|
DE59106279D1
(de)
|
1990-05-18 |
1995-09-21 |
Genentech Inc |
Neue protein-polykation-konjugate.
|
|
DE4104186A1
(de)
|
1991-02-12 |
1992-08-13 |
Genentech Inc |
Neue, ueber endozytose in hoehere eukaryotische zellen aufnehmbare, nukleinsaeure enthaltende komplexe
|
|
IL103059A0
(en)
|
1991-09-30 |
1993-02-21 |
Boehringer Ingelheim Int |
Conjugates for introducing nucleic acid into higher eucaryotic cells
|
|
NZ244306A
(en)
|
1991-09-30 |
1995-07-26 |
Boehringer Ingelheim Int |
Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation
|
|
DE19726186A1
(de)
|
1997-06-20 |
1998-12-24 |
Boehringer Ingelheim Int |
Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen
|
|
WO1999061032A1
(en)
|
1998-05-25 |
1999-12-02 |
Nippon Shinyaku Co., Ltd. |
Process for producing composite preparation containing nucleic acid
|
|
US6652886B2
(en)
|
2001-02-16 |
2003-11-25 |
Expression Genetics |
Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
|
|
US20040043030A1
(en)
|
2001-07-31 |
2004-03-04 |
Immunomedics, Inc. |
Polymeric delivery systems
|
|
GB0119346D0
(en)
|
2001-08-08 |
2001-10-03 |
Bioclones Proprietary Ltd |
Process for the maturation of dendritic cells
|
|
US7060498B1
(en)
|
2001-11-28 |
2006-06-13 |
Genta Salus Llc |
Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers
|
|
KR20030043780A
(ko)
|
2001-11-28 |
2003-06-02 |
주식회사 바이오폴리메드 |
생체적합성 비항원성 공중합체와 그 결합체 및 이들의제조방법
|
|
WO2003072636A1
(en)
|
2002-02-28 |
2003-09-04 |
Jong Sang Park |
Cationic highly branched polyaminoester
|
|
CN1720257A
(zh)
|
2002-08-06 |
2006-01-11 |
因特拉迪格姆公司 |
通过导入干扰rna在体内下调靶基因表达的方法
|
|
US7927792B2
(en)
*
|
2002-11-18 |
2011-04-19 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Targeted double stranded RNA mediated cell killing
|
|
US8969543B2
(en)
|
2003-04-03 |
2015-03-03 |
Bioneer Corporation |
SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof
|
|
US8324365B2
(en)
|
2003-04-03 |
2012-12-04 |
Korea Advanced Institute Of Science And Technology |
Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof
|
|
US7727969B2
(en)
|
2003-06-06 |
2010-06-01 |
Massachusetts Institute Of Technology |
Controlled release nanoparticle having bound oligonucleotide for targeted delivery
|
|
US20050118718A1
(en)
|
2003-09-22 |
2005-06-02 |
University Of Utah Research Foundation |
Stabilization and controlled delivery of ionic biopharmaceuticals
|
|
US20050277575A1
(en)
|
2004-03-24 |
2005-12-15 |
Alexandre Semov |
Therapeutic compositions and methods for treating diseases that involve angiogenesis
|
|
CA2587676A1
(en)
|
2004-11-19 |
2006-05-26 |
Institut Gustave Roussy |
Improved treatment of cancer by double-stranded rna
|
|
US7893244B2
(en)
|
2005-04-12 |
2011-02-22 |
Intradigm Corporation |
Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases
|
|
CN101287500A
(zh)
*
|
2005-08-19 |
2008-10-15 |
恩多塞特公司 |
多药物配体缀合物
|
|
US20090011004A1
(en)
|
2005-12-30 |
2009-01-08 |
Philadelphia Health & Education Corp., D/B/A/ Drexel University Of College Of Medicine |
Improved carriers for delivery of nucleic acid agents to cells and tissues
|
|
US20070231392A1
(en)
|
2006-01-23 |
2007-10-04 |
Ernst Wagner |
CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY
|
|
US20070225213A1
(en)
|
2006-03-23 |
2007-09-27 |
Kosak Matthew K |
Nucleic acid carriers for delivery of therapeutic agents
|
|
ES2776100T3
(es)
|
2006-03-31 |
2020-07-29 |
Massachusetts Inst Technology |
Sistema para el suministro dirigido de agentes terapéuticos
|
|
EP2136788B1
(en)
|
2007-03-30 |
2011-10-26 |
Bind Biosciences, Inc. |
Cancer cell targeting using nanoparticles
|
|
WO2008124634A1
(en)
|
2007-04-04 |
2008-10-16 |
Massachusetts Institute Of Technology |
Polymer-encapsulated reverse micelles
|
|
EP4464384A3
(en)
|
2007-08-17 |
2025-01-08 |
Purdue Research Foundation |
Psma binding ligand-linker conjugates and methods for using
|
|
WO2009030254A1
(en)
*
|
2007-09-04 |
2009-03-12 |
Curevac Gmbh |
Complexes of rna and cationic peptides for transfection and for immunostimulation
|
|
EP2630966B1
(en)
|
2007-10-12 |
2017-04-19 |
