JP7026440B2 - ハイブリッドｔＲＮＡ／プレｍｉＲＮＡ分子および使用方法 - Google Patents

ハイブリッドｔＲＮＡ／プレｍｉＲＮＡ分子および使用方法 Download PDF

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JP7026440B2
JP7026440B2 JP2016569679A JP2016569679A JP7026440B2 JP 7026440 B2 JP7026440 B2 JP 7026440B2 JP 2016569679 A JP2016569679 A JP 2016569679A JP 2016569679 A JP2016569679 A JP 2016569679A JP 7026440 B2 JP7026440 B2 JP 7026440B2
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mir
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JP2017524341A5 (enExample
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エイミング ユ
ウェイペン ワン
チウシャ チェン
メイメイ リ
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid

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JP2016569679A 2014-05-28 2015-05-21 ハイブリッドｔＲＮＡ／プレｍｉＲＮＡ分子および使用方法 Active JP7026440B2 (ja)

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Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013352156B2 (en) 2012-11-27 2018-12-06 Children's Medical Center Corporation Targeting BCL11A distal regulatory elements for fetal hemoglobin reinduction
SG10201809290SA (en) 2014-04-25 2019-01-30 Childrens Medical Ct Corp Compositions and Methods to Treating Hemoglobinopathies
WO2015183667A1 (en) * 2014-05-28 2015-12-03 The Regents Of The University Of California HYBRID tRNA/pre-miRNA MOLECULES AND METHODS OF USE
MX2017006216A (es) 2014-11-14 2018-08-29 Voyager Therapeutics Inc Composiciones y métodos para tratar la esclerosis lateral amiotrófica (ela).
KR102584655B1 (ko) 2014-11-14 2023-10-06 보이저 테라퓨틱스, 인크. 조절성 폴리뉴클레오티드
US10422003B2 (en) 2015-03-23 2019-09-24 The Regents Of The University Of California Methods for detection of RNase activity
JP7288302B2 (ja) 2015-05-08 2023-06-07 ザ チルドレンズ メディカル センター コーポレーション 胎児型ヘモグロビン再誘導のための、ｂｃｌ１１ａエンハンサー機能性領域を標的とする方法
RU2758488C2 (ru) 2016-05-18 2021-10-28 Вояджер Терапьютикс, Инк. Модулирующие полинуклеотиды
AU2017268382B2 (en) 2016-05-18 2023-09-28 Voyager Therapeutics, Inc. Compositions and methods of treating Huntington's disease
CN106032533B (zh) * 2016-08-04 2018-11-20 北京信生元生物医学科技有限公司 一种抑制肿瘤生长和转移的短链核酸及其应用
CN108295259A (zh) * 2017-01-13 2018-07-20 昆山彭济凯丰生物科技有限公司 通过miR-6792-3p进行抗癌的方法和药物及其应用
CN108310382A (zh) * 2017-01-16 2018-07-24 昆山彭济凯丰生物科技有限公司 通过miR-6846-3p进行抗癌的方法和药物及其应用
CN106987634B (zh) * 2017-04-18 2020-12-22 优联瑞康(上海)基因科技有限公司 血浆外泌体源性miRNAs在制备早期诊断原发性肝癌的试剂盒中的应用
WO2018204803A1 (en) 2017-05-05 2018-11-08 Voyager Therapeutics, Inc. Compositions and methods of treating huntington's disease
AU2018261790B2 (en) 2017-05-05 2024-10-03 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (ALS)
WO2018218135A1 (en) 2017-05-25 2018-11-29 The Children's Medical Center Corporation Bcl11a guide delivery
US11434502B2 (en) 2017-10-16 2022-09-06 Voyager Therapeutics, Inc. Treatment of amyotrophic lateral sclerosis (ALS)
EP4454654A3 (en) 2017-10-16 2025-02-19 Voyager Therapeutics, Inc. Treatment of amyotrophic lateral sclerosis (als)
TWI688655B (zh) * 2017-11-06 2020-03-21 高雄醫學大學 甘胺酸ｎ-甲基轉移酶剔除小鼠應用高通量定序法建立新穎微小核醣核酸癌症與肝臟疾病標誌物與套組
CN112368051A (zh) 2018-03-23 2021-02-12 马萨诸塞大学 用于治疗骨病的基因治疗剂
US11702657B2 (en) * 2018-04-20 2023-07-18 The Regents Of The University Of California TRNA/pre-miRNA compositions and methods for treating hepatocellular carcinoma
EP3787600A4 (en) * 2018-05-02 2022-02-16 The Children's Medical Center Corporation ENHANCED BCL11A MICRORNAS FOR THE TREATMENT OF HEMOGLOBINOPATHIES
WO2019226603A1 (en) * 2018-05-22 2019-11-28 The Regents Of The University Of California Trna/pre-mirna compositions and use in treating cancer
CN108753780B (zh) * 2018-06-11 2022-03-29 西安荣清畅生物科技有限公司 一种重组小rna的生产方法及应用
CN108707625B (zh) * 2018-07-03 2021-09-21 云笛生物科技有限公司 mir-124和HER2-shRNA双基因表达盒病毒载体、构建方法、病毒、应用
CN109022442B (zh) * 2018-08-31 2020-12-18 武汉大学中南医院 一种可有效抑制骨肉瘤生长的生物重组型miR124-3p
WO2021062096A1 (en) 2019-09-26 2021-04-01 Massachusetts Institute Of Technology Microrna-based logic gates and uses thereof
GB201919021D0 (en) 2019-12-20 2020-02-05 Reneuron Ltd Nucleic acid constructs for delivering polynucleotides into exosomes
CN113604471A (zh) * 2021-09-10 2021-11-05 西北工业大学 一种重组miR-218及其生产方法和在毛发再生中的应用
CN114854744A (zh) * 2022-04-17 2022-08-05 吉布森生物科技(陕西)有限公司 一种重组anti-miR-129-5p及其制备方法和在抗皮肤衰老中的应用
CN115181746B (zh) * 2022-06-08 2024-11-19 浙江树人学院 mgr-mir-9在调控拟禾本科根结线虫侵染水稻能力中的应用
WO2024020376A1 (en) * 2022-07-22 2024-01-25 University Of Massachusetts Aav-mediated delivery of osteoblast/osteoclast-regulating mirnas for osteoporosis therapy
WO2025155837A1 (en) * 2024-01-19 2025-07-24 Massachusetts Institute Of Technology Modular microrna expression from self-replicating rna (replicons)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090298920A1 (en) 2006-06-14 2009-12-03 Universite Rene Descartes - Paris V Chimeric transfer rna and use thereof for the production of rna by a cell
JP2010527616A (ja) 2007-05-23 2010-08-19 ダーマコン， インコーポレイテッド マイクロ−ｒｎａスキャホールドおよび非天然存在型マイクロ−ｒｎａ
US20120219958A1 (en) 2009-11-09 2012-08-30 Yale University MicroRNA Signatures Differentiating Uterine and Ovarian Papillary Serous Tumors
WO2014012081A2 (en) 2012-07-13 2014-01-16 Ontorii, Inc. Chiral control

