JP2017522025A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017522025A5 JP2017522025A5 JP2017502212A JP2017502212A JP2017522025A5 JP 2017522025 A5 JP2017522025 A5 JP 2017522025A5 JP 2017502212 A JP2017502212 A JP 2017502212A JP 2017502212 A JP2017502212 A JP 2017502212A JP 2017522025 A5 JP2017522025 A5 JP 2017522025A5
- Authority
- JP
- Japan
- Prior art keywords
- oncolytic virus
- virus
- activity
- group
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 244000309459 oncolytic virus Species 0.000 claims 27
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 230000000694 effects Effects 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims 8
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims 8
- 102000006601 Thymidine Kinase Human genes 0.000 claims 5
- 108020004440 Thymidine kinase Proteins 0.000 claims 5
- 241000700618 Vaccinia virus Species 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 102000000311 Cytosine Deaminase Human genes 0.000 claims 3
- 108010080611 Cytosine Deaminase Proteins 0.000 claims 3
- 102000000505 Ribonucleotide Reductases Human genes 0.000 claims 3
- 108010041388 Ribonucleotide Reductases Proteins 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 108091000036 uracil phosphoribosyltransferase Proteins 0.000 claims 3
- 241000711404 Avian avulavirus 1 Species 0.000 claims 2
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 2
- 101000807008 Homo sapiens Uracil phosphoribosyltransferase homolog Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 2
- 101100502554 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) FCY1 gene Proteins 0.000 claims 2
- 241000837158 Senecavirus A Species 0.000 claims 2
- 241000700584 Simplexvirus Species 0.000 claims 2
- 102100037717 Uracil phosphoribosyltransferase homolog Human genes 0.000 claims 2
- 241000711975 Vesicular stomatitis virus Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 230000002950 deficient Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 230000003308 immunostimulating effect Effects 0.000 claims 2
- 230000000415 inactivating effect Effects 0.000 claims 2
- 230000002601 intratumoral effect Effects 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 1
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 101100043727 Caenorhabditis elegans syx-2 gene Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- 101100535673 Drosophila melanogaster Syn gene Proteins 0.000 claims 1
- 101150067602 F4L gene Proteins 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 101150046249 Havcr2 gene Proteins 0.000 claims 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims 1
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 1
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 1
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 1
- 101150060895 I4L gene Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 1
- 101710101148 Probable 6-oxopurine nucleoside phosphorylase Proteins 0.000 claims 1
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102000030764 Purine-nucleoside phosphorylase Human genes 0.000 claims 1
- 108091030071 RNAI Proteins 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 241000702263 Reovirus sp. Species 0.000 claims 1
- 102100037357 Thymidylate kinase Human genes 0.000 claims 1
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
