JP2017516786A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017516786A5 JP2017516786A5 JP2016569639A JP2016569639A JP2017516786A5 JP 2017516786 A5 JP2017516786 A5 JP 2017516786A5 JP 2016569639 A JP2016569639 A JP 2016569639A JP 2016569639 A JP2016569639 A JP 2016569639A JP 2017516786 A5 JP2017516786 A5 JP 2017516786A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- seq
- amino acid
- antigen
- hvr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000282567 Macaca fascicularis Species 0.000 claims description 11
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 1
- 239000000427 antigen Substances 0.000 description 26
- 102000036639 antigens Human genes 0.000 description 26
- 108091007433 antigens Proteins 0.000 description 26
- 150000001413 amino acids Chemical class 0.000 description 13
- 230000002163 immunogen Effects 0.000 description 7
- 210000000265 leukocyte Anatomy 0.000 description 4
- 230000003053 immunization Effects 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000010171 animal model Methods 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000003398 denaturant Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14170140.9 | 2014-05-28 | ||
| EP14170140 | 2014-05-28 | ||
| EP14180572.1 | 2014-08-11 | ||
| EP14180572 | 2014-08-11 | ||
| PCT/EP2015/061457 WO2015181098A1 (en) | 2014-05-28 | 2015-05-22 | Antibodies binding to human and cynomolgus cd3 epsilon |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017516786A JP2017516786A (ja) | 2017-06-22 |
| JP2017516786A5 true JP2017516786A5 (enExample) | 2020-07-09 |
| JP6738285B2 JP6738285B2 (ja) | 2020-08-12 |
Family
ID=53268799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016569639A Expired - Fee Related JP6738285B2 (ja) | 2014-05-28 | 2015-05-22 | ヒト及びカニクイザルｃｄ３イプシロンに結合する抗体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20170233475A1 (enExample) |
| EP (2) | EP3763739A1 (enExample) |
| JP (1) | JP6738285B2 (enExample) |
| KR (1) | KR20170003591A (enExample) |
| CN (1) | CN106459201A (enExample) |
| AU (1) | AU2015266077A1 (enExample) |
| BR (1) | BR112016022819A2 (enExample) |
| CA (1) | CA2942453A1 (enExample) |
| IL (1) | IL247740A0 (enExample) |
| MX (1) | MX2016015389A (enExample) |
| RU (1) | RU2016151235A (enExample) |
| SG (1) | SG11201609950YA (enExample) |
| WO (1) | WO2015181098A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2901794T3 (es) | 2015-12-09 | 2022-03-23 | Hoffmann La Roche | Anticuerpo anti-CD20 de tipo II para reducir la formación de anticuerpos antifármaco |
| WO2017150762A1 (ko) * | 2016-02-29 | 2017-09-08 | (주)메디톡스 | 항-CD3γε 항체 및 이의 용도 |
| CA3059010A1 (en) | 2016-06-02 | 2018-12-06 | F. Hoffmann-La Roche Ag | Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer |
| EP3252078A1 (en) | 2016-06-02 | 2017-12-06 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer |
| FI3561057T3 (fi) * | 2016-12-22 | 2025-10-07 | Daiichi Sankyo Co Ltd | Anti-cd3-vasta-aine ja vasta-ainetta sisältäviä molekyylejä |
| EP3409322A1 (en) | 2017-06-01 | 2018-12-05 | F. Hoffmann-La Roche AG | Treatment method |
| EP3634998B8 (en) * | 2017-06-05 | 2025-04-09 | Numab Therapeutics AG | Anti-cd3 epsilon antibodies |
| WO2018224441A1 (en) * | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Novel anti-cd3 antibodies |
