JP2017516829A5 - - Google Patents
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- Publication number
- JP2017516829A5 JP2017516829A5 JP2016571131A JP2016571131A JP2017516829A5 JP 2017516829 A5 JP2017516829 A5 JP 2017516829A5 JP 2016571131 A JP2016571131 A JP 2016571131A JP 2016571131 A JP2016571131 A JP 2016571131A JP 2017516829 A5 JP2017516829 A5 JP 2017516829A5
- Authority
- JP
- Japan
- Prior art keywords
- dione
- pyrimidine
- pyrido
- phenylthieno
- isopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims description 39
- 150000001875 compounds Chemical class 0.000 claims description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims description 20
- 239000001257 hydrogen Substances 0.000 claims description 20
- 150000003839 salts Chemical group 0.000 claims description 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
- 229910052736 halogen Inorganic materials 0.000 claims description 10
- 150000002367 halogens Chemical class 0.000 claims description 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 10
- 125000002950 monocyclic group Chemical group 0.000 claims description 9
- 125000003545 alkoxy group Chemical group 0.000 claims description 7
- 150000002431 hydrogen Chemical class 0.000 claims description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 5
- OKPPXCKNJHABDU-UHFFFAOYSA-N 2,5-dimethyl-11-phenyl-12-propan-2-yl-4-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),5,12-tetraene-8,10-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)N(C1=C(C2=O)C=C(S1)C)C)=O)C1=CC=CC=C1 OKPPXCKNJHABDU-UHFFFAOYSA-N 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 108020004485 Nonsense Codon Proteins 0.000 claims description 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 230000037430 deletion Effects 0.000 claims description 4
- 238000012217 deletion Methods 0.000 claims description 4
- 230000037434 nonsense mutation Effects 0.000 claims description 4
- 125000001188 haloalkyl group Chemical group 0.000 claims description 3
- VEAUFVIFKZQCNX-UHFFFAOYSA-N 10-methyl-3-phenyl-2-propan-2-yl-6,7,8,9-tetrahydropyrimido[4,5-b]quinoline-4,5-dione Chemical compound C(C)(C)C=1N(C(C2=C(N(C=3CCCCC=3C2=O)C)N=1)=O)C1=CC=CC=C1 VEAUFVIFKZQCNX-UHFFFAOYSA-N 0.000 claims description 2
- HJPHKFDUTBMINF-UHFFFAOYSA-N 11-phenyl-12-propan-2-yl-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),12-triene-8,10-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)NC1=C(C2=O)CCC1)=O)C1=CC=CC=C1 HJPHKFDUTBMINF-UHFFFAOYSA-N 0.000 claims description 2
- XILDPXYZLZHTMC-UHFFFAOYSA-N 11-phenyl-12-propan-2-yl-4-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),5,12-tetraene-8,10-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)NC1=C(C2=O)C=CS1)=O)C1=CC=CC=C1 XILDPXYZLZHTMC-UHFFFAOYSA-N 0.000 claims description 2
- WDBZIUPFMXGHJM-UHFFFAOYSA-N 11-phenyl-12-propan-2-yl-5-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3,6,12-tetraene-8,10-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)NC=1C(C2=O)=CSC=1)=O)C1=CC=CC=C1 WDBZIUPFMXGHJM-UHFFFAOYSA-N 0.000 claims description 2