- 108700005077 Viral Genes Proteins 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 238000011319 anticancer therapy Methods 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 108010000742 dTMP kinase Proteins 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 102000048776 human CD274 Human genes 0.000 claims 1
- 102000046157 human CSF2 Human genes 0.000 claims 1
- 102000043321 human CTLA4 Human genes 0.000 claims 1
- 102000048362 human PDCD1 Human genes 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229950010773 pidilizumab Drugs 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229950007217 tremelimumab Drugs 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
- 208000007089 vaccinia Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14306153 | 2014-07-16 | ||
| EP14306153.9 | 2014-07-16 | ||
| PCT/EP2015/066263 WO2016008976A1 (en) | 2014-07-16 | 2015-07-16 | Oncolytic virus for expression of immune checkpoint modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020163305A Division JP7077377B2 (ja) | 2014-07-16 | 2020-09-29 | 免疫チェックポイントモジュレーターの発現用腫瘍溶解性ウイルス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017522025A JP2017522025A (ja) | 2017-08-10 |
| JP2017522025A5 true JP2017522025A5 (OSRAM) | 2018-08-16 |
| JP6895374B2 JP6895374B2 (ja) | 2021-06-30 |
Family
ID=51220528
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017502212A Active JP6895374B2 (ja) | 2014-07-16 | 2015-07-16 | 免疫チェックポイントモジュレーターの発現用腫瘍溶解性ウイルス |
| JP2020163305A Active JP7077377B2 (ja) | 2014-07-16 | 2020-09-29 | 免疫チェックポイントモジュレーターの発現用腫瘍溶解性ウイルス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020163305A Active JP7077377B2 (ja) | 2014-07-16 | 2020-09-29 | 免疫チェックポイントモジュレーターの発現用腫瘍溶解性ウイルス |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10555981B2 (OSRAM) |
| EP (2) | EP3552615B8 (OSRAM) |
| JP (2) | JP6895374B2 (OSRAM) |
| CN (2) | CN120555373A (OSRAM) |
| AU (2) | AU2015289125B2 (OSRAM) |
| CA (2) | CA2954841A1 (OSRAM) |
| DK (2) | DK3169341T3 (OSRAM) |
| ES (2) | ES2909957T3 (OSRAM) |
| HU (1) | HUE045108T2 (OSRAM) |
| IL (1) | IL250058A0 (OSRAM) |
| PL (1) | PL3169341T3 (OSRAM) |
| PT (1) | PT3169341T (OSRAM) |
| RU (1) | RU2696312C2 (OSRAM) |
| WO (1) | WO2016008976A1 (OSRAM) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210008155A (ko) * | 2012-08-30 | 2021-01-20 | 암젠 인크 | 단순 헤르페스 바이러스 및 면역 체크포인트 억제제를 사용한 흑색종의 치료방법 |
| SG11201604738TA (en) | 2013-12-12 | 2016-07-28 | Shanghai Hengrui Pharm Co Ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| AU2015289081B2 (en) * | 2014-07-16 | 2020-02-06 | Transgene Sa | Combination of oncolytic virus with immune checkpoint modulators |
| CN120555373A (zh) * | 2014-07-16 | 2025-08-29 | 特兰斯吉恩股份有限公司 | 用于表达免疫检查点调节因子的溶瘤病毒 |
| ES2841075T3 (es) | 2014-10-24 | 2021-07-07 | Calidi Biotherapeutics Inc | Enfoque de inmunoterapia de combinación para el tratamiento del cáncer |
| EP3261669B1 (en) | 2015-02-25 | 2022-08-03 | Memorial Sloan Kettering Cancer Center | Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors |
| US10548930B2 (en) | 2015-04-17 | 2020-02-04 | Memorial Sloan Kettering Cancer Center | Use of MVA or MVAΔE3L as immunotherapeutic agents against solid tumors |
| EP3875477A1 (en) | 2015-04-17 | 2021-09-08 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins with tunable affinities |
| HUE050750T2 (hu) | 2015-05-29 | 2021-01-28 | Agenus Inc | CTLA-4 elleni antitestek és eljárások alkalmazásukra |