Massachusetts Institute of Technology |
Vaccine nanotechnology
|
|
US20110027172A1
(en)
|
2007-12-10 |
2011-02-03 |
Zhuang Wang |
Drug delivery system for pharmaceuticals and radiation
|
|
US20110038888A1
(en)
|
2008-01-10 |
2011-02-17 |
Peter Emtage |
Adjuvant compositions comprising poly-ic and a cationic polymer
|
|
WO2009131435A1
(en)
|
2008-04-23 |
2009-10-29 |
Erasmus University Medical Center Rotterdam |
Linker containing bungarotoxin and a binding peptide
|
|
EP2113257A1
(en)
|
2008-04-30 |
2009-11-04 |
Consorzio per il Centro di Biomedica Moleculare Scrl |
Polyelectrolyte with positive net charge for use as medicament and diagnostic for cancer
|
|
EP2123304A1
(en)
|
2008-05-23 |
2009-11-25 |
Freie Universität Berlin |
Compounds suited as nanocarriers for active agents and their use
|
|
WO2009151539A1
(en)
|
2008-05-24 |
2009-12-17 |
Sirnaomics, Inc. |
COMPOSITIONS AND METHODS USING siRNA MOLECULES FOR TREATMENT OF GLIOMAS
|
|
WO2010005740A2
(en)
|
2008-06-16 |
2010-01-14 |
Bind Biosciences, Inc. |
Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
|
|
WO2010073247A2
(en)
*
|
2008-12-22 |
2010-07-01 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Egfr-homing double-stranded rna vector for systemic cancer treatment
|
|
WO2010088927A1
(en)
|
2009-02-09 |
2010-08-12 |
Curevac Gmbh |
Use of pei for the improvement of endosomal release and expression of transfected nucleic acids, complexed with cationic or polycationic compounds
|
|
US20100266642A1
(en)
|
2009-02-20 |
2010-10-21 |
Bind Biosciences, Inc. |
Modified cells for targeted cell trafficking and uses thereof
|
|
ES2588183T3
(es)
|
2009-03-31 |
2016-10-31 |
Japan As Represented By Director-General Of National Institute Of Infectious Diseases |
Procedimiento para la prevención de la gripe utilizando una vacuna para administración intranasal
|
|
WO2010127159A2
(en)
|
2009-04-30 |
2010-11-04 |
Intezyne Technologies, Incorporated |
Polymeric micelles for polynucleotide encapsulation
|
|
ES2368963B1
(es)
|
2009-07-04 |
2012-10-10 |
Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii |
Procedimiento de identificación de agentes terapéuticos contra el melanoma y uso de agente identificado.
|
|
CN101638484A
(zh)
*
|
2009-08-24 |
2010-02-03 |
中国科学院长春应用化学研究所 |
聚乙二醇单甲醚-聚2-甲基-2-羧基碳酸丙烯酯接枝聚乙烯亚胺共聚物与制法及应用
|
|
CA2781717C
(en)
|
2009-12-09 |
2017-09-12 |
Ibc Pharmaceuticals, Inc. |
Dock-and-lock (dnl) complexes for delivery of interference rna
|
|
JP6175237B2
(ja)
|
2009-12-15 |
2017-08-02 |
ファイザー・インク |
コルチコステロイドを含む治療用ポリマーナノ粒およびそれを製造かつ使用する方法
|
|
ES2780156T3
(es)
|
2009-12-15 |
2020-08-24 |
Pfizer |
Composiciones terapéuticas de nanopartículas poliméricas con alta temperatura de transición vítrea o copolímeros de alto peso molecular
|
|
JP5898627B2
(ja)
|
2009-12-15 |
2016-04-06 |
バインド セラピューティックス インコーポレイテッド |
エポチロンを含む治療用ポリマーナノ粒子ならびにそれを製造および使用する方法
|
|
DK2539451T3
(da)
|
2010-02-24 |
2016-04-04 |
Arrowhead Res Corp |
Sammensætninger til målrettet tilførsel af siRNA
|
|
ES2631458T3
(es)
|
2010-03-04 |
2017-08-31 |
Interna Technologies B.V. |
Molécula de ARNmi definida por su fuente y sus usos terapéuticos en el cáncer asociado a la EMT
|
|
US20110256227A1
(en)
|
2010-04-14 |
2011-10-20 |
Intezyne Technologies, Inc. |
Controlled polyplex assembly
|
|
WO2011154331A1
(en)
|
2010-06-10 |
2011-12-15 |
F. Hoffmann-La Roche Ag |
Polymers for delivery of nucleic acids
|
|
EP2395041A1
(en)
|
2010-06-10 |
2011-12-14 |
F. Hoffmann-La Roche AG |
Polymers for delivery of nucleic acids
|
|
NZ704322A
(en)
|
2010-07-06 |
2016-07-29 |
Interna Technologies Bv |
Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
|
|
US20120207795A1
(en)
|
2010-07-13 |
2012-08-16 |
The Regents Of The University Of California |
Cationic polymer coated mesoporous silica nanoparticles and uses thereof
|
|
WO2012016188A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
|
FR2963350B1
(fr)
|
2010-07-30 |
2013-11-01 |
Univ D Evry Val D Essonne |
Nouveaux copolymeres a bloc et leurs utilisations pour delivrer une substance active dans une cellule.
