JP2017511793A5 - - Google Patents
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- JP2017511793A5 JP2017511793A5 JP2016550529A JP2016550529A JP2017511793A5 JP 2017511793 A5 JP2017511793 A5 JP 2017511793A5 JP 2016550529 A JP2016550529 A JP 2016550529A JP 2016550529 A JP2016550529 A JP 2016550529A JP 2017511793 A5 JP2017511793 A5 JP 2017511793A5
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- JP
- Japan
- Prior art keywords
- antibody
- medicament
- aria
- seq
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 claims 33
- 208000024827 Alzheimer disease Diseases 0.000 claims 11
- 206010072599 Amyloid related imaging abnormalities Diseases 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 239000000939 antiparkinson agent Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 230000002411 adverse Effects 0.000 claims 3
- 229950001954 crenezumab Drugs 0.000 claims 3
- 238000011156 evaluation Methods 0.000 claims 3
- SNKZJIOFVMKAOJ-UHFFFAOYSA-N 3-Aminopropanesulfonate Chemical compound NCCCS(O)(=O)=O SNKZJIOFVMKAOJ-UHFFFAOYSA-N 0.000 claims 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 2
- 229940099433 NMDA receptor antagonist Drugs 0.000 claims 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 2
- HWHLPVGTWGOCJO-UHFFFAOYSA-N Trihexyphenidyl Chemical group C1CCCCC1C(C=1C=CC=CC=1)(O)CCN1CCCCC1 HWHLPVGTWGOCJO-UHFFFAOYSA-N 0.000 claims 2
- 102100022205 Tumor necrosis factor receptor superfamily member 21 Human genes 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 230000001078 anti-cholinergic effect Effects 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 2
- 230000006999 cognitive decline Effects 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 230000000779 depleting effect Effects 0.000 claims 2
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 2
- 230000003291 dopaminomimetic effect Effects 0.000 claims 2
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical group O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 2
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 claims 2
- 229960003946 selegiline Drugs 0.000 claims 2
- MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical compound C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- WYDUSKDSKCASEF-LJQANCHMSA-N (1s)-1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol Chemical compound C([C@](O)(C1CCCCC1)C=1C=CC=CC=1)CN1CCCC1 WYDUSKDSKCASEF-LJQANCHMSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 claims 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 claims 1
- 108010005094 Advanced Glycation End Products Proteins 0.000 claims 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 1
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims 1
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims 1
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims 1
- 108010060159 Apolipoprotein E4 Proteins 0.000 claims 1
- 229940122041 Cholinesterase inhibitor Drugs 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 1
- 108010000817 Leuprolide Proteins 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 102000015499 Presenilins Human genes 0.000 claims 1
- 108010050254 Presenilins Proteins 0.000 claims 1
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims 1
- 101710187751 Tumor necrosis factor receptor superfamily member 21 Proteins 0.000 claims 1
- 229960003805 amantadine Drugs 0.000 claims 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 1
- 108010064539 amyloid beta-protein (1-42) Proteins 0.000 claims 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000000648 anti-parkinson Effects 0.000 claims 1
- 229960004046 apomorphine Drugs 0.000 claims 1
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 claims 1
- 229950001863 bapineuzumab Drugs 0.000 claims 1
