CN114796497A - 治疗和/或预防与ifp35蛋白家族的异常水平和/或活性相关的疾病或不适的方法和组合物 - Google Patents

治疗和/或预防与ifp35蛋白家族的异常水平和/或活性相关的疾病或不适的方法和组合物 Download PDF

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CN114796497A
CN114796497A CN202210537585.5A CN202210537585A CN114796497A CN 114796497 A CN114796497 A CN 114796497A CN 202210537585 A CN202210537585 A CN 202210537585A CN 114796497 A CN114796497 A CN 114796497A
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ifp35
nmi
activity
disease
nid
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刘迎芳
梁欢欢
沈涓
夏侯志楷
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Guangzhou Yingenmai Biomedical Technology Co ltd
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Guangzhou Yingenmai Biomedical Technology Co ltd
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CN202210537585.5A 2014-08-22 2015-08-21 治疗和/或预防与ifp35蛋白家族的异常水平和/或活性相关的疾病或不适的方法和组合物 Pending CN114796497A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2014104187731 2014-08-22
CN201410418773 2014-08-22
CN201580045210.5A CN107427552B (zh) 2014-08-22 2015-08-21 防治与ifp35蛋白家族的异常水平和/或活性相关的疾病或不适的方法和组合物
PCT/CN2015/000602 WO2016026258A1 (en) 2014-08-22 2015-08-21 Methods and compositions for treating and/or preventing a disease or disorder associated with abnormal level and/or activity of the ifp35 family of proteins

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CN201580045210.5A Division CN107427552B (zh) 2014-08-22 2015-08-21 防治与ifp35蛋白家族的异常水平和/或活性相关的疾病或不适的方法和组合物

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CN202210537585.5A Pending CN114796497A (zh) 2014-08-22 2015-08-21 治疗和/或预防与ifp35蛋白家族的异常水平和/或活性相关的疾病或不适的方法和组合物
CN202210537590.6A Pending CN115054687A (zh) 2014-08-22 2015-08-21 治疗和/或预防与ifp35蛋白家族的异常水平和/或活性相关的疾病或不适的方法和组合物
CN201580045210.5A Active CN107427552B (zh) 2014-08-22 2015-08-21 防治与ifp35蛋白家族的异常水平和/或活性相关的疾病或不适的方法和组合物

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CN201580045210.5A Active CN107427552B (zh) 2014-08-22 2015-08-21 防治与ifp35蛋白家族的异常水平和/或活性相关的疾病或不适的方法和组合物

