JP2017518266A - 多目的医用撮影用マーカーおよびその製造方法 - Google Patents
多目的医用撮影用マーカーおよびその製造方法 Download PDFInfo
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Classifications
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- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
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Abstract
Description
前記撮影用マーカーに前記のような蛍光染料を用いることにより、標識部位を非侵襲的な方法によって正確に確認し、手術時間を短縮することができるだけでなく、手術で取り除かれる正常組織の範囲を最小限に抑えることができる効果を得ることができる。
ゴム剤配合液の準備
水溶液に天然ゴム(ラテックス)および天然ゴム100重量部に対して、硫黄架橋剤1.5重量部、ジエチルジチオカルバメート(diethyl dithiocarbamate)促進剤0.8重量部、酸化亜鉛0.8重量部、アミン系老化防止剤1.2重量部を混合した、ラテックス配合液を準備した。
<製造例1>
インドシアニングリーン(Indocyanine Green、シグマ−アルドリッチ社から購入、分子量774.9g/mol)1.345mgを100μLジメチルスルホキシド(dimethyl sulfoxide)溶媒に溶かした。
ラテックス水溶液内のインドシアニングリーン濃度が25μMである条件を除いては、製造例1と同様の方法を用いて、蛍光ゴムバンドを製造した。
ラテックス水溶液内のインドシアニングリーン濃度が10μMである条件を除いては、製造例1と同様の方法を用いて、蛍光ゴムバンドを製造した。
ラテックス水溶液内のインドシアニングリーン濃度が5μMの条件を除いては、製造例1と同様の方法を用いて、蛍光ゴムバンドを製造した。
ラテックス水溶液内のインドシアニングリーン濃度が2μMである条件を除いては、製造例1と同様の方法を用いて、蛍光ゴムバンドを製造した。
600nmの波長領域で蛍光を出すATTO647N染料(ATTO−TEC GmbH社から購入)を準備した。
500nm波長領域帯において蛍光信号を出すローダミン(Rhodamine)6G染料 (シグマ - アルドリッチ社から購入)を準備した。
蛍光染料が混合されたラテックス水溶液準備
前記[実施例1]の製造方法で、ラテックス水溶液を準備した。
磁気共鳴画像造影剤である、フェリーデックスI.V.(Feridex、テジュン製薬社から購入、1.2μgFe/mL)とオミスキャン(OMISCAN、Gadodiamide、500mM、GE Healthcareから購入)は、商業用製品自体が水溶液状に分散されているため、これをそのまま用いた。
MRI造影剤であるフェリーデックスI.V.50μLを、前記10μM濃度のインドシアニングリーンが混合されたラテックス水溶液5mLに添加して、ボルテックス(vortexing)した。
MRI造影剤であるフェリーデックスI.V.250μLを用いたことを除いては、製造例8と同様の方法で、フェリーデックスが533μgFe/mL配合液の濃度で溶けている溶液を準備した。
MRI造影剤として、オミスキャン(ガドジアミド(Gadodiamide)50μLを用いたことを除いては、製造例8と同様の方法でガドジアミドが、5mM Gd濃度で溶けている溶液を準備した。
MRI造影剤として、オミスキャン(ガドジアミド(Gadodiamide))250μLを用いたことを除いては、製造例8と同様の方法でガドジアミドが24mM Gd濃度で溶けている溶液を準備した。
蛍光染料が混合されたラテックス水溶液の準備
前記[実施例1]の製造方法で、ラテックス水溶液を準備した。
<製造例12>
CT造影剤として、ヨウ素を含有している試薬であるローズベンガル(Rose Bengal)を準備した。
図7および図8には、前記製造例1および製造例12のCT画像の写真が示されている。具体的には、製造例1および製造例12で製造された蛍光ゴムバンドをプラスチックチューブに入れ、CTを撮影した画像である。
Claims (12)
- ゴム剤および蛍光染料を含む多目的医用撮影用マーカー。
- 前記ゴム剤はゴム(rubber)、ラテックスが含まれていないゴム(latex−free rubber、NFR)、ネオプレン(Neoprene)、天然ラテックス、合成ラテックスのいずれかである請求項1に記載の多目的医用撮影用マーカー。
- 前記蛍光染料は、インドシアニングリーン(Indocyanine green)、ローズベンガル(Rose Bengal)、ATTO系染料、アレクサ(Alexa)系染料、ローダミン(Rhodamine)、フルオレセイン(Fluorescein)、クマリン(Cumarin)、ナフタルイミド(Naphthalimide)、ベンゾキサンテン(Benzoxanthen)およびアクリジン(Acridine)のうち、一種以上を含む請求項1に記載の多目的医用撮影用マーカー。
- MRI(磁気共鳴画像)造影剤をさらに含む、請求項1ないし3のいずれか一項に記載の多目的医用撮影用マーカー。
- 前記MRI(磁気共鳴画像)造影剤は、ガドリニウム錯化合物、マンガン錯化合物または酸化鉄ナノ粒子からなる、請求項4に記載の多目的医用撮影用マーカー。
- CT(コンピュータ断層撮影)造影剤をさらに含む、 請求項1ないし3のいずれか一項に記載の多目的医用撮影用マーカー。
- 前記CT(コンピュータ断層撮影)造影剤は、金属またはヨウ素(Iodine)が含まれた化合物またはナノ粒子からなる、請求項6に記載の多目的医用撮影用マーカー。
- ゴム剤配合液を提供する段階;
前記ゴム剤配合液に蛍光染料を混合する段階;および
前記混合物を成形して乾燥させる段階を含む、多目的医用撮影用マーカーの製造方法。 - 前記ゴム剤配合液は、ゴム剤、架橋剤、促進剤、活性剤、老化防止剤を含む、請求項8に記載の多目的医用撮影用マーカーの製造方法。
- 前記ゴム剤配合液において、前記架橋剤は、硫黄架橋剤;
前記促進剤は、スルフィド系、スルフェンアミド系およびカルバメート系のうち、一種以上を含む促進剤;
前記活性剤は、酸化亜鉛、ステアリン酸のうち、一種以上を含む活性剤;および
前記老化防止剤は、アミン系、イミダゾールおよびクイノン系のうち、一種以上を含む老化防止剤である、請求項9に記載の多目的医用撮影用マーカーの製造方法。 - 前記ゴム剤配合液において、ゴム剤100重量部に対して、硫黄架橋剤1.0ないし2.0重量部、カルバメート系促進剤0.5ないし1.0重量部、酸化亜鉛0.5ないし1.0重量部、アミン系老化防止剤0.8ないし1.6重量部を含む、請求項10に記載の多目的医用撮影用マーカーの製造方法。
- ゴム剤および蛍光染料を含む多目的医用撮影用マーカー;および
結紮組立体を含む、内視鏡用バンド結紮具。
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