SG11201610177UA - Determining antigen recognition through barcoding of mhc multimers - Google Patents

Determining antigen recognition through barcoding of mhc multimers

Info

Publication number
SG11201610177UA
SG11201610177UA SG11201610177UA SG11201610177UA SG11201610177UA SG 11201610177U A SG11201610177U A SG 11201610177UA SG 11201610177U A SG11201610177U A SG 11201610177UA SG 11201610177U A SG11201610177U A SG 11201610177UA SG 11201610177U A SG11201610177U A SG 11201610177UA
Authority
SG
Singapore
Prior art keywords
barcoding
antigen recognition
mhc multimers
determining antigen
determining
Prior art date
Application number
SG11201610177UA
Inventor
Hadrup Sine Reker
Henrik Pedersen
Søren Jakobsen
Amalie Kai Bentzen
Original Assignee
Herlev Hospital
Immudex Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59272565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201610177U(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Herlev Hospital, Immudex Aps filed Critical Herlev Hospital
Publication of SG11201610177UA publication Critical patent/SG11201610177UA/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56972White blood cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70539MHC-molecules, e.g. HLA-molecules
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1065Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804Nucleic acid analysis using immunogens
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539MHC-molecules, e.g. HLA-molecules
SG11201610177UA 2014-06-06 2015-06-08 Determining antigen recognition through barcoding of mhc multimers SG11201610177UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201470340 2014-06-06
PCT/DK2015/050150 WO2015185067A1 (en) 2014-06-06 2015-06-08 Determining antigen recognition through barcoding of mhc multimers

Publications (1)

Publication Number Publication Date
SG11201610177UA true SG11201610177UA (en) 2017-01-27

Family

ID=59272565

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202005892SA SG10202005892SA (en) 2014-06-06 2015-06-08 Determining antigen recognition through barcoding of mhc multimers
SG11201610177UA SG11201610177UA (en) 2014-06-06 2015-06-08 Determining antigen recognition through barcoding of mhc multimers

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10202005892SA SG10202005892SA (en) 2014-06-06 2015-06-08 Determining antigen recognition through barcoding of mhc multimers

Country Status (10)

