JP2017509628A5 - - Google Patents
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- JP2017509628A5 JP2017509628A5 JP2016556898A JP2016556898A JP2017509628A5 JP 2017509628 A5 JP2017509628 A5 JP 2017509628A5 JP 2016556898 A JP2016556898 A JP 2016556898A JP 2016556898 A JP2016556898 A JP 2016556898A JP 2017509628 A5 JP2017509628 A5 JP 2017509628A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461950960P | 2014-03-11 | 2014-03-11 | |
| US61/950,960 | 2014-03-11 | ||
| PCT/US2015/019362 WO2015138278A1 (en) | 2014-03-11 | 2015-03-09 | Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020094831A Division JP2020147583A (ja) | 2014-03-11 | 2020-05-29 | リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017509628A JP2017509628A (ja) | 2017-04-06 |
| JP2017509628A5 true JP2017509628A5 (enExample) | 2018-04-05 |
| JP6712230B2 JP6712230B2 (ja) | 2020-06-17 |
Family
ID=52682963
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556898A Active JP6712230B2 (ja) | 2014-03-11 | 2015-03-09 | リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法 |
| JP2020094831A Pending JP2020147583A (ja) | 2014-03-11 | 2020-05-29 | リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020094831A Pending JP2020147583A (ja) | 2014-03-11 | 2020-05-29 | リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US20170065678A1 (enExample) |
| EP (1) | EP3125921B1 (enExample) |
| JP (2) | JP6712230B2 (enExample) |
| WO (1) | WO2015138278A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY34346A (es) | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de fusión para tratar trastornos metabólicos |
| UY34347A (es) | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de función dual para tratar trastornos metabólicos |
| US11365228B2 (en) | 2017-07-06 | 2022-06-21 | Yale University | Mutant FGF21 polypeptide compositions |
| CN111601613A (zh) * | 2017-12-22 | 2020-08-28 | 诺华股份有限公司 | 用fgf21变体治疗代谢障碍的方法 |
| EP3586860A1 (en) * | 2018-06-22 | 2020-01-01 | Universität Ulm | Complement inhibitors and uses thereof |
| CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| CN1678734B (zh) * | 2002-06-27 | 2012-12-12 | 韦尔瓦制药有限公司 | 分化调节试剂及其应用 |
| JP4629047B2 (ja) | 2003-06-12 | 2011-02-09 | イーライ リリー アンド カンパニー | Glp−1アナログ複合タンパク質 |
| PT1641483E (pt) | 2003-06-12 | 2008-04-29 | Lilly Co Eli | Proteínas de fusão |
| CA2544602A1 (en) * | 2003-11-04 | 2005-05-26 | Elixir Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| AU2004303783A1 (en) | 2003-12-10 | 2005-07-07 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| EP1722778A1 (en) * | 2004-01-29 | 2006-11-22 | Applied Research Systems ARS Holding N.V. | Methods and compositions for the treatment of lipodystrophy |
| PL1751184T3 (pl) | 2004-05-13 | 2010-02-26 | Lilly Co Eli | Białka fuzyjne FGF-21 |
| EP3061461A1 (en) | 2004-10-29 | 2016-08-31 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| KR101476472B1 (ko) | 2007-03-30 | 2015-01-05 | 암브룩스, 인코포레이티드 | 변형된 fgf-21 폴리펩티드 및 그 용도 |
| US20110034373A1 (en) | 2007-08-03 | 2011-02-10 | Eli Lilly And Company | Use of an fgf-21 compound and a glp-1 compound for the treatment of obesity |
| US20110015345A1 (en) | 2008-03-19 | 2011-01-20 | Ambrx, Inc. | Modified FGF-23 Polypeptides and Their Uses |
| MX2010013333A (es) | 2008-06-04 | 2011-04-05 | Amgen Inc | Mutantes fgf21 y usos de los mismos. |
| EA032727B1 (ru) | 2008-10-10 | 2019-07-31 | Амген Инк. | Мутантный резистентный к протеолизу полипептид fgf21 и его применение |
| KR20110117666A (ko) | 2009-01-23 | 2011-10-27 | 노보 노르디스크 에이/에스 | 알부민 바인더 a-b-c-d-e-를 갖는 fgf21 유도체 및 그것의 사용 |
| WO2011089170A2 (en) | 2010-01-22 | 2011-07-28 | Novo Nordisk A/S | Process for preparing fgf-21 with low degree of o-glycosylation |
| TWI560197B (en) | 2009-05-05 | 2016-12-01 | Amgen Inc | Fgf21 mutants and uses thereof |
