JP2016507066A5 - - Google Patents
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- JP2016507066A5 JP2016507066A5 JP2015557128A JP2015557128A JP2016507066A5 JP 2016507066 A5 JP2016507066 A5 JP 2016507066A5 JP 2015557128 A JP2015557128 A JP 2015557128A JP 2015557128 A JP2015557128 A JP 2015557128A JP 2016507066 A5 JP2016507066 A5 JP 2016507066A5
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- 239000012634 fragment Substances 0.000 claims description 138
- 239000012472 biological sample Substances 0.000 claims description 128
- 238000000034 method Methods 0.000 claims description 109
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims description 103
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 97
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 97
- 229920001184 polypeptide Polymers 0.000 claims description 96
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 96
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 96
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 60
- 239000006228 supernatant Substances 0.000 claims description 49
- 230000004083 survival effect Effects 0.000 claims description 48
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 47
- 210000002966 serum Anatomy 0.000 claims description 46
- 239000000523 sample Substances 0.000 claims description 45
- 238000003556 assay Methods 0.000 claims description 41
- 238000001514 detection method Methods 0.000 claims description 41
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 41
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 40
- 238000003018 immunoassay Methods 0.000 claims description 36
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 35
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 35
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 34
- 210000001185 bone marrow Anatomy 0.000 claims description 32
- 210000005087 mononuclear cell Anatomy 0.000 claims description 32
- 238000002965 ELISA Methods 0.000 claims description 24
- 238000003127 radioimmunoassay Methods 0.000 claims description 24
- 208000034578 Multiple myelomas Diseases 0.000 claims description 19
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims description 17
- 238000012286 ELISA Assay Methods 0.000 claims description 17
- 102000004190 Enzymes Human genes 0.000 claims description 12
- 108090000790 Enzymes Proteins 0.000 claims description 12
- 230000002055 immunohistochemical effect Effects 0.000 claims description 10
- 238000012544 monitoring process Methods 0.000 claims description 8
- 238000004393 prognosis Methods 0.000 claims description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims description 4
- 210000002798 bone marrow cell Anatomy 0.000 claims description 2
- 238000003364 immunohistochemistry Methods 0.000 claims description 2
- 230000002250 progressing effect Effects 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361762753P | 2013-02-08 | 2013-02-08 | |
| US61/762,753 | 2013-02-08 | ||
| PCT/US2014/015338 WO2014124280A1 (en) | 2013-02-08 | 2014-02-07 | Improved diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018090456A Division JP2018136344A (ja) | 2013-02-08 | 2018-05-09 | 多発性骨髄腫、慢性リンパ球性白血病、およびｂ細胞非ホジキンリンパ腫の改善された診断方法、予後予測方法、およびモニタリング方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016507066A JP2016507066A (ja) | 2016-03-07 |
| JP2016507066A5 true JP2016507066A5 (enExample) | 2017-03-09 |
Family
ID=51300158
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015557128A Withdrawn JP2016507066A (ja) | 2013-02-08 | 2014-02-07 | 多発性骨髄腫、慢性リンパ球性白血病、およびｂ細胞非ホジキンリンパ腫の改善された診断方法、予後予測方法、およびモニタリング方法 |
| JP2018090456A Pending JP2018136344A (ja) | 2013-02-08 | 2018-05-09 | 多発性骨髄腫、慢性リンパ球性白血病、およびｂ細胞非ホジキンリンパ腫の改善された診断方法、予後予測方法、およびモニタリング方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018090456A Pending JP2018136344A (ja) | 2013-02-08 | 2018-05-09 | 多発性骨髄腫、慢性リンパ球性白血病、およびｂ細胞非ホジキンリンパ腫の改善された診断方法、予後予測方法、およびモニタリング方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10126301B2 (enExample) |
| EP (1) | EP2954330A4 (enExample) |
| JP (2) | JP2016507066A (enExample) |
| CA (1) | CA2900529A1 (enExample) |
| WO (1) | WO2014124280A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014124280A1 (en) | 2013-02-08 | 2014-08-14 | Institute For Myeloma & Bone Cancer Research | Improved diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma |
| AU2016347516A1 (en) | 2015-10-30 | 2018-05-10 | Glaxosmithkline Intellectual Property Development Limited | Prognostic method |
