JP2017514496A5 - - Google Patents
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- JP2017514496A5 JP2017514496A5 JP2016566228A JP2016566228A JP2017514496A5 JP 2017514496 A5 JP2017514496 A5 JP 2017514496A5 JP 2016566228 A JP2016566228 A JP 2016566228A JP 2016566228 A JP2016566228 A JP 2016566228A JP 2017514496 A5 JP2017514496 A5 JP 2017514496A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- rodent
- mouse
- human
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 241000283984 Rodentia Species 0.000 claims 58
- 108700024394 Exon Proteins 0.000 claims 24
- 101100328540 Homo sapiens C3 gene Proteins 0.000 claims 21
- 101100328542 Mus musculus C3 gene Proteins 0.000 claims 21
- 241000699666 Mus <mouse, genus> Species 0.000 claims 18
- 238000000034 method Methods 0.000 claims 17
- 101100440311 Homo sapiens C5 gene Proteins 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 101100440312 Mus musculus C5 gene Proteins 0.000 claims 10
- 101150069146 C5 gene Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical group 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 101150071258 C3 gene Proteins 0.000 claims 5
- 230000024203 complement activation Effects 0.000 claims 3
- 230000014509 gene expression Effects 0.000 claims 3
- 238000011577 humanized mouse model Methods 0.000 claims 3
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- -1 small molecule chemical compound Chemical class 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461988581P | 2014-05-05 | 2014-05-05 | |
| US61/988,581 | 2014-05-05 | ||
| US201462067836P | 2014-10-23 | 2014-10-23 | |
| US62/067,836 | 2014-10-23 | ||
| PCT/US2015/029111 WO2015171523A1 (en) | 2014-05-05 | 2015-05-04 | Humanized c5 and c3 animals |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017514496A JP2017514496A (ja) | 2017-06-08 |
| JP2017514496A5 true JP2017514496A5 (enExample) | 2018-06-28 |
| JP6598798B2 JP6598798B2 (ja) | 2019-10-30 |
Family
ID=53177902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016566228A Active JP6598798B2 (ja) | 2014-05-05 | 2015-05-04 | ヒト化ｃ５およびｃ３動物 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US9795121B2 (enExample) |
| EP (3) | EP3142483B1 (enExample) |
| JP (1) | JP6598798B2 (enExample) |
| KR (1) | KR102461511B1 (enExample) |
| CN (1) | CN106659146B (enExample) |
| AU (1) | AU2015256299C1 (enExample) |
| BR (1) | BR112016025751A2 (enExample) |
| CA (2) | CA2946412C (enExample) |
| ES (2) | ES2968749T3 (enExample) |
| IL (1) | IL248481B (enExample) |
| MA (1) | MA51519A (enExample) |
| MX (2) | MX386644B (enExample) |
| RU (2) | RU2713327C2 (enExample) |
| SG (2) | SG10202003996YA (enExample) |
| WO (1) | WO2015171523A1 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| JP6598798B2 (ja) | 2014-05-05 | 2019-10-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｃ５およびｃ３動物 |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| TW202440903A (zh) | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法（一） |
| WO2017132155A1 (en) * | 2016-01-25 | 2017-08-03 | President And Fellows Of Harvard College | Methods and compositions for detecting and treating schizophrenia |
| JP7102353B2 (ja) | 2016-06-14 | 2022-07-19 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗ｃ５抗体及びそれらの使用 |
