JP2017510576A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017510576A5 JP2017510576A5 JP2016558222A JP2016558222A JP2017510576A5 JP 2017510576 A5 JP2017510576 A5 JP 2017510576A5 JP 2016558222 A JP2016558222 A JP 2016558222A JP 2016558222 A JP2016558222 A JP 2016558222A JP 2017510576 A5 JP2017510576 A5 JP 2017510576A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- carbonyl
- pyridine
- diazepine
- carboxylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 2,3-dihydro-1H-isoindol-2-yl Chemical group 0.000 claims 59
- 150000001875 compounds Chemical class 0.000 claims 32
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 125000004076 pyridyl group Chemical group 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- 125000001188 haloalkyl group Chemical group 0.000 claims 11
- 125000002071 phenylalkoxy group Chemical group 0.000 claims 11
- 125000005359 phenoxyalkyl group Chemical group 0.000 claims 10
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 9
- 125000004438 haloalkoxy group Chemical group 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 125000003884 phenylalkyl group Chemical group 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000004244 benzofuran-2-yl group Chemical group [H]C1=C(*)OC2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 6
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 6
- 125000002249 indol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([*])=C([H])C2=C1[H] 0.000 claims 6
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 6
- 125000001544 thienyl group Chemical group 0.000 claims 6
- 125000004122 cyclic group Chemical group 0.000 claims 5
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004103 aminoalkyl group Chemical group 0.000 claims 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- HCDJQBTVYWELRZ-UHFFFAOYSA-N 1h-diazepine-7-carboxylic acid Chemical compound OC(=O)C1=CC=CC=NN1 HCDJQBTVYWELRZ-UHFFFAOYSA-N 0.000 claims 3
- 208000012902 Nervous system disease Diseases 0.000 claims 3
- 206010052779 Transplant rejections Diseases 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 3
- 230000001684 chronic effect Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 3
- 230000003176 fibrotic effect Effects 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 208000017169 kidney disease Diseases 0.000 claims 3
- 208000019423 liver disease Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- GMBGJLJXWMRPIE-UHFFFAOYSA-N 1-[2-(1,2,3,3a,4,6,7,7a-octahydrotriazolo[4,5-c]pyridine-5-carbonyl)-4,5,7,8-tetrahydropyrazolo[1,5-d][1,4]diazepin-6-yl]-3-[4-(trifluoromethoxy)phenyl]propan-1-one Chemical compound C1CN(CC2C1NNN2)C(=O)C3=NN4CCN(CCC4=C3)C(=O)CCC5=CC=C(C=C5)OC(F)(F)F GMBGJLJXWMRPIE-UHFFFAOYSA-N 0.000 claims 2
- YUOJULDAKIAAMA-UHFFFAOYSA-N CCC1=C(OCC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=CC(=C1)C#N Chemical compound CCC1=C(OCC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=CC(=C1)C#N YUOJULDAKIAAMA-UHFFFAOYSA-N 0.000 claims 2
- PRWLPVCFKAAQDK-UHFFFAOYSA-N FC(F)OC1=C(F)C=C(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=C1 Chemical compound FC(F)OC1=C(F)C=C(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=C1 PRWLPVCFKAAQDK-UHFFFAOYSA-N 0.000 claims 2
- ZVBXGHZQUZNITD-DUXPYHPUSA-N FC(F)OC1=C(F)C=C(\C=C\C(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=C1 Chemical compound FC(F)OC1=C(F)C=C(\C=C\C(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=C1 ZVBXGHZQUZNITD-DUXPYHPUSA-N 0.000 claims 2
- XYXJKFGZOCUJAV-UHFFFAOYSA-N FC1=C(C=CC(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)=C1)C#N Chemical compound FC1=C(C=CC(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)=C1)C#N XYXJKFGZOCUJAV-UHFFFAOYSA-N 0.000 claims 2