| EP3313993A4 (en) | 2015-06-29 | 2019-06-19 | Regents of the University of Minnesota | ANTI-APOBEC3 ANTIBODIES AND METHOD OF PREPARATION AND USE |
| US20200046671A1 (en) * | 2015-06-29 | 2020-02-13 | Regents Of The University Of Minnesota | Apobec3b mutagenesis and immunotherapy |
| JP7014706B2 (ja) | 2015-07-13 | 2022-02-01 | サイトメックス セラピューティクス インコーポレイテッド | 抗ｐｄ－１抗体、活性化可能抗ｐｄ－１抗体、およびその使用方法 |
| JP6788663B2 (ja) | 2015-08-11 | 2020-11-25 | カリディ・バイオセラピューティクス・インコーポレイテッドＣａｌｉｄｉ Ｂｉｏｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 癌処置のための天然痘ワクチン |
| CN109069486A (zh) | 2015-12-14 | 2018-12-21 | X4 制药有限公司 | 治疗癌症的方法 |
| JP6864296B2 (ja) | 2015-12-14 | 2021-04-28 | エックス４ ファーマシューティカルズ， インコーポレイテッド | がんを処置する方法 |
| WO2017112894A1 (en) | 2015-12-22 | 2017-06-29 | X4 Pharmaceuticals, Inc. | Methods for treating immunodeficiency disease |
| CN109312309B (zh) | 2016-01-08 | 2024-04-02 | 雷普利穆内有限公司 | 工程化的病毒 |
| EP3405203A4 (en) * | 2016-01-22 | 2019-07-24 | X4 Pharmaceuticals, Inc. | METHOD FOR THE TREATMENT OF CANCER |
| SG11201806134SA (en) | 2016-01-27 | 2018-08-30 | Oncorus Inc | Oncolytic viral vectors and uses thereof |
| IL261321B2 (en) | 2016-02-25 | 2023-12-01 | Memorial Sloan Kettering Cancer Center | Recombinant MVA or MVADELE3L expressing human FLT3L and their use as immunotherapeutic agents against solid tumors |
| WO2017147553A2 (en) | 2016-02-25 | 2017-08-31 | Memorial Sloan-Kettering Cancer Center | Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy |
| EP3440112A4 (en) | 2016-04-08 | 2019-10-09 | X4 Pharmaceuticals, Inc. | METHOD FOR THE TREATMENT OF CANCER |
| CA3019199A1 (en) | 2016-04-15 | 2017-10-19 | Alpine Immune Sciences, Inc. | Icos ligand variant immunomodulatory proteins and uses thereof |
| US11414491B2 (en) | 2016-05-18 | 2022-08-16 | Mayo Foundation For Medical Education And Research | Targeting PD-L1 on tumor cells |
| CN109640988A (zh) | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
| JP7054529B2 (ja) | 2016-06-21 | 2022-04-14 | エックス４ ファーマシューティカルズ， インコーポレイテッド | Ｃｘｃｒ４阻害剤およびその使用 |
| WO2017223243A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| CA3029426A1 (en) | 2016-06-30 | 2018-01-04 | Oncorus, Inc. | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
| EP3486322B1 (en) * | 2016-07-13 | 2021-09-29 | National University Corporation Tottori University | Method for producing vaccinia virus expressing foreign gene |
| EP3494219A1 (en) * | 2016-08-03 | 2019-06-12 | Aalborg Universitet | ANTISENSE OLIGONUCLEOTIDES (ASOs) DESIGNED TO INHIBIT IMMUNE CHECKPOINT PROTEINS |
| TW201825674A (zh) * | 2016-09-09 | 2018-07-16 | 美商艾斯合顧問有限公司 | 表現雙特異性接合分子的溶瘤病毒 |
| EP3534923A4 (en) * | 2016-11-01 | 2020-05-27 | DNAtrix, Inc. | COMBINATION THERAPY FOR THE TREATMENT OF BRAIN CARCINOMAS |
| EA201991383A1 (ru) | 2016-12-07 | 2019-12-30 | Эйдженус Инк. | Антитела против ctla-4 и способы их применения |
| KR20190112263A (ko) * | 2016-12-12 | 2019-10-04 | 멀티비르 인코포레이티드 | 암 및 감염성 질환의 치료 및 예방을 위한 바이러스 유전자 치료요법 및 면역 체크포인트 억제제를 포함하는 방법 및 조성물 |
| US11298420B2 (en) * | 2016-12-21 | 2022-04-12 | Memgen, Llc | Armed oncolytic viruses |
| CN108261426B (zh) * | 2017-01-04 | 2019-04-05 | 杭州康万达医药科技有限公司 | 药物组合物及其在治疗肿瘤和/或癌症的药物中的应用 |
| GB201700350D0 (en) * | 2017-01-09 | 2017-02-22 | Replimune Ltd | Altered virus |
| CN110741081B (zh) * | 2017-01-30 | 2024-07-23 | 埃皮辛特瑞柯斯公司 | 肿瘤选择性tata盒和caat盒突变体 |
