JP2017518335A - 紅葉した大豆の葉の抽出物を含む組成物 - Google Patents
紅葉した大豆の葉の抽出物を含む組成物 Download PDFInfo
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- JP2017518335A JP2017518335A JP2016573605A JP2016573605A JP2017518335A JP 2017518335 A JP2017518335 A JP 2017518335A JP 2016573605 A JP2016573605 A JP 2016573605A JP 2016573605 A JP2016573605 A JP 2016573605A JP 2017518335 A JP2017518335 A JP 2017518335A
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Abstract
Description
(1)DPPH還元による抗酸化能実験においてIC50が70ppm以下である特性;
(2)コラゲナーゼ生成抑制実験においてコラゲナーゼ発現程度が55%以下である特性。
(1)DPPH還元による抗酸化能実験においてIC50が70ppm以下である特性;
(2)コラゲナーゼ生成抑制実験においてコラゲナーゼ発現程度が60%以下である特性。
(1)DPPH還元による抗酸化能実験においてIC50が、70ppm以下、65ppm以下、60ppm以下、55ppm以下、50ppm以下、48ppm以下、46ppm以下、44ppm以下、42ppm以下、41ppm以下、40ppm以下、38ppm以下、36ppm以下、34ppm以下、30ppm以下、25ppm以下、20ppm以下、15ppm以下、10ppm以下、5ppm以下、または1ppm以下であってよく;
(2)コラゲナーゼ生成抑制実験においてコラゲナーゼ発現程度が、60%以下、58%以下、56%以下、55%以下、54%以下、53%以下、52%以下、51%以下、50%以下、48%以下、46%以下、44%以下、42%以下、40%以下、35%以下、30%以下、20%以下、10%以下、5%以下、または1%以下であってよい。
VE時期:種子を植えてから1〜2週後の状態、土壌から子葉が現れる
VC時期:子葉が展開し、その上に1本の葉節が伸び、外葉が展開する
V1時期:第1の外葉から1本の葉節が生成され、3本の葉が生成される
V2時期:V1時期でさらに1本の葉節が生成され、3本の葉が生成される
V3時期:V2時期でさらに1本の葉節が生成され、3本の葉が生成される
V4時期:V3時期でさらに1本の葉節が生成され、3本の葉が生成される
R2時期:大豆の花が開花した状態
R4時期:さやの生成が完了した状態
R5時期:さや中で大豆が生成されていく状態
R6時期:さや中で緑色の大豆が生成完了した状態
R7時期:さやと大豆が黄色に変わっていく状態
R8時期:葉が落ちながらさやと大豆が完全に黄色に変わった状態
生長時期別(VC/V2/V4/R2/R4/R6/R7時期、計7時期)に採取したそれぞれの大豆の葉を精製水で洗浄し乾燥してから細末化した。前記大豆の葉の粉100gを70質量%のエタノール水溶液1リットルに入れ、室温(25℃)で12時間抽出した後、300メッシュろ過布でろ過した。前記抽出液を3リットルの分液漏斗に入れ、エチルアセテート1リットルを加えた後、振って混ぜ合わせた後、二層に完全に分離されたとき、その上層(エチルアセテート層)を取る。下層(水層)を再び分液漏斗で二回さらに抽出する。それぞれの分離された上層を全て合わせた後、冷却コンデンサ付き蒸留装置を利用して50℃で減圧濃縮し乾燥した。それにより、各段階の大豆の葉の抽出物を10.3g収得した。
前記実施例1で製造したVC/V2/V4/R2/R4/R6/R7段階のそれぞれの大豆の葉の抽出物の抗酸化効果を調べてみるために、フリーラジカル(free radical)であるDPPH(1,1−ジフェニル−2−ピクリルヒドラジル;1,1−diphenyl−2−picryl hydrazyl)の還元によって発生する吸光度の変化によってDPPH酸化抑制効能を比較した。