- FCDVKPXUJSOLBD-UHFFFAOYSA-N FC1=C(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=CC(=C1)C#N Chemical compound FC1=C(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=CC(=C1)C#N FCDVKPXUJSOLBD-UHFFFAOYSA-N 0.000 claims 2
- VKVXAFZJLAELDA-UHFFFAOYSA-N FC1=C(OC(F)(F)F)C=CC(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)=C1 Chemical compound FC1=C(OC(F)(F)F)C=CC(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)=C1 VKVXAFZJLAELDA-UHFFFAOYSA-N 0.000 claims 2
- JZZLUZUCQVQRBW-UHFFFAOYSA-N N1N=NC=2CN(CCC21)C(=O)C2=NN1CCN(CCC1=C2)C(=O)OCC2=CC=CC=C2 Chemical compound N1N=NC=2CN(CCC21)C(=O)C2=NN1CCN(CCC1=C2)C(=O)OCC2=CC=CC=C2 JZZLUZUCQVQRBW-UHFFFAOYSA-N 0.000 claims 2
- TTWYWZFETSEMJI-UHFFFAOYSA-N O=C(COC1=C(C=C(C=C1)C#N)C1CC1)N1CCN2N=C(C=C2CC1)C(=O)N1CCC2=C(C1)N=NN2 Chemical compound O=C(COC1=C(C=C(C=C1)C#N)C1CC1)N1CCN2N=C(C=C2CC1)C(=O)N1CCC2=C(C1)N=NN2 TTWYWZFETSEMJI-UHFFFAOYSA-N 0.000 claims 2
- RLQNNQXQAXRJKB-UHFFFAOYSA-N O=C(OCC1=CC=C(C=C1)C#N)N1CCN2N=C(C=C2CC1)C(=O)N1CCC2=C(C1)N=NN2 Chemical compound O=C(OCC1=CC=C(C=C1)C#N)N1CCN2N=C(C=C2CC1)C(=O)N1CCC2=C(C1)N=NN2 RLQNNQXQAXRJKB-UHFFFAOYSA-N 0.000 claims 2
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 2
- 125000005081 alkoxyalkoxyalkyl group Chemical group 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 2
- 125000004858 cycloalkoxyalkyl group Chemical group 0.000 claims 2
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 2
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims 2
- 125000005171 cycloalkylsulfanyl group Chemical group 0.000 claims 2
- 125000005149 cycloalkylsulfinyl group Chemical group 0.000 claims 2
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000004439 haloalkylsulfanyl group Chemical group 0.000 claims 2
- 125000004440 haloalkylsulfinyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- UFUASNAHBMBJIX-UHFFFAOYSA-N propan-1-one Chemical compound CC[C]=O UFUASNAHBMBJIX-UHFFFAOYSA-N 0.000 claims 2
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- XSRSXIBAUWUKJZ-UHFFFAOYSA-N (4-methoxyphenyl)methyl 2-(1,2,3,3a,4,6,7,7a-octahydrotriazolo[4,5-c]pyridine-5-carbonyl)-4,5,7,8-tetrahydropyrazolo[1,5-d][1,4]diazepine-6-carboxylate Chemical compound COC1=CC=C(C=C1)COC(=O)N2CCC3=CC(=NN3CC2)C(=O)N4CCC5C(C4)NNN5 XSRSXIBAUWUKJZ-UHFFFAOYSA-N 0.000 claims 1
- FEEDXFJJEWKDQS-UHFFFAOYSA-N 1,2,3,5,6,8-hexahydroimidazo[1,2-d][1,4]diazepine-7-carboxylic acid Chemical compound C1CN2CCN(CC=C2N1)C(=O)O FEEDXFJJEWKDQS-UHFFFAOYSA-N 0.000 claims 1
- ZMJNNPMURGKLLB-UHFFFAOYSA-N 1-[2-(1,2,3,3a,4,6,7,7a-octahydrotriazolo[4,5-c]pyridine-5-carbonyl)-4,5,7,8-tetrahydropyrazolo[1,5-d][1,4]diazepin-6-yl]-3-[4-(difluoromethoxy)-3-fluorophenyl]propan-1-one Chemical compound C1CN(CC2C1NNN2)C(=O)C3=NN4CCN(CCC4=C3)C(=O)CCC5=CC(=C(C=C5)OC(F)F)F ZMJNNPMURGKLLB-UHFFFAOYSA-N 0.000 claims 1
- ICVXGVGABINVHF-UHFFFAOYSA-N COC1=C(F)C=C(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=C1 Chemical compound COC1=C(F)C=C(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=C1 ICVXGVGABINVHF-UHFFFAOYSA-N 0.000 claims 1
- NSYSENPPXUMHGR-UHFFFAOYSA-N COC1=CC(C)=C(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=C1 Chemical compound COC1=CC(C)=C(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=C1 NSYSENPPXUMHGR-UHFFFAOYSA-N 0.000 claims 1
- KCCXZLKJIBUZJK-UHFFFAOYSA-N COC1=CC=C(C=C1)CCC(=O)N1CCN2C(CC1)=CC(=N2)C(=O)N2CC1=C(CC2)NN=N1 Chemical compound COC1=CC=C(C=C1)CCC(=O)N1CCN2C(CC1)=CC(=N2)C(=O)N2CC1=C(CC2)NN=N1 KCCXZLKJIBUZJK-UHFFFAOYSA-N 0.000 claims 1
- JGLOZZNBXVELFE-UHFFFAOYSA-N FC(F)(F)OC1=C(Cl)C=C(CCC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=C1 Chemical compound FC(F)(F)OC1=C(Cl)C=C(CCC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=C1 JGLOZZNBXVELFE-UHFFFAOYSA-N 0.000 claims 1
