JP2017512185A5 - - Google Patents
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- Publication number
- JP2017512185A5 JP2017512185A5 JP2016549314A JP2016549314A JP2017512185A5 JP 2017512185 A5 JP2017512185 A5 JP 2017512185A5 JP 2016549314 A JP2016549314 A JP 2016549314A JP 2016549314 A JP2016549314 A JP 2016549314A JP 2017512185 A5 JP2017512185 A5 JP 2017512185A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- polypeptide
- reporter moiety
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 229920001184 polypeptide Chemical group 0.000 claims 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000000623 heterocyclic group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 8
- 239000000975 dye Substances 0.000 claims 8
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 108090000790 Enzymes Proteins 0.000 claims 7
- 102000004190 Enzymes Human genes 0.000 claims 7
- -1 alkenyl polyol Chemical class 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 7
- 235000014633 carbohydrates Nutrition 0.000 claims 7
- 150000001720 carbohydrates Chemical class 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 150000002632 lipids Chemical class 0.000 claims 7
- 239000002105 nanoparticle Substances 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 229920000642 polymer Polymers 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 108090000623 proteins and genes Chemical group 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 239000000758 substrate Substances 0.000 claims 7
- 235000000346 sugar Nutrition 0.000 claims 7
- 239000004094 surface-active agent Substances 0.000 claims 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
- 239000003118 drug derivative Substances 0.000 claims 6
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 4
- 231100000167 toxic agent Toxicity 0.000 claims 4
- 239000003440 toxic substance Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000003053 toxin Substances 0.000 claims 3
- 231100000765 toxin Toxicity 0.000 claims 3
- HBZBAMXERPYTFS-SECBINFHSA-N (4S)-2-(6,7-dihydro-5H-pyrrolo[3,2-f][1,3]benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)[C@H]1CSC(=N1)c1nc2cc3CCNc3cc2s1 HBZBAMXERPYTFS-SECBINFHSA-N 0.000 claims 2
- 108060001084 Luciferase Proteins 0.000 claims 2
- 239000005089 Luciferase Substances 0.000 claims 2
- 230000004700 cellular uptake Effects 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 230000023077 detection of light stimulus Effects 0.000 claims 2
- 229920005862 polyol Polymers 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 150000008163 sugars Chemical class 0.000 claims 2
- 150000001336 alkenes Chemical class 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 210000000805 cytoplasm Anatomy 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000004020 luminiscence type Methods 0.000 claims 1
- 150000003077 polyols Chemical class 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
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| CN107922428B (zh) | 2015-06-25 | 2021-02-05 | 普洛麦格公司 | 噻吩并吡咯化合物及其作为刺虾源性荧光素酶的抑制剂的用途 |
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| US10815247B2 (en) | 2016-12-28 | 2020-10-27 | Promega Corporation | Functionalized NANOLUC inhibitors |
| JP7266304B2 (ja) | 2017-04-21 | 2023-04-28 | ユニヴァーシティー オブ タスマニア | 治療化合物および方法 |
| EP3395803A1 (en) * | 2017-04-28 | 2018-10-31 | Institut Pasteur | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins |
| JP7419260B2 (ja) | 2018-05-01 | 2024-01-22 | プロメガ コーポレイション | ＮａｎｏＬｕｃ自殺基質としてのセレンテラジン化合物 |
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2015
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2020
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