JP2017518375A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017518375A5 JP2017518375A5 JP2017516031A JP2017516031A JP2017518375A5 JP 2017518375 A5 JP2017518375 A5 JP 2017518375A5 JP 2017516031 A JP2017516031 A JP 2017516031A JP 2017516031 A JP2017516031 A JP 2017516031A JP 2017518375 A5 JP2017518375 A5 JP 2017518375A5
- Authority
- JP
- Japan
- Prior art keywords
- mhc
- molecule
- major histocompatibility
- multimeric
- histocompatibility complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 46
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 46
- 238000000034 method Methods 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 150000007523 nucleic acids Chemical class 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 238000001514 detection method Methods 0.000 claims 4
- 108010090804 Streptavidin Proteins 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 108090001008 Avidin Proteins 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 229920001503 Glucan Polymers 0.000 claims 1
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 claims 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N biotin Natural products N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000005859 cell recognition Effects 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 238000012350 deep sequencing Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000007717 exclusion Effects 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 1
- 238000002523 gelfiltration Methods 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 238000012165 high-throughput sequencing Methods 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 150000001455 metallic ions Chemical class 0.000 claims 1
- 239000013642 negative control Substances 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 230000004043 responsiveness Effects 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201470340 | 2014-06-06 | ||
| DKPA201470340 | 2014-06-06 | ||
| PCT/DK2015/050150 WO2015185067A1 (en) | 2014-06-06 | 2015-06-08 | Determining antigen recognition through barcoding of mhc multimers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020043059A Division JP7271465B2 (ja) | 2014-06-06 | 2020-03-12 | Ｍｈｃ多量体のバーコード標識による抗原認識の判定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017518375A JP2017518375A (ja) | 2017-07-06 |
| JP2017518375A5 true JP2017518375A5 (https=) | 2018-07-12 |
| JP6956632B2 JP6956632B2 (ja) | 2021-11-02 |
Family
ID=59272565
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516031A Active JP6956632B2 (ja) | 2014-06-06 | 2015-06-08 | Ｍｈｃ多量体のバーコード標識による抗原認識の判定 |
| JP2020043059A Active JP7271465B2 (ja) | 2014-06-06 | 2020-03-12 | Ｍｈｃ多量体のバーコード標識による抗原認識の判定 |
| JP2023072013A Pending JP2023100746A (ja) | 2014-06-06 | 2023-04-26 | Ｍｈｃ多量体のバーコード標識による抗原認識の判定 |
| JP2025092283A Pending JP2025128229A (ja) | 2014-06-06 | 2025-06-03 | Ｍｈｃ多量体のバーコード標識による抗原認識の判定 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020043059A Active JP7271465B2 (ja) | 2014-06-06 | 2020-03-12 | Ｍｈｃ多量体のバーコード標識による抗原認識の判定 |
| JP2023072013A Pending JP2023100746A (ja) | 2014-06-06 | 2023-04-26 | Ｍｈｃ多量体のバーコード標識による抗原認識の判定 |
| JP2025092283A Pending JP2025128229A (ja) | 2014-06-06 | 2025-06-03 | Ｍｈｃ多量体のバーコード標識による抗原認識の判定 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20170343545A1 (https=) |
| EP (3) | EP3628684B1 (https=) |
| JP (4) | JP6956632B2 (https=) |
| AU (3) | AU2015271324B2 (https=) |
| CA (2) | CA3205428A1 (https=) |
| DK (1) | DK3152232T3 (https=) |
| ES (1) | ES2770634T3 (https=) |
| PT (1) | PT3152232T (https=) |
| SG (2) | SG10202005892SA (https=) |