- AHXVDAZHUDPKLC-UHFFFAOYSA-N FC(F)(F)OC1=CC=C(CCC(=O)N2CCN3N=C(N=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=C1 Chemical compound FC(F)(F)OC1=CC=C(CCC(=O)N2CCN3N=C(N=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=C1 AHXVDAZHUDPKLC-UHFFFAOYSA-N 0.000 claims 1
- MXSFTQSOVZLBEH-UHFFFAOYSA-N FC1=CC=C(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=C1 Chemical compound FC1=CC=C(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)C=C1 MXSFTQSOVZLBEH-UHFFFAOYSA-N 0.000 claims 1
- NBUPLPLOLPUNAJ-UHFFFAOYSA-N FC1=CC=CC(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)=C1 Chemical compound FC1=CC=CC(COC(=O)N2CCN3N=C(C=C3CC2)C(=O)N2CCC3=C(C2)N=NN3)=C1 NBUPLPLOLPUNAJ-UHFFFAOYSA-N 0.000 claims 1
- BJMFVUKWCFELMG-UHFFFAOYSA-N O=C(OCC1=CC=C(C=C1)C1CC1)N1CCN2N=C(C=C2CC1)C(=O)N1CCC2=C(C1)N=NN2 Chemical compound O=C(OCC1=CC=C(C=C1)C1CC1)N1CCN2N=C(C=C2CC1)C(=O)N1CCC2=C(C1)N=NN2 BJMFVUKWCFELMG-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14161756 | 2014-03-26 | ||
| EP14161756.3 | 2014-03-26 | ||
| PCT/EP2015/056041 WO2015144609A1 (en) | 2014-03-26 | 2015-03-23 | Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017510576A JP2017510576A (ja) | 2017-04-13 |
| JP2017510576A5 true JP2017510576A5 (show.php) | 2018-04-26 |
| JP6554481B2 JP6554481B2 (ja) | 2019-07-31 |
Family
ID=50389847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016558222A Expired - Fee Related JP6554481B2 (ja) | 2014-03-26 | 2015-03-23 | オートタキシン（ａｔｘ）及びリゾホスファチジン酸（ｌｐａ）産生の阻害剤としての縮合［１，４］ジアゼピン化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10669285B2 (show.php) |
| EP (1) | EP3122751B1 (show.php) |
| JP (1) | JP6554481B2 (show.php) |
| KR (1) | KR20160128428A (show.php) |
| CN (1) | CN106029667B (show.php) |
| AR (1) | AR099823A1 (show.php) |
| AU (1) | AU2015238541B2 (show.php) |
| CA (1) | CA2935612A1 (show.php) |
| CL (1) | CL2016002317A1 (show.php) |
| CR (1) | CR20160418A (show.php) |
| EA (1) | EA032357B1 (show.php) |
| IL (1) | IL246501B (show.php) |
| MX (1) | MX373236B (show.php) |
| PE (1) | PE20161223A1 (show.php) |
| PH (1) | PH12016501633B1 (show.php) |
| SG (1) | SG11201607845RA (show.php) |
| TW (1) | TWI678370B (show.php) |
| UA (1) | UA119347C2 (show.php) |
| WO (1) | WO2015144609A1 (show.php) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014030473A2 (pt) | 2012-06-13 | 2017-06-27 | Hoffmann La Roche | novo diazaespirocicloalcano e azaespirocicloalcano |
| SI2900669T1 (sl) | 2012-09-25 | 2019-12-31 | F. Hoffmann-La Roche Ag | Derivati heksahidropirolo(3,4-C)pirola in sorodne spojine kot zaviralci avtotaksina (ATX) in kot zaviralci tvorbe lizofosfatidne kisline (LPA) za zdravljenje npr. bolezni ledvic |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| JP6496730B2 (ja) | 2013-11-26 | 2019-04-03 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規なオクタヒドロ−シクロブタ［１，２−ｃ；３，４−ｃ’］ジピロール−２−イル |
| CN105940002B (zh) | 2014-02-03 | 2018-09-25 | 生命医药公司 | ROR-γ的二氢吡咯并吡啶抑制剂 |
| MX370659B (es) | 2014-03-26 | 2019-12-19 | Hoffmann La Roche | Compuestos bicíclicos como inhibidores de producción de autotaxina (atx) y ácido lisofosfatídico (lpa). |
| MX373236B (es) | 2014-03-26 | 2020-05-08 | Hoffmann La Roche | Compuestos condensados de [1,4]diazepina como inhibidores de producción de la autotaxina (atx) y ácido lisofosfatidico (lpa). |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| US10301261B2 (en) | 2015-08-05 | 2019-05-28 | Vitae Pharmaceuticals, Llc | Substituted indoles as modulators of ROR-gamma |
| MX387736B (es) | 2015-09-04 | 2025-03-18 | Hoffmann La Roche | Derivados de fenoximetilo. |
| PE20180461A1 (es) | 2015-09-24 | 2018-03-06 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores de la atx |