- AGKFBAYQGSTIID-UHFFFAOYSA-N 11-phenyl-12-propan-2-yl-6-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),4,12-tetraene-8,10-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)NC1=C(C2=O)SC=C1)=O)C1=CC=CC=C1 AGKFBAYQGSTIID-UHFFFAOYSA-N 0.000 claims description 2
- YBQGUOBNWHWVJI-UHFFFAOYSA-N 12-cyclobutyl-2,4-dimethyl-11-phenyl-5-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3,6,12-tetraene-8,10-dione Chemical compound C1(CCC1)C=1N(C(C2=C(N=1)N(C=1C(C2=O)=CSC=1C)C)=O)C1=CC=CC=C1 YBQGUOBNWHWVJI-UHFFFAOYSA-N 0.000 claims description 2
- DXYFWHDSFAJTTF-UHFFFAOYSA-N 12-cyclobutyl-2,4-dimethyl-11-phenyl-6-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),4,12-tetraene-8,10-dione Chemical compound C1(CCC1)C=1N(C(C2=C(N=1)N(C1=C(C2=O)SC=C1C)C)=O)C1=CC=CC=C1 DXYFWHDSFAJTTF-UHFFFAOYSA-N 0.000 claims description 2
- VSPQZWBKQCNOGK-UHFFFAOYSA-N 12-cyclobutyl-2,5-dimethyl-11-phenyl-4-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),5,12-tetraene-8,10-dione Chemical compound C1(CCC1)C=1N(C(C2=C(N=1)N(C1=C(C2=O)C=C(S1)C)C)=O)C1=CC=CC=C1 VSPQZWBKQCNOGK-UHFFFAOYSA-N 0.000 claims description 2
- IOWPFPFNTQWQBY-UHFFFAOYSA-N 12-cyclobutyl-2,5-dimethyl-11-phenyl-6-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),4,12-tetraene-8,10-dione Chemical compound C1(CCC1)C=1N(C(C2=C(N=1)N(C1=C(C2=O)SC(=C1)C)C)=O)C1=CC=CC=C1 IOWPFPFNTQWQBY-UHFFFAOYSA-N 0.000 claims description 2
- NOHPOMLLRKGRSK-UHFFFAOYSA-N 12-cyclobutyl-2,6-dimethyl-11-phenyl-4-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),5,12-tetraene-8,10-dione Chemical compound C1(CCC1)C=1N(C(C2=C(N=1)N(C1=C(C2=O)C(=CS1)C)C)=O)C1=CC=CC=C1 NOHPOMLLRKGRSK-UHFFFAOYSA-N 0.000 claims description 2
- CCVKBYAPFKAVTK-UHFFFAOYSA-N 12-cyclobutyl-2-methyl-11-phenyl-4-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),5,12-tetraene-8,10-dione Chemical compound C1(CCC1)C=1N(C(C2=C(N=1)N(C1=C(C2=O)C=CS1)C)=O)C1=CC=CC=C1 CCVKBYAPFKAVTK-UHFFFAOYSA-N 0.000 claims description 2
- GJTCNYAMWLXADN-UHFFFAOYSA-N 12-cyclobutyl-2-methyl-11-phenyl-6-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),4,12-tetraene-8,10-dione Chemical compound C1(CCC1)C=1N(C(C2=C(N=1)N(C1=C(C2=O)SC=C1)C)=O)C1=CC=CC=C1 GJTCNYAMWLXADN-UHFFFAOYSA-N 0.000 claims description 2
- MYINEFNHYPRBPG-UHFFFAOYSA-N 12-cyclobutyl-5-ethyl-2-methyl-11-phenyl-4-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),5,12-tetraene-8,10-dione Chemical compound C1(CCC1)C=1N(C(C2=C(N=1)N(C1=C(C2=O)C=C(S1)CC)C)=O)C1=CC=CC=C1 MYINEFNHYPRBPG-UHFFFAOYSA-N 0.000 claims description 2
- VDPZXJAHMSEMJQ-UHFFFAOYSA-N 12-cyclobutyl-5-methyl-11-phenyl-4-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),5,12-tetraene-8,10-dione Chemical compound C1(CCC1)C=1N(C(C2=C(N=1)NC1=C(C2=O)C=C(S1)C)=O)C1=CC=CC=C1 VDPZXJAHMSEMJQ-UHFFFAOYSA-N 0.000 claims description 2
- IKQHMHUYUWRWBW-UHFFFAOYSA-N 2,4-dimethyl-11-phenyl-12-propan-2-yl-6-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),4,12-tetraene-8,10-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)N(C1=C(C2=O)SC=C1C)C)=O)C1=CC=CC=C1 IKQHMHUYUWRWBW-UHFFFAOYSA-N 0.000 claims description 2