| WO (1) | WO2015185067A1 (https=) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011127099A1 (en) | 2010-04-05 | 2011-10-13 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| US11435358B2 (en) | 2011-06-23 | 2022-09-06 | Board Of Regents, The University Of Texas System | Single molecule peptide sequencing |
| CA2839702C (en) | 2011-06-23 | 2021-04-20 | Board Of Regents, The University Of Texas System | Identifying peptides at the single molecule level |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| AU2013302756C1 (en) | 2012-08-14 | 2018-05-17 | 10X Genomics, Inc. | Microcapsule compositions and methods |
| US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| CA2894694C (en) | 2012-12-14 | 2023-04-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| KR20200140929A (ko) | 2013-02-08 | 2020-12-16 | 10엑스 제노믹스, 인크. | 폴리뉴클레오티드 바코드 생성 |
| CA2916662C (en) | 2013-06-25 | 2022-03-08 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
| BR112016023625A2 (pt) | 2014-04-10 | 2018-06-26 | 10X Genomics, Inc. | dispositivos fluídicos, sistemas e métodos para encapsular e particionar reagentes, e aplicações dos mesmos |
| SG10202005892SA (en) * | 2014-06-06 | 2020-07-29 | Herlev Hospital | Determining antigen recognition through barcoding of mhc multimers |
| WO2015188839A2 (en) | 2014-06-13 | 2015-12-17 | Immudex Aps | General detection and isolation of specific cells by binding of labeled molecules |
| WO2015200893A2 (en) | 2014-06-26 | 2015-12-30 | 10X Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
| US12312640B2 (en) | 2014-06-26 | 2025-05-27 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| CA2953469A1 (en) | 2014-06-26 | 2015-12-30 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| CA3208970A1 (en) | 2014-09-15 | 2016-05-06 | Board Of Regents, The University Of Texas System | Improved single molecule peptide sequencing |
| JP6769969B2 (ja) | 2015-01-12 | 2020-10-14 | １０エックス ジェノミクス， インコーポレイテッド | 核酸配列決定ライブラリーを作製するためのプロセス及びシステム、並びにこれらを使用して作製したライブラリー |
| EP3262407B1 (en) | 2015-02-24 | 2023-08-30 | 10X Genomics, Inc. | Partition processing methods and systems |
| EP3901282B1 (en) | 2015-04-10 | 2023-06-28 | Spatial Transcriptomics AB | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| US10539564B2 (en) | 2015-07-22 | 2020-01-21 | Roche Sequencing Solutions, Inc. | Identification of antigen epitopes and immune sequences recognizing the antigens |
| EP3325646B1 (en) | 2015-07-22 | 2020-08-19 | F.Hoffmann-La Roche Ag | Identification of antigen epitopes and immune sequences recognizing the antigens |
| MX2018003532A (es) | 2015-09-24 | 2019-04-25 | Abvitro Llc | Conjugados de afinidad-oligonucleotido y usos de los mismos. |
| JP6954899B2 (ja) | 2015-12-04 | 2021-10-27 | １０エックス ゲノミクス，インコーポレイテッド | 核酸の解析のための方法及び組成物 |
| JP6929354B2 (ja) * | 2016-09-24 | 2021-09-01 | アブビトロ， エルエルシー | 親和性−オリゴヌクレオチドコンジュゲートおよびその使用 |
| US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| EP4029939B1 (en) | 2017-01-30 | 2023-06-28 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
| EP3445876B1 (en) | 2017-05-26 | 2023-07-05 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
| US10400235B2 (en) | 2017-05-26 | 2019-09-03 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
| SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
| US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
| SG11202007686VA (en) | 2018-02-12 | 2020-09-29 | 10X Genomics Inc | Methods characterizing multiple analytes from individual cells or cell populations |
| CN112262218B (zh) | 2018-04-06 | 2024-11-08 | 10X基因组学有限公司 | 用于单细胞处理中的质量控制的系统和方法 |
| US20210139985A1 (en) * | 2018-04-10 | 2021-05-13 | Board Of Regents, The University Of Texas System | Dna-barcoded antigen multimers and methods of use thereof |