Country Link
US (1) US20170343545A1 (en)
EP (2) EP3152232B1 (en)
JP (3) JP6956632B2 (en)
AU (3) AU2015271324B2 (en)
CA (2) CA3205428A1 (en)
DK (1) DK3152232T3 (en)
ES (1) ES2770634T3 (en)
PT (1) PT3152232T (en)
SG (2) SG10202005892SA (en)
WO (1) WO2015185067A1 (en)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011127099A1 (en) 2010-04-05 2011-10-13 Prognosys Biosciences, Inc. Spatially encoded biological assays
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
WO2012178023A1 (en) 2011-06-23 2012-12-27 Board Of Regents, The University Of Texas System Identifying peptides at the single molecule level
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
AU2013302756C1 (en) 2012-08-14 2018-05-17 10X Genomics, Inc. Microcapsule compositions and methods
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP3567116A1 (en) 2012-12-14 2019-11-13 10X Genomics, Inc. Methods and systems for processing polynucleotides
KR102190198B1 (en) 2013-02-08 2020-12-14 10엑스 제노믹스, 인크. Polynucleotide barcode generation
WO2014210225A1 (en) 2013-06-25 2014-12-31 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
DE202015009494U1 (en) 2014-04-10 2018-02-08 10X Genomics, Inc. Fluidic devices and systems for encapsulating and partitioning reagents, and their applications
EP3152232B1 (en) * 2014-06-06 2019-11-13 Herlev Hospital Determining antigen recognition through barcoding of mhc multimers
EP3155426B1 (en) 2014-06-13 2023-07-19 Immudex ApS General detection and isolation of specific cells by binding of labeled molecules
MX2016016902A (en) 2014-06-26 2017-03-27 10X Genomics Inc Methods of analyzing nucleic acids from individual cells or cell populations.
US10545153B2 (en) 2014-09-15 2020-01-28 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
EP3262407B1 (en) 2015-02-24 2023-08-30 10X Genomics, Inc. Partition processing methods and systems
EP3530752B1 (en) 2015-04-10 2021-03-24 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
WO2017013170A1 (en) * 2015-07-22 2017-01-26 F. Hoffmann-La Roche Ag Identification of antigen epitopes and immune sequences recognizing the antigens
US10539564B2 (en) 2015-07-22 2020-01-21 Roche Sequencing Solutions, Inc. Identification of antigen epitopes and immune sequences recognizing the antigens
WO2018057051A1 (en) * 2016-09-24 2018-03-29 Abvitro Llc Affinity-oligonucleotide conjugates and uses thereof
KR20180085717A (en) 2015-09-24 2018-07-27 에이비비트로, 엘엘씨 Affinity-oligonucleotide conjugates and their use
DK3882357T3 (en) 2015-12-04 2022-08-29 10X Genomics Inc Methods and compositions for the analysis of nucleic acids
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4029939B1 (en) 2017-01-30 2023-06-28 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
CN109526228B (en) 2017-05-26 2022-11-25 10X基因组学有限公司 Single cell analysis of transposase accessible chromatin
EP3625361A1 (en) 2017-11-15 2020-03-25 10X Genomics, Inc. Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019157529A1 (en) 2018-02-12 2019-08-15 10X Genomics, Inc. Methods characterizing multiple analytes from individual cells or cell populations
EP3775271A1 (en) 2018-04-06 2021-02-17 10X Genomics, Inc. Systems and methods for quality control in single cell processing
US20210139985A1 (en) * 2018-04-10 2021-05-13 Board Of Regents, The University Of Texas System Dna-barcoded antigen multimers and methods of use thereof
LT3773689T (en) * 2018-04-11 2023-01-25 Enterome S.A. Antigenic peptides for prevention and treatment of cancer
EP3807636B1 (en) * 2018-06-15 2024-01-31 F. Hoffmann-La Roche AG A system for identification of antigens recognized by t cell receptors expressed on tumor infiltrating lymphocytes
GB2607829B (en) * 2018-08-14 2023-08-30 Univ Texas Single molecule sequencing peptides bound to the major histocompatibility complex
SG11202102029TA (en) 2018-08-28 2021-03-30 10X Genomics Inc Methods for generating spatially barcoded arrays
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
US20210317524A1 (en) 2018-08-28 2021-10-14 10X Genomics, Inc. Resolving spatial arrays
CN110687298A (en) * 2018-09-06 2020-01-14 天津美瑞特医疗科技有限公司 Novel method for preparing MHC antigen peptide multimer detection reagent by using Chitosan polysaccharide as skeleton
EP3856925A1 (en) * 2018-09-24 2021-08-04 Bristol-Myers Squibb Company Barcoded peptide-mhc complexes and uses thereof
US20210389225A1 (en) * 2018-12-01 2021-12-16 Mingdao Innovation (Beijing) Medical-Tech Co., Ltd. A flow cytometric detection method for lymphocyte in immune cells
EP3894587A1 (en) 2018-12-10 2021-10-20 10X Genomics, Inc. Resolving spatial arrays by proximity-based deconvolution
US20220064226A1 (en) 2018-12-17 2022-03-03 Immudex Aps Panel comprising Borrelia MHC multimers
WO2020132087A1 (en) * 2018-12-18 2020-06-25 Mbl International Corp. COMPOSITIONS OF STREPTAVIDIN-OLIGO CONJUGATES OF VARYING pMHC OCCUPANCY
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
EP3931354A1 (en) 2019-02-28 2022-01-05 10X Genomics, Inc. Profiling of biological analytes with spatially barcoded oligonucleotide arrays
EP3938538A1 (en) 2019-03-15 2022-01-19 10X Genomics, Inc. Methods for using spatial arrays for single cell sequencing
WO2020198071A1 (en) 2019-03-22 2020-10-01 10X Genomics, Inc. Three-dimensional spatial analysis
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
KR102406463B1 (en) * 2019-09-03 2022-06-10 재단법인 오송첨단의료산업진흥재단 High-Throughput Screening Method using Individual Barcoding System for Identifying Optimal Signal Peptides to Enhance the Productivity of Protein
WO2021091611A1 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
US20230002812A1 (en) 2019-11-13 2023-01-05 10X Genomics, Inc. Generating capture probes for spatial analysis
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
WO2021236929A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
EP4247968A1 (en) 2020-11-20 2023-09-27 Becton, Dickinson and Company Use of dextramer in single cell analysis
WO2022162187A1 (en) * 2021-01-28 2022-08-04 Gigavax Aps pMHC MULTIPLEXERS FOR DETECTION OF ANTIGEN-SPECIFIC T CELLS
WO2022162191A2 (en) * 2021-01-28 2022-08-04 Fwd Holding Aps pMHC MULTIPLEXERS BY ADDITION OF MHC2 AND ROLLING CIRCLE PEPTIDE MULTIMER DISPLAY
EP4212653A1 (en) * 2022-01-18 2023-07-19 Universität Potsdam Molecular tagging using position-oriented nucleic acid encryption
WO2023215612A1 (en) 2022-05-06 2023-11-09 10X Genomics, Inc. Analysis of antigen and antigen receptor interactions
WO2023225294A1 (en) * 2022-05-20 2023-11-23 10X Genomics, Inc. Improved major histocompatibility complex molecules