| US10882907B2 (en) | 2017-06-21 | 2021-01-05 | Gilead Sciences, Inc. | Multispecific antibodies that target HIV GP120 and CD3 |
| TWI820041B (zh) * | 2017-09-21 | 2023-11-01 | 中國大陸商上海藥明生物技術有限公司 | 新型抗CD3ε抗體 |
| US12486325B2 (en) | 2017-09-21 | 2025-12-02 | WuXi Biologics Ireland Limited | Anti-CD3epsilon antibodies |
| WO2019105864A1 (en) | 2017-11-30 | 2019-06-06 | F. Hoffmann-La Roche Ag | B-cell cultivation method |
| CA3093330A1 (en) * | 2018-03-14 | 2019-09-19 | Novimmune Sa | Anti-cd3 epsilon antibodies and methods of use thereof |
| MX420253B (es) * | 2018-05-24 | 2025-02-10 | Janssen Biotech Inc | Anticuerpos anti-cd3 y usos de estos. |
| WO2019244107A1 (en) * | 2018-06-21 | 2019-12-26 | Daiichi Sankyo Company, Limited | Compositions including cd3 antigen binding fragments and uses thereof |
| IL298444A (en) * | 2020-05-27 | 2023-01-01 | Janssen Biotech Inc | Proteins containing cd3 antigen binding sites and uses thereof |
| JP2023542209A (ja) * | 2020-09-24 | 2023-10-05 | モルフォシス・アーゲー | ヒトｃｄ３イプシロンに結合する新規なヒト抗体 |
| CN114656562B (zh) | 2020-12-23 | 2023-11-03 | 北京天广实生物技术股份有限公司 | 结合人和猴cd3的抗体及其应用 |
| EP4314075A4 (en) * | 2021-03-24 | 2025-04-09 | Twist Bioscience Corporation | VARIANT NUCLEIC ACID BANKS FOR CD3 |
| AU2021443318A1 (en) | 2021-04-30 | 2023-09-07 | F. Hoffmann-La Roche Ag | Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate |
| EP4329800A1 (en) | 2021-04-30 | 2024-03-06 | F. Hoffmann-La Roche AG | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibody |
| CN115536740A (zh) * | 2021-06-30 | 2022-12-30 | 苏州方德门达新药开发有限公司 | 介导细胞内有效滞留cd3的空间构象表位及其应用 |
| CN113755435B (zh) * | 2021-10-15 | 2023-10-13 | 苏州药明康德新药开发有限公司 | 一种食蟹猴pbmc分离方法 |
| US20230295310A1 (en) * | 2022-03-20 | 2023-09-21 | Abcellera Biologics Inc. | CD3 T-Cell Engagers and Methods of Use |
| KR20240158351A (ko) * | 2022-03-22 | 2024-11-04 | 모르포시스 아게 | Cd3에 특이적인 탈면역화 항체 |
| MX2024011468A (es) | 2022-03-23 | 2024-09-25 | Hoffmann La Roche | Tratamiento conjunto de un anticuerpo biespecifico anti-cd20/anti-cd3 y quimioterapia. |
| AU2023251832A1 (en) | 2022-04-13 | 2024-10-17 | F. Hoffmann-La Roche Ag | Pharmaceutical compositions of anti-cd20/anti-cd3 bispecific antibodies and methods of use |
| WO2024088987A1 (en) | 2022-10-26 | 2024-05-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer |
| WO2026006495A1 (en) | 2024-06-25 | 2026-01-02 | Alloy Therapeutics, Inc. | Anti-wt1/hla-a2 antibody and uses thereof |
| WO2026006492A2 (en) | 2024-06-25 | 2026-01-02 | Ypsilon Therapeutics, Inc. | Anti-prame/hla-a2 antibodies and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD272473B3 (de) * | 1988-06-13 | 1993-01-21 | Univ Leipzig | Verfahren zur herstellung monoklonaler antikoerper gegen die epsilon-kettedes cd 3-antigens humaner t-lymphozyten |
| JPH0630786A (ja) * | 1992-07-14 | 1994-02-08 | Kyowa Hakko Kogyo Co Ltd | バイスペシフィック抗体 |
| CA2569509C (en) * | 2004-06-03 | 2014-08-12 | Novimmune S.A. | Anti-cd3 antibodies and methods of use thereof |
| EP1940881B1 (en) * | 2005-10-11 | 2016-11-30 | Amgen Research (Munich) GmbH | Compositions comprising cross-species-specific antibodies and uses thereof |
| DK2155788T3 (da) * | 2007-04-03 | 2012-10-08 | Amgen Res Munich Gmbh | Krydsartsspecifikke bispecifikke bindemidler |
