JP2017526677A5 - - Google Patents
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- Publication number
- JP2017526677A5 JP2017526677A5 JP2017511226A JP2017511226A JP2017526677A5 JP 2017526677 A5 JP2017526677 A5 JP 2017526677A5 JP 2017511226 A JP2017511226 A JP 2017511226A JP 2017511226 A JP2017511226 A JP 2017511226A JP 2017526677 A5 JP2017526677 A5 JP 2017526677A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- solvate
- acceptable salt
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 37
- 150000001875 compounds Chemical class 0.000 claims description 34
- 150000003839 salts Chemical class 0.000 claims description 19
- 239000011780 sodium chloride Substances 0.000 claims description 19
- 239000012453 solvate Substances 0.000 claims description 19
- 229910052799 carbon Inorganic materials 0.000 claims description 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 12
- 201000011510 cancer Diseases 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 8
- 125000001475 halogen functional group Chemical group 0.000 claims description 8
- 125000001041 indolyl group Chemical group 0.000 claims description 6
- 125000001624 naphthyl group Chemical group 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- -1 hydroxy, amino Chemical group 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 4
- 239000002246 antineoplastic agent Substances 0.000 claims description 4
- 125000004076 pyridyl group Chemical group 0.000 claims description 4
- 125000004432 carbon atoms Chemical group C* 0.000 claims description 3
- 125000002993 cycloalkylene group Chemical group 0.000 claims description 3
- 201000007270 liver cancer Diseases 0.000 claims description 3
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims description 2
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 2
- 125000006176 2-ethylbutyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims description 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 2
- 206010073071 Hepatocellular carcinoma Diseases 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 230000000240 adjuvant Effects 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims description 2
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 230000036457 multidrug resistance Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 239000000367 immunologic factor Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020023051A JP6905609B2 (ja) | 2014-08-25 | 2020-02-14 | 癌の処置のためのウリジンのジオキソラン類似体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1450983-0 | 2014-08-25 | ||
| SE1450983 | 2014-08-25 | ||
| SE1550858-3 | 2015-06-22 | ||
| SE1550858 | 2015-06-22 | ||
| PCT/EP2015/069370 WO2016030335A1 (en) | 2014-08-25 | 2015-08-24 | Dioxolane analogues of uridine for the treatment of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020023051A Division JP6905609B2 (ja) | 2014-08-25 | 2020-02-14 | 癌の処置のためのウリジンのジオキソラン類似体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017526677A JP2017526677A (ja) | 2017-09-14 |
| JP2017526677A5 true JP2017526677A5 (pt-PT) | 2018-09-27 |
| JP6663424B2 JP6663424B2 (ja) | 2020-03-11 |
Family
ID=54014804
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511226A Active JP6663424B2 (ja) | 2014-08-25 | 2015-08-24 | 癌の処置のためのウリジンのジオキソラン類似体 |
| JP2020023051A Active JP6905609B2 (ja) | 2014-08-25 | 2020-02-14 | 癌の処置のためのウリジンのジオキソラン類似体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020023051A Active JP6905609B2 (ja) | 2014-08-25 | 2020-02-14 | 癌の処置のためのウリジンのジオキソラン類似体 |
Country Status (24)
| Country | Link |
|---|---|
| US (7) | US10144750B2 (pt-PT) |
| EP (2) | EP3572410B1 (pt-PT) |
