JP2017512193A5 - - Google Patents
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- JP2017512193A5 JP2017512193A5 JP2016553322A JP2016553322A JP2017512193A5 JP 2017512193 A5 JP2017512193 A5 JP 2017512193A5 JP 2016553322 A JP2016553322 A JP 2016553322A JP 2016553322 A JP2016553322 A JP 2016553322A JP 2017512193 A5 JP2017512193 A5 JP 2017512193A5
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- Prior art keywords
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- skin
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- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 61
- 102000010787 Interleukin-4 Receptors Human genes 0.000 claims 11
- 108010038486 Interleukin-4 Receptors Proteins 0.000 claims 11
- 239000005557 antagonist Substances 0.000 claims 9
- 206010040872 skin infection Diseases 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 241000894007 species Species 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 206010012438 Dermatitis atopic Diseases 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 201000008937 atopic dermatitis Diseases 0.000 claims 5
- 208000015181 infectious disease Diseases 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 230000002458 infectious effect Effects 0.000 claims 4
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 4
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 4
- 230000008591 skin barrier function Effects 0.000 claims 4
- 241000222122 Candida albicans Species 0.000 claims 3
- 241000194017 Streptococcus Species 0.000 claims 3
- 239000003242 anti bacterial agent Substances 0.000 claims 3
- 229940121375 antifungal agent Drugs 0.000 claims 3
- 239000003429 antifungal agent Substances 0.000 claims 3
- 239000003443 antiviral agent Substances 0.000 claims 3
- 229940095731 candida albicans Drugs 0.000 claims 3
- 239000003246 corticosteroid Substances 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 244000005700 microbiome Species 0.000 claims 3
- 208000037851 severe atopic dermatitis Diseases 0.000 claims 3
- 241000223600 Alternaria Species 0.000 claims 2
- 241000228212 Aspergillus Species 0.000 claims 2
- 241000222290 Cladosporium Species 0.000 claims 2
- 241000709687 Coxsackievirus Species 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 241000228143 Penicillium Species 0.000 claims 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 2
- 241000700584 Simplexvirus Species 0.000 claims 2
- 206010041925 Staphylococcal infections Diseases 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 241000700618 Vaccinia virus Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 208000015339 staphylococcus aureus infection Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 241000606125 Bacteroides Species 0.000 claims 1
- 241001148536 Bacteroides sp. Species 0.000 claims 1
- 206010007882 Cellulitis Diseases 0.000 claims 1
- 208000010201 Exanthema Diseases 0.000 claims 1
- 206010016936 Folliculitis Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 1
- 206010021531 Impetigo Diseases 0.000 claims 1
- 241001480037 Microsporum Species 0.000 claims 1
- 241000223259 Trichoderma Species 0.000 claims 1
- 241000223238 Trichophyton Species 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 229950003468 dupilumab Drugs 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 208000024711 extrinsic asthma Diseases 0.000 claims 1
- 208000024386 fungal infectious disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
- 206010040882 skin lesion Diseases 0.000 claims 1
- 231100000444 skin lesion Toxicity 0.000 claims 1
- 210000000434 stratum corneum Anatomy 0.000 claims 1
- 230000005068 transpiration Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461946237P | 2014-02-28 | 2014-02-28 | |