| HRP20230007T1 (hr) * | 2018-04-11 | 2023-03-03 | Enterome S.A. | Antigenski peptidi, namijenjeni sprječavanju i liječenju raka |
| WO2019217758A1 (en) | 2018-05-10 | 2019-11-14 | 10X Genomics, Inc. | Methods and systems for molecular library generation |
| WO2019238939A1 (en) * | 2018-06-15 | 2019-12-19 | F. Hoffmann-La Roche Ag | A system for identification of antigens recognized by t cell receptors expressed on tumor infiltrating lymphocytes |
| CA3110800A1 (en) | 2018-07-12 | 2020-01-16 | Board Of Regents, The University Of Texas System | Molecular neighborhood detection by oligonucleotides |
| JP2021534394A (ja) * | 2018-08-14 | 2021-12-09 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | 主要組織適合遺伝子複合体に結合されたペプチドを配列決定する単一分子 |
| US20210332424A1 (en) | 2018-08-28 | 2021-10-28 | 10X Genomics, Inc. | Methods of generating an array |
| WO2020047005A1 (en) | 2018-08-28 | 2020-03-05 | 10X Genomics, Inc. | Resolving spatial arrays |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| CN110687298A (zh) * | 2018-09-06 | 2020-01-14 | 天津美瑞特医疗科技有限公司 | 一种以Chitosan多糖为骨架制备MHC抗原肽多聚体检测试剂的新方法 |
| WO2020056173A1 (en) * | 2018-09-13 | 2020-03-19 | Pact Pharma, Inc. | Antigen specific tcr identification using single-cell sorting |
| KR20210063379A (ko) * | 2018-09-24 | 2021-06-01 | 브리스톨-마이어스 스큅 컴퍼니 | 바코딩된 펩티드-mhc 복합체 및 그의 용도 |
| CA3117476A1 (en) | 2018-10-05 | 2020-04-09 | Board Of Regents, The University Of Texas System | Solid-phase n-terminal peptide capture and release |
| WO2020107496A1 (zh) * | 2018-12-01 | 2020-06-04 | 铭道创新（北京）医疗技术有限公司 | 一种免疫细胞中淋巴细胞的流式细胞仪检测方法 |
| WO2020123316A2 (en) | 2018-12-10 | 2020-06-18 | 10X Genomics, Inc. | Methods for determining a location of a biological analyte in a biological sample |
| US12529094B2 (en) | 2018-12-10 | 2026-01-20 | 10X Genomics, Inc. | Imaging system hardware |
| WO2020127222A2 (en) | 2018-12-17 | 2020-06-25 | Immudex Aps | Panel comprising borrelia mhc multimers |
| JP2022514574A (ja) * | 2018-12-18 | 2022-02-14 | エムビーエル インターナショナル コーポレイション | ｐＭＨＣ占有率のストレプトアビジン－オリゴコンジュゲート組成物 |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| CN114174531A (zh) | 2019-02-28 | 2022-03-11 | 10X基因组学有限公司 | 用空间条码化寡核苷酸阵列对生物分析物进行概况分析 |
| EP3938538A1 (en) | 2019-03-15 | 2022-01-19 | 10X Genomics, Inc. | Methods for using spatial arrays for single cell sequencing |
| EP3887542A1 (en) | 2019-03-22 | 2021-10-06 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| GB201909509D0 (en) * | 2019-07-02 | 2019-08-14 | Immunocore Ltd | Peptide-MHC complexes |
| KR102406463B1 (ko) * | 2019-09-03 | 2022-06-10 | 재단법인 오송첨단의료산업진흥재단 | 단백질 생산성 향상을 위한 개별 바코딩 시스템 도입한 시그널 펩타이드 초고속 선별방법 |
| AU2020358975A1 (en) * | 2019-10-03 | 2022-04-21 | Regeneron Pharmaceuticals, Inc. | High-throughput method to screen cognate T cell and epitope reactivities in primary human cells |
| WO2021091611A1 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
| ES3024383T3 (en) | 2019-11-13 | 2025-06-04 | 10X Genomics Inc | Generating capture probes for spatial analysis |
| EP4081656A1 (en) | 2019-12-23 | 2022-11-02 | 10X Genomics, Inc. | Compositions and methods for using fixed biological samples in partition-based assays |
| CN115135984B (zh) | 2019-12-23 | 2025-12-23 | 10X基因组学有限公司 | 可逆固定试剂及其使用方法 |
| JP7107535B2 (ja) * | 2020-01-10 | 2022-07-27 | シンクサイト株式会社 | 新規細胞表現型スクリーニング方法 |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11835462B2 (en) | 2020-02-11 | 2023-12-05 | 10X Genomics, Inc. | Methods and compositions for partitioning a biological sample |
| US12449419B1 (en) | 2020-02-12 | 2025-10-21 | 10X Genomics, Inc. | Methods for detecting binding of peptide-MHC monomers to T cells |