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US (4) US11466061B2 (https=)
EP (1) EP3182990A4 (https=)
JP (1) JP6968696B2 (https=)
CN (3) CN114796497A (https=)
WO (1) WO2016026258A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016026258A1 (en) 2014-08-22 2016-02-25 Institute Of Biophysics, Chinese Academy Of Sciences Methods and compositions for treating and/or preventing a disease or disorder associated with abnormal level and/or activity of the ifp35 family of proteins
WO2020200186A1 (zh) * 2019-04-01 2020-10-08 中山大学 慢性炎症和病毒感染的诊断和治疗
CN110669765B (zh) * 2019-11-04 2022-11-01 中国科学院水生生物研究所 鳜干扰素诱导蛋白启动子和应用
CN113234153B (zh) * 2021-04-07 2022-12-20 中山大学 一批识别ifp35家族蛋白的单克隆抗体及其在免疫识别等方面的应用
CN116064763B (zh) * 2021-07-09 2024-07-02 广州恩迈生物科技有限公司 以ifp35和nmi为靶点的疾病诊断和治疗
CN116239685A (zh) * 2023-02-24 2023-06-09 中山大学·深圳 一种识别ifp35蛋白的抗体及其应用
EP4682166A1 (en) * 2023-04-10 2026-01-21 Guangzhou Enmai Biotechnology Co., Ltd Anti-nmi monoclonal antibody or antigen-binding fragment thereof, and use thereof
CN120536560A (zh) * 2024-02-19 2025-08-26 中山大学·深圳 Ifp35家族蛋白在诊断脓毒症或其相关疾病中的应用
CN120842381A (zh) * 2025-07-22 2025-10-28 中山大学 一种识别nmi蛋白的单克隆抗体及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999028460A2 (en) * 1997-12-03 1999-06-10 Leadd B.V. Molecules interacting with apoptin
CN1703523A (zh) * 2002-09-30 2005-11-30 肿瘤疗法科学股份有限公司 诊断前列腺癌的方法
CN101473045A (zh) * 2006-04-24 2009-07-01 健泰科生物技术公司 用于检测自身免疫性病症的方法和组合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7476198A (en) * 1997-05-09 1998-11-27 General Hospital Corporation, The Cell proliferation related genes
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
HK1047109A1 (zh) 1999-10-15 2003-02-07 University Of Massachusetts 作为指定基因干预工具的rna干预轨迹基因
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
CN101218355A (zh) * 2004-11-05 2008-07-09 海军秘书处代表的美国政府 利用宿主血液生物基因表达标记诊断和预后判断感染性疾病的临床表型及其它生理状态
CA2621326A1 (en) * 2005-10-03 2007-04-12 Novartis Ag Conserved membrane activator of calcineurin (cmac), a novel therapeutic protein and target
FR2892730A1 (fr) * 2005-10-28 2007-05-04 Biomerieux Sa Methode pour detecter la presence ou le risque de developper un cancer
CN101479389A (zh) * 2006-04-26 2009-07-08 沃泰克斯药物股份有限公司 丙肝病毒感染生物标记
KR101326367B1 (ko) * 2006-07-03 2013-11-11 가톨릭대학교 산학협력단 항암제 저항성의 진단 방법 및 진단 키트
CA2695935A1 (en) * 2006-08-11 2008-02-28 Baylor Research Institute Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections
US20100093611A1 (en) * 2007-05-16 2010-04-15 Horrigan Stephen K Compounds and methods for treating or preventing autoimmune diseases
WO2016026258A1 (en) 2014-08-22 2016-02-25 Institute Of Biophysics, Chinese Academy Of Sciences Methods and compositions for treating and/or preventing a disease or disorder associated with abnormal level and/or activity of the ifp35 family of proteins
WO2020200186A1 (zh) 2019-04-01 2020-10-08 中山大学 慢性炎症和病毒感染的诊断和治疗

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999028460A2 (en) * 1997-12-03 1999-06-10 Leadd B.V. Molecules interacting with apoptin
CN1703523A (zh) * 2002-09-30 2005-11-30 肿瘤疗法科学股份有限公司 诊断前列腺癌的方法
CN101473045A (zh) * 2006-04-24 2009-07-01 健泰科生物技术公司 用于检测自身免疫性病症的方法和组合物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DAS A ET AL.: "Interferon-inducible protein IFI35 negatively regulates RIG-I antiviral signaling and supports vesicular stomatitis virus replication" *
JIE WANG ET AL: "Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7" *
JUAN TAN ET AL: "IFP35 Is Involved in the Antiviral Function of Interferon by Association with the Viral Tas Transactivator of Bovine Foamy Virus" *
XIANGJUN ZHOU ET AL: "Interferon- a Induces Nmi-IFP35 Heterodimeric Complex Formation That Is Affected by the Phosphorylation of IFP35" *

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JP2017528129A (ja) 2017-09-28
US20230265135A1 (en) 2023-08-24
JP6968696B2 (ja) 2021-11-17
US20250084137A1 (en) 2025-03-13
EP3182990A1 (en) 2017-06-28
CN107427552B (zh) 2022-12-20
US11466061B2 (en) 2022-10-11
EP3182990A4 (en) 2018-04-11
US20180037617A1 (en) 2018-02-08
US20250059242A1 (en) 2025-02-20
WO2016026258A1 (en) 2016-02-25
CN115054687A (zh) 2022-09-16
CN107427552A (zh) 2017-12-01

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