JP2017522046A - 生物可逆的および生物不可逆的基を有するポリヌクレオチド構築物 - Google Patents
生物可逆的および生物不可逆的基を有するポリヌクレオチド構築物 Download PDFInfo
- Publication number
- JP2017522046A JP2017522046A JP2017516650A JP2017516650A JP2017522046A JP 2017522046 A JP2017522046 A JP 2017522046A JP 2017516650 A JP2017516650 A JP 2017516650A JP 2017516650 A JP2017516650 A JP 2017516650A JP 2017522046 A JP2017522046 A JP 2017522046A
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- optionally substituted
- aryl
- polynucleotide construct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCc([o]1)c(C)c(*)c1Br Chemical compound CCc([o]1)c(C)c(*)c1Br 0.000 description 14
- BVZFVTJMCZLZTR-UHFFFAOYSA-N CC(C)SSc1c(CCO)cccc1 Chemical compound CC(C)SSc1c(CCO)cccc1 BVZFVTJMCZLZTR-UHFFFAOYSA-N 0.000 description 1
- RWGFKTVRMDUZSP-UHFFFAOYSA-N CC(C)c1ccccc1 Chemical compound CC(C)c1ccccc1 RWGFKTVRMDUZSP-UHFFFAOYSA-N 0.000 description 1
- FLAHSSHSYCYJKU-UHFFFAOYSA-N CC(CCC(NCc1ccccc1)=O)SSCCCCO Chemical compound CC(CCC(NCc1ccccc1)=O)SSCCCCO FLAHSSHSYCYJKU-UHFFFAOYSA-N 0.000 description 1
- LFINOVGTZAMNRH-UHFFFAOYSA-N CC(c1ccccc1)SSCCCCO Chemical compound CC(c1ccccc1)SSCCCCO LFINOVGTZAMNRH-UHFFFAOYSA-N 0.000 description 1
- ALVSEZZLFXRSRZ-UHFFFAOYSA-N CCC1(CC)COC(c(cc2)ccc2C(O)=O)OC1 Chemical compound CCC1(CC)COC(c(cc2)ccc2C(O)=O)OC1 ALVSEZZLFXRSRZ-UHFFFAOYSA-N 0.000 description 1
- MFRQAHHMZZKCLP-UHFFFAOYSA-N Cc1c(CCO)c(S)ccc1 Chemical compound Cc1c(CCO)c(S)ccc1 MFRQAHHMZZKCLP-UHFFFAOYSA-N 0.000 description 1
- VSNHUQURADARHR-UHFFFAOYSA-N Cc1cc(OC(C2)=O)c2cc1 Chemical compound Cc1cc(OC(C2)=O)c2cc1 VSNHUQURADARHR-UHFFFAOYSA-N 0.000 description 1
- YABOHRWGTPOWPS-UHFFFAOYSA-N Cc1cccc(SSc2ncccc2)c1CCO Chemical compound Cc1cccc(SSc2ncccc2)c1CCO YABOHRWGTPOWPS-UHFFFAOYSA-N 0.000 description 1
- WGQKYBSKWIADBV-UHFFFAOYSA-N NCc1ccccc1 Chemical compound NCc1ccccc1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 1
- GOUHYARYYWKXHS-UHFFFAOYSA-N OC(c1ccc(C=O)cc1)=O Chemical compound OC(c1ccc(C=O)cc1)=O GOUHYARYYWKXHS-UHFFFAOYSA-N 0.000 description 1
- HAXFWIACAGNFHA-UHFFFAOYSA-N c1cc(SSc2ccccn2)ncc1 Chemical compound c1cc(SSc2ccccn2)ncc1 HAXFWIACAGNFHA-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3513—Protein; Peptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009123P | 2014-06-06 | 2014-06-06 | |
| US62/009,123 | 2014-06-06 | ||
| PCT/US2015/034749 WO2015188197A2 (en) | 2014-06-06 | 2015-06-08 | Polynucleotide constructs having bioreversible and non-bioreversible groups |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017522046A true JP2017522046A (ja) | 2017-08-10 |
| JP2017522046A5 JP2017522046A5 (cg-RX-API-DMAC7.html) | 2018-07-19 |
Family
ID=54767614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516650A Pending JP2017522046A (ja) | 2014-06-06 | 2015-06-08 | 生物可逆的および生物不可逆的基を有するポリヌクレオチド構築物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20170114341A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3152308A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2017522046A (cg-RX-API-DMAC7.html) |
| CN (1) | CN107109405A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015269053A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2950960A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015188197A2 (cg-RX-API-DMAC7.html) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2019039403A1 (ja) * | 2017-08-22 | 2020-11-26 | 国立大学法人東海国立大学機構 | 修飾ポリヌクレオチド |