| US11926863B1 (en) | 2020-02-27 | 2024-03-12 | 10X Genomics, Inc. | Solid state single cell method for analyzing fixed biological cells |
| WO2021202727A2 (en) * | 2020-03-31 | 2021-10-07 | Repertoire Immune Medicines, Inc. | Barcodable exchangeable peptide-mhc multimer libraries |
| WO2021216787A1 (en) * | 2020-04-21 | 2021-10-28 | Regeneron Pharmaceuticals, Inc. | Methods and systems for analysis of receptor interaction |
| EP4414459B1 (en) | 2020-05-22 | 2025-09-03 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| US12265079B1 (en) | 2020-06-02 | 2025-04-01 | 10X Genomics, Inc. | Systems and methods for detecting analytes from captured single biological particles |
| WO2022109339A1 (en) | 2020-11-20 | 2022-05-27 | Becton, Dickinson And Company | Use of dextramer in single cell analysis |
| WO2022162187A1 (en) * | 2021-01-28 | 2022-08-04 | Gigavax Aps | pMHC MULTIPLEXERS FOR DETECTION OF ANTIGEN-SPECIFIC T CELLS |
| EP4284811A2 (en) * | 2021-01-28 | 2023-12-06 | Fwd Holding Aps | Pmhc multiplexers by addition of mhc2 and rolling circle peptide multimer display |
| EP4212653A1 (en) * | 2022-01-18 | 2023-07-19 | Universität Potsdam | Molecular tagging using position-oriented nucleic acid encryption |
| EP4519674A1 (en) | 2022-05-06 | 2025-03-12 | 10X Genomics, Inc. | Analysis of antigen and antigen receptor interactions |
| WO2023225294A1 (en) * | 2022-05-20 | 2023-11-23 | 10X Genomics, Inc. | Improved major histocompatibility complex molecules |
| AU2024268752A1 (en) | 2023-05-11 | 2026-01-08 | Immudex Aps | Mhc class i molecules |
| WO2025109111A1 (en) | 2023-11-22 | 2025-05-30 | Immudex Aps | Immune cell activating multimers |
| WO2025125477A1 (en) | 2023-12-12 | 2025-06-19 | Immudex Aps | Mhc class i molecule matched negative control reagents |
| WO2025144972A1 (en) * | 2023-12-29 | 2025-07-03 | Illumina, Inc. | Materials and methods for preparation of a spatial transcriptomics library |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001158800A (ja) * | 1999-12-03 | 2001-06-12 | Jsr Corp | アビジン粒子 |
| DE60118527D1 (de) * | 2000-01-24 | 2006-05-18 | Compound Therapeutics Inc | Sensible und multiplexe diagnostische tests zur proteinanalyse |
| US7902121B2 (en) * | 2001-07-02 | 2011-03-08 | The Board Of Trustees Of The Leland Stanford Junior University | MHC-antigen arrays for detection and characterization of immune responses |
| US20030148335A1 (en) | 2001-10-10 | 2003-08-07 | Li Shen | Detecting targets by unique identifier nucleotide tags |
| EP1649055B1 (en) * | 2003-06-27 | 2009-05-20 | Nanosphere, Inc. | Bio-barcode based detection of target analytes |
| GB2422834B8 (en) * | 2005-02-04 | 2007-01-04 | Proimmune Ltd | MHC oligomer and method of making the same |
| EP3620465B1 (en) | 2007-07-03 | 2025-02-19 | Dako Denmark A/S | Improved methods for generation, labeling and use of mhc multimers |
| WO2009077173A2 (en) * | 2007-12-19 | 2009-06-25 | Philochem Ag | Dna-encoded chemical libraries |
| CN102112626A (zh) * | 2008-04-09 | 2011-06-29 | 加州理工学院 | 用于检测和/或分类靶标的捕获剂以及相关方法和系统 |
| WO2010037397A1 (en) | 2008-10-01 | 2010-04-08 | Dako Denmark A/S | Mhc multimers in cmv immune monitoring |
| EP2337795A2 (en) * | 2008-10-01 | 2011-06-29 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
| EP2362882B1 (en) | 2008-11-03 | 2016-01-27 | Stichting Sanquin Bloedvoorziening | Detecting antigen responsive cells in a sample |
| US8735327B2 (en) * | 2010-01-07 | 2014-05-27 | Jeansee, Llc | Combinatorial DNA taggants and methods of preparation and use thereof |
| WO2012044999A2 (en) * | 2010-10-01 | 2012-04-05 | Ludwig Institute For Cancer Research Ltd. | Reversible protein multimers, methods for their production and use |
