JP2017516487A5 - - Google Patents
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- JP2017516487A5 JP2017516487A5 JP2016571229A JP2016571229A JP2017516487A5 JP 2017516487 A5 JP2017516487 A5 JP 2017516487A5 JP 2016571229 A JP2016571229 A JP 2016571229A JP 2016571229 A JP2016571229 A JP 2016571229A JP 2017516487 A5 JP2017516487 A5 JP 2017516487A5
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- Prior art keywords
- nucleic acid
- population
- oligonucleotide
- genomic dna
- single stranded
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021138555A JP2022001050A (ja) | 2014-06-06 | 2021-08-27 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
| JP2024038531A JP2024060054A (ja) | 2014-06-06 | 2024-03-13 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009047P | 2014-06-06 | 2014-06-06 | |
| US62/009,047 | 2014-06-06 | ||
| US201562136093P | 2015-03-20 | 2015-03-20 | |
| US62/136,093 | 2015-03-20 | ||
| PCT/US2015/034724 WO2015188192A2 (en) | 2014-06-06 | 2015-06-08 | Method for identification and enumeration of nucleic acid sequence, expression, copy, or dna methylation changes, using combined nuclease, ligase, polymerase, and sequencing reactions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021138555A Division JP2022001050A (ja) | 2014-06-06 | 2021-08-27 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017516487A JP2017516487A (ja) | 2017-06-22 |
| JP2017516487A5 true JP2017516487A5 (enExample) | 2018-07-19 |
| JP7008407B2 JP7008407B2 (ja) | 2022-01-25 |
Family
ID=54767613
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016571229A Active JP7008407B2 (ja) | 2014-06-06 | 2015-06-08 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
| JP2021138555A Pending JP2022001050A (ja) | 2014-06-06 | 2021-08-27 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
| JP2024038531A Pending JP2024060054A (ja) | 2014-06-06 | 2024-03-13 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021138555A Pending JP2022001050A (ja) | 2014-06-06 | 2021-08-27 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
| JP2024038531A Pending JP2024060054A (ja) | 2014-06-06 | 2024-03-13 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10407722B2 (enExample) |
| EP (4) | EP3889271B1 (enExample) |
| JP (3) | JP7008407B2 (enExample) |
| CN (2) | CN113046413A (enExample) |
| AU (2) | AU2015269103B2 (enExample) |
| CA (2) | CA3213538A1 (enExample) |
| DK (1) | DK3152331T3 (enExample) |
| ES (3) | ES2935285T3 (enExample) |
| IL (1) | IL249126B (enExample) |
| PT (3) | PT3889271T (enExample) |
| SG (2) | SG11201610134PA (enExample) |
| WO (1) | WO2015188192A2 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2707744T3 (es) | 2013-12-11 | 2019-04-04 | Accuragen Holdings Ltd | Métodos para detectar variantes de secuencia raras |
| US11859246B2 (en) * | 2013-12-11 | 2024-01-02 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| EP3889271B1 (en) * | 2014-06-06 | 2022-11-23 | Cornell University | Method for identification and enumeration of nucleic acid sequence, expression, copy, or dna methylation changes, using combined nuclease, ligase, polymerase, and sequencing reactions |
| US11085073B2 (en) * | 2015-04-24 | 2021-08-10 | Qiagen Gmbh | Method for immobilizing a nucleic acid molecule on a solid support |
| WO2016170179A1 (en) | 2015-04-24 | 2016-10-27 | Qiagen Gmbh | Method for immobilizing a nucleic acid molecule on solid support |
| WO2017089520A2 (en) | 2015-11-25 | 2017-06-01 | Genia Technologies, Inc. | Purification of polymerase complexes |
| CN108699505A (zh) * | 2015-12-03 | 2018-10-23 | 安可济控股有限公司 | 用于形成连接产物的方法和组合物 |
| US20210214781A1 (en) * | 2016-02-14 | 2021-07-15 | Abhijit Ajit Patel | Measurement of nucleic acid |
| JP7143221B2 (ja) * | 2016-04-07 | 2022-09-28 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ５－ヒドロキシメチル化無細胞系ｄｎａをシーケンシングすることによる非侵襲性診断 |
| CA3025956A1 (en) * | 2016-07-01 | 2018-01-04 | Natera, Inc. | Compositions and methods for detection of nucleic acid mutations |
| CN109844137B (zh) * | 2016-10-31 | 2022-04-26 | 豪夫迈·罗氏有限公司 | 用于鉴定嵌合产物的条形码化环状文库构建 |
| EP3559269B1 (en) * | 2016-12-20 | 2020-09-16 | F. Hoffmann-La Roche AG | Single stranded circular dna libraries for circular consensus sequencing |