前記実施例1で製造したVC/V2/V4/R2/R4/R6/R7のそれぞれの段階で得られた大豆の葉の抽出物のコラゲナーゼ(collagenase)生成抑制能をトコフェロール(比較例1)及びEGCG(比較例2)と比較して測定した。トコフェロール及びEGCGは皮膚の表皮細胞を再生させて皮膚の老化を防止する機能があると知られた物質である。
公知の抗老化物質であるレチノールと本発明において有効成分として用いられる紅葉した大豆の葉の抽出物(R7時期の抽出物)の使用性を比較するために、ヒリヒリ感、ひりつき感等の刺激感に敏感なパネル15人を対象にヒリヒリ感、ひりつき感等の刺激感の程度を実験した。
0〜0.4:刺激なし
0.5〜1.0:若干刺激あり
1.1〜2.0:普通程度の刺激あり
2.1〜3.0:刺激が激しい
本発明の一側面に係る紅葉した大豆の葉の抽出物が一般的な大豆の抽出物と構成成分が異なることを確認するために、実施例1中で紅葉した大豆の葉の抽出物(R7時期)と下記の比較例1で収得した大豆の抽出物に対し、HLPC分析実験を行った。
大豆(韓国坡州(パジュ)の長湍大豆、坡州農協から購入)を精製水で洗浄し乾燥してから細末化した。前記大豆の粉100gを70質量%エタノール水溶液1リットルに入れ、室温(25℃)で12時間抽出した後、300メッシュろ過布でろ過した。前記抽出液を3リットルの分液漏斗に入れ、エチルアセテート1リットルを加えた後、振って混ぜ合わせた後、二層に完全に分離されたとき、上層(エチルアセテート層)を取る。下層(水層)を再び分液漏斗で二回さらに抽出する。それぞれの分離された上層を全て合わせた後、冷却コンデンサ付き蒸留装置を利用して50℃で減圧濃縮して乾燥した。それにより、大豆の抽出物を13.4g収得した。
下記の表5に表した組成に従い、通常の方法にて栄養化粧水を製造した。
下記の表6に表した組成に従い、通常の方法にて栄養クリームを製造した。
下記の表7に表した組成に従い、通常の方法にてパックを製造した。
下記の表8に表した組成に従い、通常の方法にて美容液を製造した。
下記の表9に表した組成に従い、通常の方法にて縁故を記載した。
実施例1の紅葉した大豆の葉の抽出物8mg、ビタミンE 9mg、ビタミンC 9mg、パーム油2mg、植物性硬化油8mg、黄蝋4mg、及びレシチン9mgを混合し、通常の方法にて混合して軟質カプセル充填液を製造する。1カプセルあたり400mgずつ充填して、軟質カプセルを製造する。そして、前記とは別途に、ゼラチン66重量部、グリセリン24重量部及びソルビトール液10重量部の比率で軟質カプセルシートを製造し、前記充填液を充填させて、本発明の一側面に係る組成物400mgが含有された軟質カプセルを製造する。
実施例1の紅葉した大豆の葉の抽出物8mg、ビタミンE 9mg、ビタミンC 9mg、ガラクトオリゴ糖200mg、乳糖60mg、及び麦芽糖140mgを混合し、流動層乾燥機を利用して顆粒した後、糖エステル(sugar ester)6mgを添加する。これら組成物500mgを、通常の方法にて打錠して、錠剤を製造する。
実施例1の紅葉した大豆の葉の抽出物8mg、ビタミンE 9mg、ビタミンC 9mg、ブドウ糖10g、クエン酸0.6g、及び液状オリゴ糖25gを混合した後、精製水300mlを加えて、各ボトルに200mlずつとなるように充填する。ボトルに充填した後、130℃で4〜5秒間殺菌してドリンク剤を製造する。
実施例1の紅葉した大豆の葉の抽出物8mg、ビタミンE 9mg、ビタミンC 9mg、無水結晶ブドウ糖250mg、及び澱粉550mgを混合し、流動層造粒機を使用して顆粒に成形した後、包に充填して顆粒剤を製造する。
下記表10に記載された組成に従い、通常的な方法にて注射剤を製造した。
下記の表11に表した組成に従い、通常の方法にて健康機能食品を製造した。
下記の表12に表した組成に従い、通常の方法にて健康飲み物を製造した。
Claims (13)
- 紅葉した大豆の葉の抽出物を有効成分として含む皮膚外用剤組成物。
- 紅葉した大豆の葉の抽出物を有効成分として含む抗酸化用又は抗老化用組成物。
- 紅葉した大豆の葉は、大豆の生育段階のうちのR7〜R8段階の大豆の葉である、請求項1または2に記載の組成物。
- 前記組成物は、組成物の総質量に対して0.001〜20質量%の範囲の紅葉した大豆の葉の抽出物を含む、請求項1または2に記載の組成物。
- 紅葉した大豆の葉の抽出物は、水、有機溶媒、及びこれらの混合物からなる群より選択された一種以上の抽出物である、請求項1または2に記載の組成物。