| WO2013137737A1 (en) * | 2012-03-16 | 2013-09-19 | Flexgen B.V. | Methods of creating and screening of dna encoded combinatorial libraries of chemical antibodies |
| SG10202005892SA (en) | 2014-06-06 | 2020-07-29 | Herlev Hospital | Determining antigen recognition through barcoding of mhc multimers |
| WO2015188839A2 (en) * | 2014-06-13 | 2015-12-17 | Immudex Aps | General detection and isolation of specific cells by binding of labeled molecules |
| US9789974B2 (en) | 2015-10-19 | 2017-10-17 | Goodrich Corporation | Brake monitoring system |
-
2015
- 2015-06-08 SG SG10202005892SA patent/SG10202005892SA/en unknown
- 2015-06-08 ES ES15739508T patent/ES2770634T3/es active Active
- 2015-06-08 PT PT157395088T patent/PT3152232T/pt unknown
- 2015-06-08 WO PCT/DK2015/050150 patent/WO2015185067A1/en not_active Ceased
- 2015-06-08 SG SG11201610177UA patent/SG11201610177UA/en unknown
- 2015-06-08 EP EP19208285.7A patent/EP3628684B1/en active Active
- 2015-06-08 DK DK15739508.8T patent/DK3152232T3/da active
- 2015-06-08 US US15/316,584 patent/US20170343545A1/en active Pending
- 2015-06-08 EP EP24200560.1A patent/EP4484450A3/en active Pending
- 2015-06-08 CA CA3205428A patent/CA3205428A1/en active Pending
- 2015-06-08 AU AU2015271324A patent/AU2015271324B2/en active Active
- 2015-06-08 JP JP2017516031A patent/JP6956632B2/ja active Active
- 2015-06-08 EP EP15739508.8A patent/EP3152232B1/en not_active Revoked
- 2015-06-08 CA CA2951325A patent/CA2951325C/en active Active
-
2019
- 2019-11-18 AU AU2019264685A patent/AU2019264685B2/en active Active
-
2020
- 2020-03-12 JP JP2020043059A patent/JP7271465B2/ja active Active
-
2021
- 2021-06-30 AU AU2021204496A patent/AU2021204496B2/en active Active
-
2023
- 2023-04-26 JP JP2023072013A patent/JP2023100746A/ja active Pending
-
2025
- 2025-06-03 JP JP2025092283A patent/JP2025128229A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017518375A5 (https=) | ||
| AU2021204496B2 (en) | Determining antigen recognition through barcoding of MHC multimers | |
| JP6783590B2 (ja) | 増幅核酸検出方法及び検出デバイス | |
| Paniel et al. | Aptasensor and genosensor methods for detection of microbes in real world samples | |
| CN107636162B (zh) | 用针对特定群体的抗原筛选t细胞的组合物和方法 | |
| CN103890245B (zh) | 核酸编码反应 | |
| EP3619307B1 (en) | Methods of preparing a re-usable single cell and methods for analyzing the epigenome, transcriptome, and genome of a single cell | |
| US11136627B2 (en) | Controls for nucleic acid assays | |
| CN102618626A (zh) | 一种快速单核苷酸多态性的检测方法及试剂盒 | |
| EP3308164A1 (en) | High throughput optimization of content-loaded nanoparticles | |
| KR101727111B1 (ko) | 표적핵산 검출방법 및 키트 | |
| US20210341485A1 (en) | Exosome Detection in Microfluidic Droplets | |
| CN109182599A (zh) | 用于检测草鱼出血病毒的特异性引物对、探针、检测试剂盒 | |
| KR101669458B1 (ko) | 핵산 압타머로 수식된 고분자 시트 및 이의 제조방법 | |
| JP2022502029A (ja) | バーコード化ペプチド−ｍｈｃ複合体およびその使用 | |
| JP2010535019A5 (https=) | ||
| HK40118850A (en) | Determining antigen recognition through barcoding of mhc multimers | |
| WO2017006859A1 (ja) | 標的核酸の検出法 | |
| HK40018808A (en) | Probe set for analyzing a dna sample and method for using the same | |
| Xie et al. | Engineering Riboswitches For Parallel Detection Of Small Molecules | |
| KR20130113404A (ko) | 샬레의 바닥에 DNA oligomer 결합을 통한 생체 유사도 측정기 | |
| TH1501006236A (th) | ชุดของโอลิโกนิวคลีโอไทด์ (oligonucleotide) และดีเอ็นเออานาล็อก (analog DNA) สังเคราะห์ วิธีการตรวจสารพันธุกรรม และชุดตรวจสารพันธุกรรมสำหรับตรวจหา เชื้อไวรัสพีอาร์อาร์เอสสายพันธุ์ที่ก่อให้เกิดโรครุนแรง (HP-PRRS virus) ในสุกร | |
| HK1236546B (en) | Determining antigen recognition through barcoding of mhc multimers | |
| HK1236546A1 (en) | Determining antigen recognition through barcoding of mhc multimers |