JP2017516828A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017516828A5 JP2017516828A5 JP2016571118A JP2016571118A JP2017516828A5 JP 2017516828 A5 JP2017516828 A5 JP 2017516828A5 JP 2016571118 A JP2016571118 A JP 2016571118A JP 2016571118 A JP2016571118 A JP 2016571118A JP 2017516828 A5 JP2017516828 A5 JP 2017516828A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pharmaceutically acceptable
- acceptable salt
- dione
- quinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14170974.1 | 2014-06-03 | ||
| EP14170974 | 2014-06-03 | ||
| PCT/IB2015/054173 WO2015186062A1 (en) | 2014-06-03 | 2015-06-02 | PYRIMIDO[4,5-b]QUINOLINE-4,5(3H,10H)-DIONE DERIVATIVES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017516828A JP2017516828A (ja) | 2017-06-22 |
| JP2017516828A5 true JP2017516828A5 (enExample) | 2018-06-28 |
| JP6560257B2 JP6560257B2 (ja) | 2019-08-14 |
Family
ID=50841688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016571118A Expired - Fee Related JP6560257B2 (ja) | 2014-06-03 | 2015-06-02 | ピリミド［４，５−ｂ］キノリン−４，５（３Ｈ，１０Ｈ）−ジオン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9896448B2 (enExample) |
| EP (1) | EP3152208B1 (enExample) |
| JP (1) | JP6560257B2 (enExample) |
| CN (1) | CN106459041B (enExample) |
| ES (1) | ES2743184T3 (enExample) |
| WO (1) | WO2015186062A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI688565B (zh) | 2014-06-03 | 2020-03-21 | 瑞士商諾華公司 | 萘啶二酮（ｎａｐｈｔｈｙｒｉｄｉｎｅｄｉｏｎｅ）衍生物 |
| ES2743183T3 (es) | 2014-06-03 | 2020-02-18 | Novartis Ag | Derivados de piridopirimidinodiona como supresores de mutaciones finalizadoras |
| WO2019225625A1 (ja) * | 2018-05-23 | 2019-11-28 | 京都薬品工業株式会社 | リードスルー誘導剤およびその医薬用途 |
| WO2024194607A1 (en) * | 2023-03-17 | 2024-09-26 | Tay Therapeutics Limited | Pyrimido[4,5-b][1,5]naphthyridine-4,5(3h,10h)-dione derivatives for the treatment of diseases associated with ptc mutations, such as e.g. cancer |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2884170B2 (ja) | 1989-08-24 | 1999-04-19 | 株式会社フジモト・ブラザーズ | ５−デアザフラビン系化合物を有効成分とする制癌剤 |
| JP2989871B2 (ja) | 1989-08-30 | 1999-12-13 | 大日本製薬株式会社 | 三環式化合物 |
| JP2991382B2 (ja) * | 1990-07-18 | 1999-12-20 | 大日本製薬株式会社 | 縮合三環式化合物およびその塩 |
| WO1996028444A1 (en) | 1995-03-15 | 1996-09-19 | Pfizer Inc. | 5,10-DIHYDROPYRIMIDO[4,5-b]QUINOLIN-4(1H)-ONE TYROSINE KINASE INHIBITORS |
| US6037345A (en) * | 1998-01-13 | 2000-03-14 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to quinazolinedione and pyridopyrimidinedione derivatives |
| US6468990B1 (en) * | 1999-05-17 | 2002-10-22 | Queen's University At Kingston | Method of inhibiting binding of nerve growth factor to p75 NTR receptor |
| WO2004006906A2 (en) | 2002-07-15 | 2004-01-22 | Combinatorx, Incorporated | Methods for the treatment of neoplasms |
| BR0317183A (pt) * | 2002-12-12 | 2005-11-01 | Pharmacia Corp | Método de usar compostos de aminocianopiridina como inibidores de proteìna quinase-2 ativada por proteìna quinase ativada por mitógeno |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| DK3549936T3 (da) | 2003-04-11 | 2021-07-12 | Ptc Therapeutics Inc | 1,2,4-oxadiazol-benzoesyreforbindelse og dens anvendelse til nonsense-undertrykkelse og behandlingen af sygdom |
| EP3421481A1 (en) | 2006-04-03 | 2019-01-02 | Technion Research and Development Foundation Ltd. | Novel aminoglycosides and uses thereof in the treatment of genetic disorders |
| EP2061470A4 (en) | 2006-08-23 | 2010-10-06 | Neurogen Corp | HALOALKYL-SUBSTITUTED PYRIMIDINONE DERIVATIVES |
| WO2008084236A1 (en) * | 2007-01-11 | 2008-07-17 | Astrazeneca Ab | Chemical compounds 635 : pyridopyrimidinediones as pde4 inhibitors |
| CA2709784A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| EP2422817A1 (en) | 2010-07-29 | 2012-02-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Flavin-nucleic acid ligand conjugates |
| CN103189060A (zh) * | 2010-08-05 | 2013-07-03 | 里尔法律与医疗卫生第二大学 | 用于对无义突变介导的疾病进行治疗的化合物和含有所述化合物的药物组合物 |
| HK1209637A1 (en) | 2012-12-13 | 2016-04-08 | Novartis Ag | Pyrimido [4,5-b]quinoline-4,5 (3h,10h)-diones as nonsense mutation suppressors |
| ES2743183T3 (es) | 2014-06-03 | 2020-02-18 | Novartis Ag | Derivados de piridopirimidinodiona como supresores de mutaciones finalizadoras |
| TWI688565B (zh) | 2014-06-03 | 2020-03-21 | 瑞士商諾華公司 | 萘啶二酮（ｎａｐｈｔｈｙｒｉｄｉｎｅｄｉｏｎｅ）衍生物 |
-
2015
- 2015-06-02 CN CN201580028771.4A patent/CN106459041B/zh not_active Expired - Fee Related
- 2015-06-02 JP JP2016571118A patent/JP6560257B2/ja not_active Expired - Fee Related
- 2015-06-02 ES ES15731120T patent/ES2743184T3/es active Active
- 2015-06-02 US US15/315,582 patent/US9896448B2/en active Active
- 2015-06-02 EP EP15731120.0A patent/EP3152208B1/en not_active Not-in-force
- 2015-06-02 WO PCT/IB2015/054173 patent/WO2015186062A1/en not_active Ceased