- WJYMJUGXKYTZOS-UHFFFAOYSA-N 2,5-dimethyl-11-phenyl-12-propan-2-yl-6-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),4,12-tetraene-8,10-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)N(C1=C(C2=O)SC(=C1)C)C)=O)C1=CC=CC=C1 WJYMJUGXKYTZOS-UHFFFAOYSA-N 0.000 claims description 2
- YEXSBKDZVNOULE-UHFFFAOYSA-N 2-(2-aminoethyl)-12-cyclobutyl-5-methyl-11-phenyl-4-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),5,12-tetraene-8,10-dione Chemical compound NCCN1C2=C(C(C3=C1N=C(N(C3=O)C1=CC=CC=C1)C1CCC1)=O)C=C(S2)C YEXSBKDZVNOULE-UHFFFAOYSA-N 0.000 claims description 2
- VMHIRSODDGYJIF-UHFFFAOYSA-N 2-cyclobutyl-6,7-dimethyl-3-phenyl-8H-pyrido[2,3-d]pyrimidine-4,5-dione Chemical compound C1(CCC1)C=1N(C(C2=C(N=1)NC(=C(C2=O)C)C)=O)C1=CC=CC=C1 VMHIRSODDGYJIF-UHFFFAOYSA-N 0.000 claims description 2
- FEESEXLYTQWIIM-UHFFFAOYSA-N 2-methyl-11-phenyl-12-propan-2-yl-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),12-triene-8,10-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)N(C1=C(C2=O)CCC1)C)=O)C1=CC=CC=C1 FEESEXLYTQWIIM-UHFFFAOYSA-N 0.000 claims description 2
- LJOBQAUBUWFLBC-UHFFFAOYSA-N 2-methyl-11-phenyl-12-propan-2-yl-6-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),4,12-tetraene-8,10-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)N(C1=C(C2=O)SC=C1)C)=O)C1=CC=CC=C1 LJOBQAUBUWFLBC-UHFFFAOYSA-N 0.000 claims description 2
- LRVOTIFBBXZWQE-UHFFFAOYSA-N 2-methyl-6-phenyl-5-propan-2-yl-2,4,6-triazatricyclo[8.5.0.03,8]pentadeca-1(10),3(8),4-triene-7,9-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)N(C1=C(C2=O)CCCCC1)C)=O)C1=CC=CC=C1 LRVOTIFBBXZWQE-UHFFFAOYSA-N 0.000 claims description 2
- XXUDORRBTFRHIU-UHFFFAOYSA-N 4-methyl-11-phenyl-12-propan-2-yl-6-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),4,12-tetraene-8,10-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)NC1=C(C2=O)SC=C1C)=O)C1=CC=CC=C1 XXUDORRBTFRHIU-UHFFFAOYSA-N 0.000 claims description 2
- WIOSQUIAMQBCOY-UHFFFAOYSA-N 5-chloro-12-cyclobutyl-2-methyl-11-phenyl-4-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),5,12-tetraene-8,10-dione Chemical compound CN1C2=C(C=C(Cl)S2)C(=O)C2=C1N=C(C1CCC1)N(C1=CC=CC=C1)C2=O WIOSQUIAMQBCOY-UHFFFAOYSA-N 0.000 claims description 2
- FRAGAPQUCLNXKJ-UHFFFAOYSA-N 5-chloro-12-cyclobutyl-2-methyl-11-phenyl-6-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),4,12-tetraene-8,10-dione Chemical compound CN1C2=C(SC(Cl)=C2)C(=O)C2=C1N=C(C1CCC1)N(C1=CC=CC=C1)C2=O FRAGAPQUCLNXKJ-UHFFFAOYSA-N 0.000 claims description 2
- JFGJWVDTWKHXRL-UHFFFAOYSA-N 5-chloro-2-methyl-11-phenyl-12-propan-2-yl-4-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),5,12-tetraene-8,10-dione Chemical compound ClC1=CC=2C(C3=C(N=C(N(C3=O)C3=CC=CC=C3)C(C)C)N(C=2S1)C)=O JFGJWVDTWKHXRL-UHFFFAOYSA-N 0.000 claims description 2
