CN106573952A - 己糖衍生物及其制剂和用途 - Google Patents

己糖衍生物及其制剂和用途 Download PDF

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Publication number
CN106573952A
CN106573952A CN201580014386.4A CN201580014386A CN106573952A CN 106573952 A CN106573952 A CN 106573952A CN 201580014386 A CN201580014386 A CN 201580014386A CN 106573952 A CN106573952 A CN 106573952A
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CN
China
Prior art keywords
compound
salt
experiment
mmol
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580014386.4A
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English (en)
Chinese (zh)
Inventor
克里斯多夫·大卫·梅考克
玛利亚·丽塔·曼德斯·波尔达罗·范图拉·森特诺·利马
伊娃·科雷亚·洛伦索
玛利亚·海伦娜·迪亚斯·多斯·桑托斯
阿纳·索菲亚·达·库尼亚·米格尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instituto De Tecnologia Quimica Biologica Antonio Xavier E
Universidade de Lisboa
Original Assignee
Instituto De Tecnologia Quimica Biologica Antonio Xavier E
Universidade de Lisboa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto De Tecnologia Quimica Biologica Antonio Xavier E, Universidade de Lisboa filed Critical Instituto De Tecnologia Quimica Biologica Antonio Xavier E
Priority to CN202211044372.5A priority Critical patent/CN115448964A/zh
Publication of CN106573952A publication Critical patent/CN106573952A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Saccharide Compounds (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580014386.4A 2014-03-14 2015-03-13 己糖衍生物及其制剂和用途 Pending CN106573952A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211044372.5A CN115448964A (zh) 2014-03-14 2015-03-13 己糖衍生物及其制剂和用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461953392P 2014-03-14 2014-03-14
US61/953,392 2014-03-14
PCT/PT2015/050001 WO2015137838A1 (en) 2014-03-14 2015-03-13 Hexose derivatives, preparation and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202211044372.5A Division CN115448964A (zh) 2014-03-14 2015-03-13 己糖衍生物及其制剂和用途

Publications (1)

Publication Number Publication Date
CN106573952A true CN106573952A (zh) 2017-04-19

Family

ID=53264710

Family Applications (2)

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CN201580014386.4A Pending CN106573952A (zh) 2014-03-14 2015-03-13 己糖衍生物及其制剂和用途
CN202211044372.5A Pending CN115448964A (zh) 2014-03-14 2015-03-13 己糖衍生物及其制剂和用途

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Country Status (12)

Country Link
US (2) US11708387B2 (https=)
EP (1) EP3116886A1 (https=)
JP (2) JP7067867B2 (https=)
KR (3) KR102651029B1 (https=)
CN (2) CN106573952A (https=)
BR (1) BR112016021231B1 (https=)
CA (1) CA2942635C (https=)
IL (1) IL247531B (https=)
MX (1) MX386787B (https=)
RU (1) RU2731563C2 (https=)
SG (2) SG10201807891UA (https=)
WO (1) WO2015137838A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111683957A (zh) * 2017-11-13 2020-09-18 埃克斯特雷莫凯姆有限公司 作为用于生物分子的稳定剂的中性糖基化酰胺和双阴离子葡萄糖醛酸化的酸

Families Citing this family (3)

* Cited by examiner, † Cited by third party
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KR102651029B1 (ko) * 2014-03-14 2024-03-25 파쿠우다지 지 씨엔씨아스 다 우니베르시다지 지 리스보아 헥소스 유도체, 그의 제제 및 용도
FR3061013B1 (fr) * 2016-12-22 2020-04-17 Greenpharma Composition contenant le digeneaside, son procede d'obtention et son utilisation cosmetique, veterinaire ou nutraceutique
CN116251110B (zh) * 2022-11-18 2025-02-14 广东药科大学 β-D-吡喃葡萄糖基-乳酸及其衍生物在制备治疗代谢性疾病、炎症药物中的应用

Citations (2)

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WO2007097652A2 (en) * 2006-02-24 2007-08-30 STAB VIDA, Investigação e Serviços em Ciências Biológicas, Lda Synthetic mannosylglycerate derivatives for the stabilisation and preservation of biomaterials
US20130143787A1 (en) * 2010-07-27 2013-06-06 Henkel Ag & Co. Kgaa Stabilized liquid enzyme-containing surfactant preparation