| WO2012158818A2 (en) * | 2011-05-16 | 2012-11-22 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
| CN107827985A (zh) * | 2011-05-21 | 2018-03-23 | 宏观基因有限公司 | 能够与人和非人cd3结合的cd3结合分子 |
| US20170073415A1 (en) * | 2014-05-12 | 2017-03-16 | Numab Ag | Novel multispecific molecules and novel treatment methods based on such multispecific molecules |
-
2015
- 2015-05-22 JP JP2016569639A patent/JP6738285B2/ja not_active Expired - Fee Related
- 2015-05-22 KR KR1020167033022A patent/KR20170003591A/ko not_active Withdrawn
- 2015-05-22 CA CA2942453A patent/CA2942453A1/en not_active Abandoned
- 2015-05-22 BR BR112016022819A patent/BR112016022819A2/pt not_active Application Discontinuation
- 2015-05-22 MX MX2016015389A patent/MX2016015389A/es unknown
- 2015-05-22 SG SG11201609950YA patent/SG11201609950YA/en unknown
- 2015-05-22 EP EP20163877.2A patent/EP3763739A1/en not_active Withdrawn
- 2015-05-22 CN CN201580026998.5A patent/CN106459201A/zh active Pending
- 2015-05-22 WO PCT/EP2015/061457 patent/WO2015181098A1/en not_active Ceased
- 2015-05-22 EP EP15725002.8A patent/EP3149041A1/en not_active Ceased
- 2015-05-22 AU AU2015266077A patent/AU2015266077A1/en not_active Abandoned
- 2015-05-22 RU RU2016151235A patent/RU2016151235A/ru not_active Application Discontinuation
-
2016
- 2016-09-11 IL IL247740A patent/IL247740A0/en unknown
- 2016-11-22 US US15/359,199 patent/US20170233475A1/en not_active Abandoned
-
2020
- 2020-01-23 US US16/751,062 patent/US20200299385A1/en not_active Abandoned
- 2020-01-23 US US16/751,046 patent/US20200325224A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017516786A5 (enExample) | ||
| RU2016151235A (ru) | Антитела, связывающиеся с cd3 эпсилон человека и обезьян циномолгус | |
| BR112018006579A2 (pt) | anticorpos anti-humanos cd19 humanizados e métodos de uso | |
| PE20150025A1 (es) | Anticuerpos e inmunoconjugados contra ly6e y metodos de uso | |
| JP2007097598A5 (enExample) | ||
| PE20161571A1 (es) | Anticuerpos anti-ox40 y metodos de uso | |
| RU2019125027A (ru) | Афукозилированные антитела к рецептору фактора роста фибробластов fgfr2iiib | |
| RU2017104642A (ru) | Новое антитело против tie-2 человека | |
| JP2013538057A5 (enExample) | ||
| NZ592119A (en) | Anti-pd-l1 antibodies and their use to enhance t-cell function | |
| PE20120553A1 (es) | Anticuerpos anti-fgfr3 | |
| EP4252769A3 (en) | Anti-complement factor c1q antibodies and uses thereof | |
| PE20191135A1 (es) | Anticuerpos antitau y metodos de uso | |
| JP2020500538A5 (enExample) | ||
| PE20181336A1 (es) | Anticuerpos que se unen a interleucina 8 (il-8) y sus usos | |
| JP2014526898A5 (enExample) | ||
| RU2016100892A (ru) | Антитела против tweakr и их применение | |
| RU2017125758A (ru) | Антитела к с5 и способы их применения | |
| NZ603226A (en) | Anti-c5a antibodies and methods for using the antibodies | |
| AR096364A1 (es) | Anticuerpos receptores de antitransferina y métodos de uso | |
| RU2016110891A (ru) | Антитела к fcrh5, их иммуноконъюгаты и способы их применения | |
| PE20181402A1 (es) | Anticuerpos anti-c5 y metodos de uso | |
| JP2016512034A5 (enExample) | ||
| NZ626520A (en) | Anti-lrp5 antibodies and methods of use | |
| JP2017525343A5 (enExample) |