| US61/946,237 | 2014-02-28 | ||
| US201461952245P | 2014-03-13 | 2014-03-13 | |
| US61/952,245 | 2014-03-13 | ||
| US201461986371P | 2014-04-30 | 2014-04-30 | |
| US61/986,371 | 2014-04-30 | ||
| EP14306476 | 2014-09-24 | ||
| EP14306476.4 | 2014-09-24 | ||
| US201562100128P | 2015-01-06 | 2015-01-06 | |
| US62/100,128 | 2015-01-06 | ||
| PCT/US2015/017834 WO2015130975A1 (en) | 2014-02-28 | 2015-02-26 | Methods for treating skin infection by administering an il-4r antagonist |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017512193A JP2017512193A (ja) | 2017-05-18 |
| JP2017512193A5 true JP2017512193A5 (OSRAM) | 2018-03-22 |
| JP6526037B2 JP6526037B2 (ja) | 2019-06-05 |
Family
ID=51663113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553322A Active JP6526037B2 (ja) | 2014-02-28 | 2015-02-26 | Ｉｌ−４ｒアンタゴニストを投与することによる皮膚感染を処置するための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10370449B2 (OSRAM) |
| EP (2) | EP4353254A3 (OSRAM) |
| JP (1) | JP6526037B2 (OSRAM) |
| KR (3) | KR20240128110A (OSRAM) |
| CN (1) | CN106062000B (OSRAM) |
| AU (2) | AU2015222951B2 (OSRAM) |
| CA (1) | CA2939506C (OSRAM) |
| ES (1) | ES2973858T3 (OSRAM) |
| MX (1) | MX376691B (OSRAM) |
| PL (1) | PL3110848T3 (OSRAM) |
| PT (1) | PT3110848T (OSRAM) |
| RU (1) | RU2704999C2 (OSRAM) |
| WO (1) | WO2015130975A1 (OSRAM) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| RU2690675C2 (ru) | 2012-08-21 | 2019-06-05 | Санофи Байотекнолоджи | Способы лечения или предотвращения астмы посредством введения антагониста il-4r |
| TWI697334B (zh) | 2013-06-04 | 2020-07-01 | 美商再生元醫藥公司 | 藉由投與ｉｌ-４ｒ抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| WO2015130975A1 (en) | 2014-02-28 | 2015-09-03 | Regeneron Pharmaceuticals, Inc. | Methods for treating skin infection by administering an il-4r antagonist |
| MX2017006286A (es) | 2014-11-14 | 2018-01-23 | Sanofi Biotechnology | Metodos para tratar sinusitis cronica con polipos nasales por administracion de un antagonista de il-4r. |
| CN107474134B (zh) | 2016-06-08 | 2021-07-27 | 苏州康乃德生物医药有限公司 | 用于结合白细胞介素4受体的抗体 |
| EP4442323A3 (en) | 2016-09-01 | 2025-01-01 | Regeneron Pharmaceuticals, Inc. | Methods for preventing or treating allergy by administering an il-4r antagonist |
| US10485844B2 (en) | 2016-09-22 | 2019-11-26 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor |
| TWI784988B (zh) | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| WO2019028367A1 (en) | 2017-08-04 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
| KR20250111396A (ko) | 2017-09-05 | 2025-07-22 | 아지트라 인코포레이티드 | 재조합 미생물을 사용하여 염증성 피부 질환을 치료하기 위한 방법 및 조성물 |
| KR20250044796A (ko) | 2017-10-30 | 2025-04-01 | 사노피 바이오테크놀로지 | Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법 |
| MA52624A (fr) | 2018-05-13 | 2021-03-24 | Regeneron Pharma | Méthodes de traitement de la dermatite atopique par administration d'un inhibiteur de l'il-4r |
| US11312778B2 (en) | 2018-11-21 | 2022-04-26 | Brian C. Machler | Method for treating allergic contact dermatitis |
| CN111494626B (zh) | 2018-12-25 | 2022-06-21 | 江苏荃信生物医药股份有限公司 | 用于治疗il-4和/或il-13介导的信号转导相关的疾病的药物组合物 |
| EP3935085A1 (en) * | 2019-03-06 | 2022-01-12 | Regeneron Pharmaceuticals, Inc. | Il-4/il-13 pathway inhibitors for enhanced efficacy in treating cancer |
| PH12021552123A1 (en) | 2019-03-21 | 2022-08-22 | Regeneron Pharma | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
| JP7592064B2 (ja) | 2019-07-16 | 2024-11-29 | サノフィ・バイオテクノロジー | Ｉｌ－４ｒアンタゴニストを投与することにより喘息を治療するまたは予防するための方法 |
| US11504426B2 (en) | 2019-08-05 | 2022-11-22 | Regeneron Pharmaceuticals, Inc. | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist |