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US20060099567A1 (en) * 2004-04-08 2006-05-11 Biomatrica, Inc. Integration of sample storage and sample management for life science
DE102004031588A1 (de) * 2004-06-30 2006-02-09 Symrise Gmbh & Co. Kg Verwendung von Äpfelsäureglucosiden als Geschmacksstoffe
PT103441A (pt) 2006-02-24 2007-08-24 Stab Vida Investigacao E Servi Utilização de solutos compatíveis para melhorar o desempenho de técnicas utilizando materiais biológicos imobilizados
DE102011118027A1 (de) * 2011-09-12 2013-03-14 Henkel Ag & Co. Kgaa Verfahren zur Anpassung eines Hydrolytischen Enzyms an eine das hydrolytische Enzym stabilisierende Komponente
KR102651029B1 (ko) 2014-03-14 2024-03-25 파쿠우다지 지 씨엔씨아스 다 우니베르시다지 지 리스보아 헥소스 유도체, 그의 제제 및 용도
JP2020097767A (ja) 2018-12-18 2020-06-25 株式会社東芝 表面処理剤、これを用いた積層体、及び無電解めっき製品

Patent Citations (2)

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WO2007097652A2 (en) * 2006-02-24 2007-08-30 STAB VIDA, Investigação e Serviços em Ciências Biológicas, Lda Synthetic mannosylglycerate derivatives for the stabilisation and preservation of biomaterials
US20130143787A1 (en) * 2010-07-27 2013-06-06 Henkel Ag & Co. Kgaa Stabilized liquid enzyme-containing surfactant preparation

Non-Patent Citations (13)

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AHMED I. KHODAIR，等: "A Convenient Route to O-Glycosyl Lactates via Conjugate Addition to 2-Nitroglycals: Ring Closure to Novel Pyrano[2.3-b][1,4]-oxazines", 《SYNTHESIS》 *
ARKADIUSZ LISTKOWSKI，等: "Carboxymethylglycoside lactones (CMGLs): structural variations on the carbohydrate moiety", 《TETRAHEDRON: ASYMMETRY》 *
CARLOS A. STORTZ，等: "Polysaccharides from Peptostreptococcus anaerobius and structure of the species-specific antigen", 《CARBOHYDRATE RESEARCH》 *
KATSUHIKO SUZUKI，等: "Synthesis of 3‐O‐β‐D‐Glucopyranosyl‐(3R)‐hydroxybutanolide (Kinsenoside) and 3‐O‐β‐D‐Glucopyranosyl‐(3S)‐hydroxybutanolide (Goodyeroside A)", 《JOURNAL OF CARBOHYDRATE CHEMISTRY》 *
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NINA ROTZOLL，等: "Activity-Guided Identification of (S)-Malic Acid 1-O-D-Glucopyranoside (Morelid) and γ-Aminobutyric Acid as Contributors to Umami Taste and Mouth-Drying Oral Sensation of Morel Mushrooms (Morchella deliciosa Fr.)", 《J. AGRIC. FOOD CHEM.》 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111683957A (zh) * 2017-11-13 2020-09-18 埃克斯特雷莫凯姆有限公司 作为用于生物分子的稳定剂的中性糖基化酰胺和双阴离子葡萄糖醛酸化的酸

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Publication number Publication date
SG11201607530XA (en) 2016-10-28
BR112016021231B1 (pt) 2021-07-27
KR102401853B1 (ko) 2022-05-25
US12590117B2 (en) 2026-03-31
JP7077361B2 (ja) 2022-05-30
US20230357301A1 (en) 2023-11-09
IL247531A0 (en) 2016-11-30
CA2942635A1 (en) 2015-09-17
KR20220153571A (ko) 2022-11-18
KR20240045328A (ko) 2024-04-05
JP2017516838A (ja) 2017-06-22
SG10201807891UA (en) 2018-10-30
EP3116886A1 (en) 2017-01-18
MX386787B (es) 2025-03-19
US20180170955A1 (en) 2018-06-21
IL247531B (en) 2021-04-29
JP2020183383A (ja) 2020-11-12
CA2942635C (en) 2022-12-06
RU2016140337A3 (https=) 2018-10-30
KR20160145584A (ko) 2016-12-20
BR112016021231A2 (en) 2018-07-10
KR102651029B1 (ko) 2024-03-25
CN115448964A (zh) 2022-12-09
US11708387B2 (en) 2023-07-25
KR102828884B1 (ko) 2025-07-02
JP7067867B2 (ja) 2022-05-16
MX2016011808A (es) 2017-05-09
RU2016140337A (ru) 2018-04-17
RU2731563C2 (ru) 2020-09-04
WO2015137838A1 (en) 2015-09-17

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