|
NL8303657A
(nl)
|
1983-10-24 |
1985-05-17 |
Pharmachemie Bv |
Voor injectie geschikte, stabiele, waterige, zoutzuur bevattende oplossing van cisplatine, alsmede werkwijze ter bereiding daarvan.
|
|
DE3537761A1
(de)
|
1985-10-24 |
1987-04-30 |
Bayer Ag |
Infusionsloesungen der 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-chinolin-3-carbonsaeure
|
|
JPH0276860A
(ja)
|
1987-10-05 |
1990-03-16 |
Toyo Jozo Co Ltd |
６−置換アルコキシ−２−オキソ−１，２−ジヒドロキノキサリン誘導体
|
|
DE68908786T2
(de)
|
1988-06-16 |
1994-03-17 |
Smith Kline French Lab |
Condensierte Pyrimidinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen.
|
|
FR2645152B1
(fr)
|
1989-03-30 |
1991-05-31 |
Lipha |
3h-pteridinones-4, procedes de preparation et medicaments les contenant
|
|
US5043270A
(en)
|
1989-03-31 |
1991-08-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Intronic overexpression vectors
|
|
CA2029651C
(en)
|
1989-11-17 |
2000-06-06 |
David D. Davey |
Tricyclic pteridinones and a process for their preparation
|
|
US5198547A
(en)
|
1992-03-16 |
1993-03-30 |
South Alabama Medical Science Foundation, Usa |
Process for N5-formylating tetrahydropteridines
|
|
TW274550B
(https=)
|
1992-09-26 |
1996-04-21 |
Hoechst Ag |
|
|
EP1195372A1
(en)
|
1994-04-18 |
2002-04-10 |
Mitsubishi Pharma Corporation |
N-heterocyclic substituted benzamide derivatives with antihypertensive activity
|
|
GB9418499D0
(en)
|
1994-09-14 |
1994-11-02 |
Ciba Geigy Ag |
Process for producing n-methylated organic pigments
|
|
CO4410191A1
(es)
|
1994-09-19 |
1997-01-09 |
Lilly Co Eli |
SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS
|
|
IL117923A
(en)
|
1995-05-03 |
2000-06-01 |
Warner Lambert Co |
Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
|
|
ES2154825T3
(es)
|
1995-05-19 |
2001-04-16 |
Novartis Ag |
Procedimiento para la hidrogenacion catalitica de nitro compuestos aromaticos.
|
|
US5698556A
(en)
|
1995-06-07 |
1997-12-16 |
Chan; Carcy L. |
Methotrexate analogs and methods of using same
|
|
CZ299247B6
(cs)
|
1996-09-23 |
2008-05-28 |
Eli Lilly And Company |
Olanzapin dihydrát D
|
|
JP2002522541A
(ja)
|
1998-08-11 |
2002-07-23 |
ファイザー・プロダクツ・インク |
ホスホジエステラーゼ４阻害剤としての置換１，８−ナフチリジン−４（１ｈ）−オン
|
|
EP1409487A1
(en)
|
1999-09-15 |
2004-04-21 |
Warner-Lambert Company Llc |
Pteridinones as kinase inhibitors
|
|
GB2359551A
(en)
|
2000-02-23 |
2001-08-29 |
Astrazeneca Uk Ltd |
Pharmaceutically active pyrimidine derivatives
|
|
PL358271A1
(pl)
|
2000-03-06 |
2004-08-09 |
Warner-Lambert Company |
5-alkilopirydo[2,3-D]pirymidyny jako inhibitory kinazy tyrozyny
|
|
DE10018783A1
(de)
|
2000-04-15 |
2001-10-25 |
Fresenius Kabi De Gmbh |
Lagerstabile Infusionslösung des Ciprofloxacins mit verringertem Säuregehalt
|
|
US20020183292A1
(en)
|
2000-10-31 |
2002-12-05 |
Michel Pairet |
Pharmaceutical compositions based on anticholinergics and corticosteroids
|
|
DE10058119A1
(de)
|
2000-11-22 |
2002-05-23 |
Bayer Ag |
Pepinotan-Kit
|
|
US6756374B2
(en)
|
2001-01-22 |
2004-06-29 |
Hoffmann-La Roche Inc. |
Diaminothiazoles having antiproliferative activity
|
|
US6960589B2
(en)
|
2001-03-09 |
2005-11-01 |
Abbott Laboratories |
Benzimidazoles that are useful in treating sexual dysfunction
|
|
WO2002076954A1
(en)
|
2001-03-23 |
2002-10-03 |
Smithkline Beecham Corporation |
Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
