JP2017524341A5 - - Google Patents
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- JP2017524341A5 JP2017524341A5 JP2016569679A JP2016569679A JP2017524341A5 JP 2017524341 A5 JP2017524341 A5 JP 2017524341A5 JP 2016569679 A JP2016569679 A JP 2016569679A JP 2016569679 A JP2016569679 A JP 2016569679A JP 2017524341 A5 JP2017524341 A5 JP 2017524341A5
- Authority
- JP
- Japan
- Prior art keywords
- mirna
- polynucleotide
- rna
- trna
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000040430 polynucleotide Human genes 0.000 claims description 68
- 108091033319 polynucleotide Proteins 0.000 claims description 68
- 239000002157 polynucleotide Substances 0.000 claims description 68
- 210000004027 cell Anatomy 0.000 claims description 58
- 108020004566 Transfer RNA Proteins 0.000 claims description 43
- 239000002679 microRNA Substances 0.000 claims description 34
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 32
- 150000007523 nucleic acids Chemical group 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 24
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 23
- 239000004055 small Interfering RNA Substances 0.000 claims description 21
- 206010028980 Neoplasm Diseases 0.000 claims description 15
- 108091027967 Small hairpin RNA Proteins 0.000 claims description 15
- 239000013603 viral vector Substances 0.000 claims description 15
- 239000002502 liposome Substances 0.000 claims description 12
- 239000002105 nanoparticle Substances 0.000 claims description 12
- 201000011510 cancer Diseases 0.000 claims description 11
- 108700011259 MicroRNAs Proteins 0.000 claims description 9
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims description 9
- 239000002773 nucleotide Substances 0.000 claims description 7
- 125000003729 nucleotide group Chemical group 0.000 claims description 7
- 241000238631 Hexapoda Species 0.000 claims description 6
- 230000001580 bacterial effect Effects 0.000 claims description 6
- 210000004962 mammalian cell Anatomy 0.000 claims description 6
- 108091070501 miRNA Proteins 0.000 claims description 6
- 108091027963 non-coding RNA Proteins 0.000 claims description 6
- 102000042567 non-coding RNA Human genes 0.000 claims description 6
- 241000588724 Escherichia coli Species 0.000 claims description 5
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 108020005004 Guide RNA Proteins 0.000 claims description 4
- 108091007412 Piwi-interacting RNA Proteins 0.000 claims description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
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- 108020003224 Small Nucleolar RNA Proteins 0.000 claims description 4
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- 108020004459 Small interfering RNA Proteins 0.000 claims description 4
- 238000003776 cleavage reaction Methods 0.000 claims description 4
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- 230000007017 scission Effects 0.000 claims description 4
- 108091029842 small nuclear ribonucleic acid Proteins 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 3
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- 230000037431 insertion Effects 0.000 claims description 3
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 108020005098 Anticodon Proteins 0.000 claims description 2
- 108090000994 Catalytic RNA Proteins 0.000 claims description 2
- 102000053642 Catalytic RNA Human genes 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 108091007781 MIR124-1 Proteins 0.000 claims description 2
- 108091007780 MiR-122 Proteins 0.000 claims description 2
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- 108091062170 Mir-22 Proteins 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
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- 108020004422 Riboswitch Proteins 0.000 claims description 2
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- 108091091807 let-7a stem-loop Proteins 0.000 claims description 2
