JP2017523169A5 - - Google Patents
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- JP2017523169A5 JP2017523169A5 JP2017502192A JP2017502192A JP2017523169A5 JP 2017523169 A5 JP2017523169 A5 JP 2017523169A5 JP 2017502192 A JP2017502192 A JP 2017502192A JP 2017502192 A JP2017502192 A JP 2017502192A JP 2017523169 A5 JP2017523169 A5 JP 2017523169A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- group
- acceptable salt
- alkyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000003839 salts Chemical class 0.000 claims description 55
- 150000001875 compounds Chemical class 0.000 claims description 40
- 229910052757 nitrogen Inorganic materials 0.000 claims description 31
- 125000000217 alkyl group Chemical group 0.000 claims description 29
- 229910052801 chlorine Inorganic materials 0.000 claims description 24
- 229910052731 fluorine Inorganic materials 0.000 claims description 24
- 229910052799 carbon Inorganic materials 0.000 claims description 16
- 229910052760 oxygen Inorganic materials 0.000 claims description 14
- 229910052717 sulfur Inorganic materials 0.000 claims description 14
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 12
- 125000000623 heterocyclic group Chemical group 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 12
- 241000711904 Pneumoviridae Species 0.000 claims description 10
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 claims description 10
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 10
- 229920002554 vinyl polymer Polymers 0.000 claims description 10
- 230000009385 viral infection Effects 0.000 claims description 10
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims description 9
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims description 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
- 150000001721 carbon Chemical group 0.000 claims description 8
- 208000030925 respiratory syncytial virus infectious disease Diseases 0.000 claims description 8
- 241000282412 Homo Species 0.000 claims description 7
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 6
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 6
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 150000002367 halogens Chemical class 0.000 claims description 6
- 125000001072 heteroaryl group Chemical group 0.000 claims description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000006413 ring segment Chemical group 0.000 claims description 6
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims description 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 4
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 4
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 4
- 125000003107 substituted aryl group Chemical group 0.000 claims description 4
- 125000001188 haloalkyl group Chemical group 0.000 claims description 3
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims description 2
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims description 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 2
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims description 2
- 229910019946 S-S Inorganic materials 0.000 claims description 2
- 229910019939 S—S Inorganic materials 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- 125000002837 carbocyclic group Chemical group 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000002541 furyl group Chemical group 0.000 claims description 2
- 125000001475 halogen functional group Chemical group 0.000 claims description 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 2
- 229910052740 iodine Inorganic materials 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 125000001624 naphthyl group Chemical group 0.000 claims description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 125000005017 substituted alkenyl group Chemical group 0.000 claims description 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 2
- 125000004426 substituted alkynyl group Chemical group 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims 1
- 0 *C1(*)[C@](C2=C*c3c(N)nc(*)nc23)O[C@](*)(CO)[C@@]1O* Chemical compound *C1(*)[C@](C2=C*c3c(N)nc(*)nc23)O[C@](*)(CO)[C@@]1O* 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 241000711920 Human orthopneumovirus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- AWJUIBRHMBBTKR-UHFFFAOYSA-N c1ccc(cncc2)c2c1 Chemical compound c1ccc(cncc2)c2c1 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 description 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-N c1ccc2ncccc2c1 Chemical compound c1ccc2ncccc2c1 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 1
- 125000004965 chloroalkyl group Chemical group 0.000 description 1
- 125000003709 fluoroalkyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462029896P | 2014-07-28 | 2014-07-28 | |
| US62/029,896 | 2014-07-28 | ||
| PCT/US2015/041574 WO2016018697A1 (en) | 2014-07-28 | 2015-07-22 | Thieno [3,2-d] pyrimidine, furo [3,2,d] pyrimidine, and pyrrolo [3,2-d] pyrimidines useful for treating respiratory syncitial virus infections |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019212344A Division JP6991188B2 (ja) | 2014-07-28 | 2019-11-25 | 呼吸器合胞体ウイルス感染の処置のために有用な、チエノ［３，２－ｄ］ピリミジン、フロ［３，２－ｄ］ピリミジン、およびピロロ［３，２－ｄ］ピリミジン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017523169A JP2017523169A (ja) | 2017-08-17 |
