JP2017531797A5 - - Google Patents
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- Publication number
- JP2017531797A5 JP2017531797A5 JP2017517722A JP2017517722A JP2017531797A5 JP 2017531797 A5 JP2017531797 A5 JP 2017531797A5 JP 2017517722 A JP2017517722 A JP 2017517722A JP 2017517722 A JP2017517722 A JP 2017517722A JP 2017531797 A5 JP2017531797 A5 JP 2017531797A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- label
- group
- antibody conjugate
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940127121 immunoconjugate Drugs 0.000 claims 19
- 125000005647 linker group Chemical group 0.000 claims 9
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 239000003153 chemical reaction reagent Substances 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 6
- -1 di-nitrophenyl Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 229920000642 polymer Polymers 0.000 claims 5
- 125000006850 spacer group Chemical group 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 claims 2
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 claims 2
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 2
- QGJCWLBFFLOLQQ-UHFFFAOYSA-N 2,1,3-benzoxadiazole-5-carboxamide Chemical compound C1=C(C(=O)N)C=CC2=NON=C21 QGJCWLBFFLOLQQ-UHFFFAOYSA-N 0.000 claims 1
- XJSXKUVHNQWOPH-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)quinoline-4-carboxylic acid Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC(C(O)=O)=C(C=CC=C2)C2=N1 XJSXKUVHNQWOPH-UHFFFAOYSA-N 0.000 claims 1
- ZYIOOQWZZPEWHL-UHFFFAOYSA-N 3-nitro-1h-pyrazole-5-carboxamide Chemical compound NC(=O)C1=CC([N+]([O-])=O)=NN1 ZYIOOQWZZPEWHL-UHFFFAOYSA-N 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 235000013877 carbamide Nutrition 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229960000956 coumarin Drugs 0.000 claims 1
- 235000001671 coumarin Nutrition 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- LXASOSGTNFQNER-UHFFFAOYSA-N n-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)acetamide Chemical compound CC(=O)NC1=NC(C)=C(S(N)(=O)=O)S1 LXASOSGTNFQNER-UHFFFAOYSA-N 0.000 claims 1
- 125000004999 nitroaryl group Chemical group 0.000 claims 1
- 229920001484 poly(alkylene) Polymers 0.000 claims 1
- 239000002096 quantum dot Substances 0.000 claims 1
- CGJMVNVWQHPASW-UHFFFAOYSA-N quinoxaline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)N)=CN=C21 CGJMVNVWQHPASW-UHFFFAOYSA-N 0.000 claims 1
- JUVIOZPCNVVQFO-HBGVWJBISA-N rotenone Chemical compound O([C@H](CC1=C2O3)C(C)=C)C1=CC=C2C(=O)[C@@H]1[C@H]3COC2=C1C=C(OC)C(OC)=C2 JUVIOZPCNVVQFO-HBGVWJBISA-N 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462059073P | 2014-10-02 | 2014-10-02 | |
| US62/059,073 | 2014-10-02 | ||
| US201562212879P | 2015-09-01 | 2015-09-01 | |
| US62/212,879 | 2015-09-01 | ||
| PCT/EP2015/072701 WO2016050913A2 (en) | 2014-10-02 | 2015-10-01 | Polymers and conjugates comprising the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017531797A JP2017531797A (ja) | 2017-10-26 |
| JP2017531797A5 true JP2017531797A5 (https=) | 2018-11-15 |
| JP6762296B2 JP6762296B2 (ja) | 2020-09-30 |
Family
ID=54266549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017517722A Active JP6762296B2 (ja) | 2014-10-02 | 2015-10-01 | ポリマー及びポリマーを含むコンジュゲート |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11079372B2 (https=) |
| EP (1) | EP3201628B1 (https=) |
| JP (1) | JP6762296B2 (https=) |
| AU (1) | AU2015326827B2 (https=) |
| CA (2) | CA2957783C (https=) |
| WO (1) | WO2016050913A2 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017141903A1 (ja) * | 2016-02-16 | 2017-08-24 | 株式会社トッパンＴｏｍｏｅｇａｗａオプティカルフィルム | 光学積層体、偏光板及び表示装置 |
| CN114761431B (zh) * | 2019-10-16 | 2025-04-25 | 株式会社Lg化学 | 新生儿Fc受体结合AFFIMER |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1564604A (en) | 1925-06-12 | 1925-12-08 | Chas S Hodges | Water wheel |
| US4824775A (en) * | 1985-01-03 | 1989-04-25 | Molecular Diagnostics, Inc. | Cells labeled with multiple Fluorophores bound to a nucleic acid carrier |
| US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| US5641629A (en) * | 1990-06-11 | 1997-06-24 | Nexstar Pharmacueticals Inc | Spectroscopically detectable nucleic acid ligands |
