JP2017525546A - 深部脳刺激リード - Google Patents
深部脳刺激リード Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
- A61N1/0534—Electrodes for deep brain stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6868—Brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/12—Devices for detecting or locating foreign bodies
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K1/00—Printed circuits
- H05K1/02—Details
- H05K1/11—Printed elements for providing electric connections to or between printed circuits
- H05K1/118—Printed elements for providing electric connections to or between printed circuits specially for flexible printed circuits, e.g. using folded portions
Abstract
Description
深部脳刺激療法(DBS)は、ヒトの脳および身体を刺激する電気刺激システムを伴う神経刺激療法である。DBSは、数多くの神経学的疾患を治療するために使用することができる。一般に、DBSは、脳の標的区域を電気的に刺激することを含む。
本開示の一つの局面によると、神経学的リードは、内腔を画定する平面成形円柱形フィルムを含む。平面成形円柱形フィルムは末端部、基端部および複数の電極を含む。平面成形円柱形フィルムはまた、平面成形円柱形フィルムの末端部から内腔の中へと延びるリボンケーブルを含むことができる。フィルムは、第一のポリマー層、少なくとも部分的に第一のポリマー層の上に配置された第一のケイ素系バリヤ層、および少なくとも部分的に第一のケイ素系バリヤ層の上に配置された第一の金属層を含むことができる複数の層を含むことができる。他の層は、少なくとも部分的に第一の金属層または第一のケイ素系バリヤ層の上に配置された第二のケイ素系バリヤ層を含むことができる。第二のケイ素系バリヤ層は第一の複数のスルーホールを画定することができる。もう一つの層は、少なくとも部分的に第二のケイ素系バリヤ層の上に配置されている第二のポリマー層であることができる。第二のポリマー層は第二の複数のスルーホールを画定することができる。第一の複数のスルーホールが第二の複数のスルーホールと実質的に整合して、複数の電極それぞれを画定する。フィルムはまた、第一の金属層の上に配置された第二の金属層を含むことができる。
先に紹介し、以下さらに詳細に説明する様々な概念は、記載された概念が任意の特定の実現方法に限定されないため、数多くの方法のいずれかによって実現され得る。具体的な実施形態および適用の例は、主として例示目的のために提供される。
Claims (27)
- 末端部、基端部および複数の電極を含み、
平面成形円柱形フィルムの該末端部から、該平面成形円柱形フィルムによって画定される内腔の中へと延びるリボンケーブル;
第一のポリマー層;
少なくとも部分的に該第一のポリマー層の上に配置された第一のケイ素系バリヤ層;
少なくとも部分的に該第一のケイ素系バリヤ層の上に配置された第一の金属層;
少なくとも部分的に該第一の金属層および該第一のケイ素系バリヤ層の上に配置され、第一の複数のスルーホールを画定する第二のケイ素系バリヤ層;
少なくとも部分的に該第二のケイ素系バリヤ層の上に配置され、第二の複数のスルーホールを画定する第二のポリマー層であって、該第一の複数のスルーホールが、該第二の複数のスルーホールと実質的に整合して、複数の電極それぞれを画定する、第二のポリマー層;および
該第一の金属層の上に配置された第二の金属層
をさらに含む、平面成形円柱形フィルム
を含む、神経学的リード。 - 第一の金属層が複数の電極および複数のトレースを形成する、請求項1記載のリード。
- 第一の金属層が、リボンケーブル上に配置された複数のコンタクトパッドを形成し、該複数のコンタクトパッドそれぞれが、該第一の金属層中に形成されたトレースにより、複数の電極の少なくとも一つと電気的に結合している、請求項1記載のリード。
- 第二の金属層が金を含み、第一の金属層が白金、酸化イリジウムおよびチタンの少なくとも一つを含む、請求項1記載のリード。