- VJOXVKXTDKWBJM-UHFFFAOYSA-N 5-chloro-2-methyl-11-phenyl-12-propan-2-yl-6-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),4,12-tetraene-8,10-dione Chemical compound ClC1=CC2=C(C(C3=C(N=C(N(C3=O)C3=CC=CC=C3)C(C)C)N2C)=O)S1 VJOXVKXTDKWBJM-UHFFFAOYSA-N 0.000 claims description 2
- YKCQCFWQFVQWTI-UHFFFAOYSA-N 5-methyl-11-phenyl-12-propan-2-yl-6-thia-2,11,13-triazatricyclo[7.4.0.03,7]trideca-1(9),3(7),4,12-tetraene-8,10-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)NC1=C(C2=O)SC(=C1)C)=O)C1=CC=CC=C1 YKCQCFWQFVQWTI-UHFFFAOYSA-N 0.000 claims description 2
- QPELMEPYHRHLDN-UHFFFAOYSA-N 6,7,8-trimethyl-3-phenyl-2-propan-2-ylpyrido[2,3-d]pyrimidine-4,5-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)N(C(=C(C2=O)C)C)C)=O)C1=CC=CC=C1 QPELMEPYHRHLDN-UHFFFAOYSA-N 0.000 claims description 2
- SSMAGASNPUQXOK-UHFFFAOYSA-N 6,7-dimethyl-3-phenyl-2-propan-2-yl-8H-pyrido[2,3-d]pyrimidine-4,5-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)NC(=C(C2=O)C)C)=O)C1=CC=CC=C1 SSMAGASNPUQXOK-UHFFFAOYSA-N 0.000 claims description 2
- OVXOIOCTJFCBBG-UHFFFAOYSA-N 6-phenyl-5-propan-2-yl-2,4,6-triazatricyclo[8.5.0.03,8]pentadeca-1(10),3(8),4-triene-7,9-dione Chemical compound C(C)(C)C=1N(C(C2=C(N=1)NC1=C(C2=O)CCCCC1)=O)C1=CC=CC=C1 OVXOIOCTJFCBBG-UHFFFAOYSA-N 0.000 claims description 2
- WMHFLTXOLPOYGN-UHFFFAOYSA-N 7,10-dimethyl-3-phenyl-2-propan-2-yl-6,7,8,9-tetrahydropyrimido[4,5-b]quinoline-4,5-dione Chemical compound C(C)(C)C=1N(C(C2=C(N(C=3CCC(CC=3C2=O)C)C)N=1)=O)C1=CC=CC=C1 WMHFLTXOLPOYGN-UHFFFAOYSA-N 0.000 claims description 2
- QJSFNORHEUGKTM-UHFFFAOYSA-N 7-methyl-3-phenyl-2-propan-2-yl-7,8,9,10-tetrahydro-6H-pyrimido[4,5-b]quinoline-4,5-dione Chemical compound C(C)(C)C=1N(C(C2=C(NC=3CCC(CC=3C2=O)C)N=1)=O)C1=CC=CC=C1 QJSFNORHEUGKTM-UHFFFAOYSA-N 0.000 claims description 2
- ONEZULDSSHFPED-UHFFFAOYSA-N 8,10-dimethyl-3-phenyl-2-propan-2-yl-6,7,8,9-tetrahydropyrimido[4,5-b]quinoline-4,5-dione Chemical compound C(C)(C)C=1N(C(C2=C(N(C=3CC(CCC=3C2=O)C)C)N=1)=O)C1=CC=CC=C1 ONEZULDSSHFPED-UHFFFAOYSA-N 0.000 claims description 2
- MWERFMKXFYLOFP-UHFFFAOYSA-N 8-methyl-3-phenyl-2-propan-2-yl-7,8,9,10-tetrahydro-6H-pyrimido[4,5-b]quinoline-4,5-dione Chemical compound C(C)(C)C=1N(C(C2=C(NC=3CC(CCC=3C2=O)C)N=1)=O)C1=CC=CC=C1 MWERFMKXFYLOFP-UHFFFAOYSA-N 0.000 claims description 2
- 102100035028 Alpha-L-iduronidase Human genes 0.000 claims description 2
- 102100022641 Coagulation factor IX Human genes 0.000 claims description 2
- 102100026735 Coagulation factor VIII Human genes 0.000 claims description 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 2
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims description 2
- 201000003542 Factor VIII deficiency Diseases 0.000 claims description 2
- 208000009292 Hemophilia A Diseases 0.000 claims description 2
- 101001019502 Homo sapiens Alpha-L-iduronidase Proteins 0.000 claims description 2
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims description 2
- 206010056886 Mucopolysaccharidosis I Diseases 0.000 claims description 2
- 208000028781 Mucopolysaccharidosis type 1 Diseases 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims description 2