| KR20180054635A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 오토탁신(atx) 억제제로서 이환형 화합물 |
| CA2984585A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual atx/ca inhibitors |
| KR20180054634A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물 |
| AU2016355710B2 (en) | 2015-11-20 | 2021-03-25 | Vitae Pharmaceuticals, Llc | Modulators of ROR-gamma |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| EP3548484B1 (en) | 2016-12-02 | 2025-04-30 | F. Hoffmann-La Roche AG | Bicyclic amide compounds and methods of use thereof |
| CN110392679B (zh) * | 2017-03-16 | 2023-04-07 | 豪夫迈·罗氏有限公司 | 可用作双重atx/ca抑制剂的杂环化合物 |
| WO2018167113A1 (en) * | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
| PT3652178T (pt) | 2017-07-14 | 2024-03-18 | H Hoffnabb La Roche Ag | Compostos bicíclicos de cetona e métodos de utilização dos mesmos |
| SG11202000621VA (en) | 2017-07-24 | 2020-02-27 | Vitae Pharmaceuticals Llc | Inhibitors of ror? |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| WO2019086494A1 (en) | 2017-10-31 | 2019-05-09 | F. Hoffmann-La Roche Ag | Bicyclic sulfones and sulfoxides and methods of use thereof |
| AR119673A1 (es) | 2019-01-11 | 2022-01-05 | Hoffmann La Roche | Compuestos bicíclicos de cetona y métodos para utilizarlos |
| JP7656367B2 (ja) * | 2021-10-01 | 2025-04-03 | ネクストジェン バイオサイエンス カンパニー リミテッド | 新規なピペリジン誘導体及びそれを含むオートタキシン阻害用薬学組成物 |
Family Cites Families (122)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1252898B (de) | 1965-06-12 | 1967-10-26 | Bayer Ag | Verfahren zur Herstellung von Copolymerisaten des Trioxans |
| US5240928A (en) | 1989-07-03 | 1993-08-31 | Merck & Co., Inc. | Substituted quinazolinones as angiotensin II antagonists |
| DE3930262A1 (de) | 1989-09-11 | 1991-03-21 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| CA2037630C (en) | 1990-03-07 | 2001-07-03 | Akira Morimoto | Nitrogen-containing heterocylic compounds, their production and use |
| US5470975A (en) | 1990-10-16 | 1995-11-28 | E.R. Squibb & Sons, Inc. | Dihydropyrimidine derivatives |
| US5290780A (en) | 1991-01-30 | 1994-03-01 | American Cyanamid Co. | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones |
| US5238942A (en) | 1991-05-10 | 1993-08-24 | Merck & Co., Inc. | Substituted quinazolinones bearing acidic functional groups as angiotensin ii antagonists |
| US5202322A (en) | 1991-09-25 | 1993-04-13 | Merck & Co., Inc. | Quinazolinone and pyridopyrimidine a-II antagonists |
| US5532243A (en) | 1992-02-14 | 1996-07-02 | The Dupont Merck Pharmaceutical Company | Antipsychotic nitrogen-containing bicyclic compounds |
| US5358951A (en) | 1993-04-23 | 1994-10-25 | American Cyanamid Company | Angiotensin II receptor blocking 2, 3, 6 substituted quinazolinones |
| DE4407047A1 (de) | 1994-03-03 | 1995-09-07 | Merck Patent Gmbh | Acetamide |
| US20010016657A1 (en) | 1997-03-18 | 2001-08-23 | Smithkline Beecham P.L.C. | Substituted isoquinoline derivatives and their use as anticonvulsants |
| TR200002241T2 (tr) | 1998-02-04 | 2000-11-21 | Banyu Pharmaceutical Co., Ltd. | N-Asil siklik amin türevleri |
| JP2001039950A (ja) | 1999-07-30 | 2001-02-13 | Banyu Pharmaceut Co Ltd | Ｎ−アシル環状アミン誘導体 |
| WO2001030780A2 (en) | 1999-10-27 | 2001-05-03 | Cor Therapeutics, Inc. | Pyridyl-containing spirocyclic compounds as inhibitors of fibrinogen-dependent platelet aggregation |
| EP1368354A1 (en) | 2001-03-07 | 2003-12-10 | Pfizer Products Inc. | Modulators of chemokine receptor activity |
| EP1499306A4 (en) | 2002-04-12 | 2007-03-28 | Merck & Co Inc | BICYCLIC AMIDE |
| GB0303852D0 (en) | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
| WO2005023762A1 (en) | 2003-09-04 | 2005-03-17 | Abbott Laboratories | Pyrrolidine-2-carbonitrile derivatives and their use as inhibitors of dipeptidyl peptidase-iv (dpp-iv) |
