ES2986097T3 - Proteínas de fusión de interleucina-2/receptor alfa de interleucina-2 y métodos de uso - Google Patents
Proteínas de fusión de interleucina-2/receptor alfa de interleucina-2 y métodos de uso Download PDFInfo
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- ES2986097T3 ES2986097T3 ES15750560T ES15750560T ES2986097T3 ES 2986097 T3 ES2986097 T3 ES 2986097T3 ES 15750560 T ES15750560 T ES 15750560T ES 15750560 T ES15750560 T ES 15750560T ES 2986097 T3 ES2986097 T3 ES 2986097T3
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| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| PT3102595T (pt) | 2014-02-06 | 2019-01-11 | Hoffmann La Roche | Proteínas de fusão de interleucina-2 e suas utilizações |
| MA40094B1 (fr) | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
| US12202856B2 (en) * | 2016-05-19 | 2025-01-21 | The General Hospital Corporation | Tethered interleukin-2 to its receptor IL-2RBETA, a platform to enhance natural killer and regulatory T cell activity |
| US10858428B2 (en) | 2016-09-28 | 2020-12-08 | Xoma (Us) Llc | Antibodies that bind interleukin-2 and uses thereof |
| BR112019018915A2 (pt) | 2017-03-15 | 2020-04-14 | Pandion Therapeutics Inc | imunotolerância direcionada |
| AU2018273914A1 (en) | 2017-05-24 | 2019-11-14 | Pandion Operations, Inc. | Targeted immunotolerance |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US11780899B2 (en) | 2017-12-06 | 2023-10-10 | The Board Of Trustees Of The Leland Stanford Junior University | Engineered proteins to enhance sensitivity of a cell to IL-2 |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US12280119B2 (en) | 2018-03-23 | 2025-04-22 | Kite Pharma, Inc. | Chimeric transmembrane proteins and uses thereof |
| PE20210313A1 (es) * | 2018-03-28 | 2021-02-12 | Bristol Myers Squibb Co | Proteinas de fusion interleucina-2/receptor alfa de interleucina-2 y metodos de uso |
| MX2021011258A (es) * | 2019-03-18 | 2021-12-10 | Biontech Cell & Gene Therapies Gmbh | Variantes de interleucina-2 (il2) y receptor de interleucina-2 (il2r) para la activacion especifica de celulas efectoras inmunitarias. |
| CN111944036B (zh) | 2019-05-14 | 2024-09-06 | 上海盖浦生物科技有限公司 | 一种增殖免疫细胞的突变体蛋白 |
| AU2020279240A1 (en) | 2019-05-20 | 2021-12-23 | Pandion Operations, Inc. | MAdCAM targeted immunotolerance |
| AU2020285636A1 (en) * | 2019-05-24 | 2021-11-04 | Proviva Therapeutics (Hong Kong) Limited | IL-2 compositions and methods of use thereof |
| US11246906B2 (en) * | 2019-06-11 | 2022-02-15 | Alkermes Pharma Ireland Limited | Compositions and methods for subcutaneous administration of cancer immunotherapy |
| KR20260089650A (ko) * | 2019-07-12 | 2026-06-15 | 프로비바 테라퓨틱스 (홍콩) 리미티드 | Il-2 조성물 및 이의 사용 방법 |
| AU2020316002B2 (en) * | 2019-07-25 | 2026-05-07 | The University Of Chicago | Compositions and methods comprising protease-activated therapeutic agents |
| WO2021055568A1 (en) * | 2019-09-19 | 2021-03-25 | Proviva Therapeutics (Hong Kong) Limited | Il-2 compositions and methods of use thereof |
| WO2021074689A1 (en) * | 2019-10-18 | 2021-04-22 | Alkermes Pharma Ireland Limited | Immunomodulatory il-2 agents in combination with immune checkpoint inhibitors |