- 125000003342 alkenyl group Chemical group 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000009429 hemophilia B Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 4
- 102100034540 Adenomatous polyposis coli protein Human genes 0.000 claims 1
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 description 12
- 229910052799 carbon Inorganic materials 0.000 description 8
- 125000004432 carbon atom Chemical group C* 0.000 description 8
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 125000005842 heteroatom Chemical group 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 6
- 125000006574 non-aromatic ring group Chemical group 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 239000001301 oxygen Chemical group 0.000 description 6
- 229920006395 saturated elastomer Polymers 0.000 description 6
- 229910052717 sulfur Chemical group 0.000 description 6
- 239000011593 sulfur Chemical group 0.000 description 6
- 125000003282 alkyl amino group Chemical group 0.000 description 3
- 125000002947 alkylene group Chemical group 0.000 description 3
- 125000004438 haloalkoxy group Chemical group 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 125000004430 oxygen atom Chemical group O* 0.000 description 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 2
- NUIZLSAIMIRLGH-UHFFFAOYSA-N 2-cyclobutyl-6,7,8-trimethyl-3-phenylpyrido[2,3-d]pyrimidine-4,5-dione Chemical compound C1(CCC1)C=1N(C(C2=C(N=1)N(C(=C(C2=O)C)C)C)=O)C1=CC=CC=C1 NUIZLSAIMIRLGH-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000006413 ring segment Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14170971.7 | 2014-06-03 | ||
| EP14170971 | 2014-06-03 | ||
| PCT/IB2015/054172 WO2015186061A1 (en) | 2014-06-03 | 2015-06-02 | Pyridopyrimidinedione derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017516829A JP2017516829A (ja) | 2017-06-22 |
| JP2017516829A5 true JP2017516829A5 (enExample) | 2018-06-14 |
| JP6526064B2 JP6526064B2 (ja) | 2019-06-05 |
Family
ID=50841687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016571131A Expired - Fee Related JP6526064B2 (ja) | 2014-06-03 | 2015-06-02 | ピリドピリミジンジオン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9884862B2 (enExample) |
| EP (1) | EP3152207B1 (enExample) |
| JP (1) | JP6526064B2 (enExample) |
| CN (1) | CN106414443B (enExample) |
| ES (1) | ES2743183T3 (enExample) |
| WO (1) | WO2015186061A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2743184T3 (es) | 2014-06-03 | 2020-02-18 | Novartis Ag | Derivados de pirimido[4,5-b]quinolin-4,5(3H,10H)-diona como supresores de mutaciones finalizadoras |
| ES2731802T3 (es) | 2014-06-03 | 2019-11-19 | Novartis Ag | Derivados de naftiridinodiona como supresores de mutaciones sin sentido |
| WO2019225625A1 (ja) * | 2018-05-23 | 2019-11-28 | 京都薬品工業株式会社 | リードスルー誘導剤およびその医薬用途 |
| WO2024194607A1 (en) | 2023-03-17 | 2024-09-26 | Tay Therapeutics Limited | Pyrimido[4,5-b][1,5]naphthyridine-4,5(3h,10h)-dione derivatives for the treatment of diseases associated with ptc mutations, such as e.g. cancer |
