|
US4708871A
(en)
|
1983-03-08 |
1987-11-24 |
Commonwealth Serum Laboratories Commission |
Antigenically active amino acid sequences
|
|
NZ207394A
(en)
|
1983-03-08 |
1987-03-06 |
Commw Serum Lab Commission |
Detecting or determining sequence of amino acids
|
|
WO1984003506A1
(en)
|
1983-03-08 |
1984-09-13 |
Commw Serum Lab Commission |
Antigenically active amino acid sequences
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
NZ215865A
(en)
|
1985-04-22 |
1988-10-28 |
Commw Serum Lab Commission |
Method of determining the active site of a receptor-binding analogue
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
US5571689A
(en)
|
1988-06-16 |
1996-11-05 |
Washington University |
Method of N-acylating peptide and proteins with diheteroatom substituted analogs of myristic acid
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5663143A
(en)
|
1988-09-02 |
1997-09-02 |
Dyax Corp. |
Engineered human-derived kunitz domains that inhibit human neutrophil elastase
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
ES2087997T3
(es)
|
1990-01-12 |
1996-08-01 |
Cell Genesys Inc |
Generacion de anticuerpos xenogenicos.
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
CA2084987C
(en)
|
1990-06-11 |
2007-02-13 |
Gilead Sciences, Inc. |
Nucleic acid ligands
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
ES2108048T3
(es)
|
1990-08-29 |
1997-12-16 |
Genpharm Int |
Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
JP3523252B2
(ja)
|
1990-11-21 |
2004-04-26 |
ホウテン ファーマシューティカルズ インコーポレイテッド |
等モル多種オリゴマー混合物、特にオリゴペプチド混合物の合成
|
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
JPH07501451A
(ja)
|
1991-11-25 |
1995-02-16 |
エンゾン・インコーポレイテッド |
多価抗原結合タンパク質
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
EP0822830B1
(en)
|
1995-04-27 |
2008-04-02 |
Amgen Fremont Inc. |
Human anti-IL-8 antibodies, derived from immunized xenomice
|
|
CA2219486A1
(en)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
EP2305027B1
(en)
|
1996-12-03 |
2014-07-02 |
Amgen Fremont Inc. |
Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
|
|
AU760562B2
(en)
|
1997-12-05 |
2003-05-15 |
Scripps Research Institute, The |
Humanization of murine antibody
|
|
CA2419567A1
(en)
|
2000-09-01 |
2002-03-07 |
George Vande Woude |
Inhibition of mitogen-activated protein kinase (mapk) pathway: a selective therapeutic strategy against melanoma
|
|
IL149462A0
(en)
|
2001-05-09 |
2002-11-10 |
Warner Lambert Co |
Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
|
|
DE60330227D1
(de)
|
2002-03-13 |
2010-01-07 |
Array Biopharma Inc |
N3-alkylierte benzimidazol-derivate als mek-hemmer
|
|
US20040209930A1
(en)
|
2002-10-02 |
2004-10-21 |
Carboni Joan M. |
Synergistic methods and compositions for treating cancer
|
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
EP1556684A4
(en)
|
2002-11-01 |
2008-01-23 |
Univ Colorado Regents |
QUANTITATIVE ANALYSIS OF PROTEIN ISOFORMS USING FLIGHT TIME MASS SPECTROMETRY BY MATRIX ASSISTED LASER DESORPTION / IONIZATION
|
|
AU2003274576A1
(en)
|
2002-11-15 |
2004-06-15 |
Warner-Lambert Company Llc |
Combination chemotherapy comprising a mek inhibitor and capecitabine for treating cancer
|
|
JP4163738B2
(ja)
|
2004-06-11 |
2008-10-08 |
日本たばこ産業株式会社 |
癌の治療用の５−アミノ−２，４，７−トリオキソ−３，４，７，８−テトラヒドロ−２Ｈ−ピリド’２，３−ｄ！ピリミジン誘導体及び関連化合物
|
|
TW200639163A
(en)
|
2005-02-04 |
2006-11-16 |
Genentech Inc |
RAF inhibitor compounds and methods
|
|
ES2720160T3
(es)
|
2005-05-09 |
2019-07-18 |
Ono Pharmaceutical Co |
Anticuerpos monoclonales humanos contra muerte programada 1(PD-1) y métodos para tratar el cáncer usando anticuerpos dirigidos contra PD-1 solos o junto con otras sustancias inmunoterapéuticas
|
|
PL2395004T3
(pl)
|
2005-06-22 |
2016-08-31 |
Plexxikon Inc |
Pochodne pirolo[2,3-b]pirydyny jako inhibitory kinazy białkowej
|
|
EA019344B1
(ru)
|
2005-07-01 |
2014-03-31 |
МЕДАРЕКС, Эл.Эл.Си. |
Человеческие моноклональные антитела против лиганда-1 запрограммированной гибели клеток (pd-l1) и их применения
|
|
DE602006021205D1
(de)
|
2005-10-07 |
2011-05-19 |
Exelixis Inc |
Azetidine als mek-inhibitoren bei der behandlung proliferativer erkrankungen
|
|
US7612212B2
(en)
|
2006-02-22 |
2009-11-03 |
Hoffmann-La Roche Inc. |
Substituted hydantoins
|
|
EP2069354B1
(en)
|
2006-08-21 |
2011-11-02 |
Genentech, Inc. |
Aza-benzofuranyl compounds and methods of use
|
|
WO2008101840A1
(en)
|
2007-02-23 |
2008-08-28 |
F. Hoffmann-La Roche Ag |
Combination of erlotinib and mek-inhibitors for inhibiting proliferation of tumor cells
|
|
US7557221B2
(en)
|
2007-08-16 |
2009-07-07 |
Hoffman-La Roche Inc. |
Substituted hydantoins
|
|
CA2705452C
(en)
|
2007-11-12 |
2016-05-31 |
Takeda Pharmaceutical Company Limited |
Mapk/erk kinase inhibitors
|
|
TW200938224A
(en)
|
2007-11-30 |
2009-09-16 |
Medarex Inc |
Anti-B7H4 monoclonal antibody-drug conjugate and methods of use
|
|
EP2690101B1
(en)
|
2007-12-19 |
2015-06-24 |
Genentech, Inc. |
5-Anilinoimidazopyridines and Methods of Use
|
|
EP2242773B1
(en)
|
2008-02-11 |
2017-06-14 |
Cure Tech Ltd. |
Monoclonal antibodies for tumor treatment
|
|
CL2009000448A1
(es)
|
2008-02-29 |
2009-11-27 |
Genentech Inc |
Compuestos derivados de 3-sulfonilamino-n-(1h-pirazolo-[3,4-b]piridin-5il)benzamida; procesos de preparacion; compuestos intermediarios; composicion farmaceutica; y uso para el tratamiento del cancer, tal como sarcoma, carcinoma, adenoma, entre otros.