- GIJXKZJWITVLHI-PMOLBWCYSA-N benzatropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(C=1C=CC=CC=1)C1=CC=CC=C1 GIJXKZJWITVLHI-PMOLBWCYSA-N 0.000 claims 1
- 229960001081 benzatropine Drugs 0.000 claims 1
- YSXKPIUOCJLQIE-UHFFFAOYSA-N biperiden Chemical compound C1C(C=C2)CC2C1C(C=1C=CC=CC=1)(O)CCN1CCCCC1 YSXKPIUOCJLQIE-UHFFFAOYSA-N 0.000 claims 1
- 229960002802 bromocriptine Drugs 0.000 claims 1
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 claims 1
- 229960004205 carbidopa Drugs 0.000 claims 1
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 claims 1
- PBKVEOSEPXMKDN-LZHUFOCISA-N chembl2311030 Chemical class CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)C)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)CC)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)CC(C)C)C(C)C)=C3C2=CNC3=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](C(N21)=O)(NC(=O)[C@H]1CN(C)[C@H]2[C@@H](C=3C=CC=C4NC=C(C=34)C2)C1)C(C)C)C1=CC=CC=C1 PBKVEOSEPXMKDN-LZHUFOCISA-N 0.000 claims 1
- 230000003930 cognitive ability Effects 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims 1
- 229960000520 diphenhydramine Drugs 0.000 claims 1
- 229960003530 donepezil Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229960003337 entacapone Drugs 0.000 claims 1
- JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 claims 1
- 229940040520 ergoloid mesylates Drugs 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- 229940014144 folate Drugs 0.000 claims 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 230000008717 functional decline Effects 0.000 claims 1
- 229960003980 galantamine Drugs 0.000 claims 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims 1
- 229950002508 gantenerumab Drugs 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 229960000905 indomethacin Drugs 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 229940047124 interferons Drugs 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims 1
- 229960004338 leuprorelin Drugs 0.000 claims 1
- 229960004502 levodopa Drugs 0.000 claims 1
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims 1
- 229960004640 memantine Drugs 0.000 claims 1
- 229960003966 nicotinamide Drugs 0.000 claims 1
- 235000005152 nicotinamide Nutrition 0.000 claims 1
- 239000011570 nicotinamide Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 229960004851 pergolide Drugs 0.000 claims 1
- YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 claims 1
- 239000000902 placebo Substances 0.000 claims 1
- 229940068196 placebo Drugs 0.000 claims 1
- 229960003089 pramipexole Drugs 0.000 claims 1
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 claims 1
- 229960005253 procyclidine Drugs 0.000 claims 1
- 239000000186 progesterone Substances 0.000 claims 1
- 229960003387 progesterone Drugs 0.000 claims 1
- 229960000245 rasagiline Drugs 0.000 claims 1
- RUOKEQAAGRXIBM-GFCCVEGCSA-N rasagiline Chemical compound C1=CC=C2[C@H](NCC#C)CCC2=C1 RUOKEQAAGRXIBM-GFCCVEGCSA-N 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 229960004136 rivastigmine Drugs 0.000 claims 1
- 229960001879 ropinirole Drugs 0.000 claims 1
- UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical compound CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 claims 1
- 229960003179 rotigotine Drugs 0.000 claims 1
- KFQYTPMOWPVWEJ-INIZCTEOSA-N rotigotine Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229950007874 solanezumab Drugs 0.000 claims 1
- 229940037128 systemic glucocorticoids Drugs 0.000 claims 1
- 229960001685 tacrine Drugs 0.000 claims 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 claims 1
- 102000013498 tau Proteins Human genes 0.000 claims 1
- 108010026424 tau Proteins Proteins 0.000 claims 1
- 229960004603 tolcapone Drugs 0.000 claims 1