| WO2018159991A1 (ko) * | 2017-02-28 | 2018-09-07 | 한양대학교 산학협력단 | 종양 특이적 살상 아데노바이러스 및 면역 관문 억제제를 포함하는 항암용 조성물 |
| CN111107872A (zh) | 2017-05-12 | 2020-05-05 | 纪念斯隆-凯特林癌症中心 | 有用于癌症免疫疗法的牛痘病毒突变体 |
| WO2018218137A1 (en) | 2017-05-25 | 2018-11-29 | Leidos, Inc. | Pd-1 and ctla-4 dual inhibitor peptides |
| US11612625B2 (en) | 2017-07-26 | 2023-03-28 | Oncorus, Inc. | Oncolytic viral vectors and uses thereof |
| CN109576231B (zh) | 2017-09-28 | 2022-03-25 | 北京康万达医药科技有限公司 | 分离的重组溶瘤腺病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途 |
| KR102813968B1 (ko) | 2017-10-10 | 2025-05-29 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Ctla-4 변이체 면역조절 단백질 및 이의 용도 |
| TW202500579A (zh) | 2017-10-18 | 2025-01-01 | 美商艾爾潘免疫科學有限公司 | 變異型icos 配位體免疫調節蛋白及相關組合物及方法 |
| CA3075294A1 (en) * | 2017-10-27 | 2019-05-02 | Merck Sharp & Dohme Corp. | Compositions and methods for treating liver cancer |
| WO2019099947A1 (en) * | 2017-11-16 | 2019-05-23 | Virogin Biotech Canada Ltd | Targeting moiety-decorated oncolytic viruses |
| CN108165536A (zh) * | 2017-12-11 | 2018-06-15 | 浙江大学 | 一种重组溶瘤痘苗病毒及其制备方法与应用 |
| JP2021508477A (ja) | 2017-12-29 | 2021-03-11 | オンコラス， インコーポレイテッド | 治療用ポリペプチドの腫瘍溶解性ウイルス送達 |
| US12297253B2 (en) | 2018-01-03 | 2025-05-13 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
| SG11202006457YA (en) | 2018-01-05 | 2020-08-28 | Ottawa Hospital Res Inst | Modified orthopoxvirus vectors |
| US20220347244A1 (en) * | 2018-01-19 | 2022-11-03 | Kolon Life Science, Inc. | Recombinant vaccinia virus and pharmaceutical composition comprising same |
| AU2019212840B2 (en) * | 2018-01-26 | 2024-08-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Expression of metabolic modulators in tumor microenvironment to improve tumor therapy |
| WO2019151836A1 (en) * | 2018-02-05 | 2019-08-08 | Sillajen, Inc. | Oncolytic vaccinia virus expressing an immune checkpoint protein antagonist to treat cancer |
| ES2976989T3 (es) * | 2018-02-28 | 2024-08-14 | Bionoxx Inc | Composición farmacéutica para prevenir o tratar el cáncer que comprende virus antineoplásicos e hidroxicarbamida como componentes eficaces |
| CN108329378B (zh) * | 2018-03-12 | 2020-09-25 | 华中农业大学 | 塞内卡谷病毒vp1蛋白、编码基因、杂交瘤细胞株和单克隆抗体及其应用 |
| JP7438122B2 (ja) * | 2018-03-13 | 2024-02-26 | メモリアル スローン－ケタリング キャンサー センター | 免疫チェックポイント遮断を発現する癌免疫療法のための腫瘍溶解性ワクシニアウイルス |
| US12454561B2 (en) | 2018-03-19 | 2025-10-28 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and CD122/CD132 agonists for the treatment of cancer |
| US11505782B2 (en) | 2018-06-04 | 2022-11-22 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
| WO2019241758A1 (en) | 2018-06-15 | 2019-12-19 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
| AU2019321667A1 (en) * | 2018-08-16 | 2021-03-04 | Musc Foundation For Research Development | Recombinant myxoma viruses and uses thereof |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| EP3617230A1 (en) * | 2018-09-03 | 2020-03-04 | BioInvent International AB | Novel antibodies and nucleotide sequences, and uses thereof |
| JP2022502074A (ja) * | 2018-09-10 | 2022-01-11 | ジェネセイル バイオテック（シャンハイ）カンパニー リミテッド | 改変された腫瘍溶解性ウイルス、組成物、およびその使用 |
| AU2019339535B2 (en) | 2018-09-15 | 2025-11-20 | Memorial Sloan Kettering Cancer Center | Recombinant poxviruses for cancer immunotherapy |
| CN111100846A (zh) * | 2018-10-26 | 2020-05-05 | 上海元宋生物技术有限公司 | 表达pd-1结合蛋白的溶瘤病毒及其应用 |
