JP2017523810A5 - - Google Patents

Info

Publication number

JP2017523810A5

JP2017523810A5 JP2017526770A JP2017526770A JP2017523810A5 JP 2017523810 A5 JP2017523810 A5 JP 2017523810A5 JP 2017526770 A JP2017526770 A JP 2017526770A JP 2017526770 A JP2017526770 A JP 2017526770A JP 2017523810 A5 JP2017523810 A5 JP 2017523810A5

Authority

JP

Japan

Prior art keywords

seq

sequence

dna

mutant allele

cancer

Prior art date

2015-07-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108700028369 Alleles Proteins 0.000 claims 22
• 238000000034 method Methods 0.000 claims 20
• 108020004414 DNA Proteins 0.000 claims 18
• 239000000523 sample Substances 0.000 claims 18
• 230000000903 blocking effect Effects 0.000 claims 11
• 238000002844 melting Methods 0.000 claims 11
• 230000008018 melting Effects 0.000 claims 11
• 238000003752 polymerase chain reaction Methods 0.000 claims 11
• 201000011510 cancer Diseases 0.000 claims 10
• 230000035772 mutation Effects 0.000 claims 10
• 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 claims 6
• 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 claims 6
• 108091033319 polynucleotide Proteins 0.000 claims 6
• 102000040430 polynucleotide Human genes 0.000 claims 6
• 239000002157 polynucleotide Substances 0.000 claims 6
• 102000053602 DNA Human genes 0.000 claims 5
• 230000000295 complement effect Effects 0.000 claims 5
• 229910019142 PO4 Inorganic materials 0.000 claims 3
• 238000004458 analytical method Methods 0.000 claims 3
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 3
• 239000010452 phosphate Substances 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 108091034117 Oligonucleotide Proteins 0.000 claims 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
• 238000006243 chemical reaction Methods 0.000 claims 2
• 208000003174 Brain Neoplasms Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 206010008342 Cervix carcinoma Diseases 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 230000006820 DNA synthesis Effects 0.000 claims 1
• 230000004568 DNA-binding Effects 0.000 claims 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 101710130181 Protochlorophyllide reductase A, chloroplastic Proteins 0.000 claims 1
• CGNLCCVKSWNSDG-UHFFFAOYSA-N SYBR Green I Chemical compound CN(C)CCCN(CCC)C1=CC(C=C2N(C3=CC=CC=C3S2)C)=C2C=CC=CC2=[N+]1C1=CC=CC=C1 CGNLCCVKSWNSDG-UHFFFAOYSA-N 0.000 claims 1
• 208000000453 Skin Neoplasms Diseases 0.000 claims 1
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
• 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
• 230000003321 amplification Effects 0.000 claims 1
• 201000010881 cervical cancer Diseases 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 201000004101 esophageal cancer Diseases 0.000 claims 1
• 239000007850 fluorescent dye Substances 0.000 claims 1
• 206010017758 gastric cancer Diseases 0.000 claims 1
• 201000010536 head and neck cancer Diseases 0.000 claims 1
• 208000014829 head and neck neoplasm Diseases 0.000 claims 1
• 201000007270 liver cancer Diseases 0.000 claims 1
• 208000014018 liver neoplasm Diseases 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 230000003211 malignant effect Effects 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 230000001613 neoplastic effect Effects 0.000 claims 1
• 238000003199 nucleic acid amplification method Methods 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
• 201000000849 skin cancer Diseases 0.000 claims 1
• 201000011549 stomach cancer Diseases 0.000 claims 1
• 201000002510 thyroid cancer Diseases 0.000 claims 1