- 第一および第二のケイ素系バリヤ層が、窒化ケイ素、酸化ケイ素、炭化ケイ素、ポリシリコン、アモルファスシリコン、二酸化チタンおよび酸化チタン(III)の少なくとも一つを含む、請求項1記載のリード。
- 第一および第二のケイ素系バリヤ層の厚さが約100nm〜約2μmである、請求項1記載のリード。
- 平面成形円柱形フィルムの円柱形が、平面成形円柱形フィルムの第一の側を該平面成形円柱形フィルムの第二の側に結合するワイヤによって少なくとも部分的に維持される、請求項1記載のリード。
- 第一のケイ素系バリヤ層を、少なくとも部分的に第一のポリマー層の上に付着させ、
第一の金属層を、少なくとも部分的に該第一のケイ素系バリヤ層の上に付着させ、
第二のケイ素系バリヤ層を、少なくとも部分的に該第一の金属層および該第一のケイ素系バリヤ層の上に付着させ、
第二のポリマー層を、少なくとも部分的に該第二のケイ素系バリヤ層の上に付着させ、
第二の金属層を該第一の金属層の上に付着させる
ことにより、複数の電極と、平面フィルムの末端部から延びるリボンケーブルとを含む平面フィルムを形成する工程;
該平面フィルムを加熱する工程;
加熱された平面フィルムを、内腔を画定する円柱へと成形する工程;および
該リボンケーブルを、該円柱によって画定された該内腔の中へと延ばす工程
を含む、神経学的リードを形成する方法。 - 第一の金属層中に複数の電極を形成する工程;
該第一の金属層中のリボンケーブル上に複数のコンタクトパッドを形成する工程;および
該複数のコンタクトパッドそれぞれを該複数の電極の少なくとも一つに電気的に結合する複数のトレースを形成する工程
をさらに含む、請求項8記載の方法。 - 第二の金属層を複数のコンタクトパッド上に付着させる工程をさらに含む、請求項9記載の方法。
- 第二のケイ素系バリヤ層および第二のポリマー層の中に複数のスルーホールをエッチングすることによって複数の電極それぞれを画定する工程
をさらに含む、請求項8記載の方法。 - 第一および第二のケイ素系バリヤ層が、窒化ケイ素、酸化ケイ素、炭化ケイ素、ポリシリコン、アモルファスシリコン、二酸化チタンおよび酸化チタン(III)の少なくとも一つを含む、請求項8記載の方法。
- 内腔を画定し、末端部および基端部を含み、
成形された円柱の外面に配置された複数の電極;
平面成形円柱形フィルムの該末端部から該平面成形円柱形フィルムの該基端部に向けて該内腔の中へと延びるリボンケーブル;
封入用ポリマーで埋められている該平面成形円柱形フィルムの該内腔;および
該平面成形円柱形フィルムの該基端部と結合したチューブ
をさらに含む、平面成形円柱形フィルム
を含む、神経学的リード。 - リボンケーブル上に配置された複数のコンタクトパッドを含み、該複数のコンタクトパッドそれぞれが、複数の電極の少なくとも一つに電気的に結合している、請求項13記載のリード。
- 複数のコンタクトパッドそれぞれの上に配置された金層を含む、請求項14記載のリード。
- 金層が厚さ約5μm〜約50μmである、請求項15記載のリード。
- 複数の電極それぞれを部分的に包囲し、二つ以上の場所で該複数の電極それぞれと結合した周辺トレースを含む、請求項13記載のリード。
- 一つまたは複数のオリエンテーションマークを含む、請求項13記載のリード。
- 一つまたは複数のオリエンテーションマークが複数の電極の少なくとも一つまたはリボンケーブルと整合する、請求項18記載のリード。
- 一つまたは複数のオリエンテーションマークが放射線不透過性である、請求項18記載のリード。
- 複数の電極の少なくとも一つがメッシュ構成を含む、請求項13記載のリード。
- 複数の電極の少なくとも一つが、丸められた角を含む、請求項13記載のリード。
- 末端部と、基端部と、複数の電極と、平面フィルムの末端部から延びるリボンケーブルとを含む平面フィルムを提供する工程;
該平面フィルムを、内腔を画定する円柱へと成形する工程;
該リボンケーブルを、該円柱によって画定された該内腔の中へと延ばす工程;および
該内腔を封入用ポリマーで埋める工程
を含む、神経学的リードを製造する方法。 - 平面フィルムを加熱する工程を含む、請求項23記載の方法。
- 平面フィルムの基端部をカテーテルに結合する工程を含む、請求項23記載の方法。
- スタイレットをリボンケーブルと結合する工程を含む、請求項23記載の方法。
- 放射線不透過性染料を平面フィルム上に配置する工程を含む、請求項23記載の方法。
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EP3185949A1 (en) | 2017-07-05 |
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