| DK3402515T3 (da) | 2016-01-12 | 2021-11-15 | Oncotracker Inc | Forbedrede fremgangsmåder til monitorering af et individs immunstatus |
| EP3458853B1 (en) | 2016-05-16 | 2022-09-07 | Onco Tracker, Inc. | Improved methods for monitoring immune status of a subject |
| CA3052779A1 (en) | 2017-02-17 | 2018-08-23 | Fred Hutchinson Cancer Research Center | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| WO2018160553A1 (en) * | 2017-02-28 | 2018-09-07 | Menarini Silicon Biosystems, Inc. | Improved kits and assays to detect circulating multiple myeloma cells from blood |
| EP3639028B1 (en) | 2017-06-13 | 2025-10-15 | Onco Tracker, Inc. | Diagnostic, prognostic, and monitoring methods for breast cancer |
| ES2644580B2 (es) * | 2017-07-26 | 2018-06-04 | Universitat Politècnica De València | Procedimiento de diagnóstico de lupus eritematoso sistémico (les) |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| CN111886012A (zh) | 2017-11-06 | 2020-11-03 | 朱诺治疗学股份有限公司 | 细胞疗法与γ分泌酶抑制剂的组合 |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| UY38251A (es) | 2018-06-01 | 2019-12-31 | Novartis Ag | Moléculas de unión contra bcma y usos de las mismas |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| ES2983797T3 (es) * | 2018-08-31 | 2024-10-24 | Hoffmann La Roche | Timidina cinasa (TK-1) en índices pronóstico para LDLBG |
| CA3130754A1 (en) | 2019-02-21 | 2020-08-27 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| CN114127111B (zh) | 2019-02-21 | 2024-09-10 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| CN120775051A (zh) | 2019-05-21 | 2025-10-14 | 诺华股份有限公司 | Cd19结合分子及其用途 |
| CN116234829A (zh) | 2020-01-03 | 2023-06-06 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| GB2623199A (en) | 2021-04-08 | 2024-04-10 | Marengo Therapeutics Inc | Multifunctional molecules binding to TCR and uses thereof |
| CN117305458B (zh) * | 2023-10-20 | 2024-06-21 | 四川省医学科学院·四川省人民医院 | TKTmRNA检测试剂在制备多发性骨髓瘤筛查试剂盒中的用途及试剂盒 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4493795A (en) | 1983-10-17 | 1985-01-15 | Syntex (U.S.A.) Inc. | Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture |
| US5629327A (en) | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
| CA2260014A1 (en) | 1996-07-10 | 1998-01-15 | Meiji Milk Products Co., Ltd. | Novel use of mk family as hematopoietic factor |
| GB9704444D0 (en) * | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| US6355623B2 (en) * | 1998-09-24 | 2002-03-12 | Hopital-Sainte-Justine | Method of treating IBD/Crohn's disease and related conditions wherein drug metabolite levels in host blood cells determine subsequent dosage |
| US20040002068A1 (en) * | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| AU2002306596B2 (en) | 2001-02-27 | 2008-01-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Analogs of thalidomide as potential angiogenesis inhibitors |
| WO2003022877A1 (en) | 2001-09-06 | 2003-03-20 | Biogen Idec Ma Inc. | Crystal structure of baff, and use thereof in drug design |
| AU2004220078A1 (en) | 2003-03-07 | 2004-09-23 | Xencor, Inc | BAFF mutants with at least one amino acid substitution and methods of their production |
| JP5570681B2 (ja) | 2004-08-31 | 2014-08-13 | 興和株式会社 | 抗ヒトｂａｆｆ抗体 |
| CA2583900A1 (en) | 2004-10-13 | 2006-04-27 | The Washington University | Use of baff to treat sepsis |
| US7947805B2 (en) | 2004-12-23 | 2011-05-24 | Merck Serono S.A. | BCMA polypeptides and uses thereof |
| WO2007039489A1 (en) * | 2005-09-26 | 2007-04-12 | Apotech Corporation | Antibodies against april as biomarkers for early prognosis of lymphoma patients |
| WO2007053732A2 (en) * | 2005-11-01 | 2007-05-10 | Mayo Foundation For Medical Education And Research | Promoter polymorphisms of the blys gene and use in diagnostic methods |
| US8202698B2 (en) * | 2005-11-08 | 2012-06-19 | Biogen Idec Ma Inc. | Methods of evaluating BAFF |
| US9726673B2 (en) | 2005-11-23 | 2017-08-08 | Genentech, Inc. | Methods and compositions related to B cell assays |
| SI1966202T1 (sl) | 2005-12-13 | 2012-01-31 | Incyte Corp | S heteroarilom substituirani pirolo (2,3-b)piridini in pirolo (2,3-b)pirimidini kot zaviralci janus kinaze |
| US20080058316A1 (en) | 2006-02-27 | 2008-03-06 | The Johns Hopkins University | Cancer treatment with gama-secretase inhibitors |
| ES2382777T3 (es) | 2006-05-03 | 2012-06-13 | Government Of The United States Of America,As Represented By The Secretary, Department Of Health And Human Services | Receptor de células T quimérico y materiales relacionados y métodos de uso |