| JP2021509402A (ja) * | 2017-12-29 | 2021-03-25 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッドSuzhou Ribo Life Science Co., Ltd. | 複合体及びその調製方法と使用 |
| JP2022515503A (ja) * | 2018-12-28 | 2022-02-18 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| JP2022546055A (ja) * | 2019-08-29 | 2022-11-02 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 化合物、薬物複合体及びその調製方法と使用 |
| WO2023113038A1 (ja) * | 2021-12-17 | 2023-06-22 | リードファーマ株式会社 | オリゴヌクレオチドの製造方法 |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201620526A (zh) | 2014-06-17 | 2016-06-16 | 愛羅海德研究公司 | 用於抑制α-1抗胰蛋白酶基因表現之組合物及方法 |
| WO2016146143A1 (en) | 2015-03-16 | 2016-09-22 | Amal Therapeutics Sa | Cell penetrating peptides and complexes comprising the same |
| EP3314245A4 (en) | 2015-06-25 | 2019-02-27 | Roswell Biotechnologies, Inc | BIOMOLECULAR SENSORS AND METHOD |
| WO2017100461A1 (en) * | 2015-12-08 | 2017-06-15 | Solstice Biologics, Ltd. | Polynucleotide constructs having an auxiliary moiety non-bioreversibly linked to an internucleoside phosphate or phosphorothioate |
| EP3408220A4 (en) | 2016-01-28 | 2019-09-04 | Roswell Biotechnologies, Inc | METHOD AND DEVICE FOR MEASURING ANALYTES USING LARGE CALCULAR MOLECULAR ELECTRONIC SENSOR ARRAYS |
| KR102763291B1 (ko) | 2016-01-28 | 2025-02-04 | 로스웰 엠이 아이엔씨. | 대량 병렬 dna 시퀀싱 장치 |
| JP6854532B2 (ja) | 2016-02-09 | 2021-04-07 | ロズウェル バイオテクノロジーズ,インコーポレイテッド | 電子的、標識フリーのdnaおよびゲノムシークエンシング |
| US10597767B2 (en) | 2016-02-22 | 2020-03-24 | Roswell Biotechnologies, Inc. | Nanoparticle fabrication |
| HUE066998T2 (hu) | 2016-03-16 | 2024-09-28 | Amal Therapeutics Sa | Egy immunellenõrzõpont-modulátor és egy sejtpenetráló peptidet, kargót és TLR peptidagonistát tartalmazó komplex kombinációja gyógyászatban történõ alkalmazásra |
| US9829456B1 (en) | 2016-07-26 | 2017-11-28 | Roswell Biotechnologies, Inc. | Method of making a multi-electrode structure usable in molecular sensing devices |
| WO2018026855A1 (en) * | 2016-08-01 | 2018-02-08 | Roswell Biotechnologies, Inc. | Modified nucleotide triphosphates for molecular electronic sensors |
| CA3033867A1 (en) | 2016-08-17 | 2018-02-22 | Solstice Biologics, Ltd. | Polynucleotide constructs |
| CA3032165C (en) * | 2016-08-23 | 2023-05-16 | Dicerna Pharmaceuticals, Inc. | Compositions comprising reversibly modified oligonucleotides and uses thereof |
| WO2018055060A1 (en) | 2016-09-21 | 2018-03-29 | Amal Therapeutics Sa | Fusion comprising a cell penetrating peptide, a multi epitope and a tlr peptide agonist for treatment of cancer |
| TWI826365B (zh) * | 2017-01-10 | 2023-12-21 | 美商愛羅海德製藥公司 | α-1抗胰蛋白酶 (AAT) RNAi 藥劑、包含AAT RNAi 藥劑之組合物及使用方法 |
| EP3568407A4 (en) | 2017-01-10 | 2020-12-23 | Roswell Biotechnologies, Inc | DNA DATA STORAGE METHODS AND SYSTEMS |
| US11656197B2 (en) | 2017-01-19 | 2023-05-23 | Roswell ME Inc. | Solid state sequencing devices comprising two dimensional layer materials |
| WO2018189382A1 (en) * | 2017-04-14 | 2018-10-18 | Solstice Biologics, Ltd. | Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use |
| KR102879682B1 (ko) | 2017-04-25 | 2025-10-30 | 로스웰 엠이 아이엔씨. | 분자 센서들을 위한 효소 회로들 |
| US10508296B2 (en) | 2017-04-25 | 2019-12-17 | Roswell Biotechnologies, Inc. | Enzymatic circuits for molecular sensors |
| EP4023764A3 (en) | 2017-05-09 | 2022-09-21 | Roswell Biotechnologies, Inc. | Binding probe circuits for molecular sensors |
