AU2015326827B2 - Polymers and conjugates comprising the same - Google Patents

Polymers and conjugates comprising the same Download PDF

Info

Publication number
AU2015326827B2
AU2015326827B2 AU2015326827A AU2015326827A AU2015326827B2 AU 2015326827 B2 AU2015326827 B2 AU 2015326827B2 AU 2015326827 A AU2015326827 A AU 2015326827A AU 2015326827 A AU2015326827 A AU 2015326827A AU 2015326827 B2 AU2015326827 B2 AU 2015326827B2
Authority
AU
Australia
Prior art keywords
antibody
group
label
spacer
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2015326827A
Other languages
English (en)
Other versions
AU2015326827A1 (en
Inventor
Lei Tang
Wenjun Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ventana Medical Systems Inc
Original Assignee
Ventana Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventana Medical Systems Inc filed Critical Ventana Medical Systems Inc
Publication of AU2015326827A1 publication Critical patent/AU2015326827A1/en
Application granted granted Critical
Publication of AU2015326827B2 publication Critical patent/AU2015326827B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Materials For Medical Uses (AREA)
AU2015326827A 2014-10-02 2015-10-01 Polymers and conjugates comprising the same Active AU2015326827B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462059073P 2014-10-02 2014-10-02
US62/059,073 2014-10-02
US201562212879P 2015-09-01 2015-09-01
US62/212,879 2015-09-01
PCT/EP2015/072701 WO2016050913A2 (en) 2014-10-02 2015-10-01 Polymers and conjugates comprising the same

Publications (2)

Publication Number Publication Date
AU2015326827A1 AU2015326827A1 (en) 2017-02-23
AU2015326827B2 true AU2015326827B2 (en) 2019-11-07

Family

ID=54266549

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015326827A Active AU2015326827B2 (en) 2014-10-02 2015-10-01 Polymers and conjugates comprising the same

Country Status (6)

Country Link
US (3) US11079372B2 (https=)
EP (1) EP3201628B1 (https=)
JP (1) JP6762296B2 (https=)
AU (1) AU2015326827B2 (https=)
CA (2) CA2957783C (https=)
WO (1) WO2016050913A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017141903A1 (ja) * 2016-02-16 2017-08-24 株式会社トッパンＴｏｍｏｅｇａｗａオプティカルフィルム 光学積層体、偏光板及び表示装置
CN114761431B (zh) * 2019-10-16 2025-04-25 株式会社Lg化学 新生儿Fc受体结合AFFIMER

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4824775A (en) * 1985-01-03 1989-04-25 Molecular Diagnostics, Inc. Cells labeled with multiple Fluorophores bound to a nucleic acid carrier
WO1997005156A1 (en) * 1995-07-27 1997-02-13 Carsten Behrens A new achiral linker reagent for the incorporation of multiple amino groups into oligonucleotides
US5641629A (en) * 1990-06-11 1997-06-24 Nexstar Pharmacueticals Inc Spectroscopically detectable nucleic acid ligands
EP1376126A1 (en) * 2001-04-04 2004-01-02 Wako Pure Chemical Industries, Ltd. Electrophoresis
EP1489422A2 (en) * 2003-04-03 2004-12-22 Enzo Life Sciences, Inc., c/o Enzo Biochem, Inc. Multisignal labeling reagents, processes and uses therefor
WO2009112032A1 (en) * 2008-03-10 2009-09-17 Quantibact A/S Target amplification and sequencing with primers comprising triplex forming monomer units
US20100203516A1 (en) * 2007-01-25 2010-08-12 Iti Scotland Limited Detecting analytes using both an optical and an electrical measurement method
US20100248980A1 (en) * 2007-12-04 2010-09-30 Panagene Inc. Method for Selective Labeling and Detection of Target Nucleic Acids Using Immobilized Peptide Nucleic Acid Probes
EP2444807A2 (en) * 2006-11-01 2012-04-25 Ventana Medical Systems, Inc. Haptens, hapten conjugates, compositions thereof and method for their preparation and use
US20130196880A1 (en) * 2012-01-27 2013-08-01 Ventana Medical Systems, Inc. Patterned devices and methods for detecting analytes
WO2013191265A1 (ja) * 2012-06-22 2013-12-27 国立大学法人九州大学 タンパク質－核酸複合体の製造方法および標的物の検出方法
WO2015124702A1 (en) * 2014-02-21 2015-08-27 Ventana Medical Systems, Inc. Single-stranded oligonucleotide probes for chromosome or gene copy enumeration