| CN109234388B (zh) * | 2017-07-04 | 2021-09-14 | 深圳华大生命科学研究院 | 用于dna高甲基化区域富集的试剂、富集方法及应用 |
| EP3682025A1 (en) * | 2017-09-14 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Novel method for generating circular single-stranded dna libraries |
| EP3682027B1 (en) * | 2017-09-15 | 2025-02-26 | F. Hoffmann-La Roche AG | Hybridization-extension-ligation strategy for generating circular single-stranded dna libraries |
| US10350307B2 (en) * | 2017-09-18 | 2019-07-16 | General Electric Company | In vivo RNA or protein expression using double-stranded concatemeric DNA including phosphorothioated nucleotides |
| WO2019090147A1 (en) * | 2017-11-03 | 2019-05-09 | Guardant Health, Inc. | Correcting for deamination-induced sequence errors |
| WO2019024341A1 (zh) * | 2017-11-27 | 2019-02-07 | 深圳华大生命科学研究院 | 一种体液游离dna的文库构建方法及其应用 |
| CN111936634B (zh) | 2017-12-11 | 2025-05-09 | Umc乌德勒支控股有限公司 | 用于制备用于测序的核酸分子的方法 |
| WO2019157339A1 (en) * | 2018-02-09 | 2019-08-15 | Children's Medical Center Corporation | Compositions and methods for identifying a single-nucleotide variant |
| JP7013960B2 (ja) * | 2018-03-13 | 2022-02-01 | 株式会社リコー | 核酸検出方法及び核酸検出装置、並びに、核酸検出キット |
| US11203782B2 (en) | 2018-03-29 | 2021-12-21 | Accuragen Holdings Limited | Compositions and methods comprising asymmetric barcoding |
| CA3095292A1 (en) | 2018-04-02 | 2019-10-10 | Progenity, Inc. | Methods, systems, and compositions for counting nucleic acid molecules |
| EP3775198A4 (en) * | 2018-04-02 | 2022-01-05 | Grail, Inc. | METHYLATION MARKERS AND TARGETED METHYLATION PROBE PANELS |
| CN110456034B (zh) * | 2018-05-07 | 2022-07-22 | 上海市第十人民医院 | 一种循环肿瘤细胞的检测方法 |
| US12049665B2 (en) | 2018-06-12 | 2024-07-30 | Accuragen Holdings Limited | Methods and compositions for forming ligation products |
| US10876148B2 (en) * | 2018-11-14 | 2020-12-29 | Element Biosciences, Inc. | De novo surface preparation and uses thereof |
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| WO2020102766A2 (en) | 2018-11-15 | 2020-05-22 | Element Biosciences, Inc. | Methods for generating circular nucleic acid molecules |
| US20220090183A1 (en) * | 2019-02-25 | 2022-03-24 | Elegen Corporation | Methods of using microfluidic positional encoding devices |
| JP7344973B2 (ja) * | 2019-03-01 | 2023-09-14 | マーシー バイオアナリティクス， インコーポレイテッド | 標的実体を検出するためのシステム、組成物、及び方法 |
| WO2020180813A1 (en) * | 2019-03-06 | 2020-09-10 | Qiagen Sciences, Llc | Compositions and methods for adaptor design and nucleic acid library construction for rolony-based sequencing |
| WO2020206170A1 (en) | 2019-04-02 | 2020-10-08 | Progenity, Inc. | Methods, systems, and compositions for counting nucleic acid molecules |
| BR112022001539A2 (pt) * | 2019-05-13 | 2022-03-22 | Rapid Genomics Llc | Captura e análise de regiões genômicas alvo |
| CN112029841B (zh) * | 2019-06-03 | 2024-02-09 | 香港中文大学 | 定量端粒长度和基因组基序的方法 |
| CN112175939A (zh) * | 2019-07-03 | 2021-01-05 | 华大青兰生物科技(无锡)有限公司 | 一种基于同源序列的核酸拼接方法及其应用 |
| US12091669B2 (en) * | 2019-08-22 | 2024-09-17 | National University Of Singapore | Method for the generation of dumbbell-shaped DNA vectors |
| WO2021036995A1 (en) * | 2019-08-23 | 2021-03-04 | Nanjing University | Direct microrna sequencing using enzyme assisted sequencing |
| CN114641581A (zh) * | 2019-10-28 | 2022-06-17 | 深圳华大智造科技股份有限公司 | Dna接头寡核苷酸 |
| CN118834950A (zh) | 2019-11-06 | 2024-10-25 | 斯坦福大学托管董事会 | 用于分析核酸分子的方法和系统 |
| CN111154820B (zh) * | 2020-01-13 | 2021-12-21 | 上海韦翰斯生物医药科技有限公司 | 一种降低核酸扩增复制滑移率的方法 |
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| WO2021185320A1 (en) * | 2020-03-18 | 2021-09-23 | Mgi Tech Co., Ltd. | Restoring phase in massively parallel sequencing |
| US12371743B2 (en) * | 2022-03-04 | 2025-07-29 | Element Biosciences, Inc. | Double-stranded splint adaptors and methods of use |
| US12359193B2 (en) | 2022-03-04 | 2025-07-15 | Element Biosciences, Inc. | Single-stranded splint strands and methods of use |
| US12469162B2 (en) | 2020-08-31 | 2025-11-11 | Element Biosciences, Inc. | Primary analysis in next generation sequencing |
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