JP2017528129A5 - - Google Patents
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- Publication number
- JP2017528129A5 JP2017528129A5 JP2017510624A JP2017510624A JP2017528129A5 JP 2017528129 A5 JP2017528129 A5 JP 2017528129A5 JP 2017510624 A JP2017510624 A JP 2017510624A JP 2017510624 A JP2017510624 A JP 2017510624A JP 2017528129 A5 JP2017528129 A5 JP 2017528129A5
- Authority
- JP
- Japan
- Prior art keywords
- nmi
- ifp35
- seq
- activity
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000694 effects Effects 0.000 claims 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 18
- 239000012634 fragment Substances 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 14
- 102000036639 antigens Human genes 0.000 claims 14
- 108091007433 antigens Proteins 0.000 claims 14
- 208000035475 disorder Diseases 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 108020005544 Antisense RNA Proteins 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010050685 Cytokine storm Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000035269 cancer or benign tumor Diseases 0.000 claims 2
- 239000003184 complementary RNA Substances 0.000 claims 2
- 206010052015 cytokine release syndrome Diseases 0.000 claims 2
- 230000006806 disease prevention Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 229940079322 interferon Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 1
- 102000055056 N-Myc Proto-Oncogene Human genes 0.000 claims 1
- 108700026495 N-Myc Proto-Oncogene Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 102000006240 membrane receptors Human genes 0.000 claims 1
- 238000006384 oligomerization reaction Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410418773.1 | 2014-08-22 | ||
| CN201410418773 | 2014-08-22 | ||
| PCT/CN2015/000602 WO2016026258A1 (en) | 2014-08-22 | 2015-08-21 | Methods and compositions for treating and/or preventing a disease or disorder associated with abnormal level and/or activity of the ifp35 family of proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017528129A JP2017528129A (ja) | 2017-09-28 |
| JP2017528129A5 true JP2017528129A5 (https=) | 2018-10-04 |
| JP6968696B2 JP6968696B2 (ja) | 2021-11-17 |
Family
ID=55350147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017510624A Active JP6968696B2 (ja) | 2014-08-22 | 2015-08-21 | 異常なレベル及び/又は活性のifp35ファミリーのタンパク質に関連する疾患又は障害を治療及び/又は予防するための方法及び組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US11466061B2 (https=) |
| EP (1) | EP3182990A4 (https=) |
| JP (1) | JP6968696B2 (https=) |
| CN (3) | CN114796497A (https=) |
| WO (1) | WO2016026258A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016026258A1 (en) | 2014-08-22 | 2016-02-25 | Institute Of Biophysics, Chinese Academy Of Sciences | Methods and compositions for treating and/or preventing a disease or disorder associated with abnormal level and/or activity of the ifp35 family of proteins |
| CN118767136A (zh) * | 2019-04-01 | 2024-10-15 | 广州恩迈生物科技有限公司 | 慢性炎症的诊断和治疗 |
| CN110669765B (zh) * | 2019-11-04 | 2022-11-01 | 中国科学院水生生物研究所 | 鳜干扰素诱导蛋白启动子和应用 |
| CN113234153B (zh) * | 2021-04-07 | 2022-12-20 | 中山大学 | 一批识别ifp35家族蛋白的单克隆抗体及其在免疫识别等方面的应用 |
| CN118667938A (zh) * | 2021-07-09 | 2024-09-20 | 广州恩迈生物科技有限公司 | Ifp35和/或nmi在诊治疾病中的应用 |
| CN116239685A (zh) * | 2023-02-24 | 2023-06-09 | 中山大学·深圳 | 一种识别ifp35蛋白的抗体及其应用 |
| EP4682166A1 (en) * | 2023-04-10 | 2026-01-21 | Guangzhou Enmai Biotechnology Co., Ltd | Anti-nmi monoclonal antibody or antigen-binding fragment thereof, and use thereof |
| CN120536560A (zh) * | 2024-02-19 | 2025-08-26 | 中山大学·深圳 | Ifp35家族蛋白在诊断脓毒症或其相关疾病中的应用 |
| CN120842381A (zh) * | 2025-07-22 | 2025-10-28 | 中山大学 | 一种识别nmi蛋白的单克隆抗体及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0921192A1 (en) | 1997-12-03 | 1999-06-09 | Leadd B.V. | Molecules interacting with apoptin |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| CA2386270A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| TW200418988A (en) * | 2002-09-30 | 2004-10-01 | Oncotherapy Science Inc | Method for diagnosing prostate cancer |
| EP1807540A4 (en) * | 2004-11-05 | 2008-12-10 | Us Gov Sec Navy | DIAGNOSIS AND PROGNOSIS OF CLINICAL PHENOTYPES OF INFECTION DISEASES AND OTHER PHYSIOLOGICAL CONDITIONS USING GENE EXPRESSION OF A HOSTS AS BIOMARKERS IN THE BLOOD |
| RU2008117085A (ru) * | 2005-10-03 | 2009-11-10 | Новартис АГ (CH) | Консервативный мембранный активатор кальциневрина (смас), новый терапевтический белок и мишень |
| FR2892730A1 (fr) * | 2005-10-28 | 2007-05-04 | Biomerieux Sa | Methode pour detecter la presence ou le risque de developper un cancer |
| WO2007127756A2 (en) * | 2006-04-24 | 2007-11-08 | Genentech, Inc. | Methods and compositions for detecting autoimmune disorders |
| NZ573052A (en) * | 2006-04-26 | 2012-03-30 | Vertex Pharma | Hepatitis c virus infection biomarkers |
| KR101326367B1 (ko) * | 2006-07-03 | 2013-11-11 | 가톨릭대학교 산학협력단 | 항암제 저항성의 진단 방법 및 진단 키트 |
| AU2007286915B2 (en) | 2006-08-11 | 2014-05-15 | Baylor Research Institute | Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections |
| EP2170311A4 (en) * | 2007-05-16 | 2011-10-19 | Avalon Pharmaceuticals | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES |
| WO2016026258A1 (en) | 2014-08-22 | 2016-02-25 | Institute Of Biophysics, Chinese Academy Of Sciences | Methods and compositions for treating and/or preventing a disease or disorder associated with abnormal level and/or activity of the ifp35 family of proteins |
| CN118767136A (zh) | 2019-04-01 | 2024-10-15 | 广州恩迈生物科技有限公司 | 慢性炎症的诊断和治疗 |
-
2015
- 2015-08-21 WO PCT/CN2015/000602 patent/WO2016026258A1/en not_active Ceased
- 2015-08-21 US US15/505,600 patent/US11466061B2/en active Active
- 2015-08-21 JP JP2017510624A patent/JP6968696B2/ja active Active
- 2015-08-21 CN CN202210537585.5A patent/CN114796497A/zh active Pending
- 2015-08-21 EP EP15834006.7A patent/EP3182990A4/en active Pending
- 2015-08-21 CN CN202210537590.6A patent/CN115054687A/zh active Pending
- 2015-08-21 CN CN201580045210.5A patent/CN107427552B/zh active Active
-
2022
- 2022-09-08 US US17/930,635 patent/US20230265135A1/en active Pending
-
2024
- 2024-09-27 US US18/899,627 patent/US20250084137A1/en active Pending
- 2024-09-27 US US18/899,585 patent/US20250059242A1/en active Pending
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