| US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
| US11371955B2 (en) | 2017-08-30 | 2022-06-28 | Roswell Biotechnologies, Inc. | Processive enzyme molecular electronic sensors for DNA data storage |
| KR102717872B1 (ko) | 2017-10-10 | 2024-10-14 | 로스웰 엠이 아이엔씨. | 무증폭 dna 데이터 저장을 위한 방법, 장치 및 시스템 |
| PT3684377T (pt) | 2017-10-20 | 2023-01-31 | Dicerna Pharmaceuticals Inc | Métodos de tratamento de infeção de hepatite b |
| EP3718572B1 (en) | 2017-12-01 | 2024-07-31 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method and use |
| EP4455285A3 (en) | 2017-12-01 | 2025-02-26 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| AU2018374219C1 (en) | 2017-12-01 | 2023-05-11 | Suzhou Ribo Life Science Co., Ltd. | Double-stranded oligonucleotide, composition and conjugate comprising double-stranded oligonucleotide, preparation method therefor and use thereof |
| CN118291457A (zh) | 2017-12-01 | 2024-07-05 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| CN110997917B (zh) | 2017-12-01 | 2024-04-09 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| WO2019143621A1 (en) | 2018-01-16 | 2019-07-25 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting aldh2 expression |
| WO2019161105A1 (en) | 2018-02-14 | 2019-08-22 | Deep Genomics Incorporated | Oligonucleotide therapy for wilson disease |
| AU2019266207B2 (en) | 2018-05-07 | 2025-04-24 | Alnylam Pharmaceuticals, Inc. | Extrahepatic delivery |
| JP7616987B2 (ja) | 2018-07-13 | 2025-01-17 | エフ. ホフマン-ラ ロシュ アーゲー | Rtel1発現の調節用のオリゴヌクレオチド |
| WO2020038377A1 (zh) | 2018-08-21 | 2020-02-27 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的药物组合物和缀合物及其用途 |
| CN111655297A (zh) | 2018-09-30 | 2020-09-11 | 苏州瑞博生物技术有限公司 | 一种siRNA缀合物及其制备方法和用途 |
| US20220096649A1 (en) * | 2018-10-17 | 2022-03-31 | Tallac Therapeutics, Inc. | Immunomodulating polynucleotide conjugates and methods of use |
| US11249941B2 (en) * | 2018-12-21 | 2022-02-15 | Palo Alto Research Center Incorporated | Exabyte-scale data storage using sequence-controlled polymers |
| WO2020135581A1 (zh) * | 2018-12-28 | 2020-07-02 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| JP2022520653A (ja) | 2019-02-12 | 2022-03-31 | ディセルナ ファーマシューティカルズ インコーポレイテッド | Cyp27a1の発現を阻害するための方法及び組成物 |
| WO2020206350A1 (en) | 2019-04-04 | 2020-10-08 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting gene expression in the central nervous system |
| CN113227376B (zh) | 2019-05-22 | 2024-04-09 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| US20220186221A1 (en) * | 2019-05-24 | 2022-06-16 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition and conjugate, preparation method and use |
| CN112390835A (zh) * | 2019-08-14 | 2021-02-23 | 苏州瑞博生物技术股份有限公司 | 肝靶向化合物及缀合物 |
| US20220389430A1 (en) | 2019-10-02 | 2022-12-08 | Dicema Pharmaceuticals, Inc. | Chemical modifications of small interfering rna with minimal fluorine content |
| CN119607006A (zh) | 2019-12-09 | 2025-03-14 | 艾姆皮瑞克公司 | 用于治疗血管生成素样4(angptl4)相关疾病的寡核苷酸 |
| CA3163646A1 (en) | 2019-12-24 | 2021-07-01 | F. Hoffman-La Roche Ag | Pharmaceutical combination of antiviral agents targeting hbv and/or an immune modulator for treatment of hbv |
| JP2023509870A (ja) | 2019-12-24 | 2023-03-10 | エフ. ホフマン-ラ ロシュ アーゲー | Hbvの処置のためのhbvを標的とする治療用オリゴヌクレオチドとtlr7アゴニストとの医薬組合せ |