| SE0302811D0 (sv) | 2003-10-23 | 2003-10-23 | Astrazeneca Ab | Novel compounds |
| GB0324790D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Amide derivatives |
| US7226951B2 (en) | 2003-12-17 | 2007-06-05 | Allergan, Inc. | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same |
| AU2005219438B2 (en) | 2004-03-03 | 2011-02-17 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| MXPA06014404A (es) | 2004-06-09 | 2007-02-19 | Hoffmann La Roche | Compuestos heterociclicos antivirales. |
| JP5031564B2 (ja) | 2004-08-10 | 2012-09-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｈｉｖ抑制１，２，４−トリアジン−６−オン誘導体 |
| US7410949B2 (en) | 2005-01-18 | 2008-08-12 | Hoffmann-La Roche Inc. | Neuropeptide-2 receptor (Y-2R) agonists and uses thereof |
| CN101166736B (zh) | 2005-04-28 | 2013-02-06 | 惠氏公司 | 他那普戈特的多晶型ⅱ |
| US7737279B2 (en) | 2005-05-10 | 2010-06-15 | Bristol-Myers Squibb Company | 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same |
| TW200800999A (en) | 2005-09-06 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
| DK1942108T3 (da) | 2005-10-28 | 2013-12-09 | Ono Pharmaceutical Co | Forbindelse indeholdende basisk gruppe samt anvendelse deraf |
| ES2407115T3 (es) | 2005-11-18 | 2013-06-11 | Ono Pharmaceutical Co., Ltd. | Compuesto que contiene un grupo básico y uso del mismo |
| US20070208001A1 (en) | 2006-03-03 | 2007-09-06 | Jincong Zhuo | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| JP2008031064A (ja) | 2006-07-27 | 2008-02-14 | Astellas Pharma Inc | ジアシルピペラジン誘導体 |
| RU2009113612A (ru) | 2006-09-11 | 2010-10-20 | Н.В. Органон (Nl) | Ацетамидные производные хиназолинона и изохинолинона |
| WO2008033456A1 (en) | 2006-09-15 | 2008-03-20 | Schering Corporation | Spiro-condensed azetidine derivatives useful in treating pain, diabetes and disorders of lipid metabilism |
| US8735411B2 (en) | 2006-10-02 | 2014-05-27 | Abbvie Inc. | Macrocyclic benzofused pyrimidine derivatives |
| EP2097388B1 (en) | 2006-11-15 | 2011-09-07 | High Point Pharmaceuticals, LLC | Novel 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes |
| TW200831085A (en) | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
| EP1975165A1 (de) | 2007-03-27 | 2008-10-01 | Boehringer Ingelheim Pharma GmbH & Co. KG | Substituierte Pyrrolidinamide, deren Herstellung und deren Verwendung als Arzneimittel |
| EP2142520A1 (en) | 2007-03-29 | 2010-01-13 | F. Hoffmann-Roche AG | Non-nucleoside reverse transcriptase inhibitors |
| CL2008001002A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| MX2009011112A (es) | 2007-04-27 | 2009-10-28 | Sanofi Aventis | Derivados de 2-heteroaril-pirrolo[3,4-cipirrolo y su uso como inhibidores de scd. |
| DE102007047737A1 (de) | 2007-10-05 | 2009-04-30 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
| CA2958665C (en) | 2007-10-19 | 2021-03-02 | Sarcode Bioscience Inc. | Compositions and methods for treatment of diabetic retinopathy |
| TW200932236A (en) | 2007-10-31 | 2009-08-01 | Janssen Pharmaceutica Nv | Aryl-substituted bridged diamines as modulators of leukotriene A4 hydrolase |
| JP2009161449A (ja) | 2007-12-28 | 2009-07-23 | Lion Corp | Ｐｐａｒ活性促進剤並びに美容用飲食品、皮膚外用剤及び医薬 |
| JPWO2009154132A1 (ja) | 2008-06-19 | 2011-12-01 | Ｍｓｄ株式会社 | スピロジアミン−ジアリールケトオキシム誘導体 |
| WO2010028761A1 (de) | 2008-09-09 | 2010-03-18 | Sanofi-Aventis | 2-heteroaryl-pyrrolo[3, 4-c]pyrrol-derivate und ihre verwendung als scd inhibitoren |
| TW201020247A (en) | 2008-11-06 | 2010-06-01 | Gruenenthal Gmbh | Substituierte disulfonamide |
| US8188090B2 (en) | 2008-11-17 | 2012-05-29 | Hoffman-La Roche Inc. | Naphthylacetic acids |
| DE102008059578A1 (de) | 2008-11-28 | 2010-06-10 | Merck Patent Gmbh | Benzo-Naphtyridin Verbindungen |