| WO2018039499A1 (en) | 2016-08-24 | 2018-03-01 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| SG11201907606XA (en) * | 2017-02-27 | 2019-09-27 | Regeneron Pharma | Humanized model of kidney and liver disorders |
| WO2019010191A1 (en) | 2017-07-06 | 2019-01-10 | Regeneron Pharmaceuticals, Inc. | CELL CULTURE METHOD FOR PRODUCING GLYCOPROTEIN |
| KR102544051B1 (ko) * | 2017-09-29 | 2023-06-16 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 ttr 유전자좌를 포함하는 비인간 동물 및 사용 방법 |
| CN107736281A (zh) * | 2017-09-29 | 2018-02-27 | 中国水产科学研究院珠江水产研究所 | 一种利用益生菌发酵酱油渣防治池塘养殖鳜鱼寄生虫的方法 |
| KR20240128129A (ko) | 2017-09-29 | 2024-08-23 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 C1q 복합체를 발현하는 비인간 동물 |
| CN111630065A (zh) | 2017-12-13 | 2020-09-04 | 瑞泽恩制药公司 | 抗c5抗体组合及其用途 |
| JP7321159B2 (ja) | 2017-12-22 | 2023-08-04 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 薬剤生成物不純物を特性決定するためのシステム及び方法 |
| SG11202005235WA (en) | 2018-01-31 | 2020-07-29 | Regeneron Pharma | System and method for characterizing size and charge variant drug product impurities |
| TW202311746A (zh) | 2018-02-02 | 2023-03-16 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
| EP3759242A1 (en) | 2018-02-28 | 2021-01-06 | Regeneron Pharmaceuticals, Inc. | Systems and methods for identifying viral contaminants |
| US12259355B2 (en) | 2018-03-19 | 2025-03-25 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| TWI854343B (zh) | 2018-03-19 | 2024-09-01 | 美商再生元醫藥公司 | 微晶片毛細管電泳分析及試劑 |
| US12253490B2 (en) | 2018-03-19 | 2025-03-18 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| AR117565A1 (es) | 2018-04-03 | 2021-08-18 | Ngm Biopharmaceuticals Inc | Agentes de unión a c3 y método de uso de los mismos |
| TW202016125A (zh) | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | 用於定量及調節蛋白質黏度之系統與方法 |
| SMT202400300T1 (it) | 2018-07-16 | 2024-09-16 | Regeneron Pharma | Modelli di roditori della sindrome ditra e loro utilizzo |
| JP2021535739A (ja) | 2018-08-27 | 2021-12-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 下流精製でのラマン分光法の使用 |
| CA3100038A1 (en) | 2018-08-30 | 2020-03-05 | Regeneron Pharmaceuticals, Inc. | Methods for characterizing protein complexes |
| KR20210055742A (ko) * | 2018-09-06 | 2021-05-17 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 인간화된 항-c5 항체 및 이의 용도 |
| EA202191841A1 (ru) | 2019-01-16 | 2021-10-07 | Ридженерон Фармасьютикалз, Инк. | Способы для идентификации свободных тиолов в белках |
| IL286905B2 (en) | 2019-04-04 | 2024-06-01 | Regeneron Pharma | Non-human animals containing the human coagulation factor 12 locus |
| EP3958901A4 (en) * | 2019-04-24 | 2023-07-19 | The Trustees of the University of Pennsylvania | BI-FUNCTIONAL HUMANIZED ANTI-C5 ANTIBODIES AND H-FACTOR FUSION PROTEINS AND THEIR USES |
| MX2021013519A (es) | 2019-05-13 | 2021-12-10 | Regeneron Pharma | Ensayos de union de ligandos competitivos mejorados. |
| AU2020286382A1 (en) | 2019-06-04 | 2021-11-04 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized TTR locus with a beta-slip mutation and methods of use |
| TW202112229A (zh) | 2019-06-07 | 2021-04-01 | 美商雷傑納榮製藥公司 | 包含人化白蛋白基因座之非人的動物 |
| CN120334439A (zh) | 2019-09-24 | 2025-07-18 | 里珍纳龙药品有限公司 | 用于色谱介质的使用和再生的系统及方法 |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| CN119318636A (zh) | 2019-11-25 | 2025-01-17 | 里珍纳龙药品有限公司 | 使用非水性乳液的持续释放调配物 |