| JP (2) | JP6663424B2 (pt-PT) |
| KR (2) | KR102396905B1 (pt-PT) |
| CN (4) | CN110804072B (pt-PT) |
| AU (2) | AU2015308988C1 (pt-PT) |
| BR (1) | BR112017003898B1 (pt-PT) |
| CA (2) | CA2956251C (pt-PT) |
| CY (1) | CY1122945T1 (pt-PT) |
| DK (2) | DK3186244T3 (pt-PT) |
| EA (2) | EA031106B1 (pt-PT) |
| ES (2) | ES2796089T3 (pt-PT) |
| HR (1) | HRP20201023T1 (pt-PT) |
| HU (2) | HUE050705T2 (pt-PT) |
| IL (2) | IL250344B (pt-PT) |
| MX (1) | MX369649B (pt-PT) |
| MY (1) | MY188089A (pt-PT) |
| NZ (2) | NZ729118A (pt-PT) |
| PH (2) | PH12017500184A1 (pt-PT) |
| PL (2) | PL3572410T3 (pt-PT) |
| PT (2) | PT3572410T (pt-PT) |
| SG (3) | SG11201701172SA (pt-PT) |
| WO (1) | WO2016030335A1 (pt-PT) |
| ZA (1) | ZA201802864B (pt-PT) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110804072B (zh) | 2014-08-25 | 2023-05-12 | 美迪维尔公司 | 用于治疗癌症的尿苷的二氧戊环类似物 |
| CN106543220A (zh) * | 2015-09-16 | 2017-03-29 | 博瑞生物医药（苏州）股份有限公司 | 氨基磷酸酯化合物及其制备方法和晶体 |
| MX2018007083A (es) * | 2015-12-11 | 2019-02-20 | NuCana plc | Sintesis diaestereoselectiva de derivados de fosfato y del profarmaco de gemcitabina nuc-1031. |
| JP6968080B2 (ja) * | 2016-03-02 | 2021-11-17 | メディヴィル・アクチエボラーグ | ソラフェニブ又はレゴラフェニブとトロキサシタビンのホスホロアミデートプロドラッグを用いた併用療法 |
| CN106432328B (zh) * | 2016-09-14 | 2019-03-22 | 江苏福瑞生物医药有限公司 | 一种索非布韦中间体的制备方法 |
| JP2020500853A (ja) * | 2016-11-18 | 2020-01-16 | ネウロビベ プハルマセウトイカル エービー | ミトコンドリアのプロトンイオノフォアの肝臓プロドラッグ |
| GB201709471D0 (en) * | 2017-06-14 | 2017-07-26 | Nucana Biomed Ltd | Diastereoselective synthesis of hosphate derivatives |
| JP7337539B2 (ja) * | 2018-06-21 | 2023-09-04 | メディヴィル・アクチエボラーグ | 白血病療法のための塩基修飾シチジンヌクレオチド |
| WO2019245444A1 (en) | 2018-06-21 | 2019-12-26 | Medivir Ab | Base-modified cytidine nucleotides for leukemia therapy |
| RS65316B1 (sr) * | 2019-02-18 | 2024-04-30 | Medivir Ab | Kombinacija lekova za upotrebu u postupku lečenja raka jetre |
| CN110964057B (zh) * | 2019-12-25 | 2022-05-06 | 东南大学 | 一种利用微流体反应装置制备索非布韦中间体的方法 |
| CN113754692B (zh) * | 2020-06-03 | 2022-06-10 | 上海交通大学 | 瑞德西韦中间体(s,s)-氨基磷酸酯的不对称催化合成方法 |
| CN114685558A (zh) * | 2020-12-28 | 2022-07-01 | 尚科生物医药（上海）有限公司 | 一种瑞德西韦中间体的制备方法 |
| CN114249764A (zh) * | 2021-11-10 | 2022-03-29 | 宁波大学 | 一种磷酰胺酯类前药的中间体及其制备方法与应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
| US6022876A (en) | 1996-11-15 | 2000-02-08 | Yale University | L-β-dioxolane uridine analogs and methods for treating and preventing Epstein-Barr virus infections |
| MXPA03003278A (es) * | 2000-10-13 | 2005-07-01 | Shire Biochem Inc | Analogos de dioxolano para suministro intercelular mejorado. |
| GB0317009D0 (en) * | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| WO2007106450A2 (en) * | 2006-03-10 | 2007-09-20 | University Of Georgia Research Foundation, Inc. | Diketo acids with nucleobase scaffolds: anti-hiv replication inhibitors targeted at hiv integrase in combination therapy |
| CA2662147A1 (en) * | 2006-09-01 | 2008-03-13 | University Of Georgia Research Foundation, Inc. | L-oddc prodrugs for cancer |
| PL216525B1 (pl) * | 2006-10-17 | 2014-04-30 | Ct Badań Molekularnych I Makromolekularnych Polskiej Akademii Nauk | 5'-O-[(N-acylo)amidoditiofosforano] nukleozydy oraz sposób wytwarzania 5'-O-[(N-acylo)amidofosforano]-,5'-O-[(N-acylo)amidotiofosforano]-, 5'-O-[(N-acylo)amidoditiofosforano]nukleozydów |
| US20130143835A1 (en) * | 2011-12-05 | 2013-06-06 | Medivir Ab | HCV Polymerase Inhibitors |
| CN105934438A (zh) * | 2013-11-27 | 2016-09-07 | 艾登尼克斯药业有限公司 | 用于治疗肝癌的核苷酸 |
| CN110804072B (zh) * | 2014-08-25 | 2023-05-12 | 美迪维尔公司 | 用于治疗癌症的尿苷的二氧戊环类似物 |
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2015