|
|
US20110003859A1
(en)
|
2008-02-29 |
2011-01-06 |
Array Biopharma Inc. |
N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer
|
|
JP2011513329A
(ja)
|
2008-02-29 |
2011-04-28 |
アレイ バイオファーマ、インコーポレイテッド |
ＲＡＦ阻害化合物として使用されるイミダゾ［４，５−ｂ］ピリジン誘導体
|
|
MX2010009410A
(es)
|
2008-02-29 |
2010-11-30 |
Array Biopharma Inc |
Compuestos del inhibidor de raf y métodos de uso de los mismos.
|
|
EP2262837A4
(en)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
|
RU2508110C2
(ru)
|
2008-07-11 |
2014-02-27 |
Новартис Аг |
КОМБИНАЦИЯ (А) ИНГИБИТОРА ФОСФОИНОЗИТ-3-КИНАЗЫ И (Б) МОДУЛЯТОРА ПУТИ Ras/Raf/Mek
|
|
EP2328920A2
(en)
|
2008-08-25 |
2011-06-08 |
Amplimmune, Inc. |
Targeted costimulatory polypeptides and methods of use to treat cancer
|
|
RS54233B1
(sr)
|
2008-08-25 |
2015-12-31 |
Amplimmune Inc. |
Kompozicije pd-1 antagonista i postupci za njihovu primenu
|
|
WO2010056735A1
(en)
|
2008-11-11 |
2010-05-20 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for inhibiting an oncogenic protein to enhance immunogenicity
|
|
HUE065752T2
(hu)
|
2008-12-09 |
2024-06-28 |
Hoffmann La Roche |
Anti-PD-L1 antitestek és felhasználásuk T-sejt funkció elõsegítésére
|
|
US20110086837A1
(en)
|
2009-10-12 |
2011-04-14 |
Genentech, Inc. |
Combinations of a pi3k inhibitor and a mek inhibitor
|
|
MX2012005163A
(es)
|
2009-11-06 |
2012-11-22 |
Infinity Pharmaceuticals Inc |
Formulaciones orales de un inhibidor de la ruta de hedgehog.
|
|
WO2011060328A1
(en)
|
2009-11-13 |
2011-05-19 |
Infinity Pharmaceuticals, Inc. |
Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer
|
|
EP2504028A4
(en)
|
2009-11-24 |
2014-04-09 |
Amplimmune Inc |
SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
|
|
PT2504364T
(pt)
|
2009-11-24 |
2017-11-14 |
Medimmune Ltd |
Agentes de ligação direcionados contra b7-h1
|
|
DK2542256T3
(da)
|
2010-03-04 |
2019-08-26 |
Macrogenics Inc |
Antistoffer reagerende med b7-h3, immunologisk aktive fragmenter deraf og anvendelser deraf
|
|
EA026924B1
(ru)
*
|
2011-08-01 |
2017-05-31 |
Дженентек, Инк. |
Способы лечения рака с использованием антагонистов, связывающихся с осью pd-1, и ингибиторов mek
|
|
CA2850034A1
(en)
|
2011-10-28 |
2013-05-02 |
Genentech, Inc. |
Therapeutic combinations and methods of treating melanoma
|
|
EA201591750A1
(ru)
|
2013-03-14 |
2016-05-31 |
Дженентек, Инк. |
Антитела против b7-h4 и иммуноконъюгаты
|
|
US9308236B2
(en)
|
2013-03-15 |
2016-04-12 |
Bristol-Myers Squibb Company |
Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
|
|
HK1216231A1
(zh)
|
2013-06-03 |
2016-10-28 |
Novartis Ag |
Anti-pd-l1抗体及mek抑制剂及/或braf抑制剂的混合物
|
|
EP3563870A1
(en)
|
2014-07-15 |
2019-11-06 |
F. Hoffmann-La Roche AG |
Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors
|