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3647799A (en) * 1998-04-03 1999-10-25 Salk Institute For Biological Studies, The Ribozyme-mediated control of gene expression
US8106180B2 (en) 2003-08-07 2012-01-31 Whitehead Institute For Biomedical Research Methods and products for expression of micro RNAs
US8354384B2 (en) * 2005-06-23 2013-01-15 Yale University Anti-aging micrornas
DE102005059315A1 (de) * 2005-12-09 2007-06-14 Qiagen Gmbh Verfahren zur Anreicherung von kurzkettigen Nukleinsäuren
WO2008039937A2 (en) 2006-09-27 2008-04-03 Novarx Blocking of gene expression in eukaryotic cells
US20090004668A1 (en) * 2007-06-22 2009-01-01 The Board Of Trustees Of The Leland Stanford Junior University Pre-miRNA loop-modulated target regulation
US8961961B2 (en) 2010-05-03 2015-02-24 a Tyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases
WO2012078637A2 (en) 2010-12-06 2012-06-14 Immune Disease Institute, Inc. Composition and method for oligonucleotide delivery
WO2013106766A2 (en) 2012-01-13 2013-07-18 The Research Foundation Of State University Of New York THERAPEUTIC INDICATIONS OF miR-1291
WO2013170365A1 (en) 2012-05-18 2013-11-21 The University Of British Columbia Compositions of sparc polypeptide and grp78, and methods and uses thereof for sensitizing cancer cells
KR20160130392A (ko) * 2014-02-18 2016-11-11 듀크 유니버시티 바이러스 복제의 불활성화를 위한 조성물 및 그의 제조 및 사용 방법
WO2015183667A1 (en) 2014-05-28 2015-12-03 The Regents Of The University Of California HYBRID tRNA/pre-miRNA MOLECULES AND METHODS OF USE
US10422003B2 (en) 2015-03-23 2019-09-24 The Regents Of The University Of California Methods for detection of RNase activity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090298920A1 (en) 2006-06-14 2009-12-03 Universite Rene Descartes - Paris V Chimeric transfer rna and use thereof for the production of rna by a cell
JP2010527616A (ja) 2007-05-23 2010-08-19 ダーマコン， インコーポレイテッド マイクロ−ｒｎａスキャホールドおよび非天然存在型マイクロ−ｒｎａ
US20120219958A1 (en) 2009-11-09 2012-08-30 Yale University MicroRNA Signatures Differentiating Uterine and Ovarian Papillary Serous Tumors
WO2014012081A2 (en) 2012-07-13 2014-01-16 Ontorii, Inc. Chiral control

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ｍｏｌｅｃｕｌａｒ Ｃｅｌｌ， ２０１０， Ｖｏｌ．３７， ｐ．１３５－１４２

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EP3160980B1 (en) 2020-05-20
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US20180237772A1 (en) 2018-08-23
JP2021003105A (ja) 2021-01-14
WO2015183667A1 (en) 2015-12-03
JP2017524341A (ja) 2017-08-31
EP3160980A4 (en) 2018-03-21

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