- 2015-08-24 CN CN201911149251.5A patent/CN110804072B/zh active Active
- 2015-08-24 WO PCT/EP2015/069370 patent/WO2016030335A1/en active Application Filing
- 2015-08-24 US US15/506,692 patent/US10144750B2/en active Active
- 2015-08-24 KR KR1020177008235A patent/KR102396905B1/ko active IP Right Grant
- 2015-08-24 AU AU2015308988A patent/AU2015308988C1/en active Active
- 2015-08-24 CN CN201911148331.9A patent/CN110790789B/zh active Active
- 2015-08-24 SG SG11201701172SA patent/SG11201701172SA/en unknown
- 2015-08-24 HU HUE15756888A patent/HUE050705T2/hu unknown
- 2015-08-24 CN CN201580056640.7A patent/CN107074826B/zh active Active
- 2015-08-24 NZ NZ729118A patent/NZ729118A/en unknown
- 2015-08-24 PL PL19177824.0T patent/PL3572410T3/pl unknown
- 2015-08-24 DK DK15756888.2T patent/DK3186244T3/da active
- 2015-08-24 ES ES15756888T patent/ES2796089T3/es active Active
- 2015-08-24 CA CA2956251A patent/CA2956251C/en active Active
- 2015-08-24 JP JP2017511226A patent/JP6663424B2/ja active Active
- 2015-08-24 PT PT191778240T patent/PT3572410T/pt unknown
- 2015-08-24 EP EP19177824.0A patent/EP3572410B1/en active Active
- 2015-08-24 EA EA201790328A patent/EA031106B1/ru not_active IP Right Cessation
- 2015-08-24 ES ES19177824T patent/ES2927212T3/es active Active
- 2015-08-24 NZ NZ762628A patent/NZ762628A/en unknown
- 2015-08-24 SG SG10201911558UA patent/SG10201911558UA/en unknown
- 2015-08-24 PL PL15756888T patent/PL3186244T3/pl unknown
- 2015-08-24 MY MYPI2017700615A patent/MY188089A/en unknown
- 2015-08-24 SG SG10202001117YA patent/SG10202001117YA/en unknown
- 2015-08-24 BR BR112017003898-6A patent/BR112017003898B1/pt active IP Right Grant
- 2015-08-24 HU HUE19177824A patent/HUE059640T2/hu unknown
- 2015-08-24 MX MX2017002328A patent/MX369649B/es active IP Right Grant
- 2015-08-24 PT PT157568882T patent/PT3186244T/pt unknown
- 2015-08-24 CN CN202010199579.4A patent/CN111269264A/zh active Pending
- 2015-08-24 DK DK19177824.0T patent/DK3572410T3/da active
- 2015-08-24 CA CA3128645A patent/CA3128645C/en active Active
- 2015-08-24 EP EP15756888.2A patent/EP3186244B1/en active Active
- 2015-08-24 KR KR1020207008682A patent/KR102398714B1/ko active IP Right Grant
- 2015-08-24 EA EA201890648A patent/EA033300B1/ru not_active IP Right Cessation
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2017
- 2017-01-30 IL IL250344A patent/IL250344B/en active IP Right Grant
- 2017-01-31 PH PH12017500184A patent/PH12017500184A1/en unknown
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2018
- 2018-03-20 AU AU2018201980A patent/AU2018201980B2/en active Active
- 2018-05-02 ZA ZA2018/02864A patent/ZA201802864B/en unknown
- 2018-12-03 US US16/208,083 patent/US10336780B2/en active Active
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2019
- 2019-05-21 IL IL266766A patent/IL266766B/en active IP Right Grant
- 2019-07-01 US US16/459,165 patent/US10654877B2/en active Active
- 2019-08-19 PH PH12019501919A patent/PH12019501919A1/en unknown
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2020
- 2020-02-14 JP JP2020023051A patent/JP6905609B2/ja active Active
- 2020-04-13 US US16/847,477 patent/US10822360B2/en active Active
- 2020-05-22 CY CY20201100469T patent/CY1122945T1/el unknown
- 2020-06-29 HR HRP20201023TT patent/HRP20201023T1/hr unknown
- 2020-11-02 US US17/087,483 patent/US11447511B2/en active Active
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2022
- 2022-09-19 US US17/948,050 patent/US20230117570A1/en not_active Abandoned
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2023
- 2023-05-31 US US18/326,992 patent/US20230382931A1/en active Pending