| WO2010063352A1 (en) | 2008-12-01 | 2010-06-10 | Merck Patent Gmbh | 2, 5-diamino-substituted pyrido [4, 3-d] pyrimidines as autotaxin inhibitors against cancer |
| TW201035102A (en) | 2009-03-04 | 2010-10-01 | Gruenethal Gmbh | Sulfonylated tetrahydroazolopyrazines and their use as medicinal products |
| TW201038572A (en) | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
| AU2010234087B2 (en) | 2009-04-02 | 2016-05-12 | Merck Patent Gmbh | Piperidine and piperazine derivatives as autotaxin inhibitors |
| MX2011010218A (es) | 2009-04-02 | 2011-10-10 | Merck Patent Gmbh | Inhibidores de autotaxina. |
| EA201101399A1 (ru) | 2009-04-02 | 2012-08-30 | Мерк Патент Гмбх | Гетероциклические соединения в качестве ингибиторов аутотаксина |
| FR2945534B1 (fr) | 2009-05-12 | 2012-11-16 | Sanofi Aventis | DERIVES DE CYCLOPENTAL[c]PYRROLE-2-CARBOXYLATES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| BRPI1010974A2 (pt) | 2009-05-22 | 2019-09-24 | Exelixis Inc | benzoxazepinas baseada em inibidores p13k/ m tor contra doenças proliferativas |
| US20120083476A1 (en) | 2009-06-05 | 2012-04-05 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
| DE102009033392A1 (de) | 2009-07-16 | 2011-01-20 | Merck Patent Gmbh | Heterocyclische Verbindungen als Autotaxin-Inhibitoren II |
| JP2013501064A (ja) | 2009-08-04 | 2013-01-10 | アミラ ファーマシューティカルス，インコーポレーテッド | リゾホスファチジン酸受容体アンタゴニストとしての化合物 |
| UA107360C2 (en) | 2009-08-05 | 2014-12-25 | Biogen Idec Inc | Bicyclic aryl sphingosine 1-phosphate analogs |
| AR079022A1 (es) | 2009-11-02 | 2011-12-21 | Sanofi Aventis | Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion |
| JP5715646B2 (ja) | 2010-01-07 | 2015-05-13 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | 殺菌・殺カビ性ヘテロ環式化合物 |
| WO2011115813A1 (en) | 2010-03-18 | 2011-09-22 | Abbott Laboratories | Lactam acetamides as calcium channel blockers |
| BR112012023664B1 (pt) | 2010-03-19 | 2020-01-28 | Pfizer | Compostos derivados de 2,3-di-hidro-1hinden-1-il-2,7- diazaspiro [3,5] nonano e composiçãofarmacêutica compreendendo os mesmos |
| US9029387B2 (en) | 2010-03-26 | 2015-05-12 | Merck Patent Gmbh | Benzonaphthyridinamines as autotaxin inhibitors |
| GB201008005D0 (en) | 2010-05-13 | 2010-06-30 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| WO2011151461A2 (en) * | 2010-06-04 | 2011-12-08 | B.S.R.C. "Alexander Fleming" | Autotaxin pathway modulation and uses thereof |
| AR082590A1 (es) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
| WO2012024620A2 (en) | 2010-08-20 | 2012-02-23 | Amira Pharmaceuticals, Inc. | Autotaxin inhibitors and uses thereof |
| JP6039559B2 (ja) | 2010-09-02 | 2016-12-07 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｌｐａ受容体アンタゴニストとしてのピラゾロピリジノン誘導体 |
| JP5937102B2 (ja) | 2010-12-14 | 2016-06-22 | エレクトロフォレティクス リミテッド | カゼインキナーゼ１デルタ（ｃｋ１デルタ）阻害剤 |
| EP2714680B1 (en) | 2011-05-27 | 2015-11-25 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
| ES2609579T3 (es) | 2011-08-29 | 2017-04-21 | VIIV Healthcare UK (No.5) Limited | Derivados espiro de diamina bicíclica como inhibidores de la unión del VIH |
| WO2013054185A1 (en) | 2011-10-13 | 2013-04-18 | Pfizer, Inc. | Pyrimidine and pyridine derivatives useful in therapy |
| JPWO2013065712A1 (ja) | 2011-10-31 | 2015-04-02 | 東レ株式会社 | ジアザスピロウレア誘導体及びその医薬用途 |
| US8809552B2 (en) | 2011-11-01 | 2014-08-19 | Hoffmann-La Roche Inc. | Azetidine compounds, compositions and methods of use |
| EP2800745B1 (en) | 2011-12-02 | 2020-02-12 | Phenex Pharmaceuticals AG | Pyrrolo carboxamides as modulators of orphan nuclear receptor rar-related orphan receptor-gamma (rory, nr1f3) activity and for the treatment of chronic inflammatory and autoimmune diseases |
