PE20170503A1 - Proteinas de fusion de interleucina 2/receptor de interleucina-2 alfa y metodos de uso - Google Patents

Proteinas de fusion de interleucina 2/receptor de interleucina-2 alfa y metodos de uso

Info

Publication number
PE20170503A1
PE20170503A1 PE2017000128A PE2017000128A PE20170503A1 PE 20170503 A1 PE20170503 A1 PE 20170503A1 PE 2017000128 A PE2017000128 A PE 2017000128A PE 2017000128 A PE2017000128 A PE 2017000128A PE 20170503 A1 PE20170503 A1 PE 20170503A1
Authority
PE
Peru
Prior art keywords
interleukin
polypeptide
alpha receptor
methods
fusion proteins
Prior art date
Application number
PE2017000128A
Other languages
English (en)
Spanish (es)
Inventor
Thomas Malek
Original Assignee
Univ Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53836871&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20170503(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Miami filed Critical Univ Miami
Publication of PE20170503A1 publication Critical patent/PE20170503A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
PE2017000128A 2014-08-06 2015-08-05 Proteinas de fusion de interleucina 2/receptor de interleucina-2 alfa y metodos de uso PE20170503A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462033726P 2014-08-06 2014-08-06

Publications (1)

Publication Number Publication Date
PE20170503A1 true PE20170503A1 (es) 2017-05-11

Family

ID=53836871

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2017000128A PE20170503A1 (es) 2014-08-06 2015-08-05 Proteinas de fusion de interleucina 2/receptor de interleucina-2 alfa y metodos de uso

Country Status (32)

Country Link
US (3) US12084483B2 (enExample)
EP (2) EP4438621A3 (enExample)
JP (3) JP6723982B2 (enExample)
KR (1) KR102653758B1 (enExample)
CN (2) CN107074967B (enExample)
AU (3) AU2015301071C1 (enExample)
BR (1) BR112017001940A2 (enExample)
CA (1) CA2957273C (enExample)
CL (1) CL2017000284A1 (enExample)
CO (1) CO2017002166A2 (enExample)
DK (1) DK3177307T3 (enExample)
EA (2) EA202091342A3 (enExample)
ES (1) ES2986097T3 (enExample)
FI (1) FI3177307T3 (enExample)
HR (1) HRP20241258T1 (enExample)
HU (1) HUE068478T2 (enExample)
IL (2) IL250007B (enExample)
LT (1) LT3177307T (enExample)
MA (2) MA40094B1 (enExample)
MX (1) MX388977B (enExample)
MY (1) MY180831A (enExample)
PE (1) PE20170503A1 (enExample)
PH (1) PH12017500042A1 (enExample)
PT (1) PT3177307T (enExample)
RS (1) RS65930B1 (enExample)
SA (1) SA517380842B1 (enExample)
SG (2) SG10201913695PA (enExample)
SI (1) SI3177307T1 (enExample)
SM (1) SMT202400414T1 (enExample)
TN (1) TN2017000020A1 (enExample)
WO (1) WO2016022671A1 (enExample)
ZA (1) ZA201700245B (enExample)