| CA3116412A1 (en) * | 2018-10-31 | 2020-05-07 | Humanigen, Inc. | Materials and methods for treating cancer |
| CN118667024A (zh) * | 2018-11-01 | 2024-09-20 | 生物发明国际公司 | 新型拮抗性抗tnfr2抗体分子 |
| CA3116192C (en) * | 2018-11-06 | 2025-09-23 | Calidi Biotherapeutics (Nevada), Inc. | IMPROVED SYSTEMS FOR CELL-MEDIATED ONCOLYTIC VIRAL THERAPY |
| MX2021005980A (es) | 2018-11-21 | 2021-08-11 | Mayo Found Medical Education & Res | Adenovirus y metodos para usar adenovirus. |
| CN109627336A (zh) * | 2018-12-20 | 2019-04-16 | 南京昂科利医药科技创新研究院有限公司 | 一种表达pd-l1单链抗体的新城疫溶瘤病毒的制备方法及应用 |
| AU2019404639A1 (en) * | 2018-12-21 | 2021-08-12 | Ottawa Hospital Research Institute | Modified orthopoxvirus vectors |
| IL284421B2 (en) * | 2018-12-28 | 2025-05-01 | Transgene | M2-defective poxvirus |
| US20230193213A1 (en) * | 2019-01-29 | 2023-06-22 | Arno Thaller | Recombinant oncolytic newcastle disease viruses with increased activity |
| CN109913425B (zh) * | 2019-03-22 | 2021-05-11 | 中国人民解放军总医院第五医学中心 | 一种重组流感病毒拯救方法及其在肿瘤治疗中的应用 |
| CA3134140A1 (en) * | 2019-03-28 | 2020-10-01 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Oncolytic myxoma virus expressing fast p14 to treat hematological cancer |
| CN113710694A (zh) | 2019-04-29 | 2021-11-26 | 梅奥医学教育及研究基金会 | 用于治疗癌症的多价pd-l1结合化合物 |
| JP7606471B2 (ja) | 2019-05-22 | 2024-12-25 | レイドス， インコーポレイテッド | Ｌａｇ３結合ペプチド |
| BR112022000928A2 (pt) | 2019-07-19 | 2022-03-08 | Seneca Therapeutics Inc | Terapia oncolítica do vírus seneca valley de segunda geração: composições e métodos da mesma |
| CN114340649A (zh) * | 2019-08-26 | 2022-04-12 | 拜耳诺克斯有限公司 | 包含痘苗病毒和羟基脲作为活性成分的用于治疗癌症的药物组合物 |
| KR20220113467A (ko) * | 2019-12-12 | 2022-08-12 | 이그나이트 이뮤노테라피, 인크. | 변이체 종양용해성 백시니아 바이러스 및 그의 사용 방법 |
| CA3168771A1 (en) * | 2020-02-20 | 2021-08-26 | Eric Bartee | Recombinant myxoma viruses and uses thereof |
| CA3171250A1 (en) | 2020-03-10 | 2021-09-16 | E. Lynne KELLEY | Methods for treating neutropenia |
| EP4162951A4 (en) * | 2020-06-05 | 2024-07-10 | Shanghai Bao Pharmaceuticals Co., Ltd. | PHARMACEUTICAL COMPOSITION OF ENZYMES AND VIRUSES AND ASSOCIATED APPLICATION |
| US11578102B2 (en) | 2020-07-31 | 2023-02-14 | Leidos, Inc. | LAG3 binding peptides |
| US11987646B2 (en) | 2020-10-12 | 2024-05-21 | Leidos, Inc. | Immunomodulatory peptides |
| US20230381309A1 (en) * | 2020-10-13 | 2023-11-30 | Immunovaccine Technologies Inc. | Methods of treating diffuse large b-cell lymphoma |
| US20230355691A1 (en) * | 2020-11-17 | 2023-11-09 | National University Corporation Tottori University | Novel recombinant vaccinia virus and use thereof |
| CN112641798A (zh) * | 2020-12-29 | 2021-04-13 | 武汉博威德生物技术有限公司 | 一种提高重组柯萨奇病毒溶瘤作用的方法 |
| CN116782941A (zh) * | 2021-01-11 | 2023-09-19 | 塞内卡治疗公司 | 用于治疗检查点抑制剂难治性癌症的塞尼卡谷病毒组合治疗 |
| CA3207261A1 (en) * | 2021-01-19 | 2022-07-28 | Seneca Therapeutics, Inc. | Armed seneca valley virus oncolytic therapy compositions and methods thereof |
| KR20240001116A (ko) * | 2021-02-02 | 2024-01-03 | 지오박스, 인크. | 백신접종 동안 t-세포 프라이밍을 증진시키는 데 사용하기 위한 바이러스 구축물 |
| AU2022227480A1 (en) * | 2021-02-26 | 2023-09-14 | Sillajen, Inc. | Oncolytic virus and use thereof |
| CN114934065A (zh) * | 2021-11-25 | 2022-08-23 | 浙江理工大学绍兴生物医药研究院有限公司 | 携带免疫检查点分子tim-3抗体基因的溶瘤腺病毒构建方法和应用 |
| CN120648657A (zh) * | 2024-03-08 | 2025-09-16 | 上海锦斯生物技术有限公司 | 一种修饰的溶瘤病毒及其组合物 |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| FR2656800B1 (fr) | 1990-01-08 | 1992-05-15 | Roussy Inst Gustave | Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques. |