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001158800A (en) * 1999-12-03 2001-06-12 Jsr Corp Avidin particle
CA2396810A1 (en) * 2000-01-24 2001-07-26 Phylos, Inc. Sensitive, multiplexed diagnostic assays for protein analysis
WO2005003394A2 (en) * 2003-06-27 2005-01-13 Nanosphere, Inc. Bio-barcode based detection of target analytes
US7902121B2 (en) * 2001-07-02 2011-03-08 The Board Of Trustees Of The Leland Stanford Junior University MHC-antigen arrays for detection and characterization of immune responses
US20030148335A1 (en) 2001-10-10 2003-08-07 Li Shen Detecting targets by unique identifier nucleotide tags
GB2422834B8 (en) * 2005-02-04 2007-01-04 Proimmune Ltd MHC oligomer and method of making the same
EP2167536A1 (en) 2007-07-03 2010-03-31 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
WO2009077173A2 (en) 2007-12-19 2009-06-25 Philochem Ag Dna-encoded chemical libraries
CN102112626A (en) * 2008-04-09 2011-06-29 加州理工学院 Capture agents and related methods and systems for detecting and/or sorting targets
WO2010037397A1 (en) * 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cmv immune monitoring
US20110318380A1 (en) * 2008-10-01 2011-12-29 Dako Denmark A/S MHC Multimers in Cancer Vaccines and Immune Monitoring
AU2008364464B2 (en) 2008-11-03 2014-09-04 Stichting Het Nederlands Kanker Instituut Detecting antigen responsive cells in a sample
US8735327B2 (en) * 2010-01-07 2014-05-27 Jeansee, Llc Combinatorial DNA taggants and methods of preparation and use thereof
US10023657B2 (en) * 2010-10-01 2018-07-17 Ludwig Institute For Cancer Research Ltd. Reversible protein multimers, methods for their production and use
WO2013137737A1 (en) * 2012-03-16 2013-09-19 Flexgen B.V. Methods of creating and screening of dna encoded combinatorial libraries of chemical antibodies
EP3152232B1 (en) 2014-06-06 2019-11-13 Herlev Hospital Determining antigen recognition through barcoding of mhc multimers
EP3155426B1 (en) * 2014-06-13 2023-07-19 Immudex ApS General detection and isolation of specific cells by binding of labeled molecules
US9789974B2 (en) 2015-10-19 2017-10-17 Goodrich Corporation Brake monitoring system

Also Published As

Publication number Publication date
WO2015185067A9 (en) 2019-06-13
JP2023100746A (en) 2023-07-19
JP7271465B2 (en) 2023-05-11
EP3152232A1 (en) 2017-04-12
AU2015271324A1 (en) 2017-01-12
ES2770634T3 (en) 2020-07-02
CA2951325C (en) 2023-09-12
AU2021204496B2 (en) 2023-07-06
CA3205428A1 (en) 2015-12-10
AU2021204496A1 (en) 2021-07-29
AU2019264685A1 (en) 2019-12-05
SG10202005892SA (en) 2020-07-29
US20170343545A1 (en) 2017-11-30
EP3152232B1 (en) 2019-11-13
EP3628684A1 (en) 2020-04-01
WO2015185067A1 (en) 2015-12-10
JP6956632B2 (en) 2021-11-02
JP2020109114A (en) 2020-07-16
JP2017518375A (en) 2017-07-06
CA2951325A1 (en) 2015-12-10
AU2019264685B2 (en) 2021-04-01
AU2015271324B2 (en) 2019-09-12
PT3152232T (en) 2020-02-19
DK3152232T3 (en) 2020-02-24

Similar Documents

Publication Publication Date Title
SG10202005892SA (en) Determining antigen recognition through barcoding of mhc multimers
HK1217207A1 (en) Anti-c5 antibodies having improved pharmacokinetics -c5
GB2542518B (en) Virtualization of tangible interface objects
SG10201710322VA (en) Anti-c5 antibodies and methods of use
SG11201703498WA (en) Spheroid trap insert
GB201410971D0 (en) Vaccine
IL248399A0 (en) Novel antii-rnf43 antibodies and methods of use
IL273265A (en) Novel combinations for antigen based therapy
PL3185899T3 (en) Improved hvt-vectored nd-ibd vaccine
IL247754A0 (en) Anti-mcam antibodies and associated methods of use
IL250825A0 (en) Novel anti-mfi2 antibodies and methods of use
HK1244445A1 (en) Methods of using anti-ang2 antibodies
IL252972A0 (en) Antigen delivery system
IL247270B (en) Method of detecting cancer
HUE053284T2 (en) Vaccine
GB201417214D0 (en) Vaccine
GB201508154D0 (en) Modified opioids containing silicon
GB201415434D0 (en) Verification of material
GB201413459D0 (en) Identification of objects
FI10753U1 (en) heating Kitt
GB201406628D0 (en) Vaccine
AU2014900433A0 (en) Identification of Epitopes