JP2017523201A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017523201A5 JP2017523201A5 JP2017505456A JP2017505456A JP2017523201A5 JP 2017523201 A5 JP2017523201 A5 JP 2017523201A5 JP 2017505456 A JP2017505456 A JP 2017505456A JP 2017505456 A JP2017505456 A JP 2017505456A JP 2017523201 A5 JP2017523201 A5 JP 2017523201A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- disorders
- disorder
- compound
- monohalo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14179599 | 2014-08-01 | ||
| EP14179599.7 | 2014-08-01 | ||
| PCT/EP2015/067533 WO2016016381A1 (en) | 2014-08-01 | 2015-07-30 | 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017523201A JP2017523201A (ja) | 2017-08-17 |
| JP2017523201A5 true JP2017523201A5 (enExample) | 2018-09-06 |
| JP6615864B2 JP6615864B2 (ja) | 2019-12-04 |
Family
ID=51257438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505456A Expired - Fee Related JP6615864B2 (ja) | 2014-08-01 | 2015-07-30 | ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのそれらの使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10112949B2 (enExample) |
| EP (1) | EP3174880B1 (enExample) |
| JP (1) | JP6615864B2 (enExample) |
| KR (1) | KR102531693B1 (enExample) |
| CN (1) | CN106573935B (enExample) |
| AR (1) | AR101393A1 (enExample) |
| AU (1) | AU2015295299B2 (enExample) |
| BR (1) | BR112017001998A2 (enExample) |
| CA (1) | CA2954218C (enExample) |
| EA (1) | EA031038B1 (enExample) |
| ES (1) | ES2702192T3 (enExample) |
| JO (1) | JO3601B1 (enExample) |
| MX (1) | MX2017001453A (enExample) |
| TW (1) | TWI696625B (enExample) |
| WO (1) | WO2016016381A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20150177B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
| JOP20150179B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
| RU2711382C2 (ru) * | 2014-12-03 | 2020-01-16 | Янссен Фармацевтика Нв | 6,7-ДИГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИН-4(5H)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ MGLUR2 |
| EP3226915B1 (en) | 2014-12-03 | 2019-02-20 | Janssen Pharmaceutica NV | Radiolabelled mglur2 pet ligands |
| JP6929285B2 (ja) | 2015-12-18 | 2021-09-01 | ヤンセン ファーマシューティカ エヌ．ベー． | 放射性標識ｍＧｌｕＲ２／３ＰＥＴリガンド |
| RS60981B1 (sr) | 2015-12-18 | 2020-11-30 | Janssen Pharmaceutica Nv | Radiooznačeni mglur2/3 pet ligandi |
| WO2019103070A1 (ja) | 2017-11-24 | 2019-05-31 | 大日本住友製薬株式会社 | ６，７－ジヒドロピラゾロ［１，５－ａ］ピラジノン誘導体及びその医薬用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004054665A1 (de) * | 2004-11-12 | 2006-05-18 | Bayer Cropscience Gmbh | Substituierte bi- und tricyclische Pyrazol-Derivate Verfahren zur Herstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| WO2006099972A1 (en) * | 2005-03-23 | 2006-09-28 | F. Hoffmann-La Roche Ag | Acetylenyl-pyrazolo-pvrimidine derivatives as mglur2 antagonists |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
| JP2013545822A (ja) * | 2010-12-17 | 2013-12-26 | ヴァンダービルト ユニバーシティー | ｍＧｌｕＲ５受容体のアロステリック調節剤としての、二環式トリアゾールラクタムおよびピラゾールラクタム |
| WO2012172093A1 (en) * | 2011-06-17 | 2012-12-20 | Merz Pharma Gmbh & Co. Kgaa | Dihydroindolizine derivate as metabotropic glutamate receptor modulators |
| IN2014CN03234A (enExample) | 2011-11-03 | 2015-07-03 | Merck Sharp & Dohme | |
| EP2666775A1 (en) | 2012-05-21 | 2013-11-27 | Domain Therapeutics | Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors |
| US20130345205A1 (en) * | 2012-06-20 | 2013-12-26 | Vanderbilt University | Substituted bicyclic aralkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors |
