SI3693367T1 - Tieno(3,2-D)pirimidini, uporabni za zdravljenje okužb z respiratornim sincicijskim virusom - Google Patents
Tieno(3,2-D)pirimidini, uporabni za zdravljenje okužb z respiratornim sincicijskim virusomInfo
- Publication number
- SI3693367T1 SI3693367T1 SI201531826T SI201531826T SI3693367T1 SI 3693367 T1 SI3693367 T1 SI 3693367T1 SI 201531826 T SI201531826 T SI 201531826T SI 201531826 T SI201531826 T SI 201531826T SI 3693367 T1 SI3693367 T1 SI 3693367T1
- Authority
- SI
- Slovenia
- Prior art keywords
- thieno
- virus infections
- treating respiratory
- respiratory syncitial
- syncitial virus
- Prior art date
Links
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 230000009385 viral infection Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462029896P | 2014-07-28 | 2014-07-28 | |
| EP20166438.0A EP3693367B1 (en) | 2014-07-28 | 2015-07-22 | Thieno [3,2-d]pyrimidines useful for treating respiratory syncitial virus infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3693367T1 true SI3693367T1 (sl) | 2022-05-31 |
Family
ID=53765598
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201531250T SI3174870T1 (sl) | 2014-07-28 | 2015-07-22 | Tieno (3,2-D)pirimidini, furo (3,2,d)pirimidini in pirolo (3,2-d)pirimidini uporabni za zdravljenje okužb z respiratornim sincicijskim virusom |
| SI201531826T SI3693367T1 (sl) | 2014-07-28 | 2015-07-22 | Tieno(3,2-D)pirimidini, uporabni za zdravljenje okužb z respiratornim sincicijskim virusom |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201531250T SI3174870T1 (sl) | 2014-07-28 | 2015-07-22 | Tieno (3,2-D)pirimidini, furo (3,2,d)pirimidini in pirolo (3,2-d)pirimidini uporabni za zdravljenje okužb z respiratornim sincicijskim virusom |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9828388B2 (sl) |
| EP (3) | EP4023650A1 (sl) |
| JP (3) | JP2017523169A (sl) |
| KR (1) | KR102460181B1 (sl) |
| CN (1) | CN106573939B (sl) |
| AR (1) | AR101280A1 (sl) |
| AU (1) | AU2015298207C1 (sl) |
| BR (1) | BR112017001565A2 (sl) |
| CA (1) | CA2956571C (sl) |
| EA (1) | EA032490B1 (sl) |
| ES (2) | ES2910382T3 (sl) |
| IL (1) | IL249706A0 (sl) |
| MX (1) | MX2017001284A (sl) |
| NZ (1) | NZ727996A (sl) |
| PL (2) | PL3693367T3 (sl) |
| PT (2) | PT3174870T (sl) |
| SG (1) | SG11201700213SA (sl) |
| SI (2) | SI3174870T1 (sl) |
| TW (1) | TWI678369B (sl) |
| WO (1) | WO2016018697A1 (sl) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI678369B (zh) * | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類 |
| BR112017013858A2 (pt) | 2014-12-26 | 2018-02-27 | Univ Emory | n4-hidroxicitidina e derivados e usos antivirais relacionados aos mesmos |
| RS63653B1 (sr) | 2015-07-22 | 2022-11-30 | Enanta Pharm Inc | Benzodiazepinski derivati kao inhibitori rsv |
| WO2017075590A2 (en) * | 2015-10-30 | 2017-05-04 | Cocrystal Pharma, Inc. | Processes for preparing 2-dihalo ribolactones |
| EP3573992B1 (en) | 2017-01-26 | 2022-04-13 | Youla S. Tsantrizos | Substituted bicyclic pyrimidine-based compounds and compositions and uses thereof |
| EP3687543B1 (en) * | 2017-09-29 | 2024-03-20 | Enanta Pharmaceuticals, Inc. | Combinations of pharmaceutical agents as rsv inhibitors |
| KR102626210B1 (ko) | 2017-12-07 | 2024-01-18 | 에모리 유니버시티 | N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도 |
| CA3133300A1 (en) | 2019-03-18 | 2020-09-24 | Enanta Pharmaceuticals, Inc. | Benzodiazepine derivatives as rsv inhibitors |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| CN111548384B (zh) * | 2020-03-29 | 2021-04-27 | 常州安蒂卫生物科技有限公司 | 用于抗病毒治疗的被取代的n4-羟基胞苷衍生物及其前药 |