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- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 108091051828 miR-122 stem-loop Proteins 0.000 claims description 2
- 108091092839 miR-124-1 stem-loop Proteins 0.000 claims description 2
- 108091037066 miR-125-1 stem-loop Proteins 0.000 claims description 2
- 108091074094 miR-1291 stem-loop Proteins 0.000 claims description 2
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- 108091041631 miR-21-1 stem-loop Proteins 0.000 claims description 2
- 108091044442 miR-21-2 stem-loop Proteins 0.000 claims description 2
- 108091070404 miR-27b stem-loop Proteins 0.000 claims description 2
- 108091029119 miR-34a stem-loop Proteins 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 210000001236 prokaryotic cell Anatomy 0.000 claims description 2
- 230000035755 proliferation Effects 0.000 claims description 2
- 108091092562 ribozyme Proteins 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108091070522 Homo sapiens let-7a-2 stem-loop Proteins 0.000 claims 1
- 108091070514 Homo sapiens let-7b stem-loop Proteins 0.000 claims 1
- 108091070511 Homo sapiens let-7c stem-loop Proteins 0.000 claims 1
- 108091070512 Homo sapiens let-7d stem-loop Proteins 0.000 claims 1
- 108091070508 Homo sapiens let-7e stem-loop Proteins 0.000 claims 1
- 108091070510 Homo sapiens let-7f-1 stem-loop Proteins 0.000 claims 1
- 108091070526 Homo sapiens let-7f-2 stem-loop Proteins 0.000 claims 1
- 108091069047 Homo sapiens let-7i stem-loop Proteins 0.000 claims 1
- -1 Hsa-let-7a-3 Proteins 0.000 claims 1
- 108091007772 MIRLET7C Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 108091007426 microRNA precursor Proteins 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 108091030146 MiRBase Proteins 0.000 description 6
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- 108091006047 fluorescent proteins Proteins 0.000 description 4
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- 241000196324 Embryophyta Species 0.000 description 3
- 102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 description 3
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- 101000851181 Homo sapiens Epidermal growth factor receptor Proteins 0.000 description 2
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- 108010016731 PPAR gamma Proteins 0.000 description 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
- 108091005948 blue fluorescent proteins Proteins 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
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- 239000005090 green fluorescent protein Substances 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 108020004017 nuclear receptors Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 108010054624 red fluorescent protein Proteins 0.000 description 2
- 108091005957 yellow fluorescent proteins Proteins 0.000 description 2
- 108091023037 Aptamer Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 1
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 1
- 108091007417 HOX transcript antisense RNA Proteins 0.000 description 1
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 1
- 101000741790 Homo sapiens Peroxisome proliferator-activated receptor gamma Proteins 0.000 description 1
- 108090000174 Interleukin-10 Proteins 0.000 description 1
- 108010065805 Interleukin-12 Proteins 0.000 description 1
- 108050003558 Interleukin-17 Proteins 0.000 description 1
- 108090000171 Interleukin-18 Proteins 0.000 description 1
- 108010002616 Interleukin-5 Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 108090001007 Interleukin-8 Proteins 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 102000015728 Mucins Human genes 0.000 description 1
- 108010063954 Mucins Proteins 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 101710100968 Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 235000005811 Viola adunca Nutrition 0.000 description 1
