | Секвенирование нуклеиново-кислотных полимеров с использованием электронной микроскопии | |
| WO2014064444A1 (en) | Droplet interfaces | |
| JP2015508893A5 (OSRAM) | ||
| WO2018053365A8 (en) | METHODS OF PREPARING NUCLEIC ACID SAMPLE FOR ANALYSIS OF ACELLULAR DNA | |
| JP2017536846A5 (OSRAM) | ||
| EP3828284A1 (en) | One-step procedure for the purification of nucleic acids | |
| JP2017500046A (ja) | 複製ポリメラーゼおよびヘリカーゼの使用によるナノポア配列決定 |