- MIQPIUSUKVNLNT-UHFFFAOYSA-N tolcapone Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC(O)=C(O)C([N+]([O-])=O)=C1 MIQPIUSUKVNLNT-UHFFFAOYSA-N 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- WJJYZXPHLSLMGE-UHFFFAOYSA-N xaliproden Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4C=CC=CC4=CC=3)CC=2)=C1 WJJYZXPHLSLMGE-UHFFFAOYSA-N 0.000 claims 1
- 229960004664 xaliproden Drugs 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461937472P | 2014-02-08 | 2014-02-08 | |
| US61/937,472 | 2014-02-08 | ||
| US201461971479P | 2014-03-27 | 2014-03-27 | |
| US61/971,479 | 2014-03-27 | ||
| US201462010259P | 2014-06-10 | 2014-06-10 | |
| US62/010,259 | 2014-06-10 | ||
| US201462081992P | 2014-11-19 | 2014-11-19 | |
| US62/081,992 | 2014-11-19 | ||
| PCT/US2015/014758 WO2015120233A1 (en) | 2014-02-08 | 2015-02-06 | Methods of treating alzheimer's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019230200A Division JP2020073507A (ja) | 2014-02-08 | 2019-12-20 | アルツハイマー病治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017511793A JP2017511793A (ja) | 2017-04-27 |
| JP2017511793A5 true JP2017511793A5 (enExample) | 2018-03-22 |
| JP6685912B2 JP6685912B2 (ja) | 2020-04-22 |
Family
ID=52684643
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016550529A Active JP6685912B2 (ja) | 2014-02-08 | 2015-02-06 | アルツハイマー病治療方法 |
| JP2019230200A Pending JP2020073507A (ja) | 2014-02-08 | 2019-12-20 | アルツハイマー病治療方法 |
| JP2021204857A Withdrawn JP2022058369A (ja) | 2014-02-08 | 2021-12-17 | アルツハイマー病治療方法 |
| JP2023210860A Pending JP2024037893A (ja) | 2014-02-08 | 2023-12-14 | アルツハイマー病治療方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019230200A Pending JP2020073507A (ja) | 2014-02-08 | 2019-12-20 | アルツハイマー病治療方法 |
| JP2021204857A Withdrawn JP2022058369A (ja) | 2014-02-08 | 2021-12-17 | アルツハイマー病治療方法 |
| JP2023210860A Pending JP2024037893A (ja) | 2014-02-08 | 2023-12-14 | アルツハイマー病治療方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20150246963A1 (enExample) |
| EP (2) | EP3718563A1 (enExample) |
| JP (4) | JP6685912B2 (enExample) |
| KR (4) | KR20210121288A (enExample) |
| CN (1) | CN106163548A (enExample) |
| AU (1) | AU2015214058B2 (enExample) |
| BR (1) | BR112016018170A2 (enExample) |
| CA (1) | CA2938466C (enExample) |
| CL (2) | CL2016001979A1 (enExample) |
| HK (1) | HK1231401A1 (enExample) |
| IL (1) | IL246999B (enExample) |
| MX (1) | MX380252B (enExample) |
| MY (1) | MY179105A (enExample) |
| NZ (1) | NZ723884A (enExample) |
| RU (1) | RU2724190C2 (enExample) |
| SG (2) | SG10201913637RA (enExample) |
| TW (1) | TWI705824B (enExample) |
| WO (1) | WO2015120233A1 (enExample) |
| ZA (1) | ZA201605341B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015230972B2 (en) * | 2014-03-21 | 2021-05-27 | Alzheon, Inc. | Methods for treating neurological disorders |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| GB2541003A (en) * | 2015-08-05 | 2017-02-08 | Kran Life Sciences Llp | Neurodegenerative disorders |
| WO2017044840A1 (en) * | 2015-09-10 | 2017-03-16 | Alzheon, Inc. | Methods of treating neurodegenerative disorders in a particular patient population |
| CN116196410A (zh) | 2015-10-28 | 2023-06-02 | 宾夕法尼亚州大学信托人 | 鞘内施用腺伴随病毒载体用于基因治疗 |
| CN114113625A (zh) * | 2016-01-20 | 2022-03-01 | 基因泰克公司 | 用于阿尔茨海默氏病的高剂量治疗 |
| CN114796481A (zh) * | 2016-06-07 | 2022-07-29 | 生物基因国际神经科学有限责任公司 | 治疗阿尔茨海默病的方法 |
| CN109952097A (zh) * | 2016-07-29 | 2019-06-28 | 生物切萨皮克有限责任公司 | 治疗或预防与阿尔茨海默病治疗相关的淀粉样蛋白相关成像异常的方法 |
| IT201600118499A1 (it) * | 2016-11-25 | 2018-05-25 | Giacomo Koch | Uso di agonisti dopaminergici per la prevenzione della progressione della malattia di Alzheimer allo stadio precoce. |
| US12290516B2 (en) | 2017-05-12 | 2025-05-06 | The Hong Kong University Of Science And Technology | Heterocyclic compounds as EphA4 inhibitors |
| HRP20230387T1 (hr) | 2017-08-22 | 2023-07-07 | Biogen Ma Inc. | Farmaceutski pripravci koji sadrže anti-beta amiloidna antitijela |
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