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- 229920001481 poly(stearyl methacrylate) Polymers 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462003806P | 2014-05-28 | 2014-05-28 | |
| US62/003,806 | 2014-05-28 | ||
| PCT/US2015/031861 WO2015183667A1 (en) | 2014-05-28 | 2015-05-21 | HYBRID tRNA/pre-miRNA MOLECULES AND METHODS OF USE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020121186A Division JP2021003105A (ja) | 2014-05-28 | 2020-07-15 | ハイブリッドｔＲＮＡ／プレｍｉＲＮＡ分子および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017524341A JP2017524341A (ja) | 2017-08-31 |
| JP2017524341A5 true JP2017524341A5 (enExample) | 2018-06-28 |
| JP7026440B2 JP7026440B2 (ja) | 2022-02-28 |
Family
ID=54699588
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016569679A Active JP7026440B2 (ja) | 2014-05-28 | 2015-05-21 | ハイブリッドｔＲＮＡ／プレｍｉＲＮＡ分子および使用方法 |
| JP2020121186A Pending JP2021003105A (ja) | 2014-05-28 | 2020-07-15 | ハイブリッドｔＲＮＡ／プレｍｉＲＮＡ分子および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020121186A Pending JP2021003105A (ja) | 2014-05-28 | 2020-07-15 | ハイブリッドｔＲＮＡ／プレｍｉＲＮＡ分子および使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10619156B2 (enExample) |
| EP (1) | EP3160980B1 (enExample) |
| JP (2) | JP7026440B2 (enExample) |
| WO (1) | WO2015183667A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3502240T (pt) | 2012-11-27 | 2021-08-11 | Childrens Medical Ct Corp | Elementos reguladores distais de bcl11a como alvo para a reindução de hemoglobina fetal |
| JP6514717B2 (ja) | 2014-04-25 | 2019-05-15 | ザ チルドレンズ メディカル センター コーポレーション | 異常ヘモグロビン症を治療するための組成物および方法 |
| WO2015183667A1 (en) * | 2014-05-28 | 2015-12-03 | The Regents Of The University Of California | HYBRID tRNA/pre-miRNA MOLECULES AND METHODS OF USE |
| CN114717264A (zh) | 2014-11-14 | 2022-07-08 | 沃雅戈治疗公司 | 治疗肌萎缩性侧索硬化(als)的组合物和方法 |
| CA2975583A1 (en) | 2014-11-14 | 2016-05-19 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
| US10422003B2 (en) | 2015-03-23 | 2019-09-24 | The Regents Of The University Of California | Methods for detection of RNase activity |
| ES2835861T5 (en) | 2015-05-08 | 2025-02-18 | Childrens Medical Ct Corp | Targeting bcl11a enhancer functional regions for fetal hemoglobin reinduction |
| SG11201809643UA (en) | 2016-05-18 | 2018-12-28 | Voyager Therapeutics Inc | Compositions and methods of treating huntington's disease |
| IL262784B2 (en) | 2016-05-18 | 2023-10-01 | Voyager Therapeutics Inc | modulatory polynucleotides |
| CN106032533B (zh) * | 2016-08-04 | 2018-11-20 | 北京信生元生物医学科技有限公司 | 一种抑制肿瘤生长和转移的短链核酸及其应用 |
| CN108295259A (zh) * | 2017-01-13 | 2018-07-20 | 昆山彭济凯丰生物科技有限公司 | 通过miR-6792-3p进行抗癌的方法和药物及其应用 |
| CN108310382A (zh) * | 2017-01-16 | 2018-07-24 | 昆山彭济凯丰生物科技有限公司 | 通过miR-6846-3p进行抗癌的方法和药物及其应用 |
| CN106987634B (zh) * | 2017-04-18 | 2020-12-22 | 优联瑞康(上海)基因科技有限公司 | 血浆外泌体源性miRNAs在制备早期诊断原发性肝癌的试剂盒中的应用 |
| MX2019013172A (es) | 2017-05-05 | 2020-09-07 | Voyager Therapeutics Inc | Composiciones y metodos para tratar la enfermedad de huntington. |
| WO2018204786A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| US11788087B2 (en) | 2017-05-25 | 2023-10-17 | The Children's Medical Center Corporation | BCL11A guide delivery |
| US11434502B2 (en) | 2017-10-16 | 2022-09-06 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (ALS) |
| WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| TWI688655B (zh) * | 2017-11-06 | 2020-03-21 | 高雄醫學大學 | 甘胺酸ｎ-甲基轉移酶剔除小鼠應用高通量定序法建立新穎微小核醣核酸癌症與肝臟疾病標誌物與套組 |
| US12194108B2 (en) | 2018-03-23 | 2025-01-14 | University Of Massachusetts | Gene therapeutics for treating bone disorders |
| US11702657B2 (en) * | 2018-04-20 | 2023-07-18 | The Regents Of The University Of California | TRNA/pre-miRNA compositions and methods for treating hepatocellular carcinoma |
| WO2019213013A1 (en) * | 2018-05-02 | 2019-11-07 | The Children's Medical Center Corporation | Improved bcl11a micrornas for treating hemoglobinopathies |
| JP7545726B2 (ja) * | 2018-05-22 | 2024-09-05 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ｔＲＮＡ／プレｍｉＲＮＡ組成物およびがん治療における使用 |