| EP4110830A4 (en) | 2020-02-28 | 2024-09-11 | Tallac Therapeutics, Inc. | TRANSGLUTAMINASE-MEDIATED CONJUGATION |
| CA3172117A1 (en) | 2020-03-18 | 2021-09-23 | Bob D. Brown | Compositions and methods for inhibiting angptl3 expression |
| EP4192505A1 (en) | 2020-08-04 | 2023-06-14 | Dicerna Pharmaceuticals, Inc. | Systemic delivery of oligonucleotides |
| TW202221120A (zh) | 2020-08-04 | 2022-06-01 | 美商黛瑟納製藥公司 | 用於治療代謝症候群之組成物及方法 |
| CN116194120A (zh) | 2020-08-05 | 2023-05-30 | 豪夫迈·罗氏有限公司 | 乙型肝炎患者的寡核苷酸治疗 |
| IL300338A (en) | 2020-08-05 | 2023-04-01 | Dicerna Pharmaceuticals Inc | Compounds and methods for inhibiting the expression of LPA |
| JP2023548658A (ja) | 2020-10-08 | 2023-11-20 | ディセルナ ファーマシューティカルズ インコーポレイテッド | グリア細胞へのオリゴヌクレオチドの選択的送達 |
| US20230390403A1 (en) * | 2020-10-14 | 2023-12-07 | North Carolina State University | Compositions and methods for drug delivery |
| WO2022161452A1 (zh) * | 2021-01-28 | 2022-08-04 | 南京桦冠生物技术有限公司 | 缀合物及其用途 |
| MX2023012216A (es) | 2021-04-14 | 2023-10-26 | Dicerna Pharmaceuticals Inc | Composiciones y metodos para modular la expresion de pnpla3. |
| CN118284695A (zh) | 2021-11-11 | 2024-07-02 | 豪夫迈·罗氏有限公司 | 用于治疗hbv的药物组合 |
| IL313220A (en) | 2021-12-01 | 2024-07-01 | Dicerna Pharmaceuticals Inc | Compounds and methods for modulating APOC3 expressionCompounds and methods for modulating APOC3 expression |
| CN119213005A (zh) | 2022-03-16 | 2024-12-27 | 艾姆皮瑞克公司 | 用于提高siRNA生物利用度的GALNAC组合物 |
| AU2023254798A1 (en) | 2022-04-15 | 2024-09-19 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for modulating scap activity |
| CN120112641A (zh) * | 2022-10-31 | 2025-06-06 | 大睿生物医药科技(上海)有限公司 | 向细胞内递送siRNA的前药 |
| CN115925586A (zh) * | 2022-11-01 | 2023-04-07 | 青岛蓝谷多肽生物医药科技有限公司 | 一种靶向psma的母体及其衍生物的制备方法 |
| WO2024097310A2 (en) * | 2022-11-01 | 2024-05-10 | Impilo Therapeutics, Inc. | Targeted non-charged-nucleic acid (ncna) delivery and related tumor penetrating nanocomplexes |
| TW202430637A (zh) | 2022-11-16 | 2024-08-01 | 美商戴瑟納製藥股份有限公司 | Stat3靶向性寡核苷酸及其用途 |
| CN118852442A (zh) | 2023-04-26 | 2024-10-29 | 上海麦科思生物医药有限公司 | 抗ptk7抗体及其用途 |
| CN116925160B (zh) * | 2023-09-15 | 2023-12-08 | 天津全和诚科技有限责任公司 | 一种GalNAc含糖环中间体及其制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120040459A1 (en) * | 2008-09-22 | 2012-02-16 | Rxi Pharmaceuticals Corporation | Reduced size self-delivering rnai compounds |
| US20120142763A1 (en) * | 2009-06-01 | 2012-06-07 | The Regents Of The University Of California | Nucleic acid delivery compositions and methods of use thereof |
| WO2014031575A1 (en) * | 2012-08-20 | 2014-02-27 | The Regents Of The University Of California | Polynucleotides having bioreversible groups |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5441688B2 (ja) * | 2006-05-11 | 2014-03-12 | アイシス ファーマシューティカルズ, インコーポレーテッド | 5’修飾二環式核酸類似体 |
| CA2929651A1 (en) * | 2013-11-06 | 2015-05-14 | Solstice Biologics, Ltd. | Polynucleotide constructs having disulfide groups |
-
2015
- 2015-06-08 JP JP2017516650A patent/JP2017522046A/ja active Pending
- 2015-06-08 AU AU2015269053A patent/AU2015269053A1/en not_active Abandoned
- 2015-06-08 CN CN201580041889.0A patent/CN107109405A/zh active Pending
- 2015-06-08 EP EP15803887.7A patent/EP3152308A4/en not_active Withdrawn
- 2015-06-08 US US15/315,608 patent/US20170114341A1/en not_active Abandoned
- 2015-06-08 WO PCT/US2015/034749 patent/WO2015188197A2/en not_active Ceased