| MX2022008973A (es) | 2020-01-21 | 2022-08-11 | Regeneron Pharma | Metodos de desglicosilacion para electroforesis de proteinas glicosiladas. |
| BR112023003273A2 (pt) | 2020-08-31 | 2023-05-02 | Regeneron Pharma | Estratégias de alimentação de asparagina para melhorar desempenho da cultura celular e mitigar variantes da sequência de asparagina |
| EP4221496A1 (en) | 2020-10-01 | 2023-08-09 | Regeneron Pharmaceuticals, Inc. | Rodent animals expressing human cr1 |
| EP4251128A1 (en) | 2020-11-25 | 2023-10-04 | Regeneron Pharmaceuticals, Inc. | Sustained release formulations using non-aqueous membrane emulsification |
| CN116710124A (zh) | 2020-12-17 | 2023-09-05 | 瑞泽恩制药公司 | 包封蛋白质的微凝胶的制造 |
| AU2022209730A1 (en) | 2021-01-20 | 2023-07-13 | Regeneron Pharmaceuticals, Inc. | Methods of improving protein titer in cell culture |
| AU2022230987A1 (en) | 2021-03-03 | 2023-08-31 | Regeneron Pharmaceuticals, Inc. | Systems and methods for quantifying and modifying protein viscosity |
| JP2024519407A (ja) | 2021-03-26 | 2024-05-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 混合プロトコルを作成するための方法およびシステム |
| BR112023024984A2 (pt) | 2021-06-01 | 2024-02-20 | Regeneron Pharma | Tampão de amostra de eletroforese aquosa, método para identificar contaminantes ou impurezas em uma amostra de droga proteica, e, kit |
| US20230077710A1 (en) | 2021-09-08 | 2023-03-16 | Regeneron Pharmaceuticals, Inc. | HIGH-THROUGHPUT AND MASS-SPECTROMETRY-BASED METHOD FOR QUANTITATING ANTIBODIES AND OTHER Fc-CONTAINING PROTEINS |
| WO2023044139A1 (en) | 2021-09-20 | 2023-03-23 | Regeneron Pharmaceuticals, Inc. | Methods of controlling antibody heterogeneity |
| KR20240090312A (ko) | 2021-10-07 | 2024-06-21 | 리제너론 파아마슈티컬스, 인크. | Ph 미터 보정 및 교정 |
| MX2024004107A (es) | 2021-10-07 | 2024-04-19 | Regeneron Pharma | Sistemas y metodos para modelar y controlar el ph. |
| IL312372A (en) | 2021-10-26 | 2024-06-01 | Regeneron Pharma | Systems and methods for producing laboratory water and dispersing laboratory water at different temperatures |
| CN118251491A (zh) | 2021-10-28 | 2024-06-25 | 瑞泽恩制药公司 | 用于敲除C5的CRISPR/Cas相关方法及组合物 |
| CN119137473A (zh) | 2022-03-18 | 2024-12-13 | 里珍纳龙药品有限公司 | 分析多肽变体的方法及系统 |
| TW202435942A (zh) | 2022-12-16 | 2024-09-16 | 美商里珍納龍藥品有限公司 | 評估層析管柱完整性的方法及系統 |
| TW202445135A (zh) | 2023-01-25 | 2024-11-16 | 美商再生元醫藥公司 | 液態蛋白質組成物穩定性之建模方法 |
| WO2024158961A1 (en) | 2023-01-25 | 2024-08-02 | Regeneron Pharmaceuticals, Inc. | Mass spectrometry-based characterization of antibodies co-expressed in vivo |
| US20240280551A1 (en) | 2023-02-22 | 2024-08-22 | Regeneron Pharmaceuticals, Inc. | System suitability parameters and column aging |
| TW202508625A (zh) | 2023-05-01 | 2025-03-01 | 美商再生元醫藥公司 | 使用苯酚或苯甲醇之多劑量抗體藥物產品 |
| US20250086164A1 (en) | 2023-09-08 | 2025-03-13 | Regeneron Pharmaceuticals, Inc. | Methods and systems for assessing chromatographic column integrity |
| WO2025064403A2 (en) | 2023-09-18 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Methods and systems for developing chromatography protocols |
| US20250109905A1 (en) | 2023-09-29 | 2025-04-03 | Regeneron Pharmaceuticals, Inc. | Lyophilization using controlled nucleation |