| WO2022086840A1 (en) | 2020-10-19 | 2022-04-28 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| US11697666B2 (en) | 2021-04-16 | 2023-07-11 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
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| US135A (en) | 1837-03-03 | Jesse j | ||
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| FR2224175B1 (sl) | 1973-04-04 | 1978-04-14 | Isf Spa | |
| US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
| IT1017153B (it) | 1974-07-15 | 1977-07-20 | Isf Spa | Apparecchio per inalazioni |
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| US4805811A (en) | 1985-03-29 | 1989-02-21 | Aktiebolaget Draco | Dosage device |
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| TW201305185A (zh) | 2010-09-13 | 2013-02-01 | Gilead Sciences Inc | 用於抗病毒治療之２’－氟取代之碳－核苷類似物 |
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| AP2014007796A0 (en) * | 2011-12-22 | 2014-07-31 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| JP6242378B2 (ja) | 2012-03-13 | 2017-12-06 | ギリアード サイエンシーズ， インコーポレイテッド | 抗ウイルス処置のための２’−置換カルバヌクレオシド類似体 |
| ES2710506T3 (es) * | 2012-03-21 | 2019-04-25 | Alios Biopharma Inc | Nucleósidos sustituidos, nucleótidos y sus análogos |
| UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| TWI678369B (zh) * | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類 |
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2015
- 2015-07-08 TW TW104122181A patent/TWI678369B/zh active
- 2015-07-22 JP JP2017502192A patent/JP2017523169A/ja not_active Withdrawn
- 2015-07-22 PT PT157450834T patent/PT3174870T/pt unknown
- 2015-07-22 PT PT201664380T patent/PT3693367T/pt unknown
- 2015-07-22 AU AU2015298207A patent/AU2015298207C1/en active Active
- 2015-07-22 SG SG11201700213SA patent/SG11201700213SA/en unknown
- 2015-07-22 PL PL20166438T patent/PL3693367T3/pl unknown
- 2015-07-22 PL PL15745083T patent/PL3174870T3/pl unknown
- 2015-07-22 SI SI201531250T patent/SI3174870T1/sl unknown
- 2015-07-22 AR ARP150102330A patent/AR101280A1/es unknown
- 2015-07-22 EP EP22154464.6A patent/EP4023650A1/en active Pending
- 2015-07-22 EP EP20166438.0A patent/EP3693367B1/en active Active
- 2015-07-22 BR BR112017001565A patent/BR112017001565A2/pt not_active IP Right Cessation
- 2015-07-22 ES ES20166438T patent/ES2910382T3/es active Active
- 2015-07-22 US US14/806,227 patent/US9828388B2/en active Active
- 2015-07-22 CN CN201580041342.0A patent/CN106573939B/zh active Active
- 2015-07-22 EP EP15745083.4A patent/EP3174870B1/en active Active
- 2015-07-22 SI SI201531826T patent/SI3693367T1/sl unknown
- 2015-07-22 EA EA201790146A patent/EA032490B1/ru not_active IP Right Cessation
- 2015-07-22 WO PCT/US2015/041574 patent/WO2016018697A1/en active Application Filing
- 2015-07-22 MX MX2017001284A patent/MX2017001284A/es unknown
- 2015-07-22 KR KR1020177005142A patent/KR102460181B1/ko active IP Right Grant
- 2015-07-22 CA CA2956571A patent/CA2956571C/en active Active
- 2015-07-22 ES ES15745083T patent/ES2802175T3/es active Active
- 2015-07-22 NZ NZ727996A patent/NZ727996A/en unknown
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2016
- 2016-12-21 IL IL249706A patent/IL249706A0/en unknown
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2017
- 2017-09-27 US US15/717,493 patent/US10179794B2/en active Active
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2018
- 2018-11-28 US US16/203,112 patent/US10501476B2/en active Active
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2019
- 2019-11-25 JP JP2019212344A patent/JP6991188B2/ja active Active
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2021
- 2021-11-08 JP JP2021181870A patent/JP2022010149A/ja active Pending
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