- 2015-06-08 CA CA2950960A patent/CA2950960A1/en not_active Abandoned
-
2020
- 2020-02-03 US US16/780,204 patent/US20200392498A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120040459A1 (en) * | 2008-09-22 | 2012-02-16 | Rxi Pharmaceuticals Corporation | Reduced size self-delivering rnai compounds |
| US20120142763A1 (en) * | 2009-06-01 | 2012-06-07 | The Regents Of The University Of California | Nucleic acid delivery compositions and methods of use thereof |
| WO2014031575A1 (en) * | 2012-08-20 | 2014-02-27 | The Regents Of The University Of California | Polynucleotides having bioreversible groups |
Non-Patent Citations (1)
| Title |
|---|
| CURR. PROTOC. NUCLEIC ACID CHEM., 2008, VOL.35, 4.33.1-4.33.21, JPN6019028553, ISSN: 0004082367 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2019039403A1 (ja) * | 2017-08-22 | 2020-11-26 | 国立大学法人東海国立大学機構 | 修飾ポリヌクレオチド |
| JP7282379B2 (ja) | 2017-08-22 | 2023-05-29 | 国立大学法人東海国立大学機構 | 修飾ポリヌクレオチド |
| JP2021509402A (ja) * | 2017-12-29 | 2021-03-25 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッドSuzhou Ribo Life Science Co., Ltd. | 複合体及びその調製方法と使用 |
| JP7436030B2 (ja) | 2017-12-29 | 2024-02-21 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 複合体及びその調製方法と使用 |
| JP2022515503A (ja) * | 2018-12-28 | 2022-02-18 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| JP7507495B2 (ja) | 2018-12-28 | 2024-06-28 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| JP2022546055A (ja) * | 2019-08-29 | 2022-11-02 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 化合物、薬物複合体及びその調製方法と使用 |
| WO2023113038A1 (ja) * | 2021-12-17 | 2023-06-22 | リードファーマ株式会社 | オリゴヌクレオチドの製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2950960A1 (en) | 2015-12-10 |
| CN107109405A (zh) | 2017-08-29 |
| EP3152308A2 (en) | 2017-04-12 |
| AU2015269053A1 (en) | 2016-12-22 |
| US20170114341A1 (en) | 2017-04-27 |
| EP3152308A4 (en) | 2017-12-27 |
| US20200392498A1 (en) | 2020-12-17 |
| WO2015188197A3 (en) | 2016-02-25 |
| WO2015188197A2 (en) | 2015-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20200392498A1 (en) | Polynucleotide constructs having bioreversible and non-bioreversible groups | |
| US20160257961A1 (en) | Polynucleotide constructs having disulfide groups | |
| AU2013306006B2 (en) | Polynucleotides having bioreversible groups | |
| US20240247025A1 (en) | Polynucleotide constructs | |
| US20240175019A1 (en) | Skeletal Muscle Delivery Platforms and Methods of Use | |
| JP5939685B2 (ja) | 修飾1本鎖ポリヌクレオチド | |
| US20190194655A1 (en) | Polynucleotide constructs having an auxiliary moiety non-bioreversibly linked to an internucleoside phosphate or phosphorothioate | |
| CN101506368A (zh) | 通过可逆的磷酸三酯电荷中和保护基转导运输核酸 | |
| AU2022349576A1 (en) | Multivalent ligand clusters with diamine scaffold for targeted delivery of therapeutic agents |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD01 | Notification of change of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7426 Effective date: 20170511 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20170511 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180608 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180608 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190730 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20191011 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20200331 |