| US5457035A (en) | 1993-07-23 | 1995-10-10 | Immunex Corporation | Cytokine which is a ligand for OX40 |
| US5856153A (en) | 1994-11-17 | 1999-01-05 | Cayla | Suicide genes and new associations of pyrimidine nucleobase and nucleoside analogs with new suicide genes for gene therapy of acquired diseases |
| US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| FR2751343B1 (fr) | 1996-07-16 | 1998-12-18 | Transgene Sa | Procede de conservation de virus recombinants infectieux, suspension aqueuse virale et utilisation comme medicament |
| WO1998010088A1 (en) | 1996-09-06 | 1998-03-12 | Trustees Of The University Of Pennsylvania | An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase |
| WO1998056415A1 (en) | 1997-06-11 | 1998-12-17 | Aquila Biopharmaceuticals, Inc. | Purified saponins as oral adjuvants |
| FR2766091A1 (fr) | 1997-07-18 | 1999-01-22 | Transgene Sa | Composition antitumorale a base de polypeptide immunogene de localisation cellulaire modifiee |
| US6312700B1 (en) | 1998-02-24 | 2001-11-06 | Andrew D. Weinberg | Method for enhancing an antigen specific immune response with OX-40L |
| FR2777570A1 (fr) | 1998-04-17 | 1999-10-22 | Transgene Sa | Mutant ayant une activite phosphoribosyl transferase |
| US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
| US6322980B1 (en) | 1999-04-30 | 2001-11-27 | Aclara Biosciences, Inc. | Single nucleotide detection using degradation of a fluorescent sequence |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| WO2001014424A2 (en) | 1999-08-24 | 2001-03-01 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| CA2399321C (en) | 2000-03-07 | 2013-04-30 | Robert K. Evans | Adenovirus formulations |
| JP4249013B2 (ja) | 2001-07-31 | 2009-04-02 | 佑 本庶 | Ｐｄ−１に対し特異性を有する物質 |
| GB0128288D0 (en) | 2001-11-27 | 2002-01-16 | Siddall & Hilton Ltd | Spring location means |
| BR0214822A (pt) | 2001-12-10 | 2004-12-14 | Bavarian Nordic As | Formulações contendo poxvìrus e processo para preparar composições contendo poxvìrus estáveis |
| IL164376A0 (en) | 2002-04-03 | 2005-12-18 | Applied Research Systems | Ox4or binding agents, their preparation and pharmaceutical compositions containing them |
| US7550140B2 (en) | 2002-06-13 | 2009-06-23 | Crucell Holland B.V. | Antibody to the human OX40 receptor |
| US7595048B2 (en) | 2002-07-03 | 2009-09-29 | Ono Pharmaceutical Co., Ltd. | Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1 |
| US7291331B1 (en) | 2002-09-11 | 2007-11-06 | La Jolla Institute For Allergy And Immunology | Methods of treating OX40 medicated recall immune responses |
| WO2004056875A1 (en) | 2002-12-23 | 2004-07-08 | Wyeth | Antibodies against pd-1 and uses therefor |
| JP4672659B2 (ja) | 2003-07-21 | 2011-04-20 | トランジェーヌ、ソシエテ、アノニム | 改善されたシトシンデアミナーゼ活性を有するポリペプチド |
| EP1528101A1 (en) | 2003-11-03 | 2005-05-04 | ProBioGen AG | Immortalized avian cell lines for virus production |
| JP2008519590A (ja) * | 2004-11-12 | 2008-06-12 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 組換えニューカッスル病ウィルス |
| FR2884255B1 (fr) | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| DK2161336T4 (en) | 2005-05-09 | 2017-04-24 | Ono Pharmaceutical Co | Human monoclonal antibodies for programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapies |
| BRPI0611766A2 (pt) | 2005-06-08 | 2011-12-20 | Dana Farber Cancer Inst Inc | métodos e composições para o tratamento de infecções persistentes e cáncer por inibição da rota de morte celular programada |
| KR101357685B1 (ko) | 2005-11-21 | 2014-02-06 | 사노피 파스퇴르 리미티드 / 사노피 파스퇴르 리미떼 | 재조합 바이러스용 안정화 제형 |
| JP6092497B2 (ja) | 2006-03-30 | 2017-03-08 | ユニバーシティー オブ カリフォルニア | 抗ｃｔｌａ−４抗体の限局性分泌のための方法および組成物 |
| CA2656266C (en) | 2006-06-20 | 2012-07-31 | Transgene S.A. | Recombinant viral vaccine |
| EP2029756B1 (en) | 2006-06-20 | 2016-11-09 | Transgene S.A. | Process for producing poxviruses and poxvirus compositions |
| GB0705245D0 (en) | 2007-03-19 | 2007-04-25 | Stabilitech Ltd | Stable biological products |
| EP1985305A1 (en) | 2007-04-24 | 2008-10-29 | Vivalis | Duck embryonic derived stem cell lines for the production of viral vaccines |
| US8012738B2 (en) | 2007-05-14 | 2011-09-06 | Bavarian Nordic A/S | Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines |
| NZ582150A (en) | 2007-06-18 | 2012-08-31 | Msd Oss Bv | Antibodies to human programmed death receptor pd-1 |
| US8357531B2 (en) | 2007-07-03 | 2013-01-22 | Transgene S.A. | Immortalized avian cell lines |
| WO2009014708A2 (en) | 2007-07-23 | 2009-01-29 | Cell Genesys, Inc. | Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof |
| NZ584201A (en) | 2007-11-19 | 2012-06-29 | Transgene Sa | Poxviral oncolytic vectors comprising a defective f2l gene |
| US9687515B2 (en) * | 2007-11-19 | 2017-06-27 | Transgene S.A. | Poxviral oncolytic vectors |
| ES2567564T3 (es) * | 2007-11-19 | 2016-04-25 | Transgene Sa | Vectores oncolíticos de poxvirus |
| RU2473360C2 (ru) | 2007-11-30 | 2013-01-27 | Эббот Лэборетриз | Белковые композиции и способы их получения |
| MX2010008970A (es) | 2008-02-12 | 2011-05-30 | Sanofi Pasteur Ltd | Metodo que utiliza cromatografia de intercambio ionico y filtracion en gel para la purificacion de poxvirus. |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| US8470977B2 (en) | 2008-03-14 | 2013-06-25 | Transgene S.A. | Antibody against the CSF-1R |
| JP2012526532A (ja) | 2009-05-12 | 2012-11-01 | トランジェーヌ、ソシエテ、アノニム | 不死化鳥類細胞系およびその用途 |
| BR112012024565B1 (pt) | 2010-03-26 | 2022-02-08 | Trustees Of Dartmouth College | Proteína de fusão vista imunossupressora multimérica isolada ou recombinante e composição |
| ES2813413T3 (es) | 2011-08-05 | 2021-03-23 | Sillajen Biotherapeutics Inc | Métodos y composiciones para la producción de virus vaccina |
| WO2013043569A1 (en) | 2011-09-20 | 2013-03-28 | Vical Incorporated | Synergistic anti-tumor efficacy using alloantigen combination immunotherapy |
| US20150190505A1 (en) | 2012-07-30 | 2015-07-09 | Alex Wah Hin Yeung | Live and in-vivo tumor specific cancer vaccine system developed by co-administration of either at least two or all three of the following components such as tumor cells, an oncolytic virus vector with transgenic expression of gm-csf and an immune checkpoint modulator |
| US20150250837A1 (en) * | 2012-09-20 | 2015-09-10 | Morningside Technology Ventures Ltd. | Oncolytic virus encoding pd-1 binding agents and uses of the same |
| TWI690322B (zh) | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
| CN120555373A (zh) * | 2014-07-16 | 2025-08-29 | 特兰斯吉恩股份有限公司 | 用于表达免疫检查点调节因子的溶瘤病毒 |
| CN108165536A (zh) * | 2017-12-11 | 2018-06-15 | 浙江大学 | 一种重组溶瘤痘苗病毒及其制备方法与应用 |