| DE4302459A1 (de) * | 1993-01-29 | 1994-08-04 | Bayer Ag | Sulfocumarinhaltige Nukleotide und deren Verwendung in Nachweisverfahren für Nukleinsäuren |
| AU6514096A (en) * | 1995-07-27 | 1997-02-26 | Carsten Behrens | A new achiral linker reagent for the incorporation of multiple amino groups into oligonucleotides |
| WO1999043287A2 (en) * | 1998-02-25 | 1999-09-02 | Biotraces, Inc. | Phosphate-based dendrimers for bioassays |
| JP3847559B2 (ja) | 1998-02-27 | 2006-11-22 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 独立スライド加熱器を有する自動化分子病理学装置 |
| US6582962B1 (en) | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US20030211630A1 (en) | 1998-02-27 | 2003-11-13 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US6372937B1 (en) | 1998-11-09 | 2002-04-16 | Mark Norman Bobrow | Enhanced catalyzed reporter deposition |
| FR2791141B1 (fr) * | 1999-03-15 | 2001-06-01 | Cis Bio Int | Procede de reduction de l'extinction de fluorescence due au milieu de mesure |
| US6670113B2 (en) | 2001-03-30 | 2003-12-30 | Nanoprobes | Enzymatic deposition and alteration of metals |
| WO2002082083A1 (en) * | 2001-04-04 | 2002-10-17 | Wako Pure Chemical Industries, Ltd. | Electrophoresis |
| US7514551B2 (en) | 2003-04-03 | 2009-04-07 | Enzo Life Sciences, Inc. | Multisignal labeling reagents, and processes and uses therefor |
| DK1636586T3 (da) | 2003-06-24 | 2009-11-23 | Ventana Med Syst Inc | Enzymkatalyseret metaldeponering til foröget in situ-detektion af immunhistokemisker epitoper og nucleinsyresekvenser |
| DE10340143A1 (de) | 2003-08-26 | 2005-03-31 | SSI Schäfer PEEM GmbH | Kommissionierplatz und Verfahren zum Kommissionieren |
| EP1725572B1 (de) * | 2003-11-05 | 2017-05-31 | AGCT GmbH | Makromolekulare nukleotidverbindungen und methoden zu deren anwendung |
| JP2008082784A (ja) * | 2006-09-26 | 2008-04-10 | Sysmex Corp | 新規な標的物質検出用試薬 |
| DK2444807T3 (da) * | 2006-11-01 | 2014-08-11 | Ventana Med Syst Inc | Mono- og dinitropyrazolhaptenkonjugater |
| GB0701444D0 (en) * | 2007-01-25 | 2007-03-07 | Iti Scotland Ltd | Detecting analytes |
| EP2167963B1 (en) * | 2007-05-23 | 2019-04-17 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
| KR101072900B1 (ko) * | 2007-12-04 | 2011-10-17 | 주식회사 파나진 | 고정화된 펩티드핵산 프로브를 사용한 표적핵산의 선택적 표지 및 검출 방법 |
| KR101289164B1 (ko) * | 2008-03-10 | 2013-07-31 | 퀜티백트 에이/에스 | 삼중나선구조 형성 단량체 단위를 포함하는 프라이머를 이용한 표적증폭 및 서열분석 |
| FR2933520B1 (fr) | 2008-07-04 | 2011-02-11 | Canon Kk | Procede et dispositif de restauration d'une sequence video |
| EP2334827B1 (en) | 2008-08-22 | 2015-03-11 | Ventana Medical Systems, Inc. | Method for chromogenic detection of two or more target molecules in a single sample |
| DE102008062372B3 (de) * | 2008-12-17 | 2010-06-17 | Medizinische Hochschule Hannover | Nachweiskonjugat und Verfahren zur Analyse |
| CA2842661C (en) | 2009-10-19 | 2016-02-23 | Ventana Medical Systems, Inc. | Imaging system and techniques |
| EP2807272A1 (en) * | 2012-01-27 | 2014-12-03 | Ventana Medical Systems, Inc. | Devices and methods for detecting bio-analytes using optically decipherable patterns |
| ES2678211T3 (es) | 2012-03-27 | 2018-08-09 | Ventana Medical Systems, Inc. | Conjugados de señalización y procedimientos de uso |
| JP5509440B2 (ja) * | 2012-06-22 | 2014-06-04 | 国立大学法人九州大学 | タンパク質−核酸複合体の製造方法および標的物の検出方法 |
| CA2940111C (en) * | 2014-02-21 | 2022-03-15 | Ventana Medical Systems, Inc. | Single-stranded oligonucleotide probes for chromosome or gene copy enumeration |
-
2015
- 2015-10-01 CA CA2957783A patent/CA2957783C/en active Active
- 2015-10-01 JP JP2017517722A patent/JP6762296B2/ja active Active
- 2015-10-01 WO PCT/EP2015/072701 patent/WO2016050913A2/en not_active Ceased
- 2015-10-01 AU AU2015326827A patent/AU2015326827B2/en active Active
- 2015-10-01 EP EP15777651.9A patent/EP3201628B1/en active Active
- 2015-10-01 CA CA3185265A patent/CA3185265A1/en active Pending
-
2017
- 2017-03-31 US US15/476,904 patent/US11079372B2/en active Active
-
2021
- 2021-06-23 US US17/356,183 patent/US12553886B2/en active Active
-
2025
- 2025-09-08 US US19/322,313 patent/US20260056191A1/en active Pending
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