|
|
WO2002076985A1
(en)
|
2001-03-23 |
2002-10-03 |
Smithkline Beecham Corporation |
Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
|
|
US20030055026A1
(en)
|
2001-04-17 |
2003-03-20 |
Dey L.P. |
Formoterol/steroid bronchodilating compositions and methods of use thereof
|
|
US6806272B2
(en)
|
2001-09-04 |
2004-10-19 |
Boehringer Ingelheim Pharma Kg |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
|
|
PT1427730E
(pt)
|
2001-09-04 |
2006-11-30 |
Boehringer Ingelheim Pharma |
Novas di-hidropteridinonas, processo para sua preparação e sua utilização como medicamento
|
|
PT1463493E
(pt)
|
2001-12-14 |
2008-01-04 |
Serono Lab |
Método para induzir a ovulação utilizando um modulador de nível camp não polipeptídico
|
|
JP2005538048A
(ja)
|
2002-05-03 |
2005-12-15 |
シエーリング アクチエンゲゼルシャフト |
チアゾリジノン類、それらの生成及び医薬剤としての使用
|
|
FR2843114B1
(fr)
|
2002-08-01 |
2004-09-10 |
Poudres & Explosifs Ste Nale |
Procede de monomethylation d'heterocycles azotes
|
|
MXPA05001544A
(es)
|
2002-08-08 |
2005-04-19 |
Smithkline Beecham Corp |
Compuestos de tiofeno.
|
|
US20040127504A1
(en)
|
2002-09-06 |
2004-07-01 |
Cowart Marlon D. |
Benzimidazoles that are useful in treating sexual dysfunction
|
|
CN100387598C
(zh)
|
2002-09-16 |
2008-05-14 |
葛兰素集团有限公司 |
吡唑并[3,4-b]吡啶化合物及其作为磷酸二酯酶抑制剂的用途
|
|
BR0316101A
(pt)
*
|
2002-11-07 |
2005-09-27 |
Immunogen Inc |
Anticorpos anticd33 e processo para tratamento de leucemia melóide aguda usando os mesmos
|
|
GB2398565A
(en)
|
2003-02-18 |
2004-08-25 |
Cipla Ltd |
Imatinib preparation and salts
|
|
US6861422B2
(en)
|
2003-02-26 |
2005-03-01 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
|
|
BR0318145A
(pt)
|
2003-02-26 |
2006-02-21 |
Boehringer Ingelheim Pharma |
dihidropteridinonas, processos para a sua preparação e sua aplicação como medicamento
|
|
US20070134200A1
(en)
|
2003-03-26 |
2007-06-14 |
Wyeth |
Immunogenic composition and methods
|
|
JP2006522634A
(ja)
|
2003-04-14 |
2006-10-05 |
ベクトゥラ・リミテッド |
投与効率を向上させるデバイス及び製薬組成
|
|
JP2007517828A
(ja)
|
2004-01-17 |
2007-07-05 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
気道の疾患を治療するための置換プテリジンの使用
|
|
DE102004002557A1
(de)
|
2004-01-17 |
2005-08-04 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen
|
|
DE102004029784A1
(de)
|
2004-06-21 |
2006-01-05 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
|
|
DE102004033670A1
(de)
|
2004-07-09 |
2006-02-02 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
|
|
DE102004034623A1
(de)
|
2004-07-16 |
2006-02-02 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 6-Formyl-tetrahydropteridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
US7728134B2
(en)
|
2004-08-14 |
2010-06-01 |
Boehringer Ingelheim International Gmbh |
Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
|
|
US7759485B2
(en)
|
2004-08-14 |
2010-07-20 |
Boehringer Ingelheim International Gmbh |
Process for the manufacture of dihydropteridinones
|
|
US20060035903A1
(en)
|
2004-08-14 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Storage stable perfusion solution for dihydropteridinones
|
|
US20060074088A1
(en)
|
2004-08-14 |
2006-04-06 |
Boehringer Ingelheim International Gmbh |
Dihydropteridinones for the treatment of cancer diseases
|
|
US20060058311A1
(en)
|
2004-08-14 |
2006-03-16 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation
|
|
EP1630163A1
(de)
|
2004-08-25 |
2006-03-01 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
|
|
EP1632493A1
(de)
|
2004-08-25 |
2006-03-08 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
|
|
CA2575804A1
(en)
|
2004-08-26 |
2006-03-02 |
Boehringer Ingelheim International Gmbh |
Pteridinones used as plk (polo like kinase) inhibitors
|
|
JP2008510771A
(ja)
|
2004-08-27 |
2008-04-10 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
ジヒドロプテリジノン、その製造方法および医薬薬剤としてのその使用
|
|
US20060063735A1
(en)
|
2004-09-17 |
2006-03-23 |
Supergen, Inc. |
Salts of 5-azacytidine
|
|
DE102004058337A1
(de)
|
2004-12-02 |
2006-06-14 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
|
|
WO2007014838A1
(en)
|
2005-08-03 |
2007-02-08 |
Boehringer Ingelheim International Gmbh |
Dihydropteridinones in the treatment of respiratory diseases
|
|
US20070117776A1
(en)
|
2005-11-04 |
2007-05-24 |
John Lyons |
Low Dose Therapy Of DNA Methylation Inhibitors
|
|
PL1948180T3
(pl)
|
2005-11-11 |
2013-09-30 |
Boehringer Ingelheim Int |
Terapia skojarzona raka polegająca na podawaniu inhibitorów EGFR/HER2
|
|
US7439358B2
(en)
|
2006-02-08 |
2008-10-21 |
Boehringer Ingelheim International Gmbh |
Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
|
|
JP2009529038A
(ja)
|
2006-03-07 |
2009-08-13 |
アストラゼネカ・アクチエボラーグ |
ピペリジン誘導体、それらの製造法、治療剤としてのそれらの使用およびそれらを含む医薬組成物
|
|
KR101452915B1
(ko)
|
2006-05-04 |
2014-10-21 |
베링거 인겔하임 인터내셔날 게엠베하 |
다형태
|
|
EP2185559A1
(en)
|
2007-08-03 |
2010-05-19 |
Boehringer Ingelheim International GmbH |
Crystalline form of a dihydropteridione derivative
|
|
JP4642085B2
(ja)
|
2008-01-17 |
2011-03-02 |
日本下水道事業団 |
予測健全度を利用した施設管理および更新計画システム
|
|
EP2100894A1
(en)
|
2008-03-12 |
2009-09-16 |
4Sc Ag |
Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors
|
|
ES2624622T3
(es)
|
2008-12-30 |
2017-07-17 |
Rigel Pharmaceuticals, Inc. |
Inhibidores de pirimidindiamina cinasa
|
|
CN102438588B
(zh)
|
2009-03-23 |
2015-04-01 |
埃姆比特生物科学公司 |
使用联合治疗法治疗疾病的方法
|
|
WO2011022692A2
(en)
|
2009-08-20 |
2011-02-24 |
University Of Tennessee Research Foundation, The |
Furanopyridine cannabinoid compounds and related methods of use
|
|
JP2013512882A
(ja)
|
2009-12-07 |
2013-04-18 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
トリプルネガティブ乳癌の治療に使用するｂｉｂｗ２９９２
|
|
EP2536725B1
(en)
|
2010-02-17 |
2015-10-28 |
Boehringer Ingelheim International GmbH |
Dihydropteridinones, method for production and use thereof
|
|
US8546566B2
(en)
|
2010-10-12 |
2013-10-01 |
Boehringer Ingelheim International Gmbh |
Process for manufacturing dihydropteridinones and intermediates thereof
|
|
US9358233B2
(en)
*
|
2010-11-29 |
2016-06-07 |
Boehringer Ingelheim International Gmbh |
Method for treating acute myeloid leukemia
|
|
WO2012118632A1
(en)
*
|
2011-02-28 |
2012-09-07 |
Ning Xi |
Substituted quinoline compounds and methods of use
|
|
US20130131069A1
(en)
|
2011-05-13 |
2013-05-23 |
Boehringer Ingelheim International Gmbh |
Method for treatment of solid malignancies including advanced or metastatic solid malignancies
|
|
US9370535B2
(en)
|
2011-05-17 |
2016-06-21 |
Boehringer Ingelheim International Gmbh |
Method for treatment of advanced solid tumors
|
|
US20140154304A1
(en)
*
|
2012-11-30 |
2014-06-05 |
Boehringer Ingelheim International Gmbh |
Combination therapy with volasertib
|