| JP7438122B2 (ja) * | 2018-03-13 | 2024-02-26 | メモリアル スローン－ケタリング キャンサー センター | 免疫チェックポイント遮断を発現する癌免疫療法のための腫瘍溶解性ワクシニアウイルス |
| EP3617230A1 (en) * | 2018-09-03 | 2020-03-04 | BioInvent International AB | Novel antibodies and nucleotide sequences, and uses thereof |
| CN110218707B (zh) * | 2019-05-29 | 2021-10-22 | 上海市公共卫生临床中心 | 一种新型溶瘤病毒及其制备方法和应用 |
-
2015
- 2015-07-16 CN CN202510690099.0A patent/CN120555373A/zh active Pending
- 2015-07-16 EP EP19174121.4A patent/EP3552615B8/en active Active
- 2015-07-16 AU AU2015289125A patent/AU2015289125B2/en active Active
- 2015-07-16 RU RU2017103162A patent/RU2696312C2/ru active
- 2015-07-16 PT PT15738359T patent/PT3169341T/pt unknown
- 2015-07-16 ES ES19174121T patent/ES2909957T3/es active Active
- 2015-07-16 CA CA2954841A patent/CA2954841A1/en active Pending
- 2015-07-16 HU HUE15738359A patent/HUE045108T2/hu unknown
- 2015-07-16 DK DK15738359.7T patent/DK3169341T3/da active
- 2015-07-16 EP EP15738359.7A patent/EP3169341B1/en active Active
- 2015-07-16 ES ES15738359T patent/ES2743873T3/es active Active
- 2015-07-16 DK DK19174121.4T patent/DK3552615T3/da active
- 2015-07-16 WO PCT/EP2015/066263 patent/WO2016008976A1/en not_active Ceased
- 2015-07-16 CN CN201580050076.8A patent/CN107208069A/zh active Pending
- 2015-07-16 US US15/325,562 patent/US10555981B2/en active Active
- 2015-07-16 PL PL15738359T patent/PL3169341T3/pl unknown
- 2015-07-16 CA CA3190510A patent/CA3190510A1/en active Pending
- 2015-07-16 JP JP2017502212A patent/JP6895374B2/ja active Active
-
2017
- 2017-01-11 IL IL250058A patent/IL250058A0/en active IP Right Grant
-
2019
- 2019-12-23 US US16/725,485 patent/US11779619B2/en active Active
-
2020
- 2020-01-24 AU AU2020200541A patent/AU2020200541B2/en active Active
- 2020-09-29 JP JP2020163305A patent/JP7077377B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017522025A5 (OSRAM) | ||
| RU2017103162A (ru) | Онколитический вирус для экспрессии модуляторов иммунологических контрольных точек | |
| EP4232463B1 (en) | Interleukin-2-fc fusion proteins and methods of use | |
| RU2017103151A (ru) | Комбинация онколитического вируса с модуляторами иммунологических контрольных точек | |
| Pol et al. | Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors | |
| Pol et al. | Trial Watch—Oncolytic viruses and cancer therapy | |
| Li et al. | The gamble between oncolytic virus therapy and IFN | |
| JP2019508017A (ja) | 抗ｔｃｒ複合体抗体又は断片をコードするウイルス | |
| JP2019500909A5 (OSRAM) | ||
| US11142580B2 (en) | Oncolytic virus and method | |
| CN110564767A (zh) | 一种减毒病毒载体系统及其在制备抗恶性肿瘤的药物中的应用及药物使用方法 | |
| JPWO2019243847A5 (OSRAM) | ||
| CN116529258A (zh) | 白介素-2-Fc融合蛋白和使用方法 | |
| Zhang et al. | Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy | |
| US20250297002A1 (en) | Bispecific t-cell engager, recombinant oncolytic virus thereof, and use thereof | |
| JP2024517641A (ja) | 免疫細胞の遺伝子改変および治療的使用のための方法および組成物 | |
| EP4023232B1 (en) | Pharmaceutical composition for treating cancer comprising anticancer virus, immune checkpoint inhibitor and hydroxyurea as active ingredients | |
| JP2020537534A5 (OSRAM) | ||
| EP3868876A1 (en) | New oncolytic newcastle disease viruses and recombinant ndv strains | |
| Zupko | Oncolytic viruses in cancer immunotherapy | |
| HK40012869A (en) | Oncolytic viruses and therapeutic molecules | |
| HK1237666B (en) | Oncolytic virus for expression of immune checkpoint modulators |