JP2017523789A5 - - Google Patents

Info

Publication number

JP2017523789A5

JP2017523789A5 JP2017506395A JP2017506395A JP2017523789A5 JP 2017523789 A5 JP2017523789 A5 JP 2017523789A5 JP 2017506395 A JP2017506395 A JP 2017506395A JP 2017506395 A JP2017506395 A JP 2017506395A JP 2017523789 A5 JP2017523789 A5 JP 2017523789A5

Authority

JP

Japan

Prior art keywords

fusion protein

seq

polypeptide

subject

fusion

Prior art date

2015-08-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 102000037865 fusion proteins Human genes 0.000 claims description 44
• 108020001507 fusion proteins Proteins 0.000 claims description 44
• 229920001184 polypeptide Polymers 0.000 claims description 10
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 10
• 102000000588 Interleukin-2 Human genes 0.000 claims description 9
• 108010002350 Interleukin-2 Proteins 0.000 claims description 9
• 230000000694 effects Effects 0.000 claims description 7
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
• 239000002157 polynucleotide Substances 0.000 claims description 5
• 102000040430 polynucleotide Human genes 0.000 claims description 5
• 108091033319 polynucleotide Proteins 0.000 claims description 5
• 238000012217 deletion Methods 0.000 claims description 3
• 230000037430 deletion Effects 0.000 claims description 3
• 238000006467 substitution reaction Methods 0.000 claims description 2
• 210000004027 cell Anatomy 0.000 claims 7
• 229960005486 vaccine Drugs 0.000 claims 5
• 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 210000004698 lymphocyte Anatomy 0.000 claims 2
• 208000015943 Coeliac disease Diseases 0.000 claims 1
• 206010009900 Colitis ulcerative Diseases 0.000 claims 1
• 208000011231 Crohn disease Diseases 0.000 claims 1
• 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
• 102000007351 Interleukin-2 Receptor alpha Subunit Human genes 0.000 claims 1
• 108010032774 Interleukin-2 Receptor alpha Subunit Proteins 0.000 claims 1
• 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
• 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
• 206010042953 Systemic sclerosis Diseases 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
• 206010047115 Vasculitis Diseases 0.000 claims 1
• 208000004631 alopecia areata Diseases 0.000 claims 1
• 229940022399 cancer vaccine Drugs 0.000 claims 1
• 238000009566 cancer vaccine Methods 0.000 claims 1
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
• 230000002708 enhancing effect Effects 0.000 claims 1
• 208000024908 graft versus host disease Diseases 0.000 claims 1
• 230000005847 immunogenicity Effects 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 238000003780 insertion Methods 0.000 claims 1
• 230000037431 insertion Effects 0.000 claims 1
• 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 230000002688 persistence Effects 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 230000000638 stimulation Effects 0.000 claims 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 description 10
• 108090000623 proteins and genes Proteins 0.000 description 10
• 150000001413 amino acids Chemical class 0.000 description 3
• 125000000539 amino acid group Chemical group 0.000 description 2
• 206010071602 Genetic polymorphism Diseases 0.000 description 1
• 230000004071 biological effect Effects 0.000 description 1
• 239000012634 fragment Substances 0.000 description 1
• 230000004952 protein activity Effects 0.000 description 1
• 238000002864 sequence alignment Methods 0.000 description 1