- 有機溶媒は、C1〜C6の低級アルコール、アセトン、エーテル、エチルアセテート、ジエチルエーテル、エチルメチルケトン、及びクロロホルムからなる群より選択された一種以上である、請求項5に記載の組成物。
- 紅葉した大豆の葉の抽出物は、エタノール及びエチルアセテートで順次抽出した抽出物である、請求項6に記載の組成物。
- 組成物は、DPPH(1,1−diphenyl−2−picryl hydrazyl)の酸化を抑制する、請求項1または2に記載の組成物。
- 組成物は、コラゲナーゼ(collagenase)の発現を抑制する、請求項1または2に記載の組成物。
- 組成物は、薬学又は化粧料組成物である、請求項1または2に記載の組成物。
- 組成物は食品組成物である、請求項2に記載の組成物。
- 紅葉した大豆の葉の抽出物は、紅葉した大豆の葉を水、有機溶媒、またはこれらの混合物で1次抽出する段階;しかる後、1次抽出物に有機溶媒を加えて2次抽出する段階;2次抽出物を減圧濃縮及び乾燥する段階を含む方法によって収得されたものである、請求項1または2に記載の組成物。
- 組成物は、紅葉した大豆の葉の抽出物が下記の特性のうちの一つ以上を有する組成物。
(1)DPPH還元による抗酸化能実験においてIC50が70ppm以下である特性;
(2)コラゲナーゼ生成抑制実験においてコラゲナーゼ発現程度が55%以下である特性。
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KR10-2015-0085091 | 2015-06-16 | ||
PCT/KR2015/006175 WO2015194875A1 (ko) | 2014-06-19 | 2015-06-18 | 단풍콩잎 추출물을 포함하는 조성물 |
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KR20050104567A (ko) * | 2004-04-29 | 2005-11-03 | 정진호 | 트라이테르페노이드 화합물, 이의 제조방법 및 이를포함하는 피부 노화 방지용 조성물 |
JP2006111560A (ja) * | 2004-10-14 | 2006-04-27 | Nippon Menaade Keshohin Kk | セラミド合成促進剤 |
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KR20140033775A (ko) * | 2012-09-10 | 2014-03-19 | (주)아모레퍼시픽 | 콩잎 추출물을 함유하는 항산화용 조성물 |
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- 2015-06-18 US US15/320,012 patent/US20170135948A1/en not_active Abandoned
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KR20050041259A (ko) * | 2003-10-30 | 2005-05-04 | 윤성용 | 천연 화장품 개발을 위한 캘러스의 용도 |
KR20050104567A (ko) * | 2004-04-29 | 2005-11-03 | 정진호 | 트라이테르페노이드 화합물, 이의 제조방법 및 이를포함하는 피부 노화 방지용 조성물 |
JP2006111560A (ja) * | 2004-10-14 | 2006-04-27 | Nippon Menaade Keshohin Kk | セラミド合成促進剤 |
JP2006290742A (ja) * | 2005-04-05 | 2006-10-26 | Kyoei Kagaku Kogyo Kk | 老化防止化粧料 |
KR20140033775A (ko) * | 2012-09-10 | 2014-03-19 | (주)아모레퍼시픽 | 콩잎 추출물을 함유하는 항산화용 조성물 |
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HK1231372A1 (zh) | 2017-12-22 |
JP6636467B2 (ja) | 2020-01-29 |
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