| AU2020326713A1 (en) | 2019-08-05 | 2022-02-17 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| BR112022011098A2 (pt) | 2019-12-09 | 2022-09-20 | Sanofi Biotechnology | Métodos para tratamento de distúrbios relacionados a il-4/il-13 digitalmente identificados |
| EP3992974A1 (en) | 2020-11-02 | 2022-05-04 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
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| WO2015130975A1 (en) | 2014-02-28 | 2015-09-03 | Regeneron Pharmaceuticals, Inc. | Methods for treating skin infection by administering an il-4r antagonist |
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| EP4442323A3 (en) | 2016-09-01 | 2025-01-01 | Regeneron Pharmaceuticals, Inc. | Methods for preventing or treating allergy by administering an il-4r antagonist |
| US10485844B2 (en) | 2016-09-22 | 2019-11-26 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor |
| EP4345110A3 (en) | 2016-09-22 | 2024-06-12 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an il-4r inhibitor |
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| WO2019028367A1 (en) | 2017-08-04 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
| KR20250044796A (ko) | 2017-10-30 | 2025-04-01 | 사노피 바이오테크놀로지 | Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법 |
| MA52624A (fr) | 2018-05-13 | 2021-03-24 | Regeneron Pharma | Méthodes de traitement de la dermatite atopique par administration d'un inhibiteur de l'il-4r |
| PH12021552123A1 (en) | 2019-03-21 | 2022-08-22 | Regeneron Pharma | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
| US11504426B2 (en) | 2019-08-05 | 2022-11-22 | Regeneron Pharmaceuticals, Inc. | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist |
| AU2020326713A1 (en) | 2019-08-05 | 2022-02-17 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| BR112022011098A2 (pt) | 2019-12-09 | 2022-09-20 | Sanofi Biotechnology | Métodos para tratamento de distúrbios relacionados a il-4/il-13 digitalmente identificados |
| IL298257A (en) | 2020-05-22 | 2023-01-01 | Regeneron Pharma | Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor |
| US20220220211A1 (en) | 2021-01-08 | 2022-07-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating peanut allergy and enhancing peanut allergen-specific immunotherapy by administering an il-4r antagonist |
-
2015
- 2015-02-26 WO PCT/US2015/017834 patent/WO2015130975A1/en not_active Ceased
- 2015-02-26 CN CN201580010895.XA patent/CN106062000B/zh active Active
- 2015-02-26 ES ES15710650T patent/ES2973858T3/es active Active
- 2015-02-26 EP EP23219610.5A patent/EP4353254A3/en active Pending
- 2015-02-26 MX MX2016011132A patent/MX376691B/es active IP Right Grant
- 2015-02-26 JP JP2016553322A patent/JP6526037B2/ja active Active
- 2015-02-26 KR KR1020247026710A patent/KR20240128110A/ko active Pending
- 2015-02-26 CA CA2939506A patent/CA2939506C/en active Active
- 2015-02-26 PT PT157106501T patent/PT3110848T/pt unknown
- 2015-02-26 KR KR1020167023138A patent/KR20160120735A/ko not_active Ceased
- 2015-02-26 AU AU2015222951A patent/AU2015222951B2/en active Active
- 2015-02-26 EP EP15710650.1A patent/EP3110848B1/en active Active
- 2015-02-26 KR KR1020227016206A patent/KR102695088B1/ko active Active
- 2015-02-26 RU RU2016130056A patent/RU2704999C2/ru active
- 2015-02-26 US US14/632,988 patent/US10370449B2/en active Active
- 2015-02-26 PL PL15710650.1T patent/PL3110848T3/pl unknown
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2019
- 2019-05-28 US US16/424,094 patent/US11603408B2/en active Active
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2020
- 2020-06-29 AU AU2020204350A patent/AU2020204350B2/en active Active
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2023
- 2023-02-06 US US18/165,203 patent/US20230357416A1/en active Pending
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