JP2017528734A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017528734A5 JP2017528734A5 JP2017527543A JP2017527543A JP2017528734A5 JP 2017528734 A5 JP2017528734 A5 JP 2017528734A5 JP 2017527543 A JP2017527543 A JP 2017527543A JP 2017527543 A JP2017527543 A JP 2017527543A JP 2017528734 A5 JP2017528734 A5 JP 2017528734A5
- Authority
- JP
- Japan
- Prior art keywords
- lymphocytes
- lymphocyte
- level
- individual
- blood sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001744 T-lymphocyte Anatomy 0.000 claims 27
- 210000004369 blood Anatomy 0.000 claims 18
- 239000008280 blood Substances 0.000 claims 18
- 238000000034 method Methods 0.000 claims 17
- 210000004698 lymphocyte Anatomy 0.000 claims 15
- 239000003153 chemical reaction reagent Substances 0.000 claims 9
- 239000000090 biomarker Substances 0.000 claims 8
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 7
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 6
- 101100262440 Arabidopsis thaliana ECR1 gene Proteins 0.000 claims 5
- 231100000433 cytotoxic Toxicity 0.000 claims 5
- 230000001472 cytotoxic effect Effects 0.000 claims 5
- 210000000265 leukocyte Anatomy 0.000 claims 4
- 230000002159 abnormal effect Effects 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 238000000684 flow cytometry Methods 0.000 claims 2
- 239000003287 lymphocyte surface marker Substances 0.000 claims 2
- 102100037853 C-C chemokine receptor type 4 Human genes 0.000 claims 1
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims 1
- 102100025074 C-C chemokine receptor-like 2 Human genes 0.000 claims 1
- 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 claims 1
- 102100031658 C-X-C chemokine receptor type 5 Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- -1 Crth2 Proteins 0.000 claims 1
- 101000716068 Homo sapiens C-C chemokine receptor type 6 Proteins 0.000 claims 1
- 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 claims 1
- 101000922405 Homo sapiens C-X-C chemokine receptor type 5 Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 1
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462035073P | 2014-08-08 | 2014-08-08 | |
| US62/035,073 | 2014-08-08 | ||
| PCT/US2015/044372 WO2016023006A1 (en) | 2014-08-08 | 2015-08-07 | Anti-lymphocyte autoantibodies as diagnostic biomarkers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017528734A JP2017528734A (ja) | 2017-09-28 |
| JP2017528734A5 true JP2017528734A5 (enExample) | 2018-08-09 |
Family
ID=55264686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017527543A Pending JP2017528734A (ja) | 2014-08-08 | 2015-08-07 | 診断用バイオマーカーとしての抗リンパ球自己抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9709564B2 (enExample) |
| EP (1) | EP3177930A1 (enExample) |
| JP (1) | JP2017528734A (enExample) |
| CN (1) | CN107110861A (enExample) |
| BR (1) | BR112017002575B1 (enExample) |
| RU (1) | RU2017107273A (enExample) |
| WO (1) | WO2016023006A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017023781A1 (en) | 2015-07-31 | 2017-02-09 | Allegheny-Singer Research Institute | Cell-bound complement activation product assays as companion diagnostics for antibody-based drugs |
| KR101674018B1 (ko) * | 2016-05-16 | 2016-11-08 | (주)글로리바이오텍 | Cd4, cd8 세포 정보를 이용한 hiv 진단 방법 |
| JP2019522785A (ja) * | 2016-05-24 | 2019-08-15 | アレゲーニー・シンガー リサーチ インスティチュート | Ｃ４遺伝子コピー数及び細胞結合性補体活性化産物を用いてループス及びプレループスを同定する方法並びにシステム |
| EP4217744A4 (en) * | 2020-09-28 | 2024-11-06 | Allegheny Singer Research Institute | METHOD FOR DETERMINING A LEVEL OF A CELL FRAGMENT-BOUND COMPLEMENT ACTIVATION PRODUCT |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2216650A1 (en) * | 2004-04-09 | 2010-08-11 | University of Pittsburgh | Real time method of detecting acute inflammatory conditions |
| DE602005023725D1 (de) * | 2004-05-11 | 2010-11-04 | Univ Pittsburgh | Diagnose und überwachung von entzündlichen krankheiten mittels messung der zusätzlichen komponenten von leukozyten |
| EP2347259A4 (en) * | 2008-10-16 | 2012-02-29 | Cypress Bioscience Inc | METHOD FOR DIAGNOSIS AND MONITORING OF ILLICIT ACTIVITY AND RESPONSE TO TREATMENT IN SYSTEMIC LUPUS ERYTHEMATODES (SLE) AND OTHER AUTOIMMUNE DISEASES |
| US20130035254A1 (en) * | 2010-02-12 | 2013-02-07 | Tel Hashomer Medical Research Infras | Diagnosis of systemic lupus erythematosus (sle) |