| IL293978A (en) * | 2019-12-20 | 2022-08-01 | Regeneron Pharma | New il2 agonists and methods of using them |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| CN115698063A (zh) | 2020-03-06 | 2023-02-03 | 匹兹堡大学联邦高等教育系统 | 血清白蛋白结合纳米抗体组合物以及其使用方法 |
| CN115996946A (zh) | 2020-04-30 | 2023-04-21 | 免疫靶向有限公司 | 可活化il2组合物和使用方法 |
| US20230416364A1 (en) * | 2020-08-13 | 2023-12-28 | Bristol-Myers Squibb Company | Methods of redirecting of il-2 to target cells of interest |
| TW202317623A (zh) * | 2021-06-14 | 2023-05-01 | 美商再生元醫藥公司 | 基於il2之治療劑及其使用方法 |
| CA3243480A1 (en) * | 2022-02-11 | 2023-08-17 | Mural Oncology, Inc. | CANCER IMMUNOTHERAPY COMPOSITIONS AND METHODS |
| US20250154216A1 (en) * | 2022-02-16 | 2025-05-15 | University Of Miami | Il-2 and tl1a fusion proteins and methods of use thereof |
| CN114875069B (zh) * | 2022-04-22 | 2023-09-15 | 四川大学 | 基因工程修饰的il2细胞因子的重组载体、宿主细胞及其用途 |
| TW202434646A (zh) * | 2023-02-22 | 2024-09-01 | 大陸商百奧賽圖(北京)醫藥科技股份有限公司 | 抗il2ra抗體及其用途 |
| WO2025207491A1 (en) * | 2024-03-25 | 2025-10-02 | Mural Oncology, Inc. | Compositions and methods for cancer immunotherapy |
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| NZ201918A (en) | 1981-09-18 | 1987-04-30 | Genentech Inc | N-terminal methionyl analogues of bovine growth hormone |
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| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| FR2619719B1 (fr) | 1987-09-01 | 1991-05-10 | Sanofi Sa | Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices |
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| US6967092B1 (en) * | 1996-10-25 | 2005-11-22 | Mc Kearn John P | Multi-functional chimeric hematopoietic receptor agonists |
| DE19701141C1 (de) * | 1997-01-16 | 1998-04-09 | Hoechst Ag | Genkonstrukte für durch Proteasen aktivierbare Wirksubstanzen |
| DZ2788A1 (fr) | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| EP1447451A4 (en) | 2001-09-28 | 2006-06-07 | Dnavec Research Inc | MAMMALIAN INFECTIVE, EPITOPEED BETA2m CODING VIRUS VECTOR AND ITS USE |
| KR20070003934A (ko) | 2004-03-05 | 2007-01-05 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 치료제의 환자 내약성을 예측하기 위한 시험관 내 테스트시스템 |
| WO2007001677A2 (en) | 2005-05-17 | 2007-01-04 | University Of Connecticut | Compositions and methods for immunomodulation in an organism |
| CN101255197B (zh) * | 2008-03-28 | 2012-01-25 | 浙江海正药业股份有限公司 | 血清白蛋白与白介素1受体拮抗剂的融合蛋白及应用 |
| GB0815216D0 (en) | 2008-08-21 | 2008-09-24 | Asterion Ltd | Interleukin |
| US8734774B2 (en) * | 2010-04-02 | 2014-05-27 | University Of Rochester | Protease activated cytokines |
| WO2012088383A2 (en) | 2010-12-23 | 2012-06-28 | Genentech, Inc. | PILR alpha INTERACTIONS AND METHODS OF MODIFYING SAME |
| US9156897B2 (en) * | 2012-06-08 | 2015-10-13 | Alkermes, Inc. | Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide |
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| WO2014100913A1 (en) | 2012-12-24 | 2014-07-03 | Beijing Anxinhuaide Biotech. Co., Ltd | Improving the half life of a therapeutic polypeptide by fusing with a trimeric scaffold protein via a spacer |
| MA40094B1 (fr) | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
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