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MA40094B1 (fr) 2014-08-06 2022-05-31 Univ Miami Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation
JP7178906B2 (ja) * 2016-05-19 2022-11-28 ザ ジェネラル ホスピタル コーポレイション ナチュラルキラー細胞および制御性Ｔ細胞の活性を強化するためのプラットフォームである、その受容体ＩＬ－２Ｒβに繋ぎ止められたインターロイキン－２
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EP3746103A4 (en) 2017-12-06 2022-03-30 The Board of Trustees of the Leland Stanford Junior University PROTEINS ENGINEERED TO INCREASE A CELL'S SENSITIVITY TO IL-2
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EP3997115A4 (en) * 2019-07-12 2023-11-22 Proviva Therapeutics (Hong Kong) Limited Il-2 compositions and methods of use thereof
BR112022001320A2 (pt) * 2019-07-25 2022-04-12 Univ Chicago Composições e métodos compreendendo agentes terapêuticos ativados por protease
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BR112022007158A2 (pt) * 2019-10-18 2022-07-05 Alkermes Pharma Ireland Ltd Agentes imunomodulatórios de il-2 em combinação com inibidores do ponto de verificação imunológico
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CN116194480A (zh) * 2020-08-13 2023-05-30 百时美施贵宝公司 将il-2重定向到目的靶细胞的方法
TW202317623A (zh) 2021-06-14 2023-05-01 美商再生元醫藥公司 基於il2之治療劑及其使用方法
WO2023154894A2 (en) * 2022-02-11 2023-08-17 Alkermes Pharma Ireland Limited Compositions and methods for cancer immunotherapy
US20250154216A1 (en) * 2022-02-16 2025-05-15 University Of Miami Il-2 and tl1a fusion proteins and methods of use thereof
CN114875069B (zh) * 2022-04-22 2023-09-15 四川大学 基因工程修饰的il2细胞因子的重组载体、宿主细胞及其用途
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Also Published As

Publication number Publication date
CN107074967A (zh) 2017-08-18
WO2016022671A1 (en) 2016-02-11
JP2017523789A (ja) 2017-08-24
KR102653758B1 (ko) 2024-04-04
ZA201700245B (en) 2024-06-26
PT3177307T (pt) 2024-09-13
EA201790063A1 (ru) 2017-06-30
FI3177307T3 (fi) 2024-10-04
EP4438621A2 (en) 2024-10-02
MA40721A (fr) 2017-06-13
MA40094A1 (fr) 2021-09-30
SG11201700706WA (en) 2017-02-27
EA202091342A2 (ru) 2020-11-30
SA517380842B1 (ar) 2021-12-26
HRP20241258T1 (hr) 2024-12-06
PH12017500042A1 (en) 2017-05-22
SMT202400414T1 (it) 2024-11-15
US20250163118A1 (en) 2025-05-22
AU2015301071C1 (en) 2020-07-02
RS65930B1 (sr) 2024-10-31
HUE068478T2 (hu) 2025-01-28
SI3177307T1 (sl) 2024-09-30
AU2022204034A1 (en) 2022-07-14
JP6723982B2 (ja) 2020-07-15
AU2015301071B2 (en) 2020-03-05
AU2020203352B2 (en) 2022-03-10
IL250007B (en) 2020-07-30
JP7272663B2 (ja) 2023-05-12
JP2021000084A (ja) 2021-01-07
IL275944A (en) 2020-08-31
MA40094B1 (fr) 2022-05-31
AU2020203352A1 (en) 2020-07-02
DK3177307T3 (da) 2024-10-07
SG10201913695PA (en) 2020-03-30
JP2023099045A (ja) 2023-07-11
NZ728042A (en) 2024-07-26
EP3177307B1 (en) 2024-07-17
CL2017000284A1 (es) 2017-11-17
EP3177307A1 (en) 2017-06-14
KR20170030646A (ko) 2017-03-17
CA2957273C (en) 2023-03-14
IL250007A0 (en) 2017-03-30
TN2017000020A1 (en) 2018-07-04
MX388977B (es) 2025-03-20
CN107074967B (zh) 2021-06-08
MA40721B1 (fr) 2024-08-30
EA035956B1 (ru) 2020-09-04
US12084483B2 (en) 2024-09-10
EA202091342A3 (ru) 2020-12-30
MX2017001062A (es) 2017-07-14
IL275944B (en) 2022-02-01
MY180831A (en) 2020-12-10
BR112017001940A2 (pt) 2017-11-28
EP4438621A3 (en) 2024-12-18
US20170233448A1 (en) 2017-08-17
LT3177307T (lt) 2024-08-12
CO2017002166A2 (es) 2017-05-19
CN113912737A (zh) 2022-01-11
CA2957273A1 (en) 2016-02-11
AU2015301071A1 (en) 2017-02-02
US20230079120A1 (en) 2023-03-16
NZ766851A (en) 2024-07-26
ES2986097T3 (es) 2024-11-08

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