| US20130345204A1 (en) * | 2012-06-20 | 2013-12-26 | Vanderbilt University | Substituted bicyclic cycloalkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors |
| WO2013192343A1 (en) * | 2012-06-20 | 2013-12-27 | Vanderbilt University | Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mglur5 receptors |
| CN104736140A (zh) | 2012-10-23 | 2015-06-24 | 霍夫曼-拉罗奇有限公司 | 用于治疗自闭症的mGlu2/3拮抗剂 |
| CA2954091C (en) * | 2014-08-01 | 2022-08-02 | Janssen Pharmaceutica Nv | 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors |
-
2015
- 2015-07-27 JO JOP/2015/0178A patent/JO3601B1/ar active
- 2015-07-30 AU AU2015295299A patent/AU2015295299B2/en not_active Ceased
- 2015-07-30 JP JP2017505456A patent/JP6615864B2/ja not_active Expired - Fee Related
- 2015-07-30 MX MX2017001453A patent/MX2017001453A/es active IP Right Grant
- 2015-07-30 CA CA2954218A patent/CA2954218C/en active Active
- 2015-07-30 BR BR112017001998A patent/BR112017001998A2/pt not_active Application Discontinuation
- 2015-07-30 US US15/500,553 patent/US10112949B2/en active Active
- 2015-07-30 EP EP15742317.9A patent/EP3174880B1/en active Active
- 2015-07-30 EA EA201692496A patent/EA031038B1/ru not_active IP Right Cessation
- 2015-07-30 WO PCT/EP2015/067533 patent/WO2016016381A1/en not_active Ceased
- 2015-07-30 TW TW104124697A patent/TWI696625B/zh not_active IP Right Cessation
- 2015-07-30 CN CN201580041306.4A patent/CN106573935B/zh not_active Expired - Fee Related
- 2015-07-30 KR KR1020177005638A patent/KR102531693B1/ko active Active
- 2015-07-30 ES ES15742317T patent/ES2702192T3/es active Active
- 2015-07-31 AR ARP150102462A patent/AR101393A1/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017523201A5 (enExample) | ||
| JP2017522340A5 (enExample) | ||
| JP2017523202A5 (enExample) | ||
| JP2017526659A5 (enExample) | ||
| JP2017528515A5 (enExample) | ||
| CN107438593B (zh) | 治疗化合物及其用途 | |
| CY1125460T1 (el) | Ενωσεις ιμιδαζο [4,5-d]πυρρολο [2,3-β]πυριδινης ως αναστολεις κινασων janus | |
| CN112409363B (zh) | 用于治疗认知损害的苯并二氮杂䓬衍生物、组合物和方法 | |
| AU2014272695B2 (en) | Pyrazolo-pyrrolidin-4-one derivatives as BET inhibitors and their use in the treatment of disease | |
| PH12019501355A1 (en) | Small molecule inhibitors of the jak family of kinases | |
| JP6268183B2 (ja) | Ｐｉ３キナーゼモジュレータとしてのヘテロ芳香族化合物、及びその使用方法 | |
| RU2017106489A (ru) | 6,7-дигидропиразоло[1,5-а]пиразин-4(5h)-оновые соединения и их применение в качестве отрицательных аллостерических модуляторов рецепторов mglur2 | |
| AR087336A1 (es) | Compuestos de 2-(2,4,5-anilino sustituido)pirimidina | |
| JP2018510851A (ja) | 治療用ピリダジン化合物およびその使用 | |
| WO2013155506A1 (en) | Novel compositions and methods | |
| RU2017106100A (ru) | 6,7-ДИГИДРОПИРАЗОЛО[1,5-α]ПИРАЗИН-4(5Н)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ MGLUR2 | |
| CA2898294C (en) | Heteroaromatic compounds as pi3 kinase modulators | |
| JP6814730B2 (ja) | 治療用化合物およびその使用 | |
| JP2021528427A (ja) | 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法 | |
| EP3189049A1 (en) | Phthalazine derivatives of formula (i) as pcaf and gcn5 inhibitors for use in the treatment of cancer | |
| WO2018130869A1 (en) | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment | |
| RU2017123038A (ru) | 6,7-ДИГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИН-4(5H)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ MGLUR2 | |
| JP2017536399A5 (enExample) | ||
| JP2018507191A (ja) | 治療用化合物およびその使用 | |
| JP2018534314A5 (enExample) |