| CN108753780B (zh) * | 2018-06-11 | 2022-03-29 | 西安荣清畅生物科技有限公司 | 一种重组小rna的生产方法及应用 |
| CN108707625B (zh) * | 2018-07-03 | 2021-09-21 | 云笛生物科技有限公司 | mir-124和HER2-shRNA双基因表达盒病毒载体、构建方法、病毒、应用 |
| CN109022442B (zh) * | 2018-08-31 | 2020-12-18 | 武汉大学中南医院 | 一种可有效抑制骨肉瘤生长的生物重组型miR124-3p |
| WO2021062096A1 (en) * | 2019-09-26 | 2021-04-01 | Massachusetts Institute Of Technology | Microrna-based logic gates and uses thereof |
| GB201919021D0 (en) | 2019-12-20 | 2020-02-05 | Reneuron Ltd | Nucleic acid constructs for delivering polynucleotides into exosomes |
| CN113604471A (zh) * | 2021-09-10 | 2021-11-05 | 西北工业大学 | 一种重组miR-218及其生产方法和在毛发再生中的应用 |
| CN114854744A (zh) * | 2022-04-17 | 2022-08-05 | 吉布森生物科技(陕西)有限公司 | 一种重组anti-miR-129-5p及其制备方法和在抗皮肤衰老中的应用 |
| CN115181746B (zh) * | 2022-06-08 | 2024-11-19 | 浙江树人学院 | mgr-mir-9在调控拟禾本科根结线虫侵染水稻能力中的应用 |
| WO2024020376A1 (en) * | 2022-07-22 | 2024-01-25 | University Of Massachusetts | Aav-mediated delivery of osteoblast/osteoclast-regulating mirnas for osteoporosis therapy |
| WO2025155837A1 (en) * | 2024-01-19 | 2025-07-24 | Massachusetts Institute Of Technology | Modular microrna expression from self-replicating rna (replicons) |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999051755A2 (en) * | 1998-04-03 | 1999-10-14 | The Salk Institute For Biological Studies | Ribozyme-mediated control of gene expression |
| WO2005047505A2 (en) | 2003-08-07 | 2005-05-26 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro rnas |
| WO2007002528A1 (en) * | 2005-06-23 | 2007-01-04 | Yale University | Anti-aging micrornas |
| DE102005059315A1 (de) * | 2005-12-09 | 2007-06-14 | Qiagen Gmbh | Verfahren zur Anreicherung von kurzkettigen Nukleinsäuren |
| FR2902439A1 (fr) | 2006-06-14 | 2007-12-21 | Univ Rene Descartes Paris V Et | Arn de transfert chimerique et son utilisation pour la production d'arn par une cellule |
| EP2087115B1 (en) | 2006-09-27 | 2012-11-21 | Novarx | Blocking of gene expression in eukaryotic cells |
| AU2008256886B2 (en) | 2007-05-23 | 2013-02-28 | Dharmacon, Inc. | Micro-RNA scaffolds and non-naturally occurring micro-RNAs |
| US20090004668A1 (en) | 2007-06-22 | 2009-01-01 | The Board Of Trustees Of The Leland Stanford Junior University | Pre-miRNA loop-modulated target regulation |
| WO2011057304A2 (en) | 2009-11-09 | 2011-05-12 | Yale University | Microrna signatures differentiating uterine and ovarian papillary serous tumors |
| CN103096925A (zh) | 2010-05-03 | 2013-05-08 | Atyr医药公司 | 与精氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| US10378016B2 (en) | 2010-12-06 | 2019-08-13 | Children's Medical Center Corporation | Composition and method for oligonucleotide delivery |
| WO2013106766A2 (en) | 2012-01-13 | 2013-07-18 | The Research Foundation Of State University Of New York | THERAPEUTIC INDICATIONS OF miR-1291 |
| WO2013170365A1 (en) | 2012-05-18 | 2013-11-21 | The University Of British Columbia | Compositions of sparc polypeptide and grp78, and methods and uses thereof for sensitizing cancer cells |
| SG10201912895PA (en) | 2012-07-13 | 2020-02-27 | Wave Life Sciences Ltd | Chiral control |
| CA2940084A1 (en) * | 2014-02-18 | 2015-08-27 | Duke University | Compositions for the inactivation of virus replication and methods of making and using the same |
| WO2015183667A1 (en) | 2014-05-28 | 2015-12-03 | The Regents Of The University Of California | HYBRID tRNA/pre-miRNA MOLECULES AND METHODS OF USE |
| US10422003B2 (en) | 2015-03-23 | 2019-09-24 | The Regents Of The University Of California | Methods for detection of RNase activity |
-
2015
- 2015-05-21 WO PCT/US2015/031861 patent/WO2015183667A1/en not_active Ceased
- 2015-05-21 US US15/313,555 patent/US10619156B2/en active Active
- 2015-05-21 JP JP2016569679A patent/JP7026440B2/ja active Active
- 2015-05-21 EP EP15800458.0A patent/EP3160980B1/en active Active
-
2020
- 2020-07-15 JP JP2020121186A patent/JP2021003105A/ja active Pending
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