|
|
US8461224B2
(en)
|
2011-03-04 |
2013-06-11 |
National Health Research Institutes |
Single monomer derived linear-like copolymer comprising polyethylenimine and poly(ethylene glycol) for nucleic acid delivery
|
|
US10029023B2
(en)
|
2011-03-31 |
2018-07-24 |
The Johns Hopkins University |
Theranostic imaging agents and methods of use
|
|
WO2012166923A2
(en)
|
2011-05-31 |
2012-12-06 |
Bind Biosciences |
Drug loaded polymeric nanoparticles and methods of making and using same
|
|
EP3272868A1
(en)
|
2012-05-02 |
2018-01-24 |
Arrowhead Pharmaceuticals, Inc. |
Organic compositions to treat kras-related diseases
|
|
EP2852668B1
(en)
|
2012-07-12 |
2016-04-27 |
ProQR Therapeutics II B.V. |
Oligonucleotides for making a change in the sequence of a target rna molecule present in a living cell
|
|
CA2912975A1
(en)
|
2012-10-16 |
2014-04-24 |
William Marsh Rice University |
An improved nanovector based drug delivery system for overcoming drug resistance
|
|
US10201556B2
(en)
|
2012-11-06 |
2019-02-12 |
Interna Technologies B.V. |
Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated B-raf pathway
|
|
BR112015011118B1
(pt)
|
2012-11-15 |
2022-12-13 |
Endocyte, Inc |
Conjugado; composição farmacêutica; e uso de um conjugado
|
|
EP2930180B1
(en)
|
2012-12-06 |
2021-11-10 |
Kyowa Hakko Bio Co., Ltd. |
Double-stranded ribonucleic acid for adjuvants
|
|
EP3013964B1
(en)
|
2013-06-28 |
2020-05-06 |
ethris GmbH |
Compositions for introducing rna into cells
|
|
CN104341488A
(zh)
|
2013-08-02 |
2015-02-11 |
复旦大学 |
c(LyP-1)多肽及其构建的纳米递药系统和应用
|
|
WO2015065773A1
(en)
|
2013-11-04 |
2015-05-07 |
Northeastern University |
System for co-delivery of polynucleotides and drugs into protease-expressing cells
|
|
JP2017505104A
(ja)
|
2013-11-08 |
2017-02-16 |
デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド |
インビボにおける薬剤送達のための核酸ナノ構造体
|
|
MA39734B1
(fr)
|
2014-03-14 |
2019-07-31 |
Pfizer |
Nanoparticules thérapeutiques comportant un agent thérapeutique, et leurs procédés de fabrication et d'utilisation
|
|
EP3126501A1
(en)
|
2014-03-24 |
2017-02-08 |
RiboxX GmbH |
Double-stranded rna conjugates and their use
|
|
JP7348708B2
(ja)
|
2014-04-30 |
2023-09-21 |
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ |
組み合わせワクチン装置および癌細胞を殺滅する方法
|
|
KR102589295B1
(ko)
|
2014-05-14 |
2023-10-13 |
타르그이뮨 테라퓨틱스 아게 |
개선된 폴리에틸렌이민 폴리에틸렌글리콜 벡터
|
|
US20180016352A1
(en)
|
2015-02-05 |
2018-01-18 |
The University Of Queensland |
Targeting constructs for delivery of payloads
|
|
US20160331845A1
(en)
|
2015-05-14 |
2016-11-17 |
The Johns Hopkins University |
Compositions of nucleic acid-containing nanoparticles for in vivo delivery
|
|
HUE047172T2
(hu)
|
2015-11-17 |
2020-04-28 |
Bioncotech Therapeutics S L |
Újfajta gyógyszerészeti készítmény, mely egy kétszálú poli-ribonukleotid és egy polialkilén-imin egy komplexét tartalmazó részecskéket tartalmaz
|