CA2942635C - Hexose derivatives, preparation and uses thereof - Google Patents

Hexose derivatives, preparation and uses thereof Download PDF

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Publication number
CA2942635C
CA2942635C CA2942635A CA2942635A CA2942635C CA 2942635 C CA2942635 C CA 2942635C CA 2942635 A CA2942635 A CA 2942635A CA 2942635 A CA2942635 A CA 2942635A CA 2942635 C CA2942635 C CA 2942635C
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Canada
Prior art keywords
cooh
compound
salt
use according
date received
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Active
Application number
CA2942635A
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English (en)
French (fr)
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CA2942635A1 (en
Inventor
Christopher DAVID MAYCOCK
Maria Rita Mendes Bordalo Ventura Centeno Lima
Eva Correia Lourenco
Maria Helena Dias Dos Santos
Ana Sofia DA CUNHA MIGUEL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instituto De Tecnologia Quimica E Biologica Antonio Xavier
Universidade de Lisboa
Original Assignee
Instituto De Tecnologia Quimica E Biologica Antonio Xavier
Universidade de Lisboa
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Application filed by Instituto De Tecnologia Quimica E Biologica Antonio Xavier, Universidade de Lisboa filed Critical Instituto De Tecnologia Quimica E Biologica Antonio Xavier
Publication of CA2942635A1 publication Critical patent/CA2942635A1/en
Application granted granted Critical
Publication of CA2942635C publication Critical patent/CA2942635C/en
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Saccharide Compounds (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2942635A 2014-03-14 2015-03-13 Hexose derivatives, preparation and uses thereof Active CA2942635C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461953392P 2014-03-14 2014-03-14
US61/953,392 2014-03-14
PCT/PT2015/050001 WO2015137838A1 (en) 2014-03-14 2015-03-13 Hexose derivatives, preparation and uses thereof

Publications (2)

Publication Number Publication Date
CA2942635A1 CA2942635A1 (en) 2015-09-17
CA2942635C true CA2942635C (en) 2022-12-06

Family

ID=53264710

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2942635A Active CA2942635C (en) 2014-03-14 2015-03-13 Hexose derivatives, preparation and uses thereof

Country Status (12)

Country Link
US (2) US11708387B2 (https=)
EP (1) EP3116886A1 (https=)
JP (2) JP7067867B2 (https=)
KR (3) KR102651029B1 (https=)
CN (2) CN106573952A (https=)
BR (1) BR112016021231B1 (https=)
CA (1) CA2942635C (https=)
IL (1) IL247531B (https=)
MX (1) MX386787B (https=)
RU (1) RU2731563C2 (https=)
SG (2) SG10201807891UA (https=)
WO (1) WO2015137838A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102651029B1 (ko) * 2014-03-14 2024-03-25 파쿠우다지 지 씨엔씨아스 다 우니베르시다지 지 리스보아 헥소스 유도체, 그의 제제 및 용도
FR3061013B1 (fr) * 2016-12-22 2020-04-17 Greenpharma Composition contenant le digeneaside, son procede d'obtention et son utilisation cosmetique, veterinaire ou nutraceutique
US12098162B2 (en) * 2017-11-13 2024-09-24 Extremochem, Lda Neutral glycosylated amides and dianionic glucuronidated acids as stabilizers for biological molecules
CN116251110B (zh) * 2022-11-18 2025-02-14 广东药科大学 β-D-吡喃葡萄糖基-乳酸及其衍生物在制备治疗代谢性疾病、炎症药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060099567A1 (en) * 2004-04-08 2006-05-11 Biomatrica, Inc. Integration of sample storage and sample management for life science
DE102004031588A1 (de) * 2004-06-30 2006-02-09 Symrise Gmbh & Co. Kg Verwendung von Äpfelsäureglucosiden als Geschmacksstoffe
PT103442A (pt) * 2006-02-24 2007-08-31 Stab Vida Investigacao E Servi Derivados sintéticos de manosil-glicerato para a estabilização e/ou preservação de biomateriais
PT103441A (pt) 2006-02-24 2007-08-24 Stab Vida Investigacao E Servi Utilização de solutos compatíveis para melhorar o desempenho de técnicas utilizando materiais biológicos imobilizados
DE102010038496A1 (de) 2010-07-27 2012-02-02 Henkel Ag & Co. Kgaa Stabilisierte flüssige enzymhaltige Tensidzubereitung
DE102011118027A1 (de) * 2011-09-12 2013-03-14 Henkel Ag & Co. Kgaa Verfahren zur Anpassung eines Hydrolytischen Enzyms an eine das hydrolytische Enzym stabilisierende Komponente
KR102651029B1 (ko) 2014-03-14 2024-03-25 파쿠우다지 지 씨엔씨아스 다 우니베르시다지 지 리스보아 헥소스 유도체, 그의 제제 및 용도
JP2020097767A (ja) 2018-12-18 2020-06-25 株式会社東芝 表面処理剤、これを用いた積層体、及び無電解めっき製品

Also Published As

Publication number Publication date
SG11201607530XA (en) 2016-10-28
BR112016021231B1 (pt) 2021-07-27
KR102401853B1 (ko) 2022-05-25
US12590117B2 (en) 2026-03-31
JP7077361B2 (ja) 2022-05-30
US20230357301A1 (en) 2023-11-09
IL247531A0 (en) 2016-11-30
CA2942635A1 (en) 2015-09-17
KR20220153571A (ko) 2022-11-18
KR20240045328A (ko) 2024-04-05
JP2017516838A (ja) 2017-06-22
SG10201807891UA (en) 2018-10-30
EP3116886A1 (en) 2017-01-18
MX386787B (es) 2025-03-19
US20180170955A1 (en) 2018-06-21
IL247531B (en) 2021-04-29
JP2020183383A (ja) 2020-11-12
RU2016140337A3 (https=) 2018-10-30
CN106573952A (zh) 2017-04-19
KR20160145584A (ko) 2016-12-20
BR112016021231A2 (en) 2018-07-10
KR102651029B1 (ko) 2024-03-25
CN115448964A (zh) 2022-12-09
US11708387B2 (en) 2023-07-25
KR102828884B1 (ko) 2025-07-02
JP7067867B2 (ja) 2022-05-16
MX2016011808A (es) 2017-05-09
RU2016140337A (ru) 2018-04-17
RU2731563C2 (ru) 2020-09-04
WO2015137838A1 (en) 2015-09-17

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