| TWI638802B (zh) | 2012-05-24 | 2018-10-21 | 芬蘭商奧利安公司 | 兒茶酚ｏ－甲基轉移酶活性抑制化合物 |
| SI2861595T1 (sl) | 2012-06-13 | 2017-04-26 | Incyte Holdings Corporation | Substituirane triciklične spojine kot inhibitorji fgfr |
| BR112014030473A2 (pt) | 2012-06-13 | 2017-06-27 | Hoffmann La Roche | novo diazaespirocicloalcano e azaespirocicloalcano |
| ES2671194T3 (es) | 2012-07-27 | 2018-06-05 | Biogen Ma Inc. | Compuestos que son agentes moduladores de S1P y/o agentes moduladores de ATX |
| KR102127026B1 (ko) | 2012-07-27 | 2020-06-25 | 비오겐 엠에이 아이엔씨. | Atx 조절제들 |
| SI2900669T1 (sl) | 2012-09-25 | 2019-12-31 | F. Hoffmann-La Roche Ag | Derivati heksahidropirolo(3,4-C)pirola in sorodne spojine kot zaviralci avtotaksina (ATX) in kot zaviralci tvorbe lizofosfatidne kisline (LPA) za zdravljenje npr. bolezni ledvic |
| LT2900269T (lt) | 2012-09-25 | 2018-11-12 | Bayer Pharma Aktiengesellschaft | Regorafenibo ir acetilsalicilo rūgšties derinys kolorektalinio vėžio gydymui |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| CA2886263C (en) | 2012-10-25 | 2021-04-13 | Tetra Discovery Partners, LLC | Heteroaryl inhibitors of pde4 |
| US20160002247A1 (en) | 2013-03-01 | 2016-01-07 | The University Of Tokyo | 8-substituted imidazopyrimidinone derivative having autotaxin inhibitory activity |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| PE20151788A1 (es) | 2013-03-12 | 2015-12-20 | Abbvie Inc | Inhibidores de bromodominios tetraciclicos |
| US9133154B2 (en) | 2013-03-12 | 2015-09-15 | Acucela Inc. | Substituted 3-phenylpropylamine derivatives for the treatment of ophthalmic diseases and disorders |
| TWI593692B (zh) | 2013-03-12 | 2017-08-01 | 美國禮來大藥廠 | 四氫吡咯并噻嗪化合物 |
| TW201446768A (zh) * | 2013-03-15 | 2014-12-16 | Biogen Idec Inc | S1p及/或atx調節劑 |
| US9763957B2 (en) | 2013-07-18 | 2017-09-19 | Novartis Ag | Autotaxin inhibitors |
| ES2671354T3 (es) | 2013-10-17 | 2018-06-06 | Vertex Pharmaceuticals Incorporated | Inhibidores de ADN-PK |
| WO2015077503A1 (en) | 2013-11-22 | 2015-05-28 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| JP6496730B2 (ja) | 2013-11-26 | 2019-04-03 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規なオクタヒドロ−シクロブタ［１，２−ｃ；３，４−ｃ’］ジピロール−２−イル |
| AR098475A1 (es) | 2013-11-26 | 2016-06-01 | Bayer Cropscience Ag | Compuestos pesticidas y usos |
| MX373236B (es) | 2014-03-26 | 2020-05-08 | Hoffmann La Roche | Compuestos condensados de [1,4]diazepina como inhibidores de producción de la autotaxina (atx) y ácido lisofosfatidico (lpa). |
| EA201691913A1 (ru) | 2014-03-26 | 2017-02-28 | Басф Се | Замещенные [1,2,4]триазольные и имидазольные соединения в качестве фунгицидов |
| MX370659B (es) | 2014-03-26 | 2019-12-19 | Hoffmann La Roche | Compuestos bicíclicos como inhibidores de producción de autotaxina (atx) y ácido lisofosfatídico (lpa). |
| JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
| AU2015240519B2 (en) | 2014-04-04 | 2019-08-15 | X-Rx, Inc. | Substituted spirocyclic inhibitors of autotaxin |
| DK3207043T6 (da) | 2014-10-14 | 2020-01-20 | Vitae Pharmaceuticals Llc | Dihydropyrrolopyridin-inhibitorer af ror-gamma |
| EP3256463B1 (en) | 2015-02-15 | 2019-10-09 | F. Hoffmann-La Roche AG | 1-(het)arylsulfonyl-(pyrrolidine or piperidine)-2-carboxamide derivatives and their use as trpa1 antagonists |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| CN104927727B (zh) | 2015-07-06 | 2017-01-11 | 香山红叶建设有限公司 | 一种玻璃幕墙用结构密封胶及其制备方法 |
| PL415078A1 (pl) | 2015-09-04 | 2017-03-13 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków |
| MX387736B (es) | 2015-09-04 | 2025-03-18 | Hoffmann La Roche | Derivados de fenoximetilo. |
| CA2984585A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual atx/ca inhibitors |