| JP2017523169A5 true JP2017523169A5 (cg-RX-API-DMAC7.html) | 2018-08-30 |
Family
ID=53765598
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017502192A Withdrawn JP2017523169A (ja) | 2014-07-28 | 2015-07-22 | 呼吸器合胞体ウイルス感染の処置のために有用な、チエノ［３，２−ｄ］ピリミジン、フロ［３，２−ｄ］ピリミジン、およびピロロ［３，２−ｄ］ピリミジン |
| JP2019212344A Active JP6991188B2 (ja) | 2014-07-28 | 2019-11-25 | 呼吸器合胞体ウイルス感染の処置のために有用な、チエノ［３，２－ｄ］ピリミジン、フロ［３，２－ｄ］ピリミジン、およびピロロ［３，２－ｄ］ピリミジン |
| JP2021181870A Pending JP2022010149A (ja) | 2014-07-28 | 2021-11-08 | 呼吸器合胞体ウイルス感染の処置のために有用な、チエノ［３，２－ｄ］ピリミジン、フロ［３，２－ｄ］ピリミジン、およびピロロ［３，２－ｄ］ピリミジン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019212344A Active JP6991188B2 (ja) | 2014-07-28 | 2019-11-25 | 呼吸器合胞体ウイルス感染の処置のために有用な、チエノ［３，２－ｄ］ピリミジン、フロ［３，２－ｄ］ピリミジン、およびピロロ［３，２－ｄ］ピリミジン |
| JP2021181870A Pending JP2022010149A (ja) | 2014-07-28 | 2021-11-08 | 呼吸器合胞体ウイルス感染の処置のために有用な、チエノ［３，２－ｄ］ピリミジン、フロ［３，２－ｄ］ピリミジン、およびピロロ［３，２－ｄ］ピリミジン |
Country Status (20)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI678369B (zh) * | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類 |
| CN107427529A (zh) | 2014-12-26 | 2017-12-01 | 埃莫里大学 | N4‑羟基胞苷和衍生物及与其相关的抗病毒用途 |
| MX381798B (es) | 2015-07-22 | 2025-03-13 | Enanta Pharm Inc | Derivados de benzodiazepina como inhibidores de rsv |
| WO2017075590A2 (en) * | 2015-10-30 | 2017-05-04 | Cocrystal Pharma, Inc. | Processes for preparing 2-dihalo ribolactones |
| JP7078960B2 (ja) | 2017-01-26 | 2022-06-01 | エス． トサントリゾス，ヨウラ | 置換二環式ピリミジン系化合物および組成物ならびにその使用 |
| US10881666B2 (en) | 2017-09-29 | 2021-01-05 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as RSV inhibitors |
| ES2995458T3 (en) | 2017-12-07 | 2025-02-10 | Univ Emory | N4-hydroxycytidine derivative and anti-viral uses related thereto |
| BR112021018335A2 (pt) | 2019-03-18 | 2021-11-23 | Enanta Pharm Inc | Derivados de benzodiazepina como inibidores de rsv |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| TWI874791B (zh) | 2020-02-18 | 2025-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| EP4644394A2 (en) | 2020-02-18 | 2025-11-05 | Gilead Sciences, Inc. | Antiviral compounds |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| CN111548384B (zh) * | 2020-03-29 | 2021-04-27 | 常州安蒂卫生物科技有限公司 | 用于抗病毒治疗的被取代的n4-羟基胞苷衍生物及其前药 |
| WO2022086840A1 (en) | 2020-10-19 | 2022-04-28 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| KR20230170745A (ko) | 2021-04-16 | 2023-12-19 | 길리애드 사이언시즈, 인코포레이티드 | 아미드를 사용한 카르바뉴클레오시드를 제조하는 방법 |
| WO2023023527A1 (en) | 2021-08-18 | 2023-02-23 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| TW202525810A (zh) | 2022-03-02 | 2025-07-01 | 美商基利科學股份有限公司 | 用於治療病毒感染的化合物及方法 |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| WO2023211997A1 (en) | 2022-04-27 | 2023-11-02 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
| WO2025072641A1 (en) * | 2023-09-28 | 2025-04-03 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
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2015
- 2015-07-08 TW TW104122181A patent/TWI678369B/zh active
- 2015-07-22 PT PT157450834T patent/PT3174870T/pt unknown
- 2015-07-22 CA CA2956571A patent/CA2956571C/en active Active
- 2015-07-22 PL PL20166438T patent/PL3693367T3/pl unknown
- 2015-07-22 ES ES15745083T patent/ES2802175T3/es active Active
- 2015-07-22 KR KR1020177005142A patent/KR102460181B1/ko active Active
- 2015-07-22 JP JP2017502192A patent/JP2017523169A/ja not_active Withdrawn
- 2015-07-22 AR ARP150102330A patent/AR101280A1/es unknown
- 2015-07-22 EP EP15745083.4A patent/EP3174870B1/en active Active
- 2015-07-22 NZ NZ727996A patent/NZ727996A/en unknown
- 2015-07-22 PT PT201664380T patent/PT3693367T/pt unknown
- 2015-07-22 PL PL15745083T patent/PL3174870T3/pl unknown
- 2015-07-22 BR BR112017001565A patent/BR112017001565A2/pt not_active IP Right Cessation
- 2015-07-22 SI SI201531250T patent/SI3174870T1/sl unknown
- 2015-07-22 ES ES20166438T patent/ES2910382T3/es active Active
- 2015-07-22 EP EP22154464.6A patent/EP4023650A1/en active Pending
- 2015-07-22 AU AU2015298207A patent/AU2015298207C1/en active Active
- 2015-07-22 US US14/806,227 patent/US9828388B2/en active Active
- 2015-07-22 WO PCT/US2015/041574 patent/WO2016018697A1/en not_active Ceased
- 2015-07-22 EA EA201790146A patent/EA032490B1/ru not_active IP Right Cessation
- 2015-07-22 SG SG11201700213SA patent/SG11201700213SA/en unknown
- 2015-07-22 CN CN201580041342.0A patent/CN106573939B/zh active Active
- 2015-07-22 MX MX2017001284A patent/MX2017001284A/es unknown
- 2015-07-22 EP EP20166438.0A patent/EP3693367B1/en active Active
- 2015-07-22 SI SI201531826T patent/SI3693367T1/sl unknown
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2016
- 2016-12-21 IL IL249706A patent/IL249706A0/en unknown
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2017
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2018
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2019
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2021
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2024
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- 2024-10-16 US US18/917,217 patent/US20250270229A1/en active Pending