| US20120052069A1 (en) | 2009-05-05 | 2012-03-01 | Amgen Inc | Fgf21 mutants and uses thereof |
| WO2011154349A2 (en) | 2010-06-08 | 2011-12-15 | Novo Nordisk A/S | Fgf21 analogues and derivatives |
| CN102656266B (zh) | 2009-10-15 | 2016-08-03 | 霍夫曼-拉罗奇有限公司 | 具有改变的受体特异性的嵌合成纤维细胞生长因子 |
| UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
| EP2359843A1 (en) | 2010-01-21 | 2011-08-24 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
| JP2013523184A (ja) | 2010-04-15 | 2013-06-17 | アムジエン・インコーポレーテツド | ヒトFGF受容体およびβ−KLOTHO結合性タンパク質 |
| EP2595647A1 (en) | 2010-07-20 | 2013-05-29 | Novo Nordisk A/S | N-terminal modified fgf21 compounds |
| EP2619226B1 (en) | 2010-09-22 | 2018-09-12 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
| WO2012059873A2 (en) | 2010-11-05 | 2012-05-10 | Covx Technologies Ireland, Ltd. | Anti-diabetic compounds |
| US9023791B2 (en) * | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
| EP2392927A1 (en) * | 2011-03-11 | 2011-12-07 | F. Hoffmann-La Roche AG | Diagnosis of metabolic disorders in HIV infected patients |
| US20140294820A1 (en) | 2011-06-24 | 2014-10-02 | University Of Miami | Fibroblast growth factor receptor inhibition for the treatment of disease |
| WO2013006486A2 (en) | 2011-07-01 | 2013-01-10 | Ngm Biopharmaceuticals, Inc. | Compositions, uses and methods for treatment of metabolic disorders and diseases |
| EP2548570A1 (en) | 2011-07-19 | 2013-01-23 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
| EP2750695A2 (en) * | 2011-08-31 | 2014-07-09 | Amgen Inc. | Method of treating or ameliorating type 1 diabetes using fgf21 |
| UY34346A (es) | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de fusión para tratar trastornos metabólicos |
| UY34347A (es) * | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de función dual para tratar trastornos metabólicos |
| AR087973A1 (es) * | 2011-10-04 | 2014-04-30 | Lilly Co Eli | Variantes del factor 21 del crecimiento de fibroblastos |
| TWI513705B (zh) | 2012-06-11 | 2015-12-21 | Lilly Co Eli | 纖維母細胞生長因子21蛋白質 |
| AR092076A1 (es) | 2012-08-22 | 2015-03-18 | Lilly Co Eli | Proteinas homodimericas |
| CA2880929A1 (en) | 2012-09-07 | 2014-03-13 | Sanofi | Fusion proteins for treating a metabolic syndrome |
| WO2014085365A2 (en) | 2012-11-28 | 2014-06-05 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
| IL292303A (en) | 2012-12-27 | 2022-06-01 | Ngm Biopharmaceuticals Inc | Methods for modulating bile acid homeostatsis and treatment of bile acid disorders and disease |
| WO2014149699A1 (en) | 2013-03-15 | 2014-09-25 | Eli Lilly And Company | Bifunctional protein |
| WO2015148708A1 (en) | 2014-03-25 | 2015-10-01 | Regeneron Pharmaceuticals, Inc. | Fgf21 receptor agonists and uses thereof |
| WO2015183890A2 (en) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders and diseases |
| WO2015195509A2 (en) | 2014-06-16 | 2015-12-23 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| WO2016048999A2 (en) | 2014-09-23 | 2016-03-31 | Salk Institute For Biological Studies | Fgf21 truncations and mutants and uses thereof |
| BR112017008157A2 (pt) | 2014-10-24 | 2017-12-19 | Bristol Myers Squibb Co | polipeptídeos de fgf-21 modificados e usos dos mesmos |
-
2015
- 2015-03-09 EP EP15710087.6A patent/EP3125921B1/en active Active
- 2015-03-09 WO PCT/US2015/019362 patent/WO2015138278A1/en not_active Ceased
- 2015-03-09 US US15/124,877 patent/US20170065678A1/en not_active Abandoned
- 2015-03-09 JP JP2016556898A patent/JP6712230B2/ja active Active
-
2019
- 2019-05-09 US US16/407,813 patent/US11963999B2/en active Active
-
2020
- 2020-05-29 JP JP2020094831A patent/JP2020147583A/ja active Pending
-
2024
- 2024-03-19 US US18/609,420 patent/US20240293508A1/en active Pending
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