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1564604A (en) 1925-06-12 1925-12-08 Chas S Hodges Water wheel
US5595707A (en) 1990-03-02 1997-01-21 Ventana Medical Systems, Inc. Automated biological reaction apparatus
DE4302459A1 (de) * 1993-01-29 1994-08-04 Bayer Ag Sulfocumarinhaltige Nukleotide und deren Verwendung in Nachweisverfahren für Nukleinsäuren
WO1999043287A2 (en) * 1998-02-25 1999-09-02 Biotraces, Inc. Phosphate-based dendrimers for bioassays
JP3847559B2 (ja) 1998-02-27 2006-11-22 ベンタナ・メデイカル・システムズ・インコーポレーテツド 独立スライド加熱器を有する自動化分子病理学装置
US6582962B1 (en) 1998-02-27 2003-06-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US20030211630A1 (en) 1998-02-27 2003-11-13 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6372937B1 (en) 1998-11-09 2002-04-16 Mark Norman Bobrow Enhanced catalyzed reporter deposition
FR2791141B1 (fr) * 1999-03-15 2001-06-01 Cis Bio Int Procede de reduction de l'extinction de fluorescence due au milieu de mesure
US6670113B2 (en) 2001-03-30 2003-12-30 Nanoprobes Enzymatic deposition and alteration of metals
DK1636586T3 (da) 2003-06-24 2009-11-23 Ventana Med Syst Inc Enzymkatalyseret metaldeponering til foröget in situ-detektion af immunhistokemisker epitoper og nucleinsyresekvenser
DE10340143A1 (de) 2003-08-26 2005-03-31 SSI Schäfer PEEM GmbH Kommissionierplatz und Verfahren zum Kommissionieren
EP1725572B1 (de) * 2003-11-05 2017-05-31 AGCT GmbH Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
JP2008082784A (ja) * 2006-09-26 2008-04-10 Sysmex Corp 新規な標的物質検出用試薬
EP2167963B1 (en) * 2007-05-23 2019-04-17 Ventana Medical Systems, Inc. Polymeric carriers for immunohistochemistry and in situ hybridization
FR2933520B1 (fr) 2008-07-04 2011-02-11 Canon Kk Procede et dispositif de restauration d'une sequence video
EP2334827B1 (en) 2008-08-22 2015-03-11 Ventana Medical Systems, Inc. Method for chromogenic detection of two or more target molecules in a single sample
DE102008062372B3 (de) * 2008-12-17 2010-06-17 Medizinische Hochschule Hannover Nachweiskonjugat und Verfahren zur Analyse
CA2842661C (en) 2009-10-19 2016-02-23 Ventana Medical Systems, Inc. Imaging system and techniques
ES2678211T3 (es) 2012-03-27 2018-08-09 Ventana Medical Systems, Inc. Conjugados de señalización y procedimientos de uso

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4824775A (en) * 1985-01-03 1989-04-25 Molecular Diagnostics, Inc. Cells labeled with multiple Fluorophores bound to a nucleic acid carrier
US5641629A (en) * 1990-06-11 1997-06-24 Nexstar Pharmacueticals Inc Spectroscopically detectable nucleic acid ligands
WO1997005156A1 (en) * 1995-07-27 1997-02-13 Carsten Behrens A new achiral linker reagent for the incorporation of multiple amino groups into oligonucleotides
EP1376126A1 (en) * 2001-04-04 2004-01-02 Wako Pure Chemical Industries, Ltd. Electrophoresis
EP1489422A2 (en) * 2003-04-03 2004-12-22 Enzo Life Sciences, Inc., c/o Enzo Biochem, Inc. Multisignal labeling reagents, processes and uses therefor
EP2444807A2 (en) * 2006-11-01 2012-04-25 Ventana Medical Systems, Inc. Haptens, hapten conjugates, compositions thereof and method for their preparation and use
US20100203516A1 (en) * 2007-01-25 2010-08-12 Iti Scotland Limited Detecting analytes using both an optical and an electrical measurement method
US20100248980A1 (en) * 2007-12-04 2010-09-30 Panagene Inc. Method for Selective Labeling and Detection of Target Nucleic Acids Using Immobilized Peptide Nucleic Acid Probes
WO2009112032A1 (en) * 2008-03-10 2009-09-17 Quantibact A/S Target amplification and sequencing with primers comprising triplex forming monomer units
US20130196880A1 (en) * 2012-01-27 2013-08-01 Ventana Medical Systems, Inc. Patterned devices and methods for detecting analytes
WO2013191265A1 (ja) * 2012-06-22 2013-12-27 国立大学法人九州大学 タンパク質－核酸複合体の製造方法および標的物の検出方法
WO2015124702A1 (en) * 2014-02-21 2015-08-27 Ventana Medical Systems, Inc. Single-stranded oligonucleotide probes for chromosome or gene copy enumeration

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
2010203516GRZYBOWSKI, J et al., Synthesis and antibody-mediated detection of oligonucleotides containing multiple 2,4-dinitrophenyl reporter groups. Nucleic Acids Res. vol. 21, no. 8, 1 January 1993, pages 1705-1712 *

Also Published As

Publication number Publication date
JP6762296B2 (ja) 2020-09-30
US20210325376A1 (en) 2021-10-21
CA2957783C (en) 2023-02-28
JP2017531797A (ja) 2017-10-26
US20260056191A1 (en) 2026-02-26
EP3201628B1 (en) 2020-11-18
US20170205399A1 (en) 2017-07-20
EP3201628A2 (en) 2017-08-09
US11079372B2 (en) 2021-08-03
US12553886B2 (en) 2026-02-17
WO2016050913A2 (en) 2016-04-07
WO2016050913A3 (en) 2016-05-26
CA2957783A1 (en) 2016-04-07
CA3185265A1 (en) 2016-04-07
AU2015326827A1 (en) 2017-02-23

Similar Documents

Publication Publication Date Title
ES2689593T3 (es) Depósito potenciado de cromógenos que utilizan análogos de piridina
US20260056191A1 (en) Polymers and conjugates comprising the same
ES2886600T3 (es) Procedimientos de identificación de células inmunitarias en tejido tumoral positivo para PD-L1
US12173031B2 (en) Peptide nucleic acid conjugates
WO2018002015A1 (en) New colors for chromogenic ihc and ish staining with multi-dye quinone methide and tyramide conjugates
US20230151361A1 (en) Peptide nucleic acid conjugates
CN120457215A (zh) 用于检测蛋白质相互作用的系统、方法和试剂盒
HK1185634B (en) Enhanced deposition of chromogens utilizing pyrimidine analogs

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)