JP2017522861A5 - - Google Patents

Info

Publication number

JP2017522861A5

JP2017522861A5 JP2016568961A JP2016568961A JP2017522861A5 JP 2017522861 A5 JP2017522861 A5 JP 2017522861A5 JP 2016568961 A JP2016568961 A JP 2016568961A JP 2016568961 A JP2016568961 A JP 2016568961A JP 2017522861 A5 JP2017522861 A5 JP 2017522861A5

Authority

JP

Japan

Prior art keywords

antibody

gpc3

immunoconjugate

seq

amino acid

Prior art date

2015-05-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 102000004965 antibodies Human genes 0.000 claims description 52
• 108090001123 antibodies Proteins 0.000 claims description 52
• 101710037116 GAPC3 Proteins 0.000 claims description 26
• 102100007996 GPC3 Human genes 0.000 claims description 26
• 101700044749 GPC3 Proteins 0.000 claims description 26
• 150000001413 amino acids Chemical class 0.000 claims description 12
• 210000004900 C-terminal fragment Anatomy 0.000 claims description 3
• 210000004898 N-terminal fragment Anatomy 0.000 claims description 3
• 102000018748 Immunoconjugates Human genes 0.000 claims 18
• 108010027440 Immunoconjugates Proteins 0.000 claims 18
• 125000003275 alpha amino acid group Chemical group 0.000 claims 12
• 210000004027 cells Anatomy 0.000 claims 10
• 201000011510 cancer Diseases 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 6
• 239000012472 biological sample Substances 0.000 claims 5
• 125000005843 halogen group Chemical group 0.000 claims 4
• 125000005647 linker group Chemical group 0.000 claims 4
• 239000002254 cytotoxic agent Substances 0.000 claims 3
• 231100000599 cytotoxic agent Toxicity 0.000 claims 3
• 201000007270 liver cancer Diseases 0.000 claims 3
• 239000000825 pharmaceutical preparation Substances 0.000 claims 3
• 230000001629 suppression Effects 0.000 claims 3
• 125000003118 aryl group Chemical group 0.000 claims 2
• 238000001514 detection method Methods 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• CTMCWCONSULRHO-UHQPFXKFSA-N nemorubicin Chemical class C1CO[C@H](OC)CN1[C@@H]1[C@H](O)[C@H](C)O[C@@H](O[C@@H]2C3=C(O)C=4C(=O)C5=C(OC)C=CC=C5C(=O)C=4C(O)=C3C[C@](O)(C2)C(=O)CO)C1 CTMCWCONSULRHO-UHQPFXKFSA-N 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical compound C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 2
• GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 1
• 125000001963 4 membered heterocyclic group Chemical group 0.000 claims 1
• 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
• 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
• 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
• 102100000129 CHURC1 Human genes 0.000 claims 1
• 101710014631 CHURC1 Proteins 0.000 claims 1
• HXCHCVDVKSCDHU-LULTVBGHSA-N Calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 1
• 102000033147 ERVK-25 Human genes 0.000 claims 1
• 108091005771 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 125000002947 alkylene group Chemical group 0.000 claims 1
• 150000001768 cations Chemical class 0.000 claims 1
• 108091006028 chimera Proteins 0.000 claims 1
• 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
• 125000005842 heteroatoms Chemical group 0.000 claims 1
• 125000000623 heterocyclic group Chemical group 0.000 claims 1
• 150000007857 hydrazones Chemical class 0.000 claims 1
• 239000002184 metal Substances 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 102000005614 monoclonal antibodies Human genes 0.000 claims 1
• 108010045030 monoclonal antibodies Proteins 0.000 claims 1
• 125000004433 nitrogen atoms Chemical group N* 0.000 claims 1
• 230000035755 proliferation Effects 0.000 claims 1
• 239000000523 sample Substances 0.000 claims 1
• 108090001126 FURIN Proteins 0.000 description 2
• 102000004961 Furin Human genes 0.000 description 2
• 238000003776 cleavage reaction Methods 0.000 description 2