| EP4606378A3 (en) | 2007-06-13 | 2025-11-05 | Incyte Holdings Corporation | Salts of the janus kinase inhibitor (r)-3-( 4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3- cyclopentylprop anenitrile |
| AU2009239437B2 (en) | 2008-04-25 | 2014-11-13 | University Of Washington | Levels of BCMA protein expression on B cells and use in diagnostic methods |
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| US9101559B2 (en) | 2009-05-08 | 2015-08-11 | New York University | Leukemic cell CNS infiltration controlled by notch-induced chemotaxis |
| US20130101599A1 (en) | 2011-04-21 | 2013-04-25 | Boehringer Ingelheim International Gmbh | Bcma-based stratification and therapy for multiple myeloma patients |
| CA2833820C (en) * | 2011-05-27 | 2019-10-29 | Glaxo Group Limited | Bcma (cd269/tnfrsf17) -binding proteins |
| CA2889764C (en) | 2012-11-01 | 2023-10-10 | Martin Lipp | An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases |
| EP2762496A1 (en) | 2013-02-05 | 2014-08-06 | EngMab AG | Method for the selection of antibodies against BCMA |
| WO2014124280A1 (en) | 2013-02-08 | 2014-08-14 | Institute For Myeloma & Bone Cancer Research | Improved diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma |
| US20160331754A1 (en) | 2014-01-20 | 2016-11-17 | Gilead Sciences, Inc. | Therapies for treating cancers |
| KR102526945B1 (ko) | 2014-04-30 | 2023-04-27 | 막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트 | Ｃｄ269에 대한 인간화 항체 |
| EP4233870A3 (en) | 2014-05-28 | 2024-01-24 | Onco Tracker, Inc. | Anti-cancer effects of jak2 inhibitors in combination with thalidomide derivatives and glucocorticoids |
| EP3154596A4 (en) | 2014-06-10 | 2018-01-24 | Institute for Myeloma & Bone Cancer Research | Anti-cancer effects of proteasome inhibitors in combination with glucocorticoids, arsenic containing compounds, and ascorbic acid |
| PL3179992T3 (pl) | 2014-08-11 | 2022-08-16 | Acerta Pharma B.V. | Kombinacje terapeutyczne inhibitora BTK, inhibitora PD-1 i/lub inhibitora PD-L1 |
| ES2952717T3 (es) | 2014-10-14 | 2023-11-03 | Novartis Ag | Moléculas de anticuerpos contra PD-L1 y usos de las mismas |
| CN113603795A (zh) | 2014-12-05 | 2021-11-05 | 纪念斯隆-凯特琳癌症中心 | 靶向b-细胞成熟抗原的嵌合抗原受体及其用途 |
| EP3271483B1 (en) | 2015-03-17 | 2021-07-21 | Mayo Foundation for Medical Education and Research | Methods and materials for assessing and treating cancer |
| SG10201913841SA (en) | 2015-07-24 | 2020-03-30 | Oncotracker Inc | Gamma secretase modulators for the treatment of immune system dysfunction |
| UA127515C2 (uk) | 2015-08-17 | 2023-09-20 | Янссен Байотек, Інк. | Антитіло до всма, біспецифічна антигензв'язувальна молекула, що зв'язує всма і cd3, і їх використання |
| AU2016347516A1 (en) | 2015-10-30 | 2018-05-10 | Glaxosmithkline Intellectual Property Development Limited | Prognostic method |
| DK3402515T3 (da) | 2016-01-12 | 2021-11-15 | Oncotracker Inc | Forbedrede fremgangsmåder til monitorering af et individs immunstatus |
| EP3458853B1 (en) | 2016-05-16 | 2022-09-07 | Onco Tracker, Inc. | Improved methods for monitoring immune status of a subject |
| RU2019105693A (ru) | 2016-08-01 | 2020-09-01 | Новартис Аг | Лечение рака с применением химерного антигенного рецептора в комбинации с ингибитором молекулы, способствующей фенотипу m2 макрофага |
| WO2018085363A2 (en) | 2016-11-02 | 2018-05-11 | Berenson James Richard | Cd147 detection in diagnostic, prognostic and monitoring methods for multiple myeloma |
| EP3639028B1 (en) | 2017-06-13 | 2025-10-15 | Onco Tracker, Inc. | Diagnostic, prognostic, and monitoring methods for breast cancer |
| JP2020528885A (ja) | 2017-07-19 | 2020-10-01 | フェイト セラピューティクス，インコーポレイテッド | 養子免疫療法における免疫細胞調節のための組成物および方法 |
| WO2020092792A2 (en) | 2018-10-31 | 2020-05-07 | Oncotracker, Inc. | Method of enhancing immune-based therapy |
-
2014
- 2014-02-07 WO PCT/US2014/015338 patent/WO2014124280A1/en not_active Ceased
- 2014-02-07 CA CA2900529A patent/CA2900529A1/en not_active Abandoned
- 2014-02-07 US US14/766,694 patent/US10126301B2/en active Active
- 2014-02-07 EP EP14748765.6A patent/EP2954330A4/en not_active Withdrawn
- 2014-02-07 JP JP2015557128A patent/JP2016507066A/ja not_active Withdrawn
-
2018
- 2018-05-09 JP JP2018090456A patent/JP2018136344A/ja active Pending
- 2018-09-28 US US16/146,300 patent/US12174189B2/en active Active
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