JP2017516838A5 - - Google Patents

Info

Publication number

JP2017516838A5

JP2017516838A5 JP2016575290A JP2016575290A JP2017516838A5 JP 2017516838 A5 JP2017516838 A5 JP 2017516838A5 JP 2016575290 A JP2016575290 A JP 2016575290A JP 2016575290 A JP2016575290 A JP 2016575290A JP 2017516838 A5 JP2017516838 A5 JP 2017516838A5

Authority

JP

Japan

Prior art keywords

compound

salt

formula

composition

polypeptide

Prior art date

2015-03-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 26
• 150000003839 salts Chemical class 0.000 claims 17
• 238000000034 method Methods 0.000 claims 9
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
• 239000012620 biological material Substances 0.000 claims 3
• 229920001184 polypeptide Polymers 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• 102000004506 Blood Proteins Human genes 0.000 claims 2
• 108010017384 Blood Proteins Proteins 0.000 claims 2
• 108090000790 Enzymes Proteins 0.000 claims 2
• 102000004190 Enzymes Human genes 0.000 claims 2
• 102000004877 Insulin Human genes 0.000 claims 2
• 108090001061 Insulin Proteins 0.000 claims 2
• 102000013460 Malate Dehydrogenase Human genes 0.000 claims 2
• 108010026217 Malate Dehydrogenase Proteins 0.000 claims 2
• 108010059724 Micrococcal Nuclease Proteins 0.000 claims 2
• 102000016943 Muramidase Human genes 0.000 claims 2
• 108010014251 Muramidase Proteins 0.000 claims 2
• 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 2
• -1 antibody Proteins 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 229940088598 enzyme Drugs 0.000 claims 2
• 229940088597 hormone Drugs 0.000 claims 2
• 239000005556 hormone Substances 0.000 claims 2
• 229940125396 insulin Drugs 0.000 claims 2
• 229960000274 lysozyme Drugs 0.000 claims 2
• 235000010335 lysozyme Nutrition 0.000 claims 2
• 239000004325 lysozyme Substances 0.000 claims 2
• 239000000126 substance Substances 0.000 claims 2
• 238000001035 drying Methods 0.000 claims 1
• 230000000087 stabilizing effect Effects 0.000 claims 1
• 0 *C(C(*)OC(CO)C1O)C1O Chemical compound *C(C(*)OC(CO)C1O)C1O 0.000 description 6
• IBCLFTZLTSNOCK-FIZLLRJRSA-N CC(CC(O)=O)O[C@H](C1C2O)O[O]1C(CN)[C@H]2O Chemical compound CC(CC(O)=O)O[C@H](C1C2O)O[O]1C(CN)[C@H]2O IBCLFTZLTSNOCK-FIZLLRJRSA-N 0.000 description 1
• RKJBLGRZNLZBHK-RXMQYKEDSA-N CC[O]([C@H](CN)O)=C Chemical compound CC[O]([C@H](CN)O)=C RKJBLGRZNLZBHK-RXMQYKEDSA-N 0.000 description 1
• LTQIONUUDMTTOJ-NPYQJARQSA-N NC(C1O)[C@@H](O[C@@H](CO)C(O)=O)OC(CO)[C@H]1O Chemical compound NC(C1O)[C@@H](O[C@@H](CO)C(O)=O)OC(CO)[C@H]1O LTQIONUUDMTTOJ-NPYQJARQSA-N 0.000 description 1
• DOGRTOSKFWKTKZ-BJULKVSLSA-N OCC([C@H](C(C12)O)O)[O]1O[C@@H]2O[C@@H](CC(O)=O)C(O)=O Chemical compound OCC([C@H](C(C12)O)O)[O]1O[C@@H]2O[C@@H](CC(O)=O)C(O)=O DOGRTOSKFWKTKZ-BJULKVSLSA-N 0.000 description 1