| KR20180051626A (ko) | 2015-09-24 | 2018-05-16 | 아이오니스 파마수티컬즈, 인코포레이티드 | Kras 발현의 조절제 |
| KR20180054634A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물 |
| KR20180054635A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 오토탁신(atx) 억제제로서 이환형 화합물 |
| PE20180461A1 (es) | 2015-09-24 | 2018-03-06 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores de la atx |
| JP7385356B2 (ja) | 2015-11-25 | 2023-11-22 | ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド | 二価ブロモドメインインヒビターおよびそれらの使用 |
| CN108290858B (zh) | 2015-12-01 | 2021-07-06 | 日本农药株式会社 | 3h-吡咯并吡啶化合物或其n-氧化物、或它们的盐类及含有该化合物的农业园艺用杀虫剂及其使用方法 |
| WO2017139978A1 (zh) | 2016-02-19 | 2017-08-24 | 吴伟东 | 手机app更新方法及系统 |
| CN110392679B (zh) | 2017-03-16 | 2023-04-07 | 豪夫迈·罗氏有限公司 | 可用作双重atx/ca抑制剂的杂环化合物 |
| WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
| US11014927B2 (en) | 2017-03-20 | 2021-05-25 | Forma Therapeutics, Inc. | Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators |
-
2015
- 2015-03-23 MX MX2016010675A patent/MX373236B/es active IP Right Grant
- 2015-03-23 CN CN201580008228.8A patent/CN106029667B/zh not_active Expired - Fee Related
- 2015-03-23 WO PCT/EP2015/056041 patent/WO2015144609A1/en not_active Ceased
- 2015-03-23 UA UAA201610688A patent/UA119347C2/uk unknown
- 2015-03-23 SG SG11201607845RA patent/SG11201607845RA/en unknown
- 2015-03-23 KR KR1020167029704A patent/KR20160128428A/ko not_active Ceased
- 2015-03-23 EA EA201691794A patent/EA032357B1/ru not_active IP Right Cessation
- 2015-03-23 EP EP15711207.9A patent/EP3122751B1/en active Active
- 2015-03-23 AU AU2015238541A patent/AU2015238541B2/en not_active Ceased
- 2015-03-23 CA CA2935612A patent/CA2935612A1/en not_active Abandoned
- 2015-03-23 JP JP2016558222A patent/JP6554481B2/ja not_active Expired - Fee Related
- 2015-03-23 CR CR20160418A patent/CR20160418A/es unknown
- 2015-03-23 PE PE2016001541A patent/PE20161223A1/es active IP Right Grant
- 2015-03-25 TW TW104109652A patent/TWI678370B/zh not_active IP Right Cessation
- 2015-03-25 AR ARP150100864A patent/AR099823A1/es unknown
-
2016
- 2016-06-28 IL IL246501A patent/IL246501B/en active IP Right Grant
- 2016-08-16 PH PH12016501633A patent/PH12016501633B1/en unknown
- 2016-09-14 CL CL2016002317A patent/CL2016002317A1/es unknown
- 2016-09-21 US US15/272,085 patent/US10669285B2/en active Active
-
2020
- 2020-03-02 US US16/806,302 patent/US20200199155A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017510576A5 (show.php) | ||
| US10654849B2 (en) | (Hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them | |
| KR101862327B1 (ko) | 피리돈 및 아자-피리돈 화합물 및 사용 방법 | |
| JP2011527684A5 (show.php) | ||
| JP2020514267A5 (show.php) | ||
| CA2921880A1 (en) | Alkynyl alcohols and methods of use | |
| RU2018112230A (ru) | Бициклические соединения в качестве ингибиторов atx | |
| JP2020510092A5 (show.php) | ||
| JP2013520407A5 (show.php) | ||
| WO2014078813A1 (en) | Compounds and compositions for the treatment of parasitic diseases | |
| JP2014503544A5 (show.php) | ||
| JP2017535536A5 (show.php) | ||
| JP2019530725A5 (show.php) | ||
| EP3294726A1 (en) | Indazolones as modulators of tnf signaling | |
| JP2014511355A5 (show.php) | ||
| JP2020526549A5 (show.php) | ||
| EP4240363A1 (en) | 7-phenyl substituted 2-aminoquinazoline inhibitors of hpk1 | |
| JP2019537581A5 (show.php) | ||
| JP2013518823A5 (show.php) | ||
| JP2019502680A5 (show.php) | ||
| JPWO2019150119A5 (show.php) | ||
| FR3052451A1 (show.php) | ||
| OA19127A (en) | New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them. | |
| EA037563B1 (ru) | Новые (гетеро)арил-замещенные пиперидинильные производные, способ их получения и фармацевтические композиции, содержащие их | |
| HK40006367A (zh) | 新的(杂)芳基取代的哌啶基衍生物、它们的制备方法和含有它们的药物组合物 |