| EP2673644B1 (en) * | 2011-02-11 | 2016-02-10 | Exagen Diagnostics, Inc. | Methods for diagnosing systemic lupus erythematosus |
| CN102818890A (zh) * | 2011-06-10 | 2012-12-12 | 苏州卫生职业技术学院 | 一种检测系统性红斑狼疮患者自身抗体的方法 |
| HRP20181118T1 (hr) * | 2011-12-13 | 2018-09-21 | Baxalta GmbH | Mjerenje autoprotutijela u uvjetima niske vodljivosti |
| EP2880445A1 (en) | 2012-08-02 | 2015-06-10 | Sense Proteomic Limited | Auto-antigen biomarkers for lupus |
| WO2014093268A1 (en) | 2012-12-10 | 2014-06-19 | Allegheny-Singer Research Institute | Methods and systems for using complement-tagged molecules as biomarkers of disease |
| BR112015018964B1 (pt) | 2013-02-08 | 2022-08-02 | Allegheny-Singer Research Institute | Método para determinar se um paciente se classifica como não apresentando ter lupus e sistema para executar o método para determinar se um paciente se classifica como não apresentando ter lupus |
| CN103439517A (zh) * | 2013-09-11 | 2013-12-11 | 河北省健海生物芯片技术有限责任公司 | 一种系统性红斑狼疮自身抗体检测装置 |
-
2015
- 2015-08-07 BR BR112017002575-2A patent/BR112017002575B1/pt active IP Right Grant
- 2015-08-07 EP EP15754066.7A patent/EP3177930A1/en not_active Withdrawn
- 2015-08-07 RU RU2017107273A patent/RU2017107273A/ru not_active Application Discontinuation
- 2015-08-07 WO PCT/US2015/044372 patent/WO2016023006A1/en not_active Ceased
- 2015-08-07 CN CN201580053913.2A patent/CN107110861A/zh active Pending
- 2015-08-07 JP JP2017527543A patent/JP2017528734A/ja active Pending
- 2015-08-07 US US14/821,670 patent/US9709564B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Csernok et al. | Current and emerging techniques for ANCA detection in vasculitis | |
| La Manna et al. | Identification of plasma biomarkers for discrimination between tuberculosis infection/disease and pulmonary non tuberculosis disease | |
| CN106442984B (zh) | 区分细菌与病毒感染的标记物和决定因素以及其使用方法 | |
| Bae et al. | Comparison of the sensitivity of QuantiFERON-TB Gold In-Tube and T-SPOT. TB according to patient age | |
| Jansen et al. | IL-17-producing CD4+ T cells are increased in early, active axial spondyloarthritis including patients without imaging abnormalities | |
| JP4151986B2 (ja) | リンパ球機能の測定方法 | |
| JP2016507066A5 (enExample) | ||
| JP2014505264A5 (enExample) | ||
| Kim et al. | Clinical comparisons of two free light chain assays to immunofixation electrophoresis for detecting monoclonal gammopathy | |
| BR112012017014A8 (pt) | métodos para detecção de anticorpos de vírus jc | |
| JP2017528734A5 (enExample) | ||
| Kuuliala et al. | Constitutive STAT3 phosphorylation in circulating CD4+ T lymphocytes associates with disease activity and treatment response in recent-onset rheumatoid arthritis | |
| Divya et al. | Estimation of serum and salivary immunoglobulin G and immunoglobulin A in oral pre-cancer: A study in oral submucous fibrosis and oral lichen planus | |
| Valle-Arroyo et al. | Lack of cytomegalovirus (CMV)-specific cell-mediated immune response using QuantiFERON-CMV assay in CMV-seropositive healthy volunteers: fact not artifact | |
| RU2017107273A (ru) | Антилимфоцитарные аутоантитела в качестве диагностических биомаркеров | |
| McLeish et al. | Uncovering the significance of expanded CD8+ large granular lymphocytes in inclusion body myositis: Insights into T cell phenotype and functional alterations, and disease severity | |
| Zecevic et al. | Potential immune biomarkers in diagnosis and clinical management for systemic lupus erythematosus | |
| Shin et al. | Decreased PD-1 positive blood follicular helper T cells in patients with psoriasis | |
| CN106568977A (zh) | 血清中sIL‑7R在诊断系统性红斑狼疮肾炎中的应用 | |
| Hodgson et al. | Laboratory medicine and diagnostic pathology | |
| Xia et al. | Early immune surveillance to predict cytomegalovirus outcomes after allogeneic hematopoietic stem cell transplantation | |
| Sack et al. | Cellular analyses in the monitoring of autoimmune diseases | |
| AU2011215826B2 (en) | Compositions and methods for predicting cardiovascular events | |
| US20220317120A1 (en) | Use of proteins pd-1 and cd38 as markers of an active auto-immune pathology | |
| Karumanchi et al. | Evaluation of diagnostic significance and cost effectiveness of Elisa and IFA for the diagnosis of autoimmune disorders |