| WO2025085594A1 (en) | 2023-10-18 | 2025-04-24 | Regeneron Pharmaceuticals, Inc. | Rapid purification of monoclonal antibody from in-process upstream cell culture material |
| TW202535934A (zh) | 2023-11-02 | 2025-09-16 | 美商再生元醫藥公司 | 利用應力來降低脂酶活性的方法 |
| WO2025122669A1 (en) | 2023-12-05 | 2025-06-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized complement factor b gene |
| WO2025166281A1 (en) | 2024-02-01 | 2025-08-07 | Regeneron Pharmaceuticals, Inc. | Platform for charge-detection mass spectrometry analysis of aavs |
| WO2025175164A1 (en) | 2024-02-16 | 2025-08-21 | Regeneron Pharmaceuticals, Inc. | Methods of producing concentrated formulated drug substances comprising proteins, and concentrated formulated drug substance made by the methods |
| WO2025194043A1 (en) | 2024-03-15 | 2025-09-18 | Regeneron Pharmaceuticals, Inc. | Polysorbate and polyoxyethylene sorbitan as excipients for stable protein formulations |
| WO2025259840A1 (en) | 2024-06-13 | 2025-12-18 | Regeneron Pharmaceuticals, Inc. | Methods and systems for scaled chromatography |
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| JP6598798B2 (ja) | 2014-05-05 | 2019-10-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｃ５およびｃ３動物 |
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2015
- 2015-05-04 JP JP2016566228A patent/JP6598798B2/ja active Active
- 2015-05-04 RU RU2016146390A patent/RU2713327C2/ru active
- 2015-05-04 ES ES19211905T patent/ES2968749T3/es active Active
- 2015-05-04 SG SG10202003996YA patent/SG10202003996YA/en unknown
- 2015-05-04 CN CN201580034127.8A patent/CN106659146B/zh active Active
- 2015-05-04 KR KR1020167032659A patent/KR102461511B1/ko active Active
- 2015-05-04 ES ES15722639T patent/ES2779070T3/es active Active
- 2015-05-04 MX MX2019013850A patent/MX386644B/es unknown
- 2015-05-04 EP EP15722639.0A patent/EP3142483B1/en active Active
- 2015-05-04 AU AU2015256299A patent/AU2015256299C1/en not_active Ceased
- 2015-05-04 CA CA2946412A patent/CA2946412C/en active Active
- 2015-05-04 SG SG11201608696RA patent/SG11201608696RA/en unknown
- 2015-05-04 US US14/703,818 patent/US9795121B2/en not_active Expired - Fee Related
- 2015-05-04 WO PCT/US2015/029111 patent/WO2015171523A1/en not_active Ceased
- 2015-05-04 EP EP19211905.5A patent/EP3636073B1/en active Active
- 2015-05-04 BR BR112016025751A patent/BR112016025751A2/pt not_active Application Discontinuation
- 2015-05-04 EP EP23202404.2A patent/EP4317445A3/en not_active Withdrawn
- 2015-05-04 MX MX2016014504A patent/MX2016014504A/es active IP Right Grant
- 2015-05-04 CA CA3225091A patent/CA3225091A1/en active Pending
- 2015-05-04 MA MA051519A patent/MA51519A/fr unknown
- 2015-05-04 RU RU2020103811A patent/RU2020103811A/ru unknown
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2016
- 2016-10-25 IL IL248481A patent/IL248481B/en active IP Right Grant
-
2017
- 2017-07-26 US US15/660,833 patent/US10492477B2/en active Active
-
2018
- 2018-07-02 US US16/025,377 patent/US10524458B2/en active Active
-
2019
- 2019-10-21 US US16/658,541 patent/US11178860B2/en not_active Expired - Fee Related
-
2021
- 2021-10-20 US US17/505,834 patent/US20220132818A1/en not_active Abandoned
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