| GB202319857D0 (en) * | 2023-12-21 | 2024-02-07 | Tay Therapeutics Ltd | Compounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2884170B2 (ja) | 1989-08-24 | 1999-04-19 | 株式会社フジモト・ブラザーズ | ５−デアザフラビン系化合物を有効成分とする制癌剤 |
| JP2989871B2 (ja) | 1989-08-30 | 1999-12-13 | 大日本製薬株式会社 | 三環式化合物 |
| DE4035479A1 (de) | 1990-11-08 | 1992-05-14 | Basf Ag | Substituierte pyrido (2,3-d)pyrimidin-2,4(1h,3h)-dione |
| WO1996028444A1 (en) | 1995-03-15 | 1996-09-19 | Pfizer Inc. | 5,10-DIHYDROPYRIMIDO[4,5-b]QUINOLIN-4(1H)-ONE TYROSINE KINASE INHIBITORS |
| US6468990B1 (en) | 1999-05-17 | 2002-10-22 | Queen's University At Kingston | Method of inhibiting binding of nerve growth factor to p75 NTR receptor |
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| AU2003249244A1 (en) | 2002-07-15 | 2004-02-02 | Combinatorx, Incorporated | Methods for the treatment of neoplasms |
| DK1618098T3 (en) | 2003-04-11 | 2015-01-12 | Ptc Therapeutics Inc | 1,2,4-OXADIAZOLBENZOESYREFORBINDELSER AND THEIR USE FOR nonsense CONTROL AND TREATMENT OF AN ILLNESS |
| US7214813B2 (en) | 2003-05-30 | 2007-05-08 | The Penn State Research Foundation | Preparation of chiral cyclic amino acids and derivatives |
| CN101076703A (zh) * | 2004-10-13 | 2007-11-21 | Ptc医疗公司 | 用于无义抑制的化合物及其使用方法 |
| JP5345928B2 (ja) | 2006-04-03 | 2013-11-20 | テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド | 新規なアミノグリコシド類および遺伝子疾患の治療におけるその使用 |
| EP2061470A4 (en) | 2006-08-23 | 2010-10-06 | Neurogen Corp | HALOALKYL-SUBSTITUTED PYRIMIDINONE DERIVATIVES |
| WO2008084236A1 (en) * | 2007-01-11 | 2008-07-17 | Astrazeneca Ab | Chemical compounds 635 : pyridopyrimidinediones as pde4 inhibitors |
| EP2219646A4 (en) | 2007-12-21 | 2010-12-22 | Univ Rochester | PROCESS FOR EXTENDING THE LIFE OF EUKARYOTIC ORGANISMS |
| EP2422817A1 (en) | 2010-07-29 | 2012-02-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Flavin-nucleic acid ligand conjugates |
| JP5877200B2 (ja) * | 2010-08-05 | 2016-03-02 | ユニヴェルシテ ドゥ ドロワ エ サンテ ドゥ リール | ナンセンス突然変異による疾患の治療に有用な化合物及びその化合物を含む医薬組成物 |
| EP2931282B1 (en) | 2012-12-13 | 2018-10-31 | Novartis AG | Pyrimido [4,5-b]quinoline-4,5 (3h,10h)-diones as nonsense mutation suppressors |
| ES2731802T3 (es) | 2014-06-03 | 2019-11-19 | Novartis Ag | Derivados de naftiridinodiona como supresores de mutaciones sin sentido |
| ES2743184T3 (es) | 2014-06-03 | 2020-02-18 | Novartis Ag | Derivados de pirimido[4,5-b]quinolin-4,5(3H,10H)-diona como supresores de mutaciones finalizadoras |
-
2015
- 2015-06-02 CN CN201580028769.7A patent/CN106414443B/zh not_active Expired - Fee Related
- 2015-06-02 US US15/315,579 patent/US9884862B2/en active Active
- 2015-06-02 EP EP15731119.2A patent/EP3152207B1/en not_active Not-in-force
- 2015-06-02 JP JP2016571131A patent/JP6526064B2/ja not_active Expired - Fee Related
- 2015-06-02 ES ES15731119T patent/ES2743183T3/es active Active
- 2015-06-02 WO PCT/IB